JP2020511155A5 - - Google Patents

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JP2020511155A5
JP2020511155A5 JP2019552274A JP2019552274A JP2020511155A5 JP 2020511155 A5 JP2020511155 A5 JP 2020511155A5 JP 2019552274 A JP2019552274 A JP 2019552274A JP 2019552274 A JP2019552274 A JP 2019552274A JP 2020511155 A5 JP2020511155 A5 JP 2020511155A5
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compound
pharmaceutically acceptable
wing segment
compound according
modified oligonucleotide
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JP2019552274A
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JP2020511155A (ja
JP7022143B2 (ja
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Priority claimed from PCT/US2018/023936 external-priority patent/WO2018175839A1/en
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Priority to JP2021208929A priority Critical patent/JP7289347B2/ja
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JP2019552274A 2017-03-24 2018-03-23 Ｐｃｓｋ９発現のモジュレーター Active JP7022143B2 (ja)

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JP2021208929A JP7289347B2 (ja) 2017-03-24 2021-12-23 Ｐｃｓｋ９発現のモジュレーター

Applications Claiming Priority (3)

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US201762476051P 2017-03-24 2017-03-24
US62/476,051 2017-03-24
PCT/US2018/023936 WO2018175839A1 (en) 2017-03-24 2018-03-23 Modulators of pcsk9 expression

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JP2021208929A Division JP7289347B2 (ja) 2017-03-24 2021-12-23 Ｐｃｓｋ９発現のモジュレーター

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JP2020511155A JP2020511155A (ja) 2020-04-16
JP2020511155A5 true JP2020511155A5 (es) 2021-12-09
JP7022143B2 JP7022143B2 (ja) 2022-02-17

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JP2019552274A Active JP7022143B2 (ja) 2017-03-24 2018-03-23 Ｐｃｓｋ９発現のモジュレーター
JP2021208929A Active JP7289347B2 (ja) 2017-03-24 2021-12-23 Ｐｃｓｋ９発現のモジュレーター
JP2023088955A Pending JP2023109989A (ja) 2017-03-24 2023-05-30 Ｐｃｓｋ９発現のモジュレーター

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JP2023088955A Pending JP2023109989A (ja) 2017-03-24 2023-05-30 Ｐｃｓｋ９発現のモジュレーター

Country Status (27)

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US (4) US10517953B2 (es)
EP (2) EP4309732A3 (es)
JP (3) JP7022143B2 (es)
KR (1) KR102645714B1 (es)
CN (1) CN110446784A (es)
AR (1) AR113214A1 (es)
AU (2) AU2018237306B2 (es)
BR (1) BR112019015041A2 (es)
CA (1) CA3056129A1 (es)
CL (2) CL2019002574A1 (es)
CO (1) CO2019011265A2 (es)
CR (1) CR20190471A (es)
DO (1) DOP2019000232A (es)
EA (1) EA201992170A1 (es)
EC (1) ECSP19072372A (es)
IL (2) IL269273A (es)
JO (1) JOP20190215A1 (es)
MX (1) MX2019010699A (es)
MY (1) MY194227A (es)
NI (1) NI201900096A (es)
NZ (1) NZ758177A (es)
PE (1) PE20191484A1 (es)
PH (1) PH12019502174A1 (es)
SG (1) SG11201908393YA (es)
TW (2) TW202325310A (es)
UA (1) UA127390C2 (es)
WO (1) WO2018175839A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018216785A1 (ja) * 2017-05-26 2018-11-29 国立研究開発法人国立循環器病研究センター Ｐｃｓｋ９を標的としたアンチセンス核酸
US20230357768A1 (en) * 2020-09-17 2023-11-09 Astrazeneca Ab Pharmaceutical compositions comprising an antisense oligonucleotide for oral administration
US20230355653A1 (en) 2020-09-17 2023-11-09 Astrazeneca Ab Pcsk9 inhibitors and methods of treatment using same
WO2022089486A1 (zh) * 2020-10-28 2022-05-05 江苏柯菲平医药股份有限公司 抑制PCSK9基因表达的siRNA及其修饰物与应用
BR112023021766A2 (pt) 2021-04-22 2024-01-23 Civi Biopharma Inc Dispensação oral de oligonucleotídeo

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US11603532B2 (en) 2017-06-02 2023-03-14 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof

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