DE728893C - Process for the production of durable colloidal solutions of poorly soluble oxalates from rare earths - Google Patents

Process for the production of durable colloidal solutions of poorly soluble oxalates from rare earths

Info

Publication number
DE728893C
DE728893C DEC56401D DEC0056401D DE728893C DE 728893 C DE728893 C DE 728893C DE C56401 D DEC56401 D DE C56401D DE C0056401 D DEC0056401 D DE C0056401D DE 728893 C DE728893 C DE 728893C
Authority
DE
Germany
Prior art keywords
durable
production
poorly soluble
rare earths
colloidal solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEC56401D
Other languages
German (de)
Inventor
Dr Richard Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemische Fabrik Von Heyden AG
Original Assignee
Chemische Fabrik Von Heyden AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemische Fabrik Von Heyden AG filed Critical Chemische Fabrik Von Heyden AG
Priority to DEC56401D priority Critical patent/DE728893C/en
Application granted granted Critical
Publication of DE728893C publication Critical patent/DE728893C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Colloid Chemistry (AREA)

Description

Verfahren zur Herstellung haltbarer kolloider Lösungen von schwerlöslichen Oxalaten der seltenen Erden Stellt man nach den Patentschriften 621 309 oder 622 1 6o kolloide Lösungen von schwer löslichen Oxalaten der seltenen Erden her, zentrifugiert von dem gröber dispersen Anteil ab und versucht unter Umständen nach Zusatz von Schutzkolloid die so erhaltenen Sole durch Abfüllen in Ampullen und Sterilisieren in ein parenteral verwendbares Arzneimittel zu verwandeln, so zeigt sich, daß der Ampulleninhalt über kurz oder lang zu einem Gel erstarrt. In dieser Form sind die Produkte selbstverständlich nicht mehr injizierfähig.Process for the production of durable colloidal solutions of poorly soluble Oxalates of the rare earths are produced according to patent specifications 621 309 or 622 1 6o colloidal solutions of poorly soluble oxalates of the rare earths, centrifuged from the coarser disperse fraction and may try to add Protective colloid the brine obtained in this way by filling into ampoules and sterilizing to transform into a drug that can be used parenterally, it turns out that the The contents of the ampoule sooner or later solidify into a gel. They are in this form Of course, products can no longer be injected.

Es wurde nun gefunden, daß man diesem Übelstand dadurch abhelfen kann, daß bei der Herstellung, z. B. der Filtration, insbesondere.aber bei der Dialyse, wo die Lösung aus dem stark alkalischen Zustand bis fast an den Neutralpunkt gebracht wird, die Kohlensäure (z. B. aus der Luft) ausgeschlossen wird. So hergestellte Lösungen sind auch nach der Sterilisation ohne weiteres haltbar. It has now been found that this problem can be remedied in this way can that in the manufacture, for. B. filtration, but especially dialysis, where the solution is brought from the strongly alkaline state to almost the neutral point the carbon dioxide (e.g. from the air) is excluded. So made Solutions can easily be stored even after sterilization.

Beispiel 5 Teile frisch gefälltes, noch feuchtes Ceriterdenoxalat werden mit einem Teil Wassei-, o,o6 Teilen Natriumzitrat und o,I2 Teilen 200,oiger Natronlauge 5 X 24 Stunden lang vermahlen, nachdem man die Luftkohlensäure aus der Mühle durch Einseiten von durch - 5o0/oige Natronlauge von Kohlensäure befreiter Luft verdr:ingt hat. Das Sol wird rasch zentrifugiert. Man erhält eine kolloide Lösung, die etwa 12 bis I40l!o kolloides Ceritoxyd in hochkolloider Form als Ceriterdenoxalat enthält. Diese Lösung wird in Zellglasschläuchen dialysiert. Das Sol wird dabei durch Durchleiten von kohlensäurefreier Luft gerührt. Auch in allen Aufbewahrungsgefäßen wird die Luftkohlensäure usw. durch kohlensäurefreie Luft verdrängt. Example 5 parts of freshly precipitated, still moist ceriter denoxalate are with one part water, o, o6 parts sodium citrate and o, I2 parts 200, oiger Grind caustic soda 5 x 24 hours after removing the air carbonic acid from the The mill has been freed of carbonic acid by pouring in 50% sodium hydroxide solution Has displaced air. The sol is centrifuged rapidly. A colloid is obtained Solution containing about 12 to 140 liters of colloidal cerite oxide in a highly colloid form as ceriter denoxalate contains. This solution will dialyzed in cell glass tubes. That Sol is stirred by passing through carbonic acid-free air. Also in all of them In storage vessels, the air carbonic acid etc. is displaced by non-carbonated air.

Die kolloide Lösung wird schließlich unter kohlensäurefreiem Stickstoff in Ampullen abgefüllt und sterilisiert. Die fertigen Lösungen gelatinieren nicht. Die so hergestellten Erzeugilisse eignen sich ausgezeichnet u. a. zurparenteralen Anwendung. z. B. zur Bekämpfung voll postoperativen oder kachektischem Erbrechen bei Krebs, Schu-angerschaftserbrechen usw.The colloidal solution is finally placed under non-carbonated nitrogen filled into ampoules and sterilized. The finished solutions do not gelatinize. The products made in this way are excellent among other things. for parenteral Use. z. B. to combat full postoperative or cachectic vomiting cancer, school breakdowns, etc.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von haltbaren, nicht gelierenden kolloiden Lösungen der schwer löslichen Oxalate der seltenen Erden, dadurch gekennzeichnet, daß man während der Herstellung und Aufbewahrung Kohlensäure ausschließt. PATENT CLAIM: Process for the production of durable, non-gelling colloidal solutions of the poorly soluble oxalates of the rare earths, characterized by that one excludes carbon dioxide during manufacture and storage.
DEC56401D 1941-03-28 1941-03-28 Process for the production of durable colloidal solutions of poorly soluble oxalates from rare earths Expired DE728893C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEC56401D DE728893C (en) 1941-03-28 1941-03-28 Process for the production of durable colloidal solutions of poorly soluble oxalates from rare earths

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEC56401D DE728893C (en) 1941-03-28 1941-03-28 Process for the production of durable colloidal solutions of poorly soluble oxalates from rare earths

Publications (1)

Publication Number Publication Date
DE728893C true DE728893C (en) 1942-12-07

Family

ID=7028313

Family Applications (1)

Application Number Title Priority Date Filing Date
DEC56401D Expired DE728893C (en) 1941-03-28 1941-03-28 Process for the production of durable colloidal solutions of poorly soluble oxalates from rare earths

Country Status (1)

Country Link
DE (1) DE728893C (en)

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