DE666591C - Method of making a hemostatic agent - Google Patents

Method of making a hemostatic agent

Info

Publication number
DE666591C
DE666591C DET45195D DET0045195D DE666591C DE 666591 C DE666591 C DE 666591C DE T45195 D DET45195 D DE T45195D DE T0045195 D DET0045195 D DE T0045195D DE 666591 C DE666591 C DE 666591C
Authority
DE
Germany
Prior art keywords
acids
making
hemostatic agent
acid
hemostatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DET45195D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TURON GES fur PHARMAZEUTISCHE
Original Assignee
TURON GES fur PHARMAZEUTISCHE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TURON GES fur PHARMAZEUTISCHE filed Critical TURON GES fur PHARMAZEUTISCHE
Priority to DET45195D priority Critical patent/DE666591C/en
Application granted granted Critical
Publication of DE666591C publication Critical patent/DE666591C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Herstellung eines blutstillenden Mittels Gegenstand der Erfindung ist ein Verfahren zur Herstellung eines blutstillenden Mittels, das sowohl per os verabreicht als auch subkutan, intravenös oder intramuskulär appliziert werden kann. Das neue Verfahren hat zum Ziel, freie Galacturonsäuren enthaltende Lösungen von Pektinstoffen und deren Abbau- und Spaltprodukten zu gewinnen, die eine geringe Viscosität besitzen und daher leicht injiciert werden können und die neben freien Galacturonsäuren auch andere therapeutisch wertvolle freie Säuren enthalten, die infolge der Anwesenheit von Kolloiden dem Körper reizlos einverleibt werden können.Method of making a hemostatic agent Article the invention is a process for the manufacture of a hemostatic agent which administered orally as well as subcutaneously, intravenously or intramuscularly can be. The aim of the new process is to obtain free galacturonic acids To obtain solutions of pectin substances and their degradation and decomposition products, the have a low viscosity and can therefore be easily injected and the contain other therapeutically valuable free acids in addition to free galacturonic acids, which are incorporated into the body without irritation due to the presence of colloids can.

Die Lösung der Pektinstoffe und deren Spaltprodukte wird mit organischen Säuren, die stärker dissoziiert sind als die Galacturonsäuren, vorzugsweise mit Oxycarbonsäuren, wie Milchsäure, Zitronensäure, Weinsäure und ähnliehem, versetzt, so daß ein stabiles, saures Milieu entsteht, in dem die Galacturonsäuren ihre optimale Wirkung entfalten und dabei gering viscose Lösungen ergeben. Man kann die Lösungen noch gegebenenfalls durch weitere Elektrolytzustände isotonisch zum Blut einstellen.The solution of the pectin substances and their breakdown products is made with organic Acids that are more strongly dissociated than the galacturonic acids, preferably with Oxycarboxylic acids, such as lactic acid, citric acid, tartaric acid and the like, added, so that a stable, acidic environment is created in which the galacturonic acids are optimal Develop an effect and result in low-viscosity solutions. You can have the solutions set isotonic to the blood by further electrolyte states if necessary.

Die Wirkung der neuen Mittel ist nach klinischen Versuchen um ein Vielfaches größer als die der bekannten, Thrombokinasen enthaltenden Blutstillungsmittel.According to clinical trials, the effect of the new means is around one Many times larger than the known hemostatic agents containing thrombokinases.

Claims (2)

PATENTANSPRÜCHE: i. Verfahren zur Herstellung blutstillender wässeriger Lösungen von Pektinen und deren Abbau-,und Spaltprodukten von verminderter Viscosität, gekennzeichnet durch den Zusatz von Säuren. PATENT CLAIMS: i. Process for the preparation of hemostatic aqueous Solutions of pectins and their degradation and decomposition products of reduced viscosity, characterized by the addition of acids. 2. Ausbildung des Verfahrens nach Anspruch i, dadurch gekennzeichnet, daß als Säuren Oxycarbonsäuren, wie Milchsäure, Weinsäure, Zitronensäure, Apfelsäure, verwendet werden.2. Training of the method according to claim i, characterized in that the acids are oxycarboxylic acids, such as lactic acid, tartaric acid, Citric acid, malic acid, can be used.
DET45195D 1935-04-16 1935-04-16 Method of making a hemostatic agent Expired DE666591C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DET45195D DE666591C (en) 1935-04-16 1935-04-16 Method of making a hemostatic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DET45195D DE666591C (en) 1935-04-16 1935-04-16 Method of making a hemostatic agent

Publications (1)

Publication Number Publication Date
DE666591C true DE666591C (en) 1938-10-22

Family

ID=7561973

Family Applications (1)

Application Number Title Priority Date Filing Date
DET45195D Expired DE666591C (en) 1935-04-16 1935-04-16 Method of making a hemostatic agent

Country Status (1)

Country Link
DE (1) DE666591C (en)

Similar Documents

Publication Publication Date Title
DE1617576C3 (en) Process for the production of an injection preparation based on an aqueous solution of an oxytetracycline-magnesium complex
DE666591C (en) Method of making a hemostatic agent
DE966194C (en) Method for preventing daemies from sticking to the sausage mass
DE899702C (en) Process for the preparation of penicillin solutions with long-lasting effects
DE710410C (en) Process for increasing the coagulability of animal blood
DE916461C (en) Process for the manufacture of hemostatic agents
DE893726C (en) Method for treating fruit stalks
DE738994C (en) Process for the preparation of infusion solutions useful as blood fluid replacement
DE977478C (en) Process for the manufacture of injectable insulin preparations with delayed action
DE427668C (en) Process for the preparation of quinine solutions suitable for subcutaneous injections
DE321616C (en) Process for the preservation of hydrogen peroxide solutions
DE2410939A1 (en) LOCAL ANESTHETIC AGENT
DE277339C (en)
DE855614C (en) Process for the preparation of penicillin solutions with long-lasting effects
DE517935C (en) Process for the preparation of a durable water-soluble iodine and silver containing medicament
DE942534C (en) Process for the production of durable and highly effective solutions or suspensions of antibiotic agents
DE744113C (en) Process for the production of durable cosmetic and pharmaceutical preparations
DE833839C (en) Process for the preparation of water-soluble double compounds of antihistamines
DE750965C (en) Process for the preservation of food
DE384688C (en) Process for the preparation of durable guaiacol preparations in aqueous solution
DE694679C (en) Process for the production of durable solutions of the condensation products from 4,4'-diaminophenyl sulfones and aldoses
DE644078C (en) Process for the preparation of a salt of 4-oxy-3-acetylaminophenyl-1-arsic acid with the toxin of iso-octylhydrocupreine (vuzinotoxin)
DE1946067B2 (en) Aminomethyibicyclo-heptanecarboxylic acid and process for its preparation
DE918288C (en) Process for the production of a therapeutically or prophylactically acting mucous membrane treatment agent
DE530309C (en) Process for obtaining new products from yeast