AU2018217495B2 - Engineered phenylalanine ammonia lyase polypeptides - Google Patents

Engineered phenylalanine ammonia lyase polypeptides Download PDF

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Publication number
AU2018217495B2
AU2018217495B2 AU2018217495A AU2018217495A AU2018217495B2 AU 2018217495 B2 AU2018217495 B2 AU 2018217495B2 AU 2018217495 A AU2018217495 A AU 2018217495A AU 2018217495 A AU2018217495 A AU 2018217495A AU 2018217495 B2 AU2018217495 B2 AU 2018217495B2
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AU
Australia
Prior art keywords
amino acid
pal
seq
engineered
polypeptide
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Ceased
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AU2018217495A
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AU2018217495A1 (en
Inventor
Nicholas J. Agard
Oscar Alvizo
Chinping CHNG
Nikki DELLAS
William Casey Hallows
Gjalt W. Huisman
John Joseph Nicols
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Codexis Inc
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Codexis Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01024—Phenylalanine ammonia-lyase (4.3.1.24)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Dermatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
AU2018217495A 2017-02-13 2018-02-12 Engineered phenylalanine ammonia lyase polypeptides Ceased AU2018217495B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762458232P 2017-02-13 2017-02-13
US62/458,232 2017-02-13
US201762565555P 2017-09-29 2017-09-29
US62/565,555 2017-09-29
PCT/US2018/017773 WO2018148633A1 (en) 2017-02-13 2018-02-12 Engineered phenylalanine ammonia lyase polypeptides

Publications (2)

Publication Number Publication Date
AU2018217495A1 AU2018217495A1 (en) 2019-08-08
AU2018217495B2 true AU2018217495B2 (en) 2021-03-04

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AU2018217495A Ceased AU2018217495B2 (en) 2017-02-13 2018-02-12 Engineered phenylalanine ammonia lyase polypeptides

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US (4) US10995329B2 (enExample)
EP (1) EP3579867A4 (enExample)
JP (2) JP2020505942A (enExample)
KR (1) KR102573324B1 (enExample)
CN (1) CN110573175A (enExample)
AU (1) AU2018217495B2 (enExample)
BR (1) BR112019016634A2 (enExample)
CA (1) CA3051262A1 (enExample)
IL (1) IL268226A (enExample)
MX (1) MX2019009615A (enExample)
MY (1) MY196740A (enExample)
NZ (1) NZ755628A (enExample)
PH (1) PH12019501705A1 (enExample)
SG (1) SG11201906880VA (enExample)
WO (1) WO2018148633A1 (enExample)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
EP3807409A4 (en) 2018-06-12 2022-08-03 Codexis, Inc. Engineered tyrosine ammonia lyase
WO2021168060A1 (en) * 2020-02-19 2021-08-26 Trustees Of Tufts College Methods for engineering amino acid ammonia lyase enzymes and enzymes thereby obtained
CN112355034B (zh) * 2020-11-17 2021-08-06 同济大学 基于水热钙离子调配的有机固体废弃物无害化预处理方法
CN115518691B (zh) * 2022-10-14 2023-11-21 天津大学 一种具有类漆酶活性的人工酶及制备方法和应用
AU2024289192A1 (en) 2023-07-06 2026-01-08 Perseo Pharma Ag Method for immobilization of proteins
EP4739349A1 (en) 2023-07-06 2026-05-13 Perseo Pharma AG Functionalized compositions comprising an engineered phenylalanine ammonia lyase (pal)
WO2026163257A1 (en) 2025-01-29 2026-08-06 Dr. Schär S.P.A. Microorganism, production method and use for the treatment of phenylketonuria

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20140314843A1 (en) * 2013-04-18 2014-10-23 Codexis, Inc. Engineered phenylalanine ammonia lyase polypeptides

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Also Published As

Publication number Publication date
US20210222145A1 (en) 2021-07-22
EP3579867A4 (en) 2021-03-10
KR102573324B1 (ko) 2023-08-30
CN110573175A (zh) 2019-12-13
IL268226A (en) 2019-09-26
EP3579867A1 (en) 2019-12-18
KR20190117577A (ko) 2019-10-16
SG11201906880VA (en) 2019-08-27
CA3051262A1 (en) 2018-08-16
MX2019009615A (es) 2019-10-14
JP2022103296A (ja) 2022-07-07
US20180230448A1 (en) 2018-08-16
WO2018148633A1 (en) 2018-08-16
MY196740A (en) 2023-05-03
NZ755628A (en) 2023-09-29
AU2018217495A1 (en) 2019-08-08
US10995329B2 (en) 2021-05-04
PH12019501705A1 (en) 2020-07-06
BR112019016634A2 (pt) 2020-04-07
US20230295598A1 (en) 2023-09-21
US20230295599A1 (en) 2023-09-21
JP2020505942A (ja) 2020-02-27

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