JP2020073472A5 - - Google Patents
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- JP2020073472A5 JP2020073472A5 JP2019179190A JP2019179190A JP2020073472A5 JP 2020073472 A5 JP2020073472 A5 JP 2020073472A5 JP 2019179190 A JP2019179190 A JP 2019179190A JP 2019179190 A JP2019179190 A JP 2019179190A JP 2020073472 A5 JP2020073472 A5 JP 2020073472A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- substituted
- linker
- covalently bonded
- appropriately substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 150000002993 phenylalanine derivatives Chemical class 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- 150000003667 tyrosine derivatives Chemical class 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical group OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 235000009697 arginine Nutrition 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 235000004554 glutamine Nutrition 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 235000018977 lysine Nutrition 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- -1 urea compound Chemical class 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95648907P | 2007-08-17 | 2007-08-17 | |
| US60/956,489 | 2007-08-17 | ||
| US7435808P | 2008-06-20 | 2008-06-20 | |
| US61/074,358 | 2008-06-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017223872A Division JP6596479B2 (ja) | 2007-08-17 | 2017-11-21 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021019732A Division JP7079355B2 (ja) | 2007-08-17 | 2021-02-10 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020073472A JP2020073472A (ja) | 2020-05-14 |
| JP2020073472A5 true JP2020073472A5 (cg-RX-API-DMAC7.html) | 2020-09-10 |
| JP6838118B2 JP6838118B2 (ja) | 2021-03-03 |
Family
ID=40378553
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521210A Pending JP2010536790A (ja) | 2007-08-17 | 2008-08-15 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2014125603A Active JP5902237B2 (ja) | 2007-08-17 | 2014-06-18 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2016046076A Pending JP2016153410A (ja) | 2007-08-17 | 2016-03-09 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2017223872A Active JP6596479B2 (ja) | 2007-08-17 | 2017-11-21 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2018100343A Active JP6625690B2 (ja) | 2007-08-17 | 2018-05-25 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2019179190A Active JP6838118B2 (ja) | 2007-08-17 | 2019-09-30 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2021019732A Active JP7079355B2 (ja) | 2007-08-17 | 2021-02-10 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
| JP2022082105A Active JP7609824B2 (ja) | 2007-08-17 | 2022-05-19 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
| JP2024095014A Pending JP2024117783A (ja) | 2007-08-17 | 2024-06-12 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521210A Pending JP2010536790A (ja) | 2007-08-17 | 2008-08-15 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2014125603A Active JP5902237B2 (ja) | 2007-08-17 | 2014-06-18 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2016046076A Pending JP2016153410A (ja) | 2007-08-17 | 2016-03-09 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2017223872A Active JP6596479B2 (ja) | 2007-08-17 | 2017-11-21 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2018100343A Active JP6625690B2 (ja) | 2007-08-17 | 2018-05-25 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021019732A Active JP7079355B2 (ja) | 2007-08-17 | 2021-02-10 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
| JP2022082105A Active JP7609824B2 (ja) | 2007-08-17 | 2022-05-19 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
| JP2024095014A Pending JP2024117783A (ja) | 2007-08-17 | 2024-06-12 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (25) | US9193763B2 (cg-RX-API-DMAC7.html) |
| EP (7) | EP3656403B1 (cg-RX-API-DMAC7.html) |
| JP (9) | JP2010536790A (cg-RX-API-DMAC7.html) |
| CN (2) | CN104873982A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008289108C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2696627C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2187965T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2768224T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1212588A1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE047200T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL203998A (cg-RX-API-DMAC7.html) |
| NZ (2) | NZ600085A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2187965T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2187965T (cg-RX-API-DMAC7.html) |
