JP2017531642A5 - - Google Patents
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- Publication number
- JP2017531642A5 JP2017531642A5 JP2017517793A JP2017517793A JP2017531642A5 JP 2017531642 A5 JP2017531642 A5 JP 2017531642A5 JP 2017517793 A JP2017517793 A JP 2017517793A JP 2017517793 A JP2017517793 A JP 2017517793A JP 2017531642 A5 JP2017531642 A5 JP 2017531642A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- monoclonal antibody
- nos
- set forth
- ebola virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001115402 Ebolavirus Species 0.000 claims description 38
- 102000003886 Glycoproteins Human genes 0.000 claims description 38
- 108090000288 Glycoproteins Proteins 0.000 claims description 38
- 239000000427 antigen Substances 0.000 claims description 31
- 102000036639 antigens Human genes 0.000 claims description 31
- 108091007433 antigens Proteins 0.000 claims description 31
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims description 12
- 108060003951 Immunoglobulin Proteins 0.000 claims description 12
- 102000018358 immunoglobulin Human genes 0.000 claims description 12
- 238000002965 ELISA Methods 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000003472 neutralizing effect Effects 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 claims description 3
- 102000006992 Interferon-alpha Human genes 0.000 claims description 2
- 108010047761 Interferon-alpha Proteins 0.000 claims description 2
- 241001115400 Zaire ebolavirus Species 0.000 claims description 2
- 230000003013 cytotoxicity Effects 0.000 claims description 2
- 231100000135 cytotoxicity Toxicity 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462059746P | 2014-10-03 | 2014-10-03 | |
| US62/059,746 | 2014-10-03 | ||
| PCT/US2015/053871 WO2016054598A2 (en) | 2014-10-03 | 2015-10-02 | Antibodies that bind ebola glycoprotein and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020168479A Division JP2021001226A (ja) | 2014-10-03 | 2020-10-05 | エボラ糖タンパク質に結合する抗体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017531642A JP2017531642A (ja) | 2017-10-26 |
| JP2017531642A5 true JP2017531642A5 (enExample) | 2018-11-08 |
Family
ID=54291751
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017517793A Pending JP2017531642A (ja) | 2014-10-03 | 2015-10-02 | エボラ糖タンパク質に結合する抗体およびその使用 |
| JP2020168479A Pending JP2021001226A (ja) | 2014-10-03 | 2020-10-05 | エボラ糖タンパク質に結合する抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020168479A Pending JP2021001226A (ja) | 2014-10-03 | 2020-10-05 | エボラ糖タンパク質に結合する抗体およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10894818B2 (enExample) |
| EP (1) | EP3201226A2 (enExample) |
| JP (2) | JP2017531642A (enExample) |
| CN (1) | CN106999566B (enExample) |
| AU (2) | AU2015327819B2 (enExample) |
| CA (1) | CA2963470A1 (enExample) |
| SG (2) | SG10201902924RA (enExample) |
| WO (1) | WO2016054598A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| TWI710573B (zh) | 2015-01-26 | 2020-11-21 | 美商再生元醫藥公司 | 抗伊波拉病毒醣蛋白之人類抗體 |
| CN108135994B (zh) | 2015-05-13 | 2022-01-25 | 宾夕法尼亚州大学信托人 | Aav-介导的抗-流感抗体的表达及其使用方法 |
| JP2018520658A (ja) * | 2015-05-29 | 2018-08-02 | ジェネンテック， インコーポレイテッド | ヒト化抗エボラウイルス糖タンパク質抗体及びその使用 |
| MA42442B1 (fr) | 2015-07-15 | 2019-07-31 | Hoffmann La Roche | Dérivés d'éthynyle comme modulateurs du récepteur métabotropique au glutamate |
| WO2017143236A1 (en) | 2016-02-19 | 2017-08-24 | Yoshihiro Kawaoka | Improved influenza b virus replication for vaccine development |
| WO2018057916A1 (en) * | 2016-09-24 | 2018-03-29 | The Trustees Of The University Of Pennsylvania | Novel humanized anti-ebola antibodies useful in preventing ebola infections |
| JP7128829B2 (ja) | 2017-02-17 | 2022-08-31 | マップ バイオファーマシューティカル、インコーポレイテッド | エボラ感染症の処置用のモノクローナル抗体およびカクテル |
| SG11201907611WA (en) | 2017-02-28 | 2019-09-27 | Univ Pennsylvania | Influenza vaccines based on aav vectors |
| US11827906B2 (en) | 2017-02-28 | 2023-11-28 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (AAV) clade f vector and uses therefor |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| CN108570106B (zh) * | 2017-03-10 | 2021-07-16 | 北京天广实生物技术股份有限公司 | 抗埃博拉病毒单克隆抗体、其制备方法及用途 |
| CN106868025B (zh) * | 2017-03-13 | 2020-01-21 | 中国人民解放军军事医学科学院生物工程研究所 | 用酵母制备三聚体埃博拉病毒糖蛋白突变体的方法 |
| WO2019139648A2 (en) * | 2017-09-15 | 2019-07-18 | David Weiner | Dna antibody constructs for use against ebola virus |
| US11197926B2 (en) | 2017-10-25 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| CN108299559B (zh) * | 2017-12-29 | 2021-11-26 | 上海科技大学 | Zaire型埃博拉病毒检测抗体及其制备方法及应用 |
| TW202016125A (zh) * | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
| JP7783047B2 (ja) | 2018-08-07 | 2025-12-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 組換えの生物学的に封じ込められたフィロウイルスワクチン |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| US20230279152A1 (en) * | 2020-08-06 | 2023-09-07 | Abpro Corporation | Anti-claudin 18.2 multi-specific antibodies and uses thereof |
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-
2015
- 2015-10-02 WO PCT/US2015/053871 patent/WO2016054598A2/en not_active Ceased
- 2015-10-02 US US15/515,746 patent/US10894818B2/en active Active
- 2015-10-02 JP JP2017517793A patent/JP2017531642A/ja active Pending
- 2015-10-02 CN CN201580064291.3A patent/CN106999566B/zh not_active Expired - Fee Related
- 2015-10-02 SG SG10201902924RA patent/SG10201902924RA/en unknown
- 2015-10-02 EP EP15778588.2A patent/EP3201226A2/en not_active Withdrawn
- 2015-10-02 AU AU2015327819A patent/AU2015327819B2/en not_active Ceased
- 2015-10-02 SG SG11201702606TA patent/SG11201702606TA/en unknown
- 2015-10-02 CA CA2963470A patent/CA2963470A1/en not_active Abandoned
-
2020
- 2020-10-05 JP JP2020168479A patent/JP2021001226A/ja active Pending
- 2020-12-04 US US17/112,581 patent/US20210095007A1/en not_active Abandoned
-
2021
- 2021-05-17 AU AU2021203156A patent/AU2021203156A1/en not_active Abandoned
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