JP2013512676A5 - - Google Patents

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Publication number
JP2013512676A5
JP2013512676A5 JP2012542230A JP2012542230A JP2013512676A5 JP 2013512676 A5 JP2013512676 A5 JP 2013512676A5 JP 2012542230 A JP2012542230 A JP 2012542230A JP 2012542230 A JP2012542230 A JP 2012542230A JP 2013512676 A5 JP2013512676 A5 JP 2013512676A5
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JP
Japan
Prior art keywords
scf
tpo
medium
pluripotent stem
combinations
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Application number
JP2012542230A
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English (en)
Japanese (ja)
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JP2013512676A (ja
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Publication date
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Priority claimed from PCT/US2010/058990 external-priority patent/WO2011069127A1/en
Publication of JP2013512676A publication Critical patent/JP2013512676A/ja
Publication of JP2013512676A5 publication Critical patent/JP2013512676A5/ja
Pending legal-status Critical Current

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JP2012542230A 2009-12-04 2010-12-03 無間質条件下におけるヒト胚性幹細胞からの機能的巨核球および血小板の大規模生成 Pending JP2013512676A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26693909P 2009-12-04 2009-12-04
US61/266,939 2009-12-04
US38416510P 2010-09-17 2010-09-17
US61/384,165 2010-09-17
PCT/US2010/058990 WO2011069127A1 (en) 2009-12-04 2010-12-03 Large scale generation of functional megakaryocytes and platelets from human embryonic stem cells under stromal-free conditions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016086761A Division JP2016135138A (ja) 2009-12-04 2016-04-25 無間質条件下におけるヒト胚性幹細胞からの機能的巨核球および血小板の大規模生成

Publications (2)

Publication Number Publication Date
JP2013512676A JP2013512676A (ja) 2013-04-18
JP2013512676A5 true JP2013512676A5 (enExample) 2014-01-16

Family

ID=44115332

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2012542230A Pending JP2013512676A (ja) 2009-12-04 2010-12-03 無間質条件下におけるヒト胚性幹細胞からの機能的巨核球および血小板の大規模生成
JP2016086761A Pending JP2016135138A (ja) 2009-12-04 2016-04-25 無間質条件下におけるヒト胚性幹細胞からの機能的巨核球および血小板の大規模生成
JP2019039160A Pending JP2019122385A (ja) 2009-12-04 2019-03-05 無間質条件下におけるヒト胚性幹細胞からの機能的巨核球および血小板の大規模生成
JP2022011675A Pending JP2022064953A (ja) 2009-12-04 2022-01-28 無間質条件下におけるヒト胚性幹細胞からの機能的巨核球および血小板の大規模生成

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2016086761A Pending JP2016135138A (ja) 2009-12-04 2016-04-25 無間質条件下におけるヒト胚性幹細胞からの機能的巨核球および血小板の大規模生成
JP2019039160A Pending JP2019122385A (ja) 2009-12-04 2019-03-05 無間質条件下におけるヒト胚性幹細胞からの機能的巨核球および血小板の大規模生成
JP2022011675A Pending JP2022064953A (ja) 2009-12-04 2022-01-28 無間質条件下におけるヒト胚性幹細胞からの機能的巨核球および血小板の大規模生成

Country Status (10)

Country Link
US (2) US9988603B2 (enExample)
EP (1) EP2507359A4 (enExample)
JP (4) JP2013512676A (enExample)
KR (4) KR20120128605A (enExample)
AU (4) AU2010325811A1 (enExample)
BR (1) BR112012013497A2 (enExample)
CA (2) CA2782013C (enExample)
IN (1) IN2012DN05054A (enExample)
RU (1) RU2012127810A (enExample)
WO (1) WO2011069127A1 (enExample)