| SI (1) | SI2187965T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009026177A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2316349C2 (ru) | 2001-05-02 | 2008-02-10 | Пердью Рисерч Фаундейшн | Лечение и диагностика заболеваний, опосредованных макрофагами |
| US8043603B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| CA2527196C (en) | 2003-05-30 | 2012-10-16 | Purdue Research Foundation | Diagnostic method for atherosclerosis |
| EP1789391B1 (en) | 2004-07-23 | 2017-06-28 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| WO2007006041A2 (en) | 2005-07-05 | 2007-01-11 | Purdue Research Foundation | Imaging and therapeutic method using monocytes |
| WO2007038346A2 (en) | 2005-09-23 | 2007-04-05 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| US8685752B2 (en) | 2006-11-03 | 2014-04-01 | Purdue Research Foundation | Ex vivo flow cytometry method and device |
| PL3699162T3 (pl) * | 2006-11-08 | 2022-10-31 | Molecular Insight Pharmaceuticals, Inc. | Heterodimery kwasu glutaminowego |
| JP5869205B2 (ja) | 2007-02-07 | 2016-02-24 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | ポジトロン放射断層画像法 |
| CN101678124A (zh) | 2007-03-14 | 2010-03-24 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| US8961926B2 (en) | 2007-05-25 | 2015-02-24 | Purdue Research Foundation | Method of imaging localized infections |
| EP3569251A1 (en) | 2007-06-25 | 2019-11-20 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| GB0718967D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Peptide imaging agents |
| US9193763B2 (en) | 2007-08-17 | 2015-11-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| PL2291659T3 (pl) * | 2008-05-13 | 2016-04-29 | Univ Yale | Małe cząsteczki chimerowe do rekrutacji przeciwciał do komórek nowotworowych |
| US8852630B2 (en) * | 2008-05-13 | 2014-10-07 | Yale University | Chimeric small molecules for the recruitment of antibodies to cancer cells |
| EP4420730A3 (en) * | 2009-03-19 | 2024-11-13 | The Johns Hopkins University | Psma-targeting compounds and uses thereof |
| US20180009767A9 (en) | 2009-03-19 | 2018-01-11 | The Johns Hopkins University | Psma targeted fluorescent agents for image guided surgery |
| US20120183847A1 (en) | 2009-05-19 | 2012-07-19 | Aic Blab | Composite current collector and methods therefor |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| US12083191B2 (en) | 2009-10-19 | 2024-09-10 | Case Western Reserve University | Composition and methods for imaging cells |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| WO2011106639A1 (en) * | 2010-02-25 | 2011-09-01 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| US10363309B2 (en) | 2011-02-04 | 2019-07-30 | Case Western Reserve University | Targeted nanoparticle conjugates |
| TWI603741B (zh) | 2011-06-10 | 2017-11-01 | 梅爾莎納醫療公司 | 蛋白質-聚合物-藥物共軛體 |
| CN107325127B (zh) * | 2011-06-15 | 2020-09-01 | 癌靶技术有限责任公司 | 螯合的psma抑制剂 |
| US8784774B2 (en) | 2011-09-16 | 2014-07-22 | General Electric Company | Labeled molecular imaging agents and methods of use |
| US20130116404A1 (en) | 2011-11-08 | 2013-05-09 | Case Western Reserve University | Targeted non-invasive imaging probes of egfr expressing cells |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| EP3348280A1 (en) | 2012-07-12 | 2018-07-18 | Hangzhou Dac Biotech Co., Ltd | Conjugates of cell binding molecules with cytotoxic agents |
| US20140081659A1 (en) | 2012-09-17 | 2014-03-20 | Depuy Orthopaedics, Inc. | Systems and methods for surgical and interventional planning, support, post-operative follow-up, and functional recovery tracking |
| KR20150070318A (ko) | 2012-10-16 | 2015-06-24 | 엔도사이트, 인코포레이티드 | 비천연 아미노산을 함유하는 약물 전달 컨쥬게이트 및 사용 방법 |
| EP3858341A1 (en) | 2012-11-15 | 2021-08-04 | Endocyte, Inc. | Psma ligand-containing conjugates for the treatment of prostate cancer |
| AU2012395148B2 (en) | 2012-11-24 | 2016-10-27 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| EP2928504B1 (en) | 2012-12-10 | 2019-02-20 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| EP2931316B1 (en) | 2012-12-12 | 2019-02-20 | Mersana Therapeutics, Inc. | Hydroxyl-polymer-drug-protein conjugates |
| BR112015019432A2 (pt) | 2013-02-14 | 2017-08-22 | Bristol Myers Squibb Co | Compostos de tubulisina, métodos de produção e uso |
| US9889199B2 (en) * | 2013-02-15 | 2018-02-13 | Case Western Reserve University | PSMA ligands and uses thereof |
| US10207005B2 (en) | 2013-02-15 | 2019-02-19 | Case Western Reserve University | Photodynamic therapy composition |
