JP2020500007A5 - - Google Patents
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- Publication number
- JP2020500007A5 JP2020500007A5 JP2019520104A JP2019520104A JP2020500007A5 JP 2020500007 A5 JP2020500007 A5 JP 2020500007A5 JP 2019520104 A JP2019520104 A JP 2019520104A JP 2019520104 A JP2019520104 A JP 2019520104A JP 2020500007 A5 JP2020500007 A5 JP 2020500007A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- antigen
- binding portion
- isolated monoclonal
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000427 antigen Substances 0.000 claims description 74
- 102000036639 antigens Human genes 0.000 claims description 74
- 108091007433 antigens Proteins 0.000 claims description 74
- 238000000034 method Methods 0.000 claims description 41
- 241000907316 Zika virus Species 0.000 claims description 27
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- 108010003533 Viral Envelope Proteins Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 7
- 239000013604 expression vector Substances 0.000 claims description 6
- 230000001605 fetal effect Effects 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 239000002773 nucleotide Substances 0.000 claims description 3
- 125000003729 nucleotide group Chemical group 0.000 claims description 3
- 230000005570 vertical transmission Effects 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000003472 neutralizing effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 10
- 241000282994 Cervidae Species 0.000 claims 4
- 208000036142 Viral infection Diseases 0.000 claims 3
- 230000009385 viral infection Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 description 71
- 238000006467 substitution reaction Methods 0.000 description 15
- 208000001455 Zika Virus Infection Diseases 0.000 description 8
- 208000035332 Zika virus disease Diseases 0.000 description 8
- 208000020329 Zika virus infectious disease Diseases 0.000 description 8
- 125000000539 amino acid group Chemical group 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 6
- 238000012217 deletion Methods 0.000 description 5
- 230000037430 deletion Effects 0.000 description 5
- 108010026961 trifluoroacetyl-leucyl-alanyl-4-trifluoromethylanilide Proteins 0.000 description 3
- 238000002955 isolation Methods 0.000 description 2
- 230000003169 placental effect Effects 0.000 description 2
- 102100027723 Endogenous retrovirus group K member 6 Rec protein Human genes 0.000 description 1
- 101710091045 Envelope protein Proteins 0.000 description 1
- 102220491788 High mobility group protein B1_S53E_mutation Human genes 0.000 description 1
- 102220604090 Homeobox protein SIX3_S52A_mutation Human genes 0.000 description 1
- 102220604007 Homeobox protein SIX3_Y55A_mutation Human genes 0.000 description 1
- 102220537293 Protein NDRG2_A32L_mutation Human genes 0.000 description 1
- 101710188315 Protein X Proteins 0.000 description 1
- 102220524532 Tumor necrosis factor receptor superfamily member 19_S31T_mutation Human genes 0.000 description 1
- 102220534415 Tyrosine-protein phosphatase non-receptor type 1_S50D_mutation Human genes 0.000 description 1
- 102220393123 c.290C>G Human genes 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 102200012113 rs11466016 Human genes 0.000 description 1
- 102200077165 rs118204021 Human genes 0.000 description 1
- 102200007939 rs128626231 Human genes 0.000 description 1
- 102220239229 rs148307285 Human genes 0.000 description 1
- 102220008795 rs193922245 Human genes 0.000 description 1
- 102220036189 rs273585616 Human genes 0.000 description 1
- 102220040126 rs371657037 Human genes 0.000 description 1
- 102220074096 rs45471099 Human genes 0.000 description 1
- 102220041067 rs587778601 Human genes 0.000 description 1
- 102220276607 rs750954949 Human genes 0.000 description 1
- 102200069315 rs751222088 Human genes 0.000 description 1
- 102220157890 rs886047216 Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662408020P | 2016-10-13 | 2016-10-13 | |
| US62/408,020 | 2016-10-13 | ||
