CA2914815A1 - Urea derivatives and uses thereof - Google Patents

Info

Publication number

CA2914815A1

CA2914815A1 CA2914815A CA2914815A CA2914815A1 CA 2914815 A1 CA2914815 A1 CA 2914815A1 CA 2914815 A CA2914815 A CA 2914815A CA 2914815 A CA2914815 A CA 2914815A CA 2914815 A1 CA2914815 A1 CA 2914815A1

Authority

CA

Canada

Prior art keywords

substituted

unsubstituted

compound

certain embodiments

instance

Prior art date

2013-06-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

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• CIPO
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• 150000003672 ureas Chemical class 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 403
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• 238000000034 method Methods 0.000 claims abstract description 34
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• 208000002780 macular degeneration Diseases 0.000 claims abstract description 20
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• 230000011664 signaling Effects 0.000 claims abstract description 14
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• 230000002062 proliferating effect Effects 0.000 claims abstract description 9
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 426
• 125000000217 alkyl group Chemical group 0.000 claims description 302
• 125000004452 carbocyclyl group Chemical group 0.000 claims description 289
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 258
• 125000001072 heteroaryl group Chemical group 0.000 claims description 240
• 229910052757 nitrogen Inorganic materials 0.000 claims description 233
• 125000003118 aryl group Chemical group 0.000 claims description 204
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 169
• 229910052717 sulfur Inorganic materials 0.000 claims description 159
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 147
• 125000004429 atom Chemical group 0.000 claims description 147
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• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 103
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• 125000001624 naphthyl group Chemical group 0.000 description 39
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• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 34
• 125000000547 substituted alkyl group Chemical group 0.000 description 34
• 239000000463 material Substances 0.000 description 33
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• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 31
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 31
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• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 28
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 27
• 125000004076 pyridyl group Chemical group 0.000 description 26
• 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 26
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• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 21
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• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 19
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