JP2020505942A5 - - Google Patents
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- Publication number
- JP2020505942A5 JP2020505942A5 JP2019543213A JP2019543213A JP2020505942A5 JP 2020505942 A5 JP2020505942 A5 JP 2020505942A5 JP 2019543213 A JP2019543213 A JP 2019543213A JP 2019543213 A JP2019543213 A JP 2019543213A JP 2020505942 A5 JP2020505942 A5 JP 2020505942A5
- Authority
- JP
- Japan
- Prior art keywords
- engineered
- amino acid
- composition
- polypeptide
- phenylalanine ammonia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims description 69
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 69
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 69
- 239000000203 mixture Substances 0.000 claims description 50
- 108700023158 Phenylalanine ammonia-lyases Proteins 0.000 claims description 49
- 150000001413 amino acids Chemical group 0.000 claims description 42
- 238000006467 substitution reaction Methods 0.000 claims description 30
- 239000008280 blood Substances 0.000 claims description 16
- 210000004369 blood Anatomy 0.000 claims description 16
- 108091033319 polynucleotide Proteins 0.000 claims description 16
- 102000040430 polynucleotide Human genes 0.000 claims description 16
- 239000002157 polynucleotide Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- 241000078013 Trichormus variabilis Species 0.000 claims description 12
- 201000011252 Phenylketonuria Diseases 0.000 claims description 11
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 10
- 239000013604 expression vector Substances 0.000 claims description 10
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- 230000017854 proteolysis Effects 0.000 claims description 6
- 201000011296 tyrosinemia Diseases 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 230000037213 diet Effects 0.000 claims description 4
- 235000005911 diet Nutrition 0.000 claims description 4
- 229940088598 enzyme Drugs 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 239000007897 gelcap Substances 0.000 claims description 4
- 238000001415 gene therapy Methods 0.000 claims description 4
- 108020004999 messenger RNA Proteins 0.000 claims description 4
- 239000006187 pill Substances 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 2
- 102000005367 Carboxypeptidases Human genes 0.000 claims description 2
- 108010006303 Carboxypeptidases Proteins 0.000 claims description 2
- 108090000317 Chymotrypsin Proteins 0.000 claims description 2
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- 108010067372 Pancreatic elastase Proteins 0.000 claims description 2
- 102000016387 Pancreatic elastase Human genes 0.000 claims description 2
- 108090000631 Trypsin Proteins 0.000 claims description 2
- 102000004142 Trypsin Human genes 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 230000001668 ameliorated effect Effects 0.000 claims description 2
- 229960002376 chymotrypsin Drugs 0.000 claims description 2
- 229930016911 cinnamic acid Natural products 0.000 claims description 2
- 235000013985 cinnamic acid Nutrition 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 239000002702 enteric coating Substances 0.000 claims description 2
- 238000009505 enteric coating Methods 0.000 claims description 2
- 230000002496 gastric effect Effects 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 239000012588 trypsin Substances 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022080791A JP2022103296A (ja) | 2017-02-13 | 2022-05-17 | フェニルアラニンアンモニアリアーゼポリペプチド |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762458232P | 2017-02-13 | 2017-02-13 | |
| US62/458,232 | 2017-02-13 | ||
| US201762565555P | 2017-09-29 | 2017-09-29 | |
| US62/565,555 | 2017-09-29 | ||