| PCT/US2017/056596 WO2018071822A2 (en) | 2016-10-13 | 2017-10-13 | Antibodies that bind zika virus envelope protein and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020500007A JP2020500007A (ja) | 2020-01-09 |
| JP2020500007A5 true JP2020500007A5 (enExample) | 2020-11-26 |
Family
ID=60191507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520104A Ceased JP2020500007A (ja) | 2016-10-13 | 2017-10-13 | ジカウイルスエンベロープタンパク質に結合する抗体およびその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US11267873B2 (enExample) |
| EP (1) | EP3525815A2 (enExample) |
| JP (1) | JP2020500007A (enExample) |
| CN (1) | CN109996560A (enExample) |
| AU (1) | AU2017343778A1 (enExample) |
| CA (1) | CA3040189A1 (enExample) |
| CL (3) | CL2019000999A1 (enExample) |
| CO (1) | CO2019003759A2 (enExample) |
| CR (2) | CR20210094A (enExample) |
| CU (3) | CU20200105A7 (enExample) |
| DO (1) | DOP2019000098A (enExample) |
| EC (1) | ECSP19026593A (enExample) |
| MX (1) | MX2019004371A (enExample) |
| MY (1) | MY191894A (enExample) |
| NI (1) | NI201900034A (enExample) |
| PE (1) | PE20191469A1 (enExample) |
| PH (1) | PH12019500802A1 (enExample) |
| SG (2) | SG11201903154YA (enExample) |
| WO (1) | WO2018071822A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017343778A1 (en) | 2016-10-13 | 2019-05-02 | Massachusetts Institute Of Technology | Antibodies that bind Zika virus envelope protein and uses thereof |
| US11884718B2 (en) | 2018-04-24 | 2024-01-30 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Potent zika virus-specific and cross-neutralizing monoclonal antibodies to zika and dengue viruses following ZIKV infection or vaccination |
| WO2020061159A1 (en) * | 2018-09-20 | 2020-03-26 | Vanderbilt University | Human antibodies to zika virus |
| BR112021008217A2 (pt) * | 2018-10-31 | 2021-08-17 | Icahn School Of Medicine At Mount Sinai | anticorpos humanos que têm como alvo vírus zika ns1, polipeptídeos ns1 e seus usos |
| CN111138534B (zh) * | 2019-12-31 | 2021-09-28 | 武汉班科生物技术股份有限公司 | 寨卡病毒囊膜蛋白的鼠源单克隆抗体 |
| CN111100201B (zh) * | 2019-12-31 | 2021-09-28 | 武汉班科生物技术股份有限公司 | 针对寨卡病毒囊膜蛋白的鼠源单克隆抗体 |
| EP4144365A4 (en) | 2020-05-01 | 2024-06-05 | Sinocelltech Ltd. | METHODS FOR IMPROVING THE IMMUNOGENERICITY OF PROTEIN/PEPTIDE ANTIGEN |
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-
2017
- 2017-10-13 AU AU2017343778A patent/AU2017343778A1/en not_active Abandoned
- 2017-10-13 CN CN201780072291.7A patent/CN109996560A/zh active Pending
- 2017-10-13 SG SG11201903154YA patent/SG11201903154YA/en unknown
- 2017-10-13 JP JP2019520104A patent/JP2020500007A/ja not_active Ceased
- 2017-10-13 CR CR20210094A patent/CR20210094A/es unknown
- 2017-10-13 CU CU2020000105A patent/CU20200105A7/es unknown
- 2017-10-13 MX MX2019004371A patent/MX2019004371A/es unknown
- 2017-10-13 CU CU2019000036A patent/CU20190036A7/es unknown
- 2017-10-13 WO PCT/US2017/056596 patent/WO2018071822A2/en not_active Ceased
- 2017-10-13 US US16/341,845 patent/US11267873B2/en active Active
- 2017-10-13 SG SG10201912925SA patent/SG10201912925SA/en unknown
- 2017-10-13 CR CR20190193A patent/CR20190193A/es unknown
- 2017-10-13 CU CU2021000030A patent/CU20210030A7/es unknown
- 2017-10-13 US US15/783,655 patent/US10829545B2/en active Active
- 2017-10-13 CA CA3040189A patent/CA3040189A1/en not_active Abandoned
- 2017-10-13 MY MYPI2019002031A patent/MY191894A/en unknown
- 2017-10-13 PE PE2019000820A patent/PE20191469A1/es unknown
- 2017-10-13 EP EP17791825.7A patent/EP3525815A2/en not_active Withdrawn
-
2019
- 2019-04-12 PH PH12019500802A patent/PH12019500802A1/en unknown
- 2019-04-12 NI NI201900034A patent/NI201900034A/es unknown
- 2019-04-12 DO DO2019000098A patent/DOP2019000098A/es unknown
- 2019-04-12 CL CL2019000999A patent/CL2019000999A1/es unknown
- 2019-04-12 CO CONC2019/0003759A patent/CO2019003759A2/es unknown
- 2019-04-12 EC ECSENADI201926593A patent/ECSP19026593A/es unknown
-
2020
- 2020-05-20 CL CL2020001334A patent/CL2020001334A1/es unknown
- 2020-09-28 US US17/034,840 patent/US20210009663A1/en not_active Abandoned
-
2021
- 2021-04-06 CL CL2021000849A patent/CL2021000849A1/es unknown
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