JP2020503856A5 - - Google Patents
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- JP2020503856A5 JP2020503856A5 JP2019531088A JP2019531088A JP2020503856A5 JP 2020503856 A5 JP2020503856 A5 JP 2020503856A5 JP 2019531088 A JP2019531088 A JP 2019531088A JP 2019531088 A JP2019531088 A JP 2019531088A JP 2020503856 A5 JP2020503856 A5 JP 2020503856A5
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- reaction mixture
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- 239000000523 sample Substances 0.000 claims 53
- 239000003054 catalyst Substances 0.000 claims 37
- 239000011541 reaction mixture Substances 0.000 claims 30
- 108091028732 Concatemer Proteins 0.000 claims 25
- 230000000295 complement effect Effects 0.000 claims 22
- 238000000034 method Methods 0.000 claims 20
- 230000003197 catalytic effect Effects 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 8
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 8
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 8
- 238000003384 imaging method Methods 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 4
- 229930024421 Adenine Natural products 0.000 claims 4
- 229960000643 adenine Drugs 0.000 claims 4
- 229940104302 cytosine Drugs 0.000 claims 4
- 229940113082 thymine Drugs 0.000 claims 4
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 3
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 238000006116 polymerization reaction Methods 0.000 claims 3
- HDAVJPSXEPLOMF-UHFFFAOYSA-N 3-(9h-carbazol-3-yl)prop-2-enenitrile Chemical compound C1=CC=C2C3=CC(C=CC#N)=CC=C3NC2=C1 HDAVJPSXEPLOMF-UHFFFAOYSA-N 0.000 claims 2
- 230000006154 adenylylation Effects 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- LCCNCVORNKJIRZ-UHFFFAOYSA-N parathion Chemical compound CCOP(=S)(OCC)OC1=CC=C([N+]([O-])=O)C=C1 LCCNCVORNKJIRZ-UHFFFAOYSA-N 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762444734P | 2017-01-10 | 2017-01-10 | |
| US62/444,734 | 2017-01-10 | ||
| US201762546418P | 2017-08-16 | 2017-08-16 | |
| US62/546,418 | 2017-08-16 | ||
| US201762546836P | 2017-08-17 | 2017-08-17 | |
| US62/546,836 | 2017-08-17 | ||
| PCT/US2018/013019 WO2018132392A2 (en) | 2017-01-10 | 2018-01-09 | Multiplexed signal amplification |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020503856A JP2020503856A (ja) | 2020-02-06 |
| JP2020503856A5 true JP2020503856A5 (enExample) | 2021-02-25 |
| JP7116062B2 JP7116062B2 (ja) | 2022-08-09 |
Family
ID=62840238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531088A Active JP7116062B2 (ja) | 2017-01-10 | 2018-01-09 | 多重化シグナル増幅 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11492661B2 (enExample) |
| EP (1) | EP3568492B1 (enExample) |
| JP (1) | JP7116062B2 (enExample) |
| CN (1) | CN110168101A (enExample) |
| WO (1) | WO2018132392A2 (enExample) |
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2018
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- 2018-01-09 JP JP2019531088A patent/JP7116062B2/ja active Active
- 2018-01-09 CN CN201880006249.XA patent/CN110168101A/zh active Pending
- 2018-01-09 WO PCT/US2018/013019 patent/WO2018132392A2/en not_active Ceased
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2022
- 2022-10-05 US US17/938,273 patent/US20230159996A1/en active Pending
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