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AU2007238660C1 (en) 2006-04-14 2013-11-07 Astellas Institute For Regenerative Medicine Hemangio-colony forming cells
KR20120128605A (ko) 2009-12-04 2012-11-27 스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크. 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성
PL2785359T3 (pl) 2011-11-30 2018-12-31 Astellas Institute For Regenerative Medicine Mezenchymalne komórki zrębowe i związane z nimi zastosowania
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
GB201210857D0 (en) 2012-06-19 2012-08-01 Cambridge Entpr Ltd Transcription factor mediated programming towards megakaryocytes
CN104471059B (zh) 2012-07-12 2018-04-17 珠海横琴爱姆斯坦生物科技有限公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
US9074186B2 (en) 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
JP6580329B2 (ja) 2014-03-31 2019-09-25 シスメックス株式会社 未分化細胞から分化細胞および／または分化細胞の産生物を取得する方法
US10538738B2 (en) 2014-05-19 2020-01-21 Eleftherios Papoutsakis Megakaryocytic particles and microparticles for cell therapy and fate modification of stem and progenitor cells
EP3277293A4 (en) * 2015-03-30 2019-01-16 Jeffrey Thomas Loh PROCESS FOR IN VITRO PRODUCTION OF BLOOD PLATES AND COMPOSITIONS AND USES THEREOF
KR102411018B1 (ko) 2015-08-18 2022-06-20 아스텔라스 인스티튜트 포 리제너러티브 메디슨 임상 제제
RU2766177C2 (ru) * 2015-10-14 2022-02-08 Мегакарион Корпорейшн Способ получения очищенных тромбоцитов
CA3087344A1 (en) 2018-01-05 2019-07-11 Platelet Biogenesis, Inc. Compositions and methods for producing megakaryocytes
JP2021529770A (ja) 2018-06-29 2021-11-04 プレートレット バイオジェネシス， インコーポレイテッド 薬物送達のための組成物およびその使用方法
US12697307B2 (en) 2020-05-11 2026-08-04 Strm.Bio Incorporated Compositions and methods related to megakaryocyte-derived extracellular vesicles
WO2022087505A1 (en) 2020-10-23 2022-04-28 Strm.Bio Incorporated Compositions and methods related to megakaryocyte-derived extracellular vesicles for treating myeloproliferative neoplasms
AU2022264498A1 (en) 2021-04-26 2023-09-28 Strm.Bio Incorporated Compositions and methods related to megakaryocyte-derived extracellular vesicles for fanconi anemia

Family Cites Families (18)

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US5128259A (en) 1989-10-27 1992-07-07 Hahnemann University Factor-dependent hematopoietic cell line exhibiting epo-induced erythrocyte maturation
AU2002335610C1 (en) * 2001-01-29 2008-09-25 Hemogenix, Inc. High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation
WO2002078449A2 (en) 2001-04-02 2002-10-10 Advanced Cell Technology, Inc. Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells
US20030232430A1 (en) * 2001-11-26 2003-12-18 Advanced Cell Technology Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
US20040052771A1 (en) 2002-07-12 2004-03-18 Lim Sai Kiang Hemangioblast progenitor cells
US20040229350A1 (en) 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
CN1286970C (zh) 2003-12-30 2006-11-29 上海伯瑞生物技术发展有限公司 由脐血cd34+细胞体外诱导生成巨核细胞的方法
WO2005097979A2 (en) 2004-03-31 2005-10-20 Newlink Genetics Corporation Methods and compositions for obtaining hematopoietic stem cells derived from embryonic stem cells and uses thereof
NZ554866A (en) 2004-11-01 2010-12-24 Wisconsin Alumni Res Found Platelets from stem cells
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
EP1989296A2 (en) 2006-02-09 2008-11-12 Wisconsin Alumni Research Foundation Erythroid cells producing adult-type -hemoglobin generated from human embryonic stem cells
CN101045914A (zh) 2006-03-29 2007-10-03 中国人民解放军军事医学科学院野战输血研究所 体外诱导造血干/祖细胞分化为成熟红细胞的方法与应用
AU2007238660C1 (en) * 2006-04-14 2013-11-07 Astellas Institute For Regenerative Medicine Hemangio-colony forming cells
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US9683232B2 (en) * 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
US20110086424A1 (en) 2008-05-06 2011-04-14 Advanced Cell Technology, Inc. Methods for producing enucleated erythroid cells derived from pluripotent stem cells
BRPI0912201A2 (pt) 2008-05-06 2019-09-24 Advanced Cell Tech Inc células formadoras de colônias de hemangios e células de hemangio não enxertantes
KR20120128605A (ko) 2009-12-04 2012-11-27 스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크. 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성

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