JP2020143129A5 - - Google Patents
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- Publication number
- JP2020143129A5 JP2020143129A5 JP2020090240A JP2020090240A JP2020143129A5 JP 2020143129 A5 JP2020143129 A5 JP 2020143129A5 JP 2020090240 A JP2020090240 A JP 2020090240A JP 2020090240 A JP2020090240 A JP 2020090240A JP 2020143129 A5 JP2020143129 A5 JP 2020143129A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- compound according
- compound
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 40
- 125000000623 heterocyclic group Chemical group 0.000 claims 16
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000004452 carbocyclyl group Chemical group 0.000 claims 11
- 150000002431 hydrogen Chemical class 0.000 claims 11
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000002252 acyl group Chemical group 0.000 claims 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022063260A JP2022092625A (ja) | 2013-06-11 | 2022-04-06 | 尿素誘導体及びその使用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361833853P | 2013-06-11 | 2013-06-11 | |
| US61/833,853 | 2013-06-11 | ||
| US201361898720P | 2013-11-01 | 2013-11-01 | |
| US61/898,720 | 2013-11-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019004872A Division JP2019070027A (ja) | 2013-06-11 | 2019-01-16 | 尿素誘導体及びその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022063260A Division JP2022092625A (ja) | 2013-06-11 | 2022-04-06 | 尿素誘導体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020143129A JP2020143129A (ja) | 2020-09-10 |
| JP2020143129A5 true JP2020143129A5 (enExample) | 2021-02-25 |
| JP7058885B2 JP7058885B2 (ja) | 2022-04-25 |
Family
ID=52022933
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519614A Expired - Fee Related JP6469661B2 (ja) | 2013-06-11 | 2014-06-11 | 尿素誘導体及びその使用 |
| JP2019004872A Pending JP2019070027A (ja) | 2013-06-11 | 2019-01-16 | 尿素誘導体及びその使用 |
| JP2020090240A Active JP7058885B2 (ja) | 2013-06-11 | 2020-05-25 | 尿素誘導体及びその使用 |
| JP2022063260A Pending JP2022092625A (ja) | 2013-06-11 | 2022-04-06 | 尿素誘導体及びその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519614A Expired - Fee Related JP6469661B2 (ja) | 2013-06-11 | 2014-06-11 | 尿素誘導体及びその使用 |
| JP2019004872A Pending JP2019070027A (ja) | 2013-06-11 | 2019-01-16 | 尿素誘導体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022063260A Pending JP2022092625A (ja) | 2013-06-11 | 2022-04-06 | 尿素誘導体及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (9) | US9212145B2 (enExample) |
| EP (1) | EP3030239A4 (enExample) |
| JP (4) | JP6469661B2 (enExample) |
| AU (3) | AU2014278231B2 (enExample) |
| CA (1) | CA2914815A1 (enExample) |
| WO (1) | WO2014201127A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3030239A4 (en) | 2013-06-11 | 2017-03-08 | Kala Pharmaceuticals, Inc. | Urea derivatives and uses thereof |
| CA2969467A1 (en) | 2014-12-10 | 2016-06-16 | Kala Pharmaceuticals, Inc. | 1-amino-triazolo(1,5-a)pyridine-substituted urea derivative and uses thereof |
| CA3005723A1 (en) * | 2015-11-20 | 2017-05-26 | Mingsight Pharmaceuticals, Inc. | Treatment of autoimmune disease |
| CN110167554B (zh) * | 2016-11-17 | 2023-05-23 | 思路迪（北京）医药科技有限公司 | 一种具有抗癌作用的化合物及其制备方法和应用 |
| EP4079303A4 (en) * | 2019-12-16 | 2023-08-23 | Suzhou Raymon Pharmaceuticals Company, Ltd. | USE OF A NAPHTHYLUREA COMPOUND |
| WO2021138434A1 (en) * | 2019-12-31 | 2021-07-08 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| HUE068185T2 (hu) | 2020-05-08 | 2024-12-28 | Halia Therapeutics Inc | NEK7-kináz inhibitorok |
| CN115487183B (zh) * | 2021-06-18 | 2024-07-26 | 苏州锐明新药研发有限公司 | 萘脲类化合物在制备治疗翼状胬肉的药物中的应用 |
| JP2025538351A (ja) * | 2022-12-13 | 2025-11-28 | スーチョウ レイモン ファーマシューティカルズ カンパニー リミテッド | 翼状片の治療の医薬の調製におけるナフチルウレア系化合物の使用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| JPH0959276A (ja) * | 1995-08-11 | 1997-03-04 | Kumiai Chem Ind Co Ltd | 縮合ヘテロ環誘導体及び除草剤 |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| EP1545514A1 (en) | 2002-08-14 | 2005-06-29 | Boehringer Ingelheim Pharmaceuticals Inc. | Anticoagulant and fibrinolytic therapy using p38 map kinase inhibitors |
| US7297709B2 (en) * | 2003-05-22 | 2007-11-20 | Abbott Laboratories | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors |
| PT1638941E (pt) * | 2003-05-22 | 2010-08-24 | Abbott Lab | Inibidores de quinases de indazole, benzisoxazole e benzisotiazole |
| EP1683796A1 (en) * | 2005-01-24 | 2006-07-26 | Schering Aktiengesellschaft | Pyrazolopyridines, their preparation and their medical use |
| TW200640443A (en) * | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| WO2008080110A1 (en) * | 2006-12-21 | 2008-07-03 | Alcon, Inc. | Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor |
| CN101239978A (zh) * | 2008-03-05 | 2008-08-13 | 南方医科大学 | 一种咪唑并吡啶类化合物 |
| JP2013508295A (ja) * | 2009-10-16 | 2013-03-07 | デューク・ユニヴァーシティ | 薬物誘発性手足症候群を治療するための組成物および方法 |
| WO2012003141A1 (en) * | 2010-07-02 | 2012-01-05 | Alcon Research, Ltd. | Compounds for the treatment of posterior segment disorders and diseases |
| AU2011323250B2 (en) | 2010-11-05 | 2015-11-19 | The Johns Hopkins University | Compositions and methods relating to reduced mucoadhesion |
| WO2012158810A1 (en) | 2011-05-17 | 2012-11-22 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| EP3030239A4 (en) | 2013-06-11 | 2017-03-08 | Kala Pharmaceuticals, Inc. | Urea derivatives and uses thereof |
-
2014
- 2014-06-11 EP EP14811423.4A patent/EP3030239A4/en not_active Withdrawn
- 2014-06-11 AU AU2014278231A patent/AU2014278231B2/en not_active Ceased
- 2014-06-11 JP JP2016519614A patent/JP6469661B2/ja not_active Expired - Fee Related
- 2014-06-11 WO PCT/US2014/041930 patent/WO2014201127A2/en not_active Ceased
- 2014-06-11 US US14/301,653 patent/US9212145B2/en active Active
- 2014-06-11 CA CA2914815A patent/CA2914815A1/en not_active Abandoned
-
2015
- 2015-11-12 US US14/939,727 patent/US9580421B2/en not_active Expired - Fee Related
-
2017
- 2017-01-20 US US15/411,485 patent/US9802922B2/en not_active Expired - Fee Related
- 2017-08-24 AU AU2017219063A patent/AU2017219063B2/en not_active Ceased
- 2017-10-12 US US15/782,696 patent/US10059692B2/en active Active
- 2017-10-12 US US15/782,743 patent/US10059693B2/en active Active
-
2018
- 2018-07-23 US US16/043,007 patent/US10329280B2/en active Active
- 2018-07-23 US US16/043,000 patent/US10316022B2/en active Active
-
2019
- 2019-01-16 JP JP2019004872A patent/JP2019070027A/ja active Pending
- 2019-05-01 US US16/400,672 patent/US10723719B2/en not_active Expired - Fee Related
-
2020
- 2020-05-25 JP JP2020090240A patent/JP7058885B2/ja active Active
- 2020-06-12 US US16/900,657 patent/US11352343B2/en active Active
- 2020-09-16 AU AU2020233692A patent/AU2020233692B2/en not_active Expired - Fee Related
-
2022
- 2022-04-06 JP JP2022063260A patent/JP2022092625A/ja active Pending
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