| US11975074B2 (en) | 2013-02-15 | 2024-05-07 | Case Western Reserve University | Photodynamic therapy composition |
| US12465651B2 (en) | 2013-02-15 | 2025-11-11 | Case Western Reserve University | Photodynamic therapy composition |
| PT2968552T (pt) | 2013-03-14 | 2020-05-18 | Scripps Research Inst | Anticorpo dos agentes alvo, combinações e uso para os mesmos |
| US10434194B2 (en) * | 2013-06-20 | 2019-10-08 | Case Western Reserve University | PSMA targeted nanobubbles for diagnostic and therapeutic applications |
| WO2015057692A1 (en) * | 2013-10-14 | 2015-04-23 | The Johns Hopkins University | Prostate-specific membrane antigen-targeted photosensitizers for photodynamic therapy |
| ES2741308T3 (es) * | 2013-10-15 | 2020-02-10 | Scripps Research Inst | Interruptores de células T con receptores de antígenos quiméricos y usos de los mismos |
| ES2845924T3 (es) | 2013-10-15 | 2021-07-28 | Scripps Research Inst | Interruptores de células T con receptores de antígenos quiméricos peptídicos y usos de los mismos |
| KR101947053B1 (ko) | 2013-10-18 | 2019-02-12 | 도이체스 크렙스포르슝스첸트룸 | 전립선 특이적 막 항원（ｐｓｍａ）의 표지된 억제제, 조영제로서의 이의 용도 및 전립선암 치료용 약제 |
| JP2017501115A (ja) * | 2013-11-06 | 2017-01-12 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | Ｄｕｐａ−インデノイソキノリン複合体 |
| EP3533473A3 (en) * | 2013-11-14 | 2019-12-18 | Endocyte, Inc. | Compounds for positron emission tomography |
| US9468692B2 (en) | 2014-01-23 | 2016-10-18 | General Electric Company | Labeled molecular imaging agents and methods of use |
| US9468693B2 (en) | 2014-01-23 | 2016-10-18 | General Electric Company | Labeled molecular imaging agents and methods of use |
| PT3122757T (pt) | 2014-02-28 | 2023-11-03 | Hangzhou Dac Biotech Co Ltd | Ligantes carregados e as suas utilizações em conjugação |
| CN106660943B (zh) | 2014-05-06 | 2020-03-17 | 约翰霍普金斯大学 | 用于psma靶向的成像和放射疗法的金属/放射性金属标记的psma抑制物 |
| MA39970A (fr) | 2014-05-14 | 2015-11-19 | Alex Levitzki Man And Holdings Ltd | Vecteurs améliorés a base de polyéthylèneimine polyéthylèneglycol |
| CN104262458B (zh) * | 2014-08-29 | 2017-02-01 | 邵国强 | 一种与psma膜外区靶向性结合的多肽、放射性核素标记多肽及其应用 |
| JPWO2016047794A1 (ja) * | 2014-09-26 | 2017-09-28 | 株式会社カネカ | 疎水性ペプチドの製造法 |
| US10736974B2 (en) | 2014-10-22 | 2020-08-11 | The Johns Hopkins University | Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy |
| US10077287B2 (en) | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| IL237525A (en) | 2015-03-03 | 2017-05-29 | Shalom Eli | Method for labeling a prostate-specific membrane antigen with a radioactive isotope |
| WO2016154621A1 (en) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF |
| EP3283113A4 (en) | 2015-04-15 | 2018-12-05 | The California Institute for Biomedical Research | Optimized pne-based chimeric receptor t cell switches and uses thereof |
| WO2016183131A1 (en) * | 2015-05-11 | 2016-11-17 | Purdue Research Foundation | Ligand ionophore conjugates |
| WO2015151081A2 (en) | 2015-07-12 | 2015-10-08 | Suzhou M-Conj Biotech Co., Ltd | Bridge linkers for conjugation of a cell-binding molecule |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| WO2017030893A1 (en) | 2015-08-14 | 2017-02-23 | Endocyte, Inc. | Method of imaging with a chelating compound |
| US9808538B2 (en) | 2015-09-09 | 2017-11-07 | On Target Laboratories, LLC | PSMA-targeted NIR dyes and their uses |
| US10842887B2 (en) | 2015-09-09 | 2020-11-24 | On Target Laboratories, LLC | PSMA-targeted NIR dyes and their uses |
| KR102233726B1 (ko) * | 2015-09-30 | 2021-03-31 | 도이체스 크렙스포르슝스첸트룸 | 전립선 특이적 막 항원（psma)의 18f-태그된 저해제 및 전립선암에 대한 조영제로서 이의 용도 |
| EA201890941A1 (ru) * | 2015-10-23 | 2018-11-30 | Сорренто Терапьютикс, Инк. | Программируемые универсальные клеточные рецепторы и способы их применения |
| US10405753B2 (en) * | 2015-11-10 | 2019-09-10 | Intuitive Surgical Operations, Inc. | Pharmaceutical compositions of near IR closed chain, sulfo-cyanine dyes |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| AU2016363013B2 (en) | 2015-12-04 | 2022-03-10 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| ES2992761T3 (en) | 2016-02-04 | 2024-12-17 | Scripps Research Inst | Humanized anti-cd3 antibodies, conjugates and uses thereof |
| JP2019515880A (ja) | 2016-03-16 | 2019-06-13 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | 炭酸無水酵素ｉｘ阻害剤抱合体およびその使用 |
| EP3429575A4 (en) * | 2016-03-16 | 2019-10-23 | Purdue Research Foundation | AGAINST CARBOANHYDRASE-IX DRUGS AND METHODS |
| US20170296679A1 (en) * | 2016-04-18 | