BR0014864A - Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem - Google Patents

Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem

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Publication number
BR0014864A
BR0014864A BR0014864-4A BR0014864A BR0014864A BR 0014864 A BR0014864 A BR 0014864A BR 0014864 A BR0014864 A BR 0014864A BR 0014864 A BR0014864 A BR 0014864A
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cells
progenitor cells
differentiated progenitor
methods
embryonic stem
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BR0014864-4A
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English (en)
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Jose Cibelli
Michael D West
Robert P Lanza
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Advanced Cell Tech Inc
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Abstract

"MéTODOS DE PRODUZIR CéLULAS PROGENITORAS DIFERENCIADAS E CéLULAS TRONCO EMBRIÈNICAS DEFEITUOSAS EM LINHAGEM". Um método aperfeiçoado de produzir células progenitoras aperfeiçoadas compreendendo obtendo células de massa de célula interna de um blastócisto e induzindo diferenciação das células de massa de célula interna para produzir células progenitoras diferenciadas. As células progenitoras diferenciadas podem ser transfectadas tais que exista além disso, anulação ou alteração de um gene desejado. As células progenitoras diferenciadas são úteis em terapia de célula e como uma fonte I de células para a produção de tecidos e orgãos para transplantação. Também fornecido é um método para produzir uma célula de tronco embriónica humana defeituosa em linhagem.
BR0014864-4A 1999-10-15 2000-10-13 Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem BR0014864A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15955099P 1999-10-15 1999-10-15
PCT/US2000/028285 WO2001029206A1 (en) 1999-10-15 2000-10-13 Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells

Publications (1)

Publication Number Publication Date
BR0014864A true BR0014864A (pt) 2002-11-19

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BR0014864-4A BR0014864A (pt) 1999-10-15 2000-10-13 Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem

Country Status (11)

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US (3) US20050265976A1 (pt)
EP (1) EP1226239A4 (pt)
JP (1) JP2003512052A (pt)
CN (1) CN1413250A (pt)
AU (1) AU782385B2 (pt)
BR (1) BR0014864A (pt)
CA (1) CA2388497A1 (pt)
IL (2) IL149043A0 (pt)
MX (1) MXPA02003733A (pt)
NZ (1) NZ518191A (pt)
WO (1) WO2001029206A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
EP1214403A4 (en) * 1999-09-07 2005-03-09 Advanced Cell Tech Inc METHOD OF GENERATING IMMUNOCOMPATIBLE CELLS AND TISSUE USING NUCLEAR TRANSFER TECHNIQUES
US20020142397A1 (en) 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
CA2433419A1 (en) 2001-01-02 2002-07-25 Stemron, Inc. A method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same
EP1367899A4 (en) 2001-02-14 2004-07-28 Leo T Furcht TOTIPOTENT ADULT STEM CELLS, SOURCES OF SUCH CELLS, METHODS FOR OBTAINING AND MAINTAINING SAME, METHODS FOR DIFFERENTIATING THESE CELLS, METHODS OF USING SAME, AND CELLS DERIVED FROM THE ABOVE-MENTIONED CELLS
CA2453068C (en) * 2001-07-06 2018-02-20 Geron Corporation Mesenchymal cells and osteoblasts from human embryonic stem cell
AU2002246132A1 (en) * 2002-03-13 2003-09-22 Fundacion Ivi Para El Estudio De La Reproduccion Humana (Fivier) Method of producing cell lines
WO2004061092A1 (ja) 2002-12-27 2004-07-22 Mitsubishi Heavy Industries, Ltd. 多能性幹細胞の培養方法とそのための培養装置
US7838727B2 (en) 2004-11-04 2010-11-23 Advanced Cell Technology, Inc. Derivation of embryonic stem cells
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
WO2006112390A1 (ja) * 2005-04-14 2006-10-26 Japan As Represented By General Director Of Agency Of National Cardiovascular Center 脂肪由来前駆細胞およびその利用
CA2659945C (en) 2005-08-03 2014-12-16 Advanced Cell Technology, Inc. Improved methods of reprogramming animal somatic cells
KR20170102040A (ko) 2006-04-14 2017-09-06 아스텔라스 인스티튜트 포 리제너러티브 메디슨 혈관 콜로니 형성 세포
KR20150142061A (ko) 2006-05-03 2015-12-21 오카타 세라퓨틱스, 인크. 배아 줄기 세포 및 배-유도 세포의 유도
EP2087101A2 (en) 2006-11-24 2009-08-12 Regents of the University of Minnesota Endodermal progenitor cells
EP3190178A1 (en) 2007-02-23 2017-07-12 Astellas Institute for Regenerative Medicine Highly efficient methods for reprogramming differentiated cells and for generating animals and embryonic stem cells from reprogrammed cells
CN102083963A (zh) 2008-05-06 2011-06-01 先进细胞技术公司 血管瘤集落形成细胞和非移植血管瘤细胞
CN104328087A (zh) 2008-05-06 2015-02-04 先进细胞技术公司 用于制备衍生自多能干细胞的去核类红细胞的方法
US10386360B2 (en) 2009-03-13 2019-08-20 University Of Central Florida Research Foundation, Inc. Bio-microelectromechanical system transducer and associated methods
US8815584B1 (en) 2009-04-23 2014-08-26 University Of Central Florida Research Foundation, Inc. Method of co-culturing mammalian muscle cells and motoneurons
US9404140B1 (en) 2009-11-03 2016-08-02 The University Of Central Florida Research Foundation, Inc. Patterned cardiomyocyte culture on microelectrode array
EP2585171B1 (en) 2010-04-23 2018-12-26 University Of Central Florida Research Foundation, Inc. Formation of neuromuscular junctions in a defined system
JP2010193910A (ja) * 2010-06-14 2010-09-09 Mitsubishi Heavy Ind Ltd 多能性幹細胞の培養方法、多能性幹細胞の培養システム、及び多能性幹細胞培養装置
EP2606608B1 (de) 2010-08-20 2019-12-18 Hirschmann Automation and Control GmbH Erweiterung für das simple network management protocol (snmp) um informationen über den status von set-pdus zu ermitteln
CN105349492B (zh) * 2011-05-18 2019-04-16 加利福尼亚大学董事会 用于治疗视网膜疾病的组合物及方法
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
WO2014100779A1 (en) 2012-12-21 2014-06-26 Advanced Cell Technology, Inc. Methods ofr production of platelets from pluripotent stem cells and compositions thereof
US20150369791A1 (en) * 2013-01-30 2015-12-24 University Of Central Florida Research Foundation, Inc. Devices and systems for mimicking heart function
US10935541B2 (en) 2014-08-07 2021-03-02 University Of Central Florida Research Foundation, Inc. Devices and methods comprising neuromuscular junctions
WO2017048193A1 (en) * 2015-09-15 2017-03-23 Agency For Science, Technology And Research (A*Star) Derivation of liver organoids from human pluripotent stem cells
MX2018014016A (es) 2016-05-16 2019-08-01 Intarcia Therapeutics Inc Polipéptidos selectivos del receptor de glucagón y métodos para utilizarlos.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1298202B1 (en) 1992-10-28 2010-10-06 NeuroSpheres Holdings Ltd. Biological factors and neural stem cells
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5532156A (en) * 1993-10-08 1996-07-02 The United States Of America As Represented By The Secretary Of Agriculture Hepatocyte cell line derived from the epiblast of pig blastocysts
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
IL128348A (en) * 1996-08-19 2008-08-07 Univ Massachusetts Method of producing embryonic or stem like cell lines by transplantation of cell nuclei from animal or mammal, such cells and uses thereof
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
CN101003800A (zh) * 1997-07-03 2007-07-25 马萨诸塞大学 使用来自无血清饥饿的分化细胞的供体细胞核进行克隆
ES2285785T3 (es) * 1997-09-29 2007-11-16 Point Therapeutics, Inc. Estimulacion de celulas hematopoyeticas in vitro.
JP2002505100A (ja) * 1998-03-02 2002-02-19 ユニヴァーシティー オヴ マサチューセッツ アパブリック インスティテューション オヴ ハイアー エデュケイション オヴ ザ コモンウェルス オヴ マサチューセッツ リプレゼンティド バイイッツ アム 種間核移植によって作製された胚性または幹細胞様細胞株
BR0013999A (pt) * 1999-09-14 2002-05-21 Univ Massachusetts Public Inst Linhagens de célula embriÈnicas ou semelhantes a células tronco produzidas por transplante nuclear de espécies cruzadas e métodos para melhorar o desenvolvimento embriÈnico por alteração genética de células doadoras ou por condições de cultura de tecido
US6576464B2 (en) * 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
US7947499B2 (en) * 2002-11-29 2011-05-24 Technion Research & Development Foundation Ltd. Method of dynamically culturing embryonic stem cells

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CN1413250A (zh) 2003-04-23
US20090104697A1 (en) 2009-04-23
NZ518191A (en) 2004-01-30
AU1200001A (en) 2001-04-30
WO2001029206A1 (en) 2001-04-26
JP2003512052A (ja) 2003-04-02
EP1226239A1 (en) 2002-07-31
US8753884B2 (en) 2014-06-17
MXPA02003733A (es) 2003-10-14
IL149043A (en) 2010-11-30
CA2388497A1 (en) 2001-04-26
EP1226239A4 (en) 2003-02-12
AU782385B2 (en) 2005-07-21
US20140248700A1 (en) 2014-09-04
IL149043A0 (en) 2002-11-10
US20050265976A1 (en) 2005-12-01

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