| PCT/US2018/017773 WO2018148633A1 (en) | 2017-02-13 | 2018-02-12 | Engineered phenylalanine ammonia lyase polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080791A Division JP2022103296A (ja) | 2017-02-13 | 2022-05-17 | フェニルアラニンアンモニアリアーゼポリペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020505942A JP2020505942A (ja) | 2020-02-27 |
| JP2020505942A5 true JP2020505942A5 (enExample) | 2021-03-18 |
Family
ID=63106144
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019543213A Pending JP2020505942A (ja) | 2017-02-13 | 2018-02-12 | フェニルアラニンアンモニアリアーゼポリペプチド |
| JP2022080791A Pending JP2022103296A (ja) | 2017-02-13 | 2022-05-17 | フェニルアラニンアンモニアリアーゼポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080791A Pending JP2022103296A (ja) | 2017-02-13 | 2022-05-17 | フェニルアラニンアンモニアリアーゼポリペプチド |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10995329B2 (enExample) |
| EP (1) | EP3579867A4 (enExample) |
| JP (2) | JP2020505942A (enExample) |
| KR (1) | KR102573324B1 (enExample) |
| CN (1) | CN110573175A (enExample) |
| AU (1) | AU2018217495B2 (enExample) |
| BR (1) | BR112019016634A2 (enExample) |
| CA (1) | CA3051262A1 (enExample) |
| IL (1) | IL268226A (enExample) |
| MX (1) | MX2019009615A (enExample) |
| MY (1) | MY196740A (enExample) |
| NZ (1) | NZ755628A (enExample) |
| PH (1) | PH12019501705A1 (enExample) |
| SG (1) | SG11201906880VA (enExample) |
| WO (1) | WO2018148633A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3807409A4 (en) | 2018-06-12 | 2022-08-03 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| WO2021168060A1 (en) * | 2020-02-19 | 2021-08-26 | Trustees Of Tufts College | Methods for engineering amino acid ammonia lyase enzymes and enzymes thereby obtained |
| CN112355034B (zh) * | 2020-11-17 | 2021-08-06 | 同济大学 | 基于水热钙离子调配的有机固体废弃物无害化预处理方法 |
| CN115518691B (zh) * | 2022-10-14 | 2023-11-21 | 天津大学 | 一种具有类漆酶活性的人工酶及制备方法和应用 |
| AU2024289192A1 (en) | 2023-07-06 | 2026-01-08 | Perseo Pharma Ag | Method for immobilization of proteins |
| EP4739349A1 (en) | 2023-07-06 | 2026-05-13 | Perseo Pharma AG | Functionalized compositions comprising an engineered phenylalanine ammonia lyase (pal) |
| WO2026163257A1 (en) | 2025-01-29 | 2026-08-06 | Dr. Schär S.P.A. | Microorganism, production method and use for the treatment of phenylketonuria |
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-
2018
- 2018-02-12 AU AU2018217495A patent/AU2018217495B2/en not_active Ceased
- 2018-02-12 KR KR1020197025645A patent/KR102573324B1/ko active Active
- 2018-02-12 NZ NZ755628A patent/NZ755628A/en not_active IP Right Cessation
- 2018-02-12 JP JP2019543213A patent/JP2020505942A/ja active Pending
- 2018-02-12 CN CN201880025923.9A patent/CN110573175A/zh active Pending
- 2018-02-12 CA CA3051262A patent/CA3051262A1/en active Pending
- 2018-02-12 MX MX2019009615A patent/MX2019009615A/es unknown
- 2018-02-12 WO PCT/US2018/017773 patent/WO2018148633A1/en not_active Ceased
- 2018-02-12 MY MYPI2019004314A patent/MY196740A/en unknown
- 2018-02-12 EP EP18750620.9A patent/EP3579867A4/en not_active Withdrawn
- 2018-02-12 US US15/894,446 patent/US10995329B2/en not_active Expired - Fee Related
- 2018-02-12 SG SG11201906880VA patent/SG11201906880VA/en unknown
- 2018-02-12 BR BR112019016634A patent/BR112019016634A2/pt not_active Application Discontinuation
-
2019
- 2019-07-23 IL IL268226A patent/IL268226A/en unknown
- 2019-07-24 PH PH12019501705A patent/PH12019501705A1/en unknown
-
2021
- 2021-03-31 US US17/219,494 patent/US20210222145A1/en not_active Abandoned
-
2022
- 2022-05-17 JP JP2022080791A patent/JP2022103296A/ja active Pending
-
2023
- 2023-01-13 US US18/154,475 patent/US20230295599A1/en not_active Abandoned
- 2023-01-13 US US18/154,388 patent/US20230295598A1/en not_active Abandoned
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