JP2020193233A5 - - Google Patents
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- Publication number
- JP2020193233A5 JP2020193233A5 JP2020148292A JP2020148292A JP2020193233A5 JP 2020193233 A5 JP2020193233 A5 JP 2020193233A5 JP 2020148292 A JP2020148292 A JP 2020148292A JP 2020148292 A JP2020148292 A JP 2020148292A JP 2020193233 A5 JP2020193233 A5 JP 2020193233A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- aqueous liquid
- container
- buffer
- brimonidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 9
- 239000007788 liquid Substances 0.000 claims 8
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 4
- 229960003679 brimonidine Drugs 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 229960001484 edetic acid Drugs 0.000 claims 3
- IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical compound CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 claims 2
- 229960003933 dorzolamide Drugs 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 239000007983 Tris buffer Substances 0.000 claims 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 1
- 239000004327 boric acid Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 238000004321 preservation Methods 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024020182A JP2024040421A (ja) | 2018-03-30 | 2024-02-14 | 水性液剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018066378 | 2018-03-30 | ||
| JP2018066378 | 2018-03-30 | ||
| JP2020009831A JP6802936B2 (ja) | 2018-03-30 | 2020-01-24 | 水性液剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020009831A Division JP6802936B2 (ja) | 2018-03-30 | 2020-01-24 | 水性液剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024020182A Division JP2024040421A (ja) | 2018-03-30 | 2024-02-14 | 水性液剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020193233A JP2020193233A (ja) | 2020-12-03 |
| JP2020193233A5 true JP2020193233A5 (enrdf_load_stackoverflow) | 2022-04-05 |
| JP7438899B2 JP7438899B2 (ja) | 2024-02-27 |
Family
ID=68061910
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019065250A Active JP6653037B2 (ja) | 2018-03-30 | 2019-03-29 | 水性液剤 |
| JP2020009831A Active JP6802936B2 (ja) | 2018-03-30 | 2020-01-24 | 水性液剤 |
| JP2020148292A Active JP7438899B2 (ja) | 2018-03-30 | 2020-09-03 | 水性液剤 |
| JP2024020182A Pending JP2024040421A (ja) | 2018-03-30 | 2024-02-14 | 水性液剤 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019065250A Active JP6653037B2 (ja) | 2018-03-30 | 2019-03-29 | 水性液剤 |
| JP2020009831A Active JP6802936B2 (ja) | 2018-03-30 | 2020-01-24 | 水性液剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024020182A Pending JP2024040421A (ja) | 2018-03-30 | 2024-02-14 | 水性液剤 |
Country Status (2)
| Country | Link |
|---|---|
| JP (4) | JP6653037B2 (enrdf_load_stackoverflow) |
| WO (1) | WO2019189720A1 (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019189720A1 (ja) * | 2018-03-30 | 2019-10-03 | 千寿製薬株式会社 | 水性液剤 |
| JP2020033290A (ja) * | 2018-08-29 | 2020-03-05 | 興和株式会社 | 水性組成物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH092517A (ja) * | 1995-06-26 | 1997-01-07 | Taisho Pharmaceut Co Ltd | 液状薬剤の包装用材料 |
| US6211238B1 (en) * | 1998-10-27 | 2001-04-03 | Alcon Laboratories, Inc. | Preservative system for topically administrable pharmaceutical compositions |
| JP2001206454A (ja) * | 2000-01-24 | 2001-07-31 | Material Eng Tech Lab Inc | 抗菌性容器 |
| JP4580524B2 (ja) * | 2000-09-12 | 2010-11-17 | 株式会社日本点眼薬研究所 | フィルター付き吐出容器 |
| JP4357159B2 (ja) * | 2002-07-22 | 2009-11-04 | ニプロ株式会社 | 薬液容器 |
| JP4574236B2 (ja) * | 2004-06-07 | 2010-11-04 | ロート製薬株式会社 | 容器の注出口構造及び包装用容器 |
| US8034813B2 (en) * | 2008-11-18 | 2011-10-11 | Bausch & Lomb Incorporated | Polymorphs of brimonidine pamoate |
| US20120312840A1 (en) * | 2011-05-13 | 2012-12-13 | Ayako Hasegawa | Container closure system with integral antimicrobial additives |
| CN103006662A (zh) * | 2011-09-20 | 2013-04-03 | 北京秦武田制药有限公司 | 用于局部眼科应用的溴莫尼定和倍他洛尔组合物 |
| JP6567648B2 (ja) * | 2014-07-28 | 2019-08-28 | サン、ファーマ、アドバンスト、リサーチ、カンパニー、リミテッドＳｕｎ Ｐｈａｒｍａ Ａｄｖａｎｃｅｄ Ｒｅｓｅａｒｃｈ Ｃｏｍｐａｎｙ Ｌｉｍｉｔｅｄ | 薬物のバイオアベイラビリティーの増加および／または眼作用の持続方法 |
| JP2016132465A (ja) * | 2015-01-19 | 2016-07-25 | 参天製薬株式会社 | 点眼容器 |
| AU2016222902A1 (en) * | 2015-02-24 | 2017-08-31 | Ocugen, Inc. | Methods and compositions for treating dry eye disease and other eye disorders |
| US20190038598A1 (en) * | 2016-02-22 | 2019-02-07 | Santen Pharmaceutical Co., Ltd. | Pharmaceutical composition including dorzolamide and brimonidine |
| JP6495379B2 (ja) * | 2016-06-15 | 2019-04-03 | 興和株式会社 | 水性の組成物 |
| JP7120789B2 (ja) * | 2017-09-29 | 2022-08-17 | 積水化学工業株式会社 | 水性ポリビニルアセタール樹脂組成物 |
| WO2019189720A1 (ja) | 2018-03-30 | 2019-10-03 | 千寿製薬株式会社 | 水性液剤 |
-
2019
- 2019-03-29 WO PCT/JP2019/013921 patent/WO2019189720A1/ja active Application Filing
- 2019-03-29 JP JP2019065250A patent/JP6653037B2/ja active Active
-
2020
- 2020-01-24 JP JP2020009831A patent/JP6802936B2/ja active Active
- 2020-09-03 JP JP2020148292A patent/JP7438899B2/ja active Active
-
2024
- 2024-02-14 JP JP2024020182A patent/JP2024040421A/ja active Pending
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