JP2022036159A5 - - Google Patents
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- Publication number
- JP2022036159A5 JP2022036159A5 JP2021212111A JP2021212111A JP2022036159A5 JP 2022036159 A5 JP2022036159 A5 JP 2022036159A5 JP 2021212111 A JP2021212111 A JP 2021212111A JP 2021212111 A JP2021212111 A JP 2021212111A JP 2022036159 A5 JP2022036159 A5 JP 2022036159A5
- Authority
- JP
- Japan
- Prior art keywords
- aqueous solution
- salt
- filter
- brimonidine
- adsorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007864 aqueous solution Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 238000001179 sorption measurement Methods 0.000 claims 9
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 7
- 229960003679 brimonidine Drugs 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 3
- IWEGDQUCWQFKHS-UHFFFAOYSA-N 1-(1,3-dioxolan-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole Chemical group O1C(C)(C)C(C)(C)OB1C1=CN(CC2OCCO2)N=C1 IWEGDQUCWQFKHS-UHFFFAOYSA-N 0.000 claims 2
- 239000002033 PVDF binder Substances 0.000 claims 2
- 239000004695 Polyether sulfone Substances 0.000 claims 2
- 229960001724 brimonidine tartrate Drugs 0.000 claims 2
- 239000003889 eye drop Substances 0.000 claims 2
- 229940012356 eye drops Drugs 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229920006393 polyether sulfone Polymers 0.000 claims 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000001954 sterilising effect Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 229910001510 metal chloride Inorganic materials 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021212111A JP7447072B2 (ja) | 2020-11-18 | 2021-12-27 | 水性液剤 |
| JP2022160514A JP7269425B2 (ja) | 2020-11-18 | 2022-10-04 | 水性液剤 |
| JP2024028248A JP2024052871A (ja) | 2020-11-18 | 2024-02-28 | 水性液剤 |
| JP2025037251A JP2025078837A (ja) | 2020-11-18 | 2025-03-10 | 水性液剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020191883A JP6901619B2 (ja) | 2019-09-30 | 2020-11-18 | 水性液剤 |
| JP2021100791A JP7002692B2 (ja) | 2020-11-18 | 2021-06-17 | 水性液剤 |
| JP2021212111A JP7447072B2 (ja) | 2020-11-18 | 2021-12-27 | 水性液剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021100791A Division JP7002692B2 (ja) | 2020-11-18 | 2021-06-17 | 水性液剤 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022160514A Division JP7269425B2 (ja) | 2020-11-18 | 2022-10-04 | 水性液剤 |
| JP2024028248A Division JP2024052871A (ja) | 2020-11-18 | 2024-02-28 | 水性液剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022036159A JP2022036159A (ja) | 2022-03-04 |
| JP2022036159A5 true JP2022036159A5 (enrdf_load_stackoverflow) | 2022-10-07 |
| JP7447072B2 JP7447072B2 (ja) | 2024-03-11 |
Family
ID=77887204
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021100791A Active JP7002692B2 (ja) | 2020-11-18 | 2021-06-17 | 水性液剤 |
| JP2021212111A Active JP7447072B2 (ja) | 2020-11-18 | 2021-12-27 | 水性液剤 |
| JP2024028248A Pending JP2024052871A (ja) | 2020-11-18 | 2024-02-28 | 水性液剤 |
| JP2025037251A Pending JP2025078837A (ja) | 2020-11-18 | 2025-03-10 | 水性液剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021100791A Active JP7002692B2 (ja) | 2020-11-18 | 2021-06-17 | 水性液剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024028248A Pending JP2024052871A (ja) | 2020-11-18 | 2024-02-28 | 水性液剤 |
| JP2025037251A Pending JP2025078837A (ja) | 2020-11-18 | 2025-03-10 | 水性液剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (4) | JP7002692B2 (enrdf_load_stackoverflow) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050026924A1 (en) * | 2000-07-14 | 2005-02-03 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| CN102883708A (zh) * | 2010-04-07 | 2013-01-16 | 阿勒根公司 | 用于眼用组合物的防腐剂联合 |
| JP2020502270A (ja) | 2016-12-15 | 2020-01-23 | ハロー ヘルス インコーポレイテッド | 緑内障を処置するための医薬製剤ならびにそれを製造および使用するための方法 |
-
2021
- 2021-06-17 JP JP2021100791A patent/JP7002692B2/ja active Active
- 2021-12-27 JP JP2021212111A patent/JP7447072B2/ja active Active
-
2024
- 2024-02-28 JP JP2024028248A patent/JP2024052871A/ja active Pending
-
2025
- 2025-03-10 JP JP2025037251A patent/JP2025078837A/ja active Pending
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