JP2020108397A5 - - Google Patents
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- JP2020108397A5 JP2020108397A5 JP2020047981A JP2020047981A JP2020108397A5 JP 2020108397 A5 JP2020108397 A5 JP 2020108397A5 JP 2020047981 A JP2020047981 A JP 2020047981A JP 2020047981 A JP2020047981 A JP 2020047981A JP 2020108397 A5 JP2020108397 A5 JP 2020108397A5
- Authority
- JP
- Japan
- Prior art keywords
- culture medium
- pluripotent stem
- stem cells
- cells
- human pluripotent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 22
- 239000001963 growth medium Substances 0.000 claims 13
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 11
- 210000003566 hemangioblast Anatomy 0.000 claims 7
- 210000005167 vascular cell Anatomy 0.000 claims 7
- 102000003951 Erythropoietin Human genes 0.000 claims 6
- 108090000394 Erythropoietin Proteins 0.000 claims 6
- 102000036693 Thrombopoietin Human genes 0.000 claims 6
- 108010041111 Thrombopoietin Proteins 0.000 claims 6
- 229940105423 erythropoietin Drugs 0.000 claims 6
- 210000003593 megakaryocyte Anatomy 0.000 claims 6
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 6
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 5
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 5
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 5
- 210000002242 embryoid body Anatomy 0.000 claims 5
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 4
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 4
- 102000000646 Interleukin-3 Human genes 0.000 claims 4
- 108010002386 Interleukin-3 Proteins 0.000 claims 4
- 229940076264 interleukin-3 Drugs 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 102100028404 Homeobox protein Hox-B4 Human genes 0.000 claims 3
- 101000839788 Homo sapiens Homeobox protein Hox-B4 Proteins 0.000 claims 3
- 230000004069 differentiation Effects 0.000 claims 3
- 239000003102 growth factor Substances 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 2
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 229940100601 interleukin-6 Drugs 0.000 claims 2
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 230000000921 morphogenic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12680308P | 2008-05-06 | 2008-05-06 | |
| US61/126,803 | 2008-05-06 | ||
| US18949108P | 2008-08-19 | 2008-08-19 | |
| US61/189,491 | 2008-08-19 | ||
| US19028208P | 2008-08-26 | 2008-08-26 | |
| US61/190,282 | 2008-08-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017206725A Division JP2018027095A (ja) | 2008-05-06 | 2017-10-26 | 多能性幹細胞に由来する除核赤血球細胞を産生するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020108397A JP2020108397A (ja) | 2020-07-16 |
| JP2020108397A5 true JP2020108397A5 (enExample) | 2020-11-19 |
Family
ID=41265390
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011508646A Expired - Fee Related JP5748654B2 (ja) | 2008-05-06 | 2009-05-06 | 多能性幹細胞に由来する除核赤血球細胞を産生するための方法 |
| JP2014261935A Pending JP2015061539A (ja) | 2008-05-06 | 2014-12-25 | 多能性幹細胞に由来する除核赤血球細胞を産生するための方法 |
| JP2017206725A Pending JP2018027095A (ja) | 2008-05-06 | 2017-10-26 | 多能性幹細胞に由来する除核赤血球細胞を産生するための方法 |
| JP2020047981A Pending JP2020108397A (ja) | 2008-05-06 | 2020-03-18 | 多能性幹細胞に由来する除核赤血球細胞を産生するための方法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011508646A Expired - Fee Related JP5748654B2 (ja) | 2008-05-06 | 2009-05-06 | 多能性幹細胞に由来する除核赤血球細胞を産生するための方法 |
| JP2014261935A Pending JP2015061539A (ja) | 2008-05-06 | 2014-12-25 | 多能性幹細胞に由来する除核赤血球細胞を産生するための方法 |
| JP2017206725A Pending JP2018027095A (ja) | 2008-05-06 | 2017-10-26 | 多能性幹細胞に由来する除核赤血球細胞を産生するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20110086424A1 (enExample) |
| EP (2) | EP2288690B1 (enExample) |
| JP (4) | JP5748654B2 (enExample) |
| KR (4) | KR101803562B1 (enExample) |
| CN (3) | CN112280739A (enExample) |
| AU (1) | AU2009244236B2 (enExample) |
| BR (1) | BRPI0912517A2 (enExample) |
| CA (2) | CA2722766A1 (enExample) |
| MX (1) | MX2010012089A (enExample) |
| WO (1) | WO2009137629A2 (enExample) |
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| EP3441462A1 (en) | 2008-05-06 | 2019-02-13 | Astellas Institute for Regenerative Medicine | Hemangio colony forming cells and non-engrafting hemangio cells |
| KR101803099B1 (ko) | 2008-05-16 | 2017-11-30 | 타이가 바이오테크놀로지스, 인코포레이티드 | 항체 및 그 제조 방법 |
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| KR20190142424A (ko) * | 2009-12-04 | 2019-12-26 | 스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크. | 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성 |
| RU2012127811A (ru) * | 2009-12-04 | 2014-01-10 | Стем Селл Энд Ридженерэйтив Медсин Интернэшнл, Инк. | Способ получения клеток-натуральных киллеров и дендритных клеток из человеческих эмбриональных гемангиобластов, полученных из стволовых клеток |
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2009
- 2009-05-06 CN CN202010783311.5A patent/CN112280739A/zh active Pending
- 2009-05-06 KR KR1020107027292A patent/KR101803562B1/ko not_active Expired - Fee Related
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- 2009-05-06 US US12/991,111 patent/US20110086424A1/en not_active Abandoned
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