JP2021152047A5 - - Google Patents

Claims (24)

For aqueous liquids that pass through the filter
With brimonidine and / or its salt,
With a buffer,
With polyhexanide and / or its salt
A method for suppressing the adsorption of brimonidine and / or a salt thereof on a filter. The adsorption suppression method according to claim 1, wherein the brimonidine and / or a salt thereof is brimonidine tartrate. The adsorption suppression method according to claim 1 or 2, wherein the concentration of brimonidine and / or a salt thereof in the aqueous solution is 0.05 to 0.2 w / v%. The adsorption inhibition according to any one of claims 1 to 3, wherein the buffer is at least one selected from the group consisting of a boric acid buffer, a phosphate buffer, a Tris buffer, and a citric acid buffer. Method. The adsorption suppression method according to any one of claims 1 to 4, wherein the buffer is a boric acid buffer. The adsorption suppression method according to any one of claims 1 to 5, wherein the polyhexanide and / or a salt thereof is polyhexanide hydrochloride. The adsorption suppression method according to any one of claims 1 to 6, wherein the concentration of polyhexanide and / or a salt thereof in the aqueous solution is 0.00001 to 0.1 w / v%. The adsorption suppression method according to any one of claims 1 to 7, wherein the aqueous liquid does not contain a viscous agent. The adsorption suppression method according to any one of claims 1 to 8, wherein the aqueous liquid is an eye drop. The adsorption suppression method according to any one of claims 1 to 9, wherein the material of the filter is polyether sulfone or polyvinylidene fluoride. The adsorption suppression method according to any one of claims 1 to 10, wherein the filter is a filter used in a filtration sterilization step. One of claims 1 to 11, wherein the aqueous liquid is an aqueous liquid that passes through a filter in a filtration sterilization step at the time of manufacture, and is provided by being housed in a multi-dose type container not provided with a filter after the filtration sterilization step. The adsorption suppression method according to. The adsorption suppression method according to any one of claims 1 to 12, wherein the filter is a filter of a container with a filter. A step of preparing an aqueous solution containing brimonidine and / or a salt thereof, a buffer, and polyhexanide and / or a salt thereof, and
A step of subjecting the aqueous liquid obtained in the above step to a filtration sterilization step using a filter,
A method for producing an aqueous liquid preparation including. The production method according to claim 14, wherein the brimonidine and / or a salt thereof is brimonidine tartrate. The production method according to claim 14 or 15, wherein the concentration of brimonidine and / or a salt thereof in the aqueous solution is 0.05 to 0.2 w / v%. The production method according to any one of claims 14 to 16, wherein the buffer is at least one selected from the group consisting of a boric acid buffer, a phosphate buffer, a Tris buffer, and a citric acid buffer. .. The production method according to any one of claims 14 to 17, wherein the buffer is a boric acid buffer. The production method according to any one of claims 14 to 18, wherein the polyhexanide and / or a salt thereof is polyhexanide hydrochloride. The production method according to any one of claims 14 to 19, wherein the concentration of polyhexanide and / or a salt thereof in the aqueous solution is 0.00001 to 0.1 w / v%. The production method according to any one of claims 14 to 20, wherein the aqueous liquid does not contain a viscous agent. The production method according to any one of claims 14 to 21, wherein the aqueous liquid is an eye drop. The production method according to any one of claims 14 to 22, wherein the material of the filter is polyether sulfone or polyvinylidene fluoride. The production method according to any one of claims 14 to 23, wherein the aqueous liquid agent is provided in a multi-dose type container not provided with a filter after the filtration sterilization step.