JP2020504292A - 液体アッセイの複数順次波長測定 - Google Patents
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Abstract
Description
本特許出願は、2016年9月18日に出願された「MULTIPLE SEQUENTIAL WAVELENGTH MEASUREMENT OF A LIQUID ASSAY」という名称の米国特許仮出願第62/424,110号の優先権を主張し、同仮出願を参照により組み入れる。
Claims (21)
- 分析器であって:
液体試験試料・試薬混合物を含む試験カートリッジを受けるようにサイズ設定され構成された試験カートリッジスペースを取り囲むハウジングと;
該ハウジングによって支持され、試験カートリッジスペースを通過する光の第1のビームを生成する第1の光源であって、光の第1のビームは第1の波長範囲内の第1の波長を有する、第1の光源と;
ハウジングによって支持され、試験カートリッジスペースを通過する光の第2のビームを生成する第2の光源であって、光の第2のビームは第1の波長範囲と異なる第2の波長範囲内の第2の波長を有する、第2の光源と;
ハウジングによって支持され、第1および光の第2のビームを第1および光の第2のビームが試験カートリッジスペースを通過した後に受けるように位置する試料検出器と;
コンピュータシステムであって:
第1の時点に試料検出器によって捕捉された光を示す第1の信号、および第1の時点と異なる第2の時点に試料検出器によって捕捉された放射を示す第2の信号を受けるように、かつ第1の信号および第2の信号を使用して液体試験試料・試薬混合物中の分析物の量を決定するように構成されたプロセッサ
を有するコンピュータシステムとを含む、前記分析器。 - 第1の波長範囲は580nmから660nmまでである、請求項1に記載の分析器。
- 第2の波長範囲は660nmから790nmまでである、請求項1または2のいずれか1項に記載の分析器。
- 第2の波長範囲は700nmから740nmまでである、請求項1または2のいずれか1項に記載の分析器。
- ハウジングによって支持され、試験カートリッジスペースを通過する光の第3のビームを生成する第3の光源であって、光の第3のビームは第1および第2の波長範囲と異なる第3の波長範囲を有する、第3の光源をさらに含む、請求項1〜4のいずれか1項に記載の分析器。
- 第3の波長範囲は480nmから580nmまでである、請求項5に記載の分析器。
- 第1の光源および第2の光源は、光の第1のビームおよび光の第2のビームを生成し出力する能力を有する単一の光源である、請求項1〜6のいずれか1項に記載の分析器。
- 第1の光源と第2の光源が分離している、請求項1〜6のいずれか1項に記載の分析器。
- 第1の波長範囲は480nmから580nmである、請求項1、3〜5および7〜8のいずれか1項に記載の分析器。
- 方法であって:
液体アッセイの複数の吸収読み取り値を光検出器によって、少なくとも2つの別個で独立した波長範囲内のそれぞれの第1および第2の波長を有する複数の光源を使用して得ることであって、吸収読み取り値のそれぞれは別個の時点に取得されること;
少なくとも1つのプロセッサおよび液体アッセイの較正情報を使用して、液体アッセイ中の少なくとも1つの分析物の量を、複数の吸収読み取り値を用いて決定することを含む、前記方法。 - 液体アッセイの複数の吸収読み取り値を得る前に、液体アッセイを動かして液体アッセイ中の試薬を液体試験試料と混合することをさらに含む、請求項10に記載の方法。
- 対象の少なくとも1つの分析物はヘモグロビンである、請求項10〜11のいずれか1項に記載の方法。
- 対象の少なくとも1つの分析物はヘモグロビンA1cである、請求項10〜11のいずれか1項に記載の方法。
- 対象の少なくとも1つの分析物はアルブミンを含む、請求項10〜11のいずれか1項に記載の方法。
- 対象の少なくとも1つの分析物はクレアチニンを含む、請求項10〜11のいずれか1項に記載の方法。
- 複数の光源は、第1の波長範囲内の第1の波長および第2の波長範囲内の第2の波長を生成および出力する能力を有する単一の光源であり、第1および第2の波長範囲は2つの別個で独立した波長範囲である、請求項10〜15のいずれか1項に記載の方法。
- 複数の光源は分離している、請求項10〜15のいずれか1項に記載の方法。
- 方法であって:
複数の光源を光源スペース内に取り付けることを含み、光源の一方は、第1の波長範囲内の第1の光の波長を生成および出力する第1の能力を有し、光源のもう一方は、第2の波長範囲内の第2の光の波長を生成および出力する第2の能力を有し、ここで、第1および第2の波長範囲は別個で独立している波長範囲であり、光源は、光源で生成された光ビームが、液体アッセイを含む試験カートリッジを受けるようにサイズ設定され寸法設定された試験カートリッジスペース内を通過するように取り付けられ;さらに、
試料光検出器を試料光検出器スペース内に、試料光検出器が光源によって生成された光の少なくとも一部分を、光ビームが試験カートリッジスペース内を通過した後に受けるべく構成されるように取り付けること;および、
光源および試料光検出器を、コンピュータ実行可能な論理を有する主プロセッサに連結することを含み、この論理は、主プロセッサによって実行されると、主プロセッサに、試料光検出器によって液体アッセイの複数の吸収読み取り値を取得させ、それぞれの吸収読み取り値は別個の時点に取得され、液体アッセイ中の少なくとも1つの分析物の量を、液体アッセイの較正情報および複数の吸収読み取り値を使用して決定させる、前記方法。 - 主プロセッサはコンピュータ実行可能な論理を有し、この論理は、主プロセッサによって実行されると、主プロセッサに、液体アッセイの複数の吸収読み取り値を得る前に、液体アッセイを動かして液体アッセイ中の試薬を液体試験試料と混合させる、請求項18に記載の方法。
- 複数の光源は、2つの別個で独立した波長範囲を生成および出力する能力を有する単一の光源である、請求項18〜19のいずれか1項に記載の方法。
- 複数の光源は分離している、請求項18〜19のいずれか1項に記載の方法。
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JP6836522B2 (ja) * | 2018-01-26 | 2021-03-03 | 株式会社日立ハイテク | 自動分析装置、及び自動分析装置の制御方法 |
WO2020159599A1 (en) * | 2019-01-29 | 2020-08-06 | Siemens Healthcare Diagnostics Inc. | TURBIDITY NORMALIZATION ALGORITHM AND METHODS OF REDUCING INTRALIPID/LIPEMIA INTERFERENCE IN HEMOGLOBIN A1c ASSAYS |
JP7462043B2 (ja) * | 2019-11-22 | 2024-04-04 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 凝集体を含む液体を移送する装置、システム、および方法 |
CN115165744B (zh) * | 2022-07-05 | 2023-06-30 | 上海太阳生物技术有限公司 | 一种凝血分析仪测试方法、装置、设备和系统 |
CN117717334A (zh) * | 2024-02-07 | 2024-03-19 | 荣耀终端有限公司 | 数据获取方法及电子设备 |
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WO2018093573A1 (en) | 2018-05-24 |
JP2022043109A (ja) | 2022-03-15 |
EP3542146A4 (en) | 2019-10-30 |
MX2019005697A (es) | 2020-02-07 |
CN110192097A (zh) | 2019-08-30 |
EP3542146A1 (en) | 2019-09-25 |
CN110192097B (zh) | 2023-02-07 |
CA3044226C (en) | 2022-07-12 |
CA3044226A1 (en) | 2018-05-24 |
JP7228512B2 (ja) | 2023-02-24 |
US20190346364A1 (en) | 2019-11-14 |
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