DE427668C - Process for the preparation of quinine solutions suitable for subcutaneous injections - Google Patents

Process for the preparation of quinine solutions suitable for subcutaneous injections

Info

Publication number
DE427668C
DE427668C DEC35140D DEC0035140D DE427668C DE 427668 C DE427668 C DE 427668C DE C35140 D DEC35140 D DE C35140D DE C0035140 D DEC0035140 D DE C0035140D DE 427668 C DE427668 C DE 427668C
Authority
DE
Germany
Prior art keywords
quinine
subcutaneous injections
preparation
solutions suitable
quinine solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEC35140D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHEMISCH PHARMAZEUTISCHE A G B
Original Assignee
CHEMISCH PHARMAZEUTISCHE A G B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHEMISCH PHARMAZEUTISCHE A G B filed Critical CHEMISCH PHARMAZEUTISCHE A G B
Priority to DEC35140D priority Critical patent/DE427668C/en
Application granted granted Critical
Publication of DE427668C publication Critical patent/DE427668C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Fats And Perfumes (AREA)

Description

Verfahren zur Herstellung von zu subkutanen Injektionen geeigneten Chininlösungen. Die in neuerer Zeit nach manchen Richtungen erweiterte therapeutische Indikation für Chinin hat z. B. die eigenartige spezifische Wirkung bei Pneumokokkenpneumonie sicher festgestellt. Abgesehen davon, daB die hierzu verwendeten wässerigen Chininsalzlösungen häufig sehr starke Reizerscheinungen hervorrufen, wäre es zur Verstärkung der Wirkung erwünscht, an Stelle der Salze die weit stärker wirkende Base zu verwenden (vgl. z. B. L. IVI i c h a eli s, Zeitschrift für Immunitätsforschung und exper. Therapie 1922, I. Teil, Bd. 34 Originale, S. 19q. ff.). Die Verwendung der Chininbase zu subkutanen Injektionen scheiterte bisher an der Schwerlöslichkeit von Chinin in Flüssigkeiten, wie sie zu subkutanen Injektionen gebraucht werden. Eine ilr/2prozentige Chininlösung in Olivenöl ist zwar in der Wärme herstellbar, kristallisiert aber bei gewöhnlicher Temperatur nach längerer Zeit zum Teil wieder aus. Es wurde nun gefunden, daB man Lösungen von Chinin in Olivenöl und anderen Ölen, und zwar in Konzentrationen, wie sie praktisch nötig sind, herstellen kann, wenn man die Chininbase in dem betreffenden Öl bei Gegenwart von Terpenen, wie Terpineol, Menthol, Linaloeöl und entsprechenden Körpern, zur Lösung bringt. Beispiel I.Process for the preparation of injections suitable for subcutaneous use Quinine solutions. The therapeutic one, which has recently been expanded in some directions Indication for quinine has z. B. the peculiar specific action in pneumococcal pneumonia determined for sure. Apart from the fact that the aqueous quinine salt solutions used for this purpose often cause very strong irritation, it would be to intensify the effect it is desirable to use the far more powerful base instead of the salts (cf. z. B. L. IVI i c h a eli s, Journal for Immunity Research and exper. therapy 1922, Part I, vol. 34 originals, p. 19q. ff.). The use of the quinine base too So far, subcutaneous injections have failed due to the poor solubility of quinine in Fluids such as those used for subcutaneous injections. An ilr / 2 percent Quinine solution in olive oil can be produced in the heat, but crystallizes at normal temperature partly off again after a long period of time. It was now found that solutions of quinine in olive oil and other oils can be found in Concentrations that are practically necessary can be produced if one uses the quinine base in the oil in question in the presence of terpenes, such as terpineol, menthol, linalo oil and corresponding bodies to solve. Example I.

i g Chinin wird in 3 ccm Terpineol warm gelöst und mit 8 ccm Olivenöl versetzt. Es entsteht eine klare, haltbare Lösung, die etwa io Prozent Chinin enthält und sich vorzüglich zu subkutanen Injektionen eignet.i g quinine is dissolved warm in 3 cc terpineol and 8 cc olive oil offset. The result is a clear, durable solution that contains around 10 percent quinine and is particularly suitable for subcutaneous injections.

Beispiel IL 2 g Chinin werden in einem Gemisch von io g Menthol, io ccm Eucalyptol und 20 ccm Olivenöl in der Wärme gelöst. Die Lösung bildet eine schwach gefärbte haltbare Flüssigkeit, die sich bei subkutaner Verwendung als völlig reizlos erweist.Example IL 2 g of quinine are in a mixture of 10 g of menthol, io ccm eucalyptol and 20 ccm olive oil dissolved in the heat. The solution forms a weak colored, durable liquid which proves to be completely irritant-free when used subcutaneously proves.

Da Eucalyptol ein die Schleimhäute der Bronchien anregendes Mittel ist, das durch die Lungen zur Ausscheidung kommt, und Chinin in den Lungen gespeichert wird, ist die Kombination von Eucalyptol mit genügenden Mengen von Chinin therapeutisch besonders wertvoll.Because eucalyptol stimulates the bronchial mucous membranes is excreted by the lungs and quinine is stored in the lungs the combination of eucalyptol with sufficient amounts of quinine is therapeutic particularly valuable.

Claims (1)

PATENT-ANspRUcH: Verfahren zur Hersteliung von zu subkutanen Injektionen -(eigneten Chininlösungen, darin bestehend, daß man Chinin bei Gegenwart von Terpenen, wie Terpineol, Menthol, Linaloeöl oder ätherischen Ölen, die diese Stoffe enthalten, in Olivenöl oder ähnlichen Ölen zur Lösung bringt.PATENT CLAIM: Process for the production of injections that are too subcutaneous - (suitable quinine solutions, consisting in that quinine in the presence of terpenes, such as terpineol, menthol, linaloe oil or essential oils that contain these substances, dissolves in olive oil or similar oils.
DEC35140D 1924-07-14 1924-07-15 Process for the preparation of quinine solutions suitable for subcutaneous injections Expired DE427668C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEC35140D DE427668C (en) 1924-07-14 1924-07-15 Process for the preparation of quinine solutions suitable for subcutaneous injections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1648487X 1924-07-14
DEC35140D DE427668C (en) 1924-07-14 1924-07-15 Process for the preparation of quinine solutions suitable for subcutaneous injections

Publications (1)

Publication Number Publication Date
DE427668C true DE427668C (en) 1926-04-14

Family

ID=25970017

Family Applications (1)

Application Number Title Priority Date Filing Date
DEC35140D Expired DE427668C (en) 1924-07-14 1924-07-15 Process for the preparation of quinine solutions suitable for subcutaneous injections

Country Status (1)

Country Link
DE (1) DE427668C (en)

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