JP2020105169A5 - - Google Patents
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- Publication number
- JP2020105169A5 JP2020105169A5 JP2019227342A JP2019227342A JP2020105169A5 JP 2020105169 A5 JP2020105169 A5 JP 2020105169A5 JP 2019227342 A JP2019227342 A JP 2019227342A JP 2019227342 A JP2019227342 A JP 2019227342A JP 2020105169 A5 JP2020105169 A5 JP 2020105169A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- lysosomal enzyme
- expression vector
- vlp
- lysosomal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 36
- 102000004190 Enzymes Human genes 0.000 claims 29
- 108090000790 Enzymes Proteins 0.000 claims 29
- 230000002132 lysosomal effect Effects 0.000 claims 28
- 239000013604 expression vector Substances 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 101710132601 Capsid protein Proteins 0.000 claims 8
- 101710197658 Capsid protein VP1 Proteins 0.000 claims 8
- 101710118046 RNA-directed RNA polymerase Proteins 0.000 claims 8
- 101710108545 Viral protein 1 Proteins 0.000 claims 8
- 201000011442 Metachromatic leukodystrophy Diseases 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 238000012377 drug delivery Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 101000901140 Homo sapiens Arylsulfatase A Proteins 0.000 claims 3
- 230000008499 blood brain barrier function Effects 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 210000004248 oligodendroglia Anatomy 0.000 claims 3
- 210000001130 astrocyte Anatomy 0.000 claims 2
- 210000001218 blood-brain barrier Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000000274 microglia Anatomy 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 102100022146 Arylsulfatase A Human genes 0.000 claims 1
- 108010036867 Cerebroside-Sulfatase Proteins 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 241000701460 JC polyomavirus Species 0.000 claims 1
- 208000015439 Lysosomal storage disease Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108010067390 Viral Proteins Proteins 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000007971 neurological deficit Effects 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| WOPCT/EP2018/085699 | 2018-12-18 | ||
| PCT/EP2018/085699 WO2020125962A1 (en) | 2018-12-18 | 2018-12-18 | A novel drug delivery system and methods providing thereof |
| WOPCT/EP2019/060814 | 2019-04-26 | ||
| PCT/EP2019/060814 WO2020126116A1 (en) | 2018-12-18 | 2019-04-26 | Vlp for the treatment of a lysosomal storage disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020105169A JP2020105169A (ja) | 2020-07-09 |
| JP2020105169A5 true JP2020105169A5 (enExample) | 2022-12-26 |
Family
ID=65009711
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538254A Expired - Fee Related JP6884432B2 (ja) | 2018-12-18 | 2018-12-18 | 新規薬物送達システムおよびそれを提供する方法 |
| JP2019227342A Pending JP2020105169A (ja) | 2018-12-18 | 2019-12-17 | リソソーム蓄積症の処置のためのｖｌｐ |
| JP2022521659A Pending JP2022551531A (ja) | 2018-12-18 | 2020-10-13 | Ｊｏｈｎ ＣｕｎｎｉｎｇｈａｍウイルスＶＬＰを提供するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538254A Expired - Fee Related JP6884432B2 (ja) | 2018-12-18 | 2018-12-18 | 新規薬物送達システムおよびそれを提供する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022521659A Pending JP2022551531A (ja) | 2018-12-18 | 2020-10-13 | Ｊｏｈｎ ＣｕｎｎｉｎｇｈａｍウイルスＶＬＰを提供するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US11279938B2 (enExample) |
| EP (2) | EP3688147B8 (enExample) |
| JP (3) | JP6884432B2 (enExample) |
| CN (3) | CN111587289B (enExample) |
| BR (3) | BR112019014209A2 (enExample) |
| CA (3) | CA3049197C (enExample) |
| DK (1) | DK3688147T3 (enExample) |
| ES (1) | ES2933275T3 (enExample) |
| HU (1) | HUE060952T2 (enExample) |
| PL (1) | PL3688147T3 (enExample) |
