JP2021152047A5 - - Google Patents

Download PDF

Info

Publication number
JP2021152047A5
JP2021152047A5 JP2021100791A JP2021100791A JP2021152047A5 JP 2021152047 A5 JP2021152047 A5 JP 2021152047A5 JP 2021100791 A JP2021100791 A JP 2021100791A JP 2021100791 A JP2021100791 A JP 2021100791A JP 2021152047 A5 JP2021152047 A5 JP 2021152047A5
Authority
JP
Japan
Prior art keywords
salt
filter
buffer
brimonidine
production method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021100791A
Other languages
Japanese (ja)
Other versions
JP2021152047A (en
JP7002692B2 (en
Filing date
Publication date
Priority claimed from JP2020191883A external-priority patent/JP6901619B2/en
Application filed filed Critical
Priority claimed from JP2021100791A external-priority patent/JP7002692B2/en
Priority to JP2021100791A priority Critical patent/JP7002692B2/en
Publication of JP2021152047A publication Critical patent/JP2021152047A/en
Publication of JP2021152047A5 publication Critical patent/JP2021152047A5/ja
Priority to JP2021212111A priority patent/JP7447072B2/en
Publication of JP7002692B2 publication Critical patent/JP7002692B2/en
Application granted granted Critical
Priority to JP2022160514A priority patent/JP7269425B2/en
Priority to JP2024028248A priority patent/JP2024052871A/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Claims (24)

