JP2022036159A5 - - Google Patents

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JP2022036159A5
JP2022036159A5 JP2021212111A JP2021212111A JP2022036159A5 JP 2022036159 A5 JP2022036159 A5 JP 2022036159A5 JP 2021212111 A JP2021212111 A JP 2021212111A JP 2021212111 A JP2021212111 A JP 2021212111A JP 2022036159 A5 JP2022036159 A5 JP 2022036159A5
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Japan
Prior art keywords
aqueous solution
salt
filter
brimonidine
adsorption
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JP2021212111A
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Japanese (ja)
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JP7447072B2 (en
JP2022036159A (en
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Priority claimed from JP2020191883A external-priority patent/JP6901619B2/en
Priority claimed from JP2021100791A external-priority patent/JP7002692B2/en
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Priority to JP2021212111A priority Critical patent/JP7447072B2/en
Publication of JP2022036159A publication Critical patent/JP2022036159A/en
Priority to JP2022160514A priority patent/JP7269425B2/en
Publication of JP2022036159A5 publication Critical patent/JP2022036159A5/ja
Priority to JP2024028248A priority patent/JP2024052871A/en
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Publication of JP7447072B2 publication Critical patent/JP7447072B2/en
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Claims (16)

フィルターを通過させる水性液剤に、ブリモニジン及び／又はその塩と、クエン酸及び／又はその塩と、塩化ナトリウムと、グリセリンとを含有させる、ブリモニジン及び／又はその塩のフィルターへの吸着抑制方法。 A method for suppressing adsorption of brimonidine and/or a salt thereof to a filter, wherein an aqueous solution to be passed through a filter contains brimonidine and/or a salt thereof, citric acid and/or a salt thereof, sodium chloride, and glycerin. 前記ブリモニジン及び／又はその塩が、ブリモニジン酒石酸塩である、請求項１に記載の吸着抑制方法。 2. The adsorption suppression method according to claim 1, wherein said brimonidine and/or its salt is brimonidine tartrate. 前記水性液剤におけるブリモニジン及び／又はその塩の濃度が、０．０５～０．２ｗ／ｖ％である、請求項１又は２に記載の吸着抑制方法。 The method for inhibiting adsorption according to claim 1 or 2, wherein the concentration of brimonidine and/or a salt thereof in the aqueous solution is 0.05 to 0.2 w/v%. 前記水性液剤における塩化ナトリウムの濃度が、０．０１～５ｗ/ｖ％である、請求項１～３のいずれかに記載の吸着抑制方法。 The method for suppressing adsorption according to any one of claims 1 to 3, wherein the concentration of sodium chloride in the aqueous solution is 0.01 to 5 w/v%. 前記水性液剤が、保存剤を実質的に含まない、請求項１～４のいずれかに記載の吸着抑制方法。 The method for inhibiting adsorption according to any one of claims 1 to 4, wherein the aqueous liquid agent does not substantially contain a preservative. 前記水性液剤が、点眼液である、請求項１～５のいずれかに記載の吸着抑制方法。 The method for inhibiting adsorption according to any one of claims 1 to 5, wherein the aqueous solution is eye drops. 前記フィルターの素材が、ポリエーテルスルホン、又はポリフッ化ビニリデンである、請求項１～６のいずれかに記載の吸着抑制方法。 The adsorption suppressing method according to any one of claims 1 to 6, wherein the filter material is polyethersulfone or polyvinylidene fluoride. 前記フィルターが、フィルター付き容器のフィルターである、請求項１～７のいずれかに記載の吸着抑制方法。 The method for inhibiting adsorption according to any one of claims 1 to 7, wherein the filter is a filter for a container with a filter. 前記フィルターが、ろ過滅菌工程で使用されるフィルターである、請求項１～７のいずれかに記載の吸着抑制方法。 The adsorption suppression method according to any one of claims 1 to 7, wherein the filter is a filter used in a filtration sterilization step. ブリモニジン及び／又はその塩と、クエン酸及び／又はその塩と、塩化ナトリウムと、グリセリンとを含む水性液剤を調製する工程、並びに
前記工程で得られた水性液剤を、フィルターを用いたろ過滅菌工程に供する工程、
を含む、水性液剤の製造方法。 A step of preparing an aqueous solution containing brimonidine and/or a salt thereof, citric acid and/or a salt thereof, sodium chloride, and glycerin, and filtering and sterilizing the aqueous solution obtained in the above step using a filter. a step of providing to
A method for producing an aqueous solution, comprising: 前記ブリモニジン及び／又はその塩が、ブリモニジン酒石酸塩である、請求項１０に記載の製造方法。 11. The production method according to claim 10, wherein the brimonidine and/or its salt is brimonidine tartrate. 前記水性液剤におけるブリモニジン及び／又はその塩の濃度が、０．０５～０．２ｗ／ｖ％である、請求項１０又は１１に記載の製造方法。 The production method according to claim 10 or 11, wherein the concentration of brimonidine and/or its salt in the aqueous solution is 0.05 to 0.2 w/v%. 前記水性液剤における金属塩化物の濃度が、０．０１～５ｗ/ｖ％である、請求項１０～１２のいずれかに記載の製造方法。 The production method according to any one of claims 10 to 12, wherein the concentration of metal chloride in the aqueous solution is 0.01 to 5 w/v%. 前記水性液剤が、保存剤を実質的に含まない、請求項１０～１３のいずれかに記載の製造方法。 The production method according to any one of claims 10 to 13, wherein the aqueous liquid formulation is substantially free of preservatives. 前記水性液剤が、点眼液である、請求項１０～１４のいずれかに記載の製造方法。 The production method according to any one of claims 10 to 14, wherein the aqueous solution is eye drops. 前記フィルターの素材が、ポリエーテルスルホン、又はポリフッ化ビニリデンである、請求項１０～１５のいずれかに記載の製造方法。

