JP7228512B2 - 液体アッセイの複数順次波長測定 - Google Patents
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Description
本特許出願は、2016年9月18日に出願された「MULTIPLE SEQUENTIAL WAVELENGTH MEASUREMENT OF A LIQUID ASSAY」という名称の米国特許仮出願第62/424,110号の優先権を主張し、同仮出願を参照により組み入れる。
Claims (10)
- 分析器であって:
ヘモグロビンを含む液体試験試料・試薬混合物を含む試験カートリッジを受けるようにサイズ設定され構成された試験カートリッジスペースを取り囲むハウジングと;
該ハウジングによって支持され、試験カートリッジスペースを通過する光の第1のビームを生成する第1の光源であって、光の第1のビームは、ヘモグロビンの吸収スペクトルの第1の局所的なピークに対応する第1の波長範囲内の第1の波長を有する、第1の光源と;
ハウジングによって支持され、試験カートリッジスペースを通過する光の第2のビームを生成する別個の第2の光源であって、光の第2のビームは、第1の波長範囲より高く、ヘモグロビンの吸収スペクトルの第2の局所的なピークに対応する第2の波長範囲内の第2の波長を有する、第2の光源と;
ハウジングによって支持され、第1および光の第2のビームを第1および光の第2のビームが試験カートリッジスペースを通過した後に受けるように位置する試料光検出器と;
コンピュータシステムであって:
第1の時点に試料光検出器によって捕捉された光を示す第1の信号、および第1の時点と異なる第2の時点に試料光検出器によって捕捉された放射を示す第2の信号を受けるように、かつ第1の信号および第2の信号を組み合わせて使用して液体試験試料・試薬混合物中のヘモグロビンの量を決定するように構成されたプロセッサを有するコンピュータシステムとを含み、
ここで、第1の波長範囲は、480nmから580nmであり、第2の波長範囲が580nmから660nmであり、
第1および/または第2の光源から発せられる光は、ヘモグロビンを含む液体試験試料・試薬混合物を含む試験カートリッジを通過し、試料光検出器で受け取られる試料ビームと試験カートリッジを回避し、参照光検出器で受け取られる参照ビームとに分割される、前記分析器。 - ハウジングによって支持され、試験カートリッジスペースを通過する光の第3のビーム
を生成する第3の光源であって、光の第3のビームは第1および第2の波長範囲と異なる第3の波長範囲を有する、第3の光源をさらに含む、請求項1に記載の分析器。 - 第3の波長範囲は660nmから780nmまでである、請求項2に記載の分析器。
- 方法であって:
対象の少なくとも1つの分析物を含む液体アッセイの複数の吸収読み取り値を試料光検出器によって、少なくとも2つの別個で独立した波長範囲、第1の波長範囲及び第2の波長範囲、内のそれぞれの第1および第2の波長を有する複数の別個の光源を使用して得ることであって、吸収読み取り値のそれぞれは別個の時点に取得されること;
少なくとも1つのプロセッサおよび試験カートリッジに対する較正パラメータ値を使用して、液体アッセイ中の対象の少なくとも1つの分析物の量を、複数の吸収読み取り値と試験カートリッジに対する較正パラメータ値とを組み合わせて用いて決定することを含み、
ここで、対象の少なくとも1つの分析物の1つはヘモグロビンであって、ヘモグロビンの吸収スペクトルの第1の局所的なピークに対応する第1の波長範囲は480nmから580nmであり、そして、ヘモグロビンの吸収スペクトルの第2の局所的なピークに対応する第2の波長範囲は580nmから660nmであり、
複数の別個の光源から発せられる光は、液体アッセイを含む試験カートリッジを通過し、試料光検出器で受け取られる試料ビームと試験カートリッジを回避し、参照光検出器で受け取られる参照ビームとに分割される、前記方法。 - 液体アッセイの複数の吸収読み取り値を得る前に、液体アッセイを動かして液体アッセイ中の試薬を液体試験試料と混合することをさらに含む、請求項4に記載の方法。
- 対象の少なくとも1つの分析物はさらにアルブミンを含む、請求項4または5のいずれか1項に記載の方法。
- 対象の少なくとも1つの分析物はさらにクレアチニンを含む、請求項4または5のいずれか1項に記載の方法。
- 複数の光源は分離している、請求項4~7のいずれか1項に記載の方法。
- 方法であって:
複数の光源を光源スペース内に取り付けることを含み、光源の一方は、第1の波長範囲内の第1の光の波長を生成および出力する第1の能力を有し、もう一方の別個の光源は、第2の波長範囲内の第2の光の波長を生成および出力する第2の能力を有し、ここで、第1および第2の波長範囲は別個で独立している波長範囲であり、そして、第2の波長範囲は第1の波長範囲より高く、光源は、光源で生成された光ビームが、液体アッセイを含む試験カートリッジを受けるようにサイズ設定され寸法設定された試験カートリッジスペース内を通過するように取り付けられ;
試料光検出器を試料検出器スペース内に、試料光検出器が光源によって生成された光の少なくとも一部分を、光ビームが試験カートリッジスペース内を通過した後に受けるべく構成されるように取り付けられ;
試験カートリッジに対する較正パラメータ値を得て;そして
光源および試料光検出器を、コンピュータ実行可能な論理を有する主プロセッサに連結することを含み、この論理は、主プロセッサによって実行されると、主プロセッサに、各光源が出力し試料光検出器によって受け取られる波長から液体アッセイの複数の吸収読み取り値を取得させ、それぞれの吸収読み取り値は別個の時点に取得され、液体アッセイ中の少なくとも1つの分析物の量を、試験カートリッジに対する較正パラメータ値と複数の
吸収読み取り値とを組み合わせて使用して決定させることを含み、
ここで、少なくとも1つの分析物はヘモグロビンを含み、そして、ヘモグロビンの吸収スペクトルの第1の局所的なピークに対応する第1の波長範囲は480nmから580nmであり、ヘモグロビンの吸収スペクトルの第2の局所的なピークに対応する第2の波長範囲が580nmから660nmであり、
複数の光源から発せられる光は、液体アッセイを含む試験カートリッジを通過し、試料光検出器で受け取られる試料ビームと試験カートリッジを回避し、参照光検出器で受け取られる参照ビームとに分割される、前記方法。 - 主プロセッサはコンピュータ実行可能な論理を有し、この論理は、主プロセッサによって実行されると、主プロセッサに、液体アッセイの複数の吸収読み取り値を得る前に、液体アッセイを動かして液体アッセイ中の試薬を液体試験試料と混合させる、請求項9に記載の方法。
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