フィルターを通過させる水性液剤に、For aqueous liquids that pass through the filter
ブリモニジン及び/又はその塩と、With brimonidine and / or its salt,
緩衝剤と、With a buffer,
ポリヘキサニド及び/又はその塩とWith polyhexanide and / or its salt
を含有させる、ブリモニジン及び/又はその塩のフィルターへの吸着抑制方法。A method for suppressing the adsorption of brimonidine and / or a salt thereof on a filter.
前記ブリモニジン及び/又はその塩が、ブリモニジン酒石酸塩である、請求項1に記載の吸着抑制方法。The adsorption suppression method according to claim 1, wherein the brimonidine and / or a salt thereof is brimonidine tartrate. 前記水性液剤におけるブリモニジン及び/又はその塩の濃度が、0.05〜0.2w/v%である、請求項1又は2に記載の吸着抑制方法。The adsorption suppression method according to claim 1 or 2, wherein the concentration of brimonidine and / or a salt thereof in the aqueous solution is 0.05 to 0.2 w / v%. 前記緩衝剤が、ホウ酸緩衝剤、リン酸緩衝剤、トリス緩衝剤、及びクエン酸緩衝剤よりなる群から選択される少なくとも1種である、請求項1〜3のいずれかに記載の吸着抑制方法。The adsorption inhibition according to any one of claims 1 to 3, wherein the buffer is at least one selected from the group consisting of a boric acid buffer, a phosphate buffer, a Tris buffer, and a citric acid buffer. Method. 前記緩衝剤が、ホウ酸緩衝剤である、請求項1〜4のいずれかに記載の吸着抑制方法。The adsorption suppression method according to any one of claims 1 to 4, wherein the buffer is a boric acid buffer. 前記ポリヘキサニド及び/又はその塩が、塩酸ポリヘキサニドである、請求項1〜5のいずれかに記載の吸着抑制方法。The adsorption suppression method according to any one of claims 1 to 5, wherein the polyhexanide and / or a salt thereof is polyhexanide hydrochloride. 前記水性液剤におけるポリヘキサニド及び/又はその塩の濃度が0.00001〜0.1w/v%である、請求項1〜6のいずれかに記載の吸着抑制方法。The adsorption suppression method according to any one of claims 1 to 6, wherein the concentration of polyhexanide and / or a salt thereof in the aqueous solution is 0.00001 to 0.1 w / v%. 前記水性液剤が粘稠剤を含まない、請求項1〜7のいずれかに記載の吸着抑制方法。The adsorption suppression method according to any one of claims 1 to 7, wherein the aqueous liquid does not contain a viscous agent. 前記水性液剤が、点眼液である、請求項1〜8のいずれかに記載の吸着抑制方法。The adsorption suppression method according to any one of claims 1 to 8, wherein the aqueous liquid is an eye drop. 前記フィルターの素材が、ポリエーテルスルホン、又はポリフッ化ビニリデンである、請求項1〜9のいずれかに記載の吸着抑制方法。The adsorption suppression method according to any one of claims 1 to 9, wherein the material of the filter is polyether sulfone or polyvinylidene fluoride. 前記フィルターが、ろ過滅菌工程で使用されるフィルターである、請求項1〜10のいずれかに記載の吸着抑制方法。The adsorption suppression method according to any one of claims 1 to 10, wherein the filter is a filter used in a filtration sterilization step. 前記水性液剤が、製造時にろ過滅菌工程でフィルターを通過させる水性液剤であって、ろ過滅菌工程後にフィルターを備えていないマルチドーズ型容器に収容して提供される、請求項1〜11のいずれかに記載の吸着抑制方法。One of claims 1 to 11, wherein the aqueous liquid is an aqueous liquid that passes through a filter in a filtration sterilization step at the time of manufacture, and is provided by being housed in a multi-dose type container not provided with a filter after the filtration sterilization step. The adsorption suppression method according to. 前記フィルターが、フィルター付き容器のフィルターである、請求項1〜12のいずれかに記載の吸着抑制方法。The adsorption suppression method according to any one of claims 1 to 12, wherein the filter is a filter of a container with a filter. ブリモニジン及び/又はその塩と、緩衝剤と、ポリヘキサニド及び/又はその塩とを含む水性液剤を調製する工程、並びにA step of preparing an aqueous solution containing brimonidine and / or a salt thereof, a buffer, and polyhexanide and / or a salt thereof, and
前記工程で得られた水性液剤を、フィルターを用いたろ過滅菌工程に供する工程、A step of subjecting the aqueous liquid obtained in the above step to a filtration sterilization step using a filter,
を含む、水性液剤の製造方法。A method for producing an aqueous liquid preparation including.
前記ブリモニジン及び/又はその塩が、ブリモニジン酒石酸塩である、請求項14に記載の製造方法。The production method according to claim 14, wherein the brimonidine and / or a salt thereof is brimonidine tartrate. 前記水性液剤におけるブリモニジン及び/又はその塩の濃度が、0.05〜0.2w/v%である、請求項14又は15に記載の製造方法。The production method according to claim 14 or 15, wherein the concentration of brimonidine and / or a salt thereof in the aqueous solution is 0.05 to 0.2 w / v%. 前記緩衝剤が、ホウ酸緩衝剤、リン酸緩衝剤、トリス緩衝剤、及びクエン酸緩衝剤よりなる群から選択される少なくとも1種である、請求項14〜16のいずれかに記載の製造方法。The production method according to any one of claims 14 to 16, wherein the buffer is at least one selected from the group consisting of a boric acid buffer, a phosphate buffer, a Tris buffer, and a citric acid buffer. .. 前記緩衝剤が、ホウ酸緩衝剤である、請求項14〜17のいずれかに記載の製造方法。The production method according to any one of claims 14 to 17, wherein the buffer is a boric acid buffer. 前記ポリヘキサニド及び/又はその塩が、塩酸ポリヘキサニドである、請求項14〜18のいずれかに記載の製造方法。The production method according to any one of claims 14 to 18, wherein the polyhexanide and / or a salt thereof is polyhexanide hydrochloride. 前記水性液剤におけるポリヘキサニド及び/又はその塩の濃度が0.00001〜0.1w/v%である、請求項14〜19のいずれかに記載の製造方法。The production method according to any one of claims 14 to 19, wherein the concentration of polyhexanide and / or a salt thereof in the aqueous solution is 0.00001 to 0.1 w / v%. 前記水性液剤が粘稠剤を含まない、請求項14〜20のいずれかに記載の製造方法。The production method according to any one of claims 14 to 20, wherein the aqueous liquid does not contain a viscous agent. 前記水性液剤が、点眼液である、請求項14〜21のいずれかに記載の製造方法。The production method according to any one of claims 14 to 21, wherein the aqueous liquid is an eye drop. 前記フィルターの素材が、ポリエーテルスルホン、又はポリフッ化ビニリデンである、請求項14〜22のいずれかに記載の製造方法。The production method according to any one of claims 14 to 22, wherein the material of the filter is polyether sulfone or polyvinylidene fluoride. 前記水性液剤が、ろ過滅菌工程後にフィルターを備えていないマルチドーズ型容器に収容して提供される、請求項14〜23のいずれかに記載の製造方法。The production method according to any one of claims 14 to 23, wherein the aqueous liquid agent is provided in a multi-dose type container not provided with a filter after the filtration sterilization step.
JP2021100791A 2020-11-18 2021-06-17 Aqueous liquid Active JP7002692B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2021100791A JP7002692B2 (en) 2020-11-18 2021-06-17 Aqueous liquid
JP2021212111A JP7447072B2 (en) 2020-11-18 2021-12-27 aqueous liquid
JP2022160514A JP7269425B2 (en) 2020-11-18 2022-10-04 aqueous solution
JP2024028248A JP2024052871A (en) 2020-11-18 2024-02-28 Water-based liquid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020191883A JP6901619B2 (en) 2019-09-30 2020-11-18 Aqueous solution
JP2021100791A JP7002692B2 (en) 2020-11-18 2021-06-17 Aqueous liquid