| SI (1) | SI3688147T1 (enExample) |
| WO (4) | WO2020125962A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115968403A (zh) * | 2020-05-22 | 2023-04-14 | 纽卫制药有限公司 | 用于治疗脑白质营养不良的vlp |
| WO2022227287A1 (zh) * | 2021-04-25 | 2022-11-03 | 中南大学 | Dnj及其衍生物在制备预防和/或治疗肺动脉高压药物中的应用 |
| CN115448980A (zh) * | 2021-06-08 | 2022-12-09 | 戴德森医疗财团法人嘉义基督教医院 | 表面链结标靶多肽的类病毒颗粒及其用途 |
| EP4166672A1 (en) | 2021-10-15 | 2023-04-19 | NEUWAY Pharma GmbH | A novel method for purification of protein- or peptide-based capsules |
| WO2024079361A1 (en) | 2022-10-14 | 2024-04-18 | Neuway Pharma Gmbh | A PROTEIN- OR PEPTIDE-BASED CAPSULE (PPC), PREFERABLY A VLP, LOADED WITH A MESSENGER RNA (mRNA) AND A METHOD OF PRODUCTION AND PURIFICATION THEREOF |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19543553B4 (de) | 1995-11-22 | 2009-04-09 | Deutsches Primatenzentrum Gmbh | VP-Antigene des JC-Virus |
| EP1463512B1 (en) | 2002-01-11 | 2014-05-28 | biOasis Technologies Inc. | Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes |
| US7442372B2 (en) | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| FR2920158B1 (fr) | 2007-08-24 | 2010-03-12 | Centre Nat Rech Scient | Production de plasmides et expression de proteines recombinantes dans des cellules cultivees sans antibiotiques |
| EP2554664A1 (de) | 2011-08-02 | 2013-02-06 | Life Science Inkubator | Verfahren zur Aufreinigung von Virus-ähnlichen Partikeln (VLP) |
| EP2636746A1 (en) | 2012-03-06 | 2013-09-11 | Life Science Inkubator | A novel drug delivery system based on JCV-VLP |
| JP6634073B2 (ja) * | 2014-05-14 | 2020-01-22 | エステベ ファーマシューティカルズ, ソシエダッド アノニマEsteve Pharmaceuticals, S.A. | リソソーム蓄積症処置用のアデノ随伴ウイルスベクター |
-
2018
- 2018-12-18 EP EP18830794.6A patent/EP3688147B8/en active Active
- 2018-12-18 CA CA3049197A patent/CA3049197C/en active Active
- 2018-12-18 BR BR112019014209-6A patent/BR112019014209A2/pt not_active Application Discontinuation
- 2018-12-18 WO PCT/EP2018/085699 patent/WO2020125962A1/en not_active Ceased
- 2018-12-18 CN CN201880006448.0A patent/CN111587289B/zh not_active Expired - Fee Related
- 2018-12-18 SI SI201830824T patent/SI3688147T1/sl unknown
- 2018-12-18 DK DK18830794.6T patent/DK3688147T3/da active
- 2018-12-18 ES ES18830794T patent/ES2933275T3/es active Active
- 2018-12-18 PL PL18830794.6T patent/PL3688147T3/pl unknown
- 2018-12-18 US US16/476,724 patent/US11279938B2/en active Active
- 2018-12-18 HU HUE18830794A patent/HUE060952T2/hu unknown
- 2018-12-18 JP JP2019538254A patent/JP6884432B2/ja not_active Expired - Fee Related
-
2019
- 2019-04-26 WO PCT/EP2019/060814 patent/WO2020126116A1/en not_active Ceased
- 2019-10-14 WO PCT/EP2019/077807 patent/WO2020126151A1/en not_active Ceased
- 2019-10-14 US US17/311,480 patent/US20230157972A1/en not_active Abandoned
- 2019-10-14 BR BR112021010758-4A patent/BR112021010758A2/pt unknown
- 2019-10-14 CA CA3121689A patent/CA3121689A1/en active Pending
- 2019-12-16 BR BR102019026837-9A patent/BR102019026837A2/pt not_active IP Right Cessation
- 2019-12-16 CA CA3065548A patent/CA3065548A1/en active Pending
- 2019-12-17 JP JP2019227342A patent/JP2020105169A/ja active Pending
- 2019-12-17 US US16/717,033 patent/US20200224205A1/en not_active Abandoned
- 2019-12-17 CN CN201911300544.9A patent/CN111333702A/zh active Pending
-
2020
- 2020-10-13 EP EP20789150.8A patent/EP4045638A1/en not_active Withdrawn
- 2020-10-13 JP JP2022521659A patent/JP2022551531A/ja active Pending
- 2020-10-13 WO PCT/EP2020/078733 patent/WO2021074123A1/en not_active Ceased
- 2020-10-13 CN CN202080081855.5A patent/CN115135757A/zh active Pending
-
2022
- 2022-11-07 US US18/053,198 patent/US20230159938A1/en not_active Abandoned
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