CN113827506A - 一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯 - Google Patents
一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯 Download PDFInfo
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Abstract
本发明涉及一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯，其特征在于由以下重量份数比的原料组成：抑菌剂0.1‑0.5份；防龋齿物质0.2‑0.8份；美白牙齿物质1.0‑5.0份；口腔黏膜粘合、成膜剂，抗过敏的物质：1‑10份；去除异味物质0.1‑2份；泡沫增强稳定剂：0.1‑0.5%；表面活性剂1.0‑5.0份；矫味剂0.1‑0.2份；香精0.1‑2份；保湿剂5‑20份；pH调节剂0.1‑2份和余量的去离子水。本发明优点：本发明具有抑菌、防龋齿、美白牙齿、抗过敏、去除口腔异味等功能，通过加入口腔黏膜粘合、成膜剂，可将有效因子长时间作用在口腔黏膜、牙齿上实现功效性，还可以封闭暴露的牙本质小管，达到抗过敏的效果，不仅实现各功能有效整合且互不干扰，而且实现了从配方到工艺、生产的转化。
Description
技术领域
本发明涉及日用化工品领域，具体涉及一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯。
背景技术
随着人们生活水平的提高，越来越多的人开始追求生活品质，抑菌、防龋齿、美白牙齿、抗过敏、去除口腔异味都是人们追求的口腔护理功能，单一功能的产品研发比较容易实现，集多功能为一体的产品在研发过程中会存在功能性物质互相干扰和工艺难以实现的问题，而且市场上口腔护理产品多数为漱口水和喷雾剂的类型，漱口水含有上述功能后存在一定的刺激性，在口腔中不够柔和，带来不好的使用体验，喷雾剂以雾状液态小水滴在口腔中不能充满口腔，更不可能完全包裹牙齿，所以很难实现牙齿美白和防龋齿等功能。
发明内容
本发明的目的一是为了解决现有市面上单一功能的口腔护理产品护理不够全面；二是为了解决多功能口腔护理产品各原料混合、加工等工艺上的难点；三是为了解决现有喷雾剂不能完全充满口腔、包裹牙齿，不能发挥美白和防龋齿等功能，漱口水与慕斯泡沫相比不够柔和，对口腔黏膜有刺激性的问题；四是为了解决目前市场上的口腔护理产品不能将有效因子长时间作用在口腔黏膜、牙齿上实现功效性的问题。提供一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯。
为了实现上述目的，本发明采用的技术方案如下：
一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯，其特征在于由以下重量份数比的原料组成：
抑菌剂0.1-0.5份；防龋齿物质0.2-0.8份；美白牙齿物质1.0-5.0份；口腔黏膜粘合、成膜剂，抗过敏的物质：1-10份；去除异味物质0.1-2份；泡沫增强稳定剂：0.1-0.5份；表面活性剂1.0-5.0份；矫味剂0.1-0.2份；香精0.1-2份；保湿剂5-20份；pH调节剂0.1-2份和余量的去离子水。
进一步，所述抑菌剂为醋酸氯己定。
进一步，所述防龋齿物质为氟化钠、单氟磷酸钠中任一种或两种的混合物。
进一步，所述美白牙齿物质为聚乙烯吡咯烷酮、过氧化氢、海盐、竹盐任意一种或多种的混合物。
进一步，所述口腔黏膜黏合、成膜剂、抗过敏物质为PVM/MA共聚物。
进一步，所述去除异味物质为麝香草酚、薄荷醇中任一种或两种的混合物，且需要用丙二醇做为溶剂才能将麝香草酚、薄荷醇完全溶解。
进一步，所述泡沫增强稳定剂为羧甲基纤维素钠、羟丙基甲基纤维素、羟乙基纤维素任意一种或多种的混合物；表面活性剂为十二烷基硫酸钠、月桂酰谷氨酸钠、椰油酰胺丙基甜菜碱任意一种或多种的混合物。
进一步，所述矫味剂为木糖醇、山梨糖醇、三氯蔗糖任意一种或多种的混合物，保湿剂为甘油、丙二醇中任一种或两种的混合物，pH调节剂为柠檬酸、柠檬酸钠中任一种或两种的混合物。
本产品的生产工艺中无需加热就可以快速的将泡沫增强稳定剂羧甲基纤维素钠或者羟乙基纤维素溶解，而不会出现物料遇水结团现象：将泡沫增强稳定剂与粉末细腻的表面活性剂十二烷基硫酸钠混合均匀后倒入水中搅拌可以使二者快速完全溶解，而不会结团；去除异味物质麝香草酚、薄荷醇不能溶于水，需要用丙二醇做为溶剂才能将其完全溶解；抑菌剂醋酸氯己定与表面活性剂十二烷基硫酸钠和泡沫增强稳定剂羧甲基纤维素钠同时加入水中会相互干扰，使得醋酸氯己定不能溶解，需要将醋酸氯己定先加入水中完全溶解后，再加入十二烷基硫酸钠和羧甲基纤维素钠。
一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯的制备方法，其特征在于包括如下步骤：
（1）按上述份数比称量好各物质备用；
（2）将抑菌剂加入水中，搅拌至完全溶解；
（3）将表面活性剂和泡沫增强稳定剂混合均匀后倒入步骤（2）的溶液中，搅拌均匀；
（4）将去除异味物质加入丙二醇中搅拌至完全溶解，随后加入步骤（3）制备的溶液中，搅拌均匀；
（5）将防龋齿物质，美白牙齿物质，矫味剂，防腐剂，pH调节剂，香精，口腔黏膜黏合、成膜剂、抗过敏物质，保湿剂依次加入到步骤（4）制备的溶液中，搅拌均匀、过滤灌装在起泡瓶中。
要实现抑菌、防龋齿、美白牙齿、抗过敏、去除口腔异味这些功能，第一需要作用因子（功能性物质）和作用部位有效结合；第二要有充分有效的作用时间。本发明以慕斯泡沫的形式可以使作用因子（功能性物质）充满整个口腔，包裹住牙齿，很好的和作用部位结合；作用因子（功能性物质）要想在湿润的口腔中保留充分有效的作用时间，需要将作用因子（功能性物质）粘附在口腔、牙齿上，不容易随唾液流失，这时候需要有口腔黏膜粘合剂形成膜，承载传递这些功能性成分并长时间的粘附在口腔黏膜和牙齿上，泡沫型慕斯中加入这种口腔黏膜粘合、成膜剂既可以有出色的生物粘着性，可以发挥上述功效性，还可以封闭暴露的牙本质小管，抗过敏。
相比于现有技术，本发明具有如下优点：
（1）杀灭细菌：本发明含有杀菌成分，因为加入了口腔黏膜粘合、成膜剂，将口腔黏膜粘合、成膜剂作为载体，承载、传递抑菌成分可以长时间粘附在口腔里，起到杀菌的作用；
（2）美白：本发明含有美白成分，通过口腔黏膜粘合、成膜剂作为载体，将美白因子长时间粘附在牙齿上起到美白的功效；
（3）抗过敏：本发明含有可以封闭牙小管的成分，也就是口腔黏膜黏合、成膜剂，从而起到抗过敏的作用；
（4）防龋齿：本发明含有氟，可以通过口腔黏膜粘合、成膜剂作为载体将氟粘附在牙齿上，可以起到防龋齿，稳固牙齿的作用；
（5）去除口腔异味：本发明中含有天然的薄荷醇、麝香草酚，可以去除口腔异味，清新口气；
（6）本发明以慕斯泡沫的形式将作用因子（功能性物质）充满整个口腔，包裹住牙齿，很好的和作用部位结合，口感柔和，对口腔无刺激；
（7）本发明通过加入口腔黏膜粘合、成膜剂，可以将作用因子长时间作用在口腔黏膜、牙齿上实现功效性，还可以封闭暴露的牙本质小管，达到抗过敏的效果，不仅实现各功能有效整合且互不干扰，而且实现了从配方到工艺、生产的转化，解决了工艺上的难题。
具体实施方式
一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯的制备方法，具体实施步骤如下：
实施例1：将按下表1中各实例的配方称量各组分物质，具体实施步骤如下，试验结果见表1。
（1）按上述份数比称量好各物质备用；
（2）将醋酸氯己定加入水中，搅拌至完全溶解；
（3）将十二烷基硫酸钠和羧甲基纤维素钠混合均匀后倒入步骤（2）的溶液中，搅拌均匀；
（4）将薄荷醇和麝香草酚加入丙二醇中搅拌至完全溶解，随后加入步骤（3）制备的溶液中，搅拌均匀；
（5）将氟化钠、聚乙烯吡咯烷酮、木糖醇、苯甲酸钠、柠檬酸、柠檬酸钠、香精、PVM/MA共聚物、甘油依次加入到步骤（4）制备的溶液中，搅拌均匀、过滤灌装在起泡瓶中。
对比实施例1：
将按下表1中实施例1的配方称量各组分物质，具体实施步骤如下：
将称量好的各物质混匀后倒入水中搅拌，发现有水中有结块成团现象，长时间搅拌也不能溶解。此制备方法不可行。
对比实施例2：
按下表1中实施例1配方称量各组分物质，具体实施步骤如下：
①将称量好的十二烷基硫酸钠和羧甲基纤维素钠混合均匀后加入水中搅拌均匀；
②将称量好的醋酸氯己定加入①中搅拌，发现有难容的絮状物，长时间搅拌不能溶解。此制备方法不可行。
对比实施例3：
按下表1中实施例1配方称量各组分物质，具体实施步骤如下：
①将称量好的醋酸氯己定加入水中搅拌至完全溶解；
②将称量好的十二烷基硫酸钠和羧甲基纤维素钠混合均匀后加入①中搅拌均匀；
③将称量好的薄荷醇和麝香草酚加入②中搅拌，发现薄荷醇和麝香草酚长时间搅拌不能溶于水。此制备方法不可行。
（1）泡沫状态稳定性试验：
将口腔护理液从起泡瓶中按压出来，观察状态：泡沫细腻，且泡沫可以稳定保持5分钟以上不塌陷为合格，否则记为不合格。
（2）美白试验：
将牛牙在咖啡和浓茶混合液中浸泡2小时进行上色，将上色后的牛牙放入口腔护理慕斯5分钟，然后用纯化水将牛牙上的泡沫冲洗干净；空白对照：将上色后的牛牙放置在纯化水中浸泡5分钟。美白试验每天4次，进行7天，7天后用白度计检测白度值，若牛牙在口腔护理慕斯浸泡前后的白度差值＞牛牙在纯化水中浸泡前后的白度差值，则为合格，否则为不合格；
（3）抑菌试验：
将细菌用本发明实例1-5和对比实例1-3的口腔护理液处理，然后分别在同样条件下培养，（在细菌培养基上37℃培养72小时）观察是否有菌落成长，+表示有菌落生长，-表示无菌落成生长。
（4）杀菌试验：
本发明的实例1-5和对比实例1-3的口腔护理液对金黄色葡萄球菌、大肠杆菌、白色念珠菌30min的杀菌试验。
（5）去除异味检测：
将韭菜、大蒜、鸡蛋用豆浆机打碎取混合液涂抹在滤纸上，将本发明的口腔护理慕斯喷在滤纸的混合液上，每隔1分钟评价混合液的残留味道，10人评价取平均值，5分钟后残留味道≤50%为合格，否则为不合格。
表1：
Claims (9)
1.一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯，其特征在于由以下重量份数比的原料组成：抑菌剂0.1-0.5份；防龋齿物质0.2-0.8份；美白牙齿物质1.0-5.0份；口腔黏膜粘合、成膜剂，抗过敏的物质：1-10份；去除异味物质0.1-2份；泡沫增强稳定剂：0.1-0.5%；表面活性剂1.0-5.0份；矫味剂0.1-0.2份；香精0.1-2份；保湿剂5-20份；pH调节剂0.1-2份和余量的去离子水。
2.根据权利要求1所述一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯，其特征在于：所述抑菌剂为醋酸氯己定。
3.根据权利要求1所述一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯，其特征在于：所述防龋齿物质为氟化钠、单氟磷酸钠中任一种或两种的混合物。
4.根据权利要求1所述一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯，其特征在于：所述美白牙齿物质为聚乙烯吡咯烷酮、过氧化氢、海盐、竹盐任意一种或多种的混合物。
5.根据权利要求1所述一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯，其特征在于：所述口腔黏膜粘合、成膜剂，抗过敏物质为PVM/MA共聚物。
6.根据权利要求1所述一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯，其特征在于：所述去除异味物质为麝香草酚、薄荷醇中任一种或两种的混合物，且其溶剂为丙二醇。
7.根据权利要求1-6所述一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯，其特征在于：所述泡沫增强稳定剂为羧甲基纤维素钠、羟丙基甲基纤维素、羟乙基纤维素任意一种或多种的混合物；表面活性剂为十二烷基硫酸钠、月桂酰谷氨酸钠、椰油酰胺丙基甜菜碱任意一种或多种的混合物。
8.根据权利要求1-6所述一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯，其特征在于：所述矫味剂为木糖醇、山梨糖醇、三氯蔗糖任意一种或多种的混合物，保湿剂为甘油、丙二醇中任一种或两种的混合物，pH调节剂为柠檬酸、柠檬酸钠中任一种或两种的混合物。
9.根据权利要求1所述一种抑菌、防龋齿、美白牙齿、抗过敏、去除异味的口腔护理慕斯的制备方法，其特征在于包括如下步骤：
（1）按上述份数比称量好各物质备用；
（2）将抑菌剂加入水中，搅拌至完全溶解；
（3）将表面活性剂和泡沫增强稳定剂混合均匀后倒入步骤（2）的溶液中，搅拌均匀；
（4）将去除异味物质加入到丙二醇中搅拌至完全溶解，随后加入步骤（3）制备的溶液中，搅拌均匀；
（5）将防龋齿物质，美白牙齿物质，矫味剂，防腐剂，pH调节剂，香精，口腔黏膜粘合、成膜剂，抗过敏物质，保湿剂依次加入到步骤（4）制备的溶液中，搅拌均匀、过滤灌装在起泡瓶中。
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| CN116077355A (zh) * | 2022-09-21 | 2023-05-09 | 安乐唯医疗科技(北京)有限公司 | 氟防龋组合物、氟防龋剂及其在矫正牙齿中的应用 |
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