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2020191883A Division JP6901619B2 (en) 2019-09-30 2020-11-18 Aqueous solution

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021212111A Division JP7447072B2 (en) 2020-11-18 2021-12-27 aqueous liquid

Publications (3)

Publication Number Publication Date
JP2021152047A JP2021152047A (en) 2021-09-30
JP2021152047A5 true JP2021152047A5 (en) 2021-11-18
JP7002692B2 JP7002692B2 (en) 2022-02-04

Family

ID=77887204

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021100791A Active JP7002692B2 (en) 2020-11-18 2021-06-17 Aqueous liquid
JP2021212111A Active JP7447072B2 (en) 2020-11-18 2021-12-27 aqueous liquid
JP2024028248A Pending JP2024052871A (en) 2020-11-18 2024-02-28 Water-based liquid

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021212111A Active JP7447072B2 (en) 2020-11-18 2021-12-27 aqueous liquid
JP2024028248A Pending JP2024052871A (en) 2020-11-18 2024-02-28 Water-based liquid

Country Status (1)

Country Link
JP (3) JP7002692B2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026924A1 (en) * 2000-07-14 2005-02-03 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
WO2011127151A2 (en) * 2010-04-07 2011-10-13 Allergan, Inc. Combinations of preservatives for ophthalmic compositions
CA3047279A1 (en) 2016-12-15 2018-06-21 Harrow Health, Inc. Pharmaceutical formulations for treating glaucoma and methods for fabricating and using thereof

Similar Documents

Publication Publication Date Title
JP7042762B2 (en) Diquafosol-containing eye drops
JP2013518926A5 (en)
HRP20170625T1 (en) Process for manufacturing a pharmaceutical preparation containing glatiramer acetate
WO2014008400A3 (en) Fill-finish process for peptide solutions
DE2243800B1 (en) PROCESS FOR PRODUCING REDUCED ALCOHOL BEER
JP2019104727A5 (en)
JP2021152047A5 (en)
JP2020193233A5 (en)
RU2018140131A (en) Acetyl-leucine or its pharmaceutically acceptable salt to improve motor function and cognitive function
JP5828383B2 (en) Intraoral disinfectant and method for producing the same
JP2022036159A5 (en)
CN105796402A (en) Alcohol-free antibacterial long-acting mouthrinse and preparation method thereof
JP2024052871A5 (en)
RU2016111957A (en) OPHTHALMIC COMPOSITION FOR ZWITTERION SOFT CONTACT LENSES
RU2016147400A (en) A method of treating cataracts and eye drops for its implementation
DE102004045848B3 (en) Process for producing hollow fiber membranes
JP2015015905A5 (en)
RU2016103215A (en) METHOD OF INDUSTRIAL PRODUCTION OF SEA WATER, WHOLE SUITABLE FOR FOOD APPLICATION
WO2013004776A1 (en) Supply of substances upstream of the haemodialysis membrane, e.g. of acetylcysteine, in dialysis methods for removing protein-bonded toxins from the blood
JP2017079791A5 (en)
JP2015057077A5 (en)
JP2018102174A (en) Process for producing food product and germicidal solution for food
AT513652A3 (en) Apparatus and process for the preparation, dosing and packaging of medicaments
JP2017529867A5 (en)
DE728893C (en) Process for the production of durable colloidal solutions of poorly soluble oxalates from rare earths