The manufacturing method according to any one of claims 10 to 15, wherein the filter material is polyethersulfone or polyvinylidene fluoride.
JP2021212111A 2020-11-18 2021-12-27 aqueous liquid Active JP7447072B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021212111A JP7447072B2 (en) 2020-11-18 2021-12-27 aqueous liquid
JP2022160514A JP7269425B2 (en) 2020-11-18 2022-10-04 aqueous solution
JP2024028248A JP2024052871A (en) 2020-11-18 2024-02-28 Water-based liquid

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020191883A JP6901619B2 (en) 2019-09-30 2020-11-18 Aqueous solution
JP2021100791A JP7002692B2 (en) 2020-11-18 2021-06-17 Aqueous liquid
JP2021212111A JP7447072B2 (en) 2020-11-18 2021-12-27 aqueous liquid

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JP2021100791A Division JP7002692B2 (en) 2020-11-18 2021-06-17 Aqueous liquid

Related Child Applications (2)

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JP2022160514A Division JP7269425B2 (en) 2020-11-18 2022-10-04 aqueous solution
JP2024028248A Division JP2024052871A (en) 2020-11-18 2024-02-28 Water-based liquid

Publications (3)

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JP2022036159A JP2022036159A (en) 2022-03-04
JP2022036159A5 true JP2022036159A5 (en) 2022-10-07
JP7447072B2 JP7447072B2 (en) 2024-03-11

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JP2021100791A Active JP7002692B2 (en) 2020-11-18 2021-06-17 Aqueous liquid
JP2021212111A Active JP7447072B2 (en) 2020-11-18 2021-12-27 aqueous liquid
JP2024028248A Pending JP2024052871A (en) 2020-11-18 2024-02-28 Water-based liquid

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JP2021100791A Active JP7002692B2 (en) 2020-11-18 2021-06-17 Aqueous liquid

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JP2024028248A Pending JP2024052871A (en) 2020-11-18 2024-02-28 Water-based liquid

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JP (3) JP7002692B2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026924A1 (en) 2000-07-14 2005-02-03 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
JP2013523828A (en) 2010-04-07 2013-06-17 アラーガン インコーポレイテッド Preservative combinations for ophthalmic compositions
BR112019012299A2 (en) 2016-12-15 2019-11-12 Harrow Health Inc pharmaceutical formulations for the treatment of glaucoma and methods for the manufacture and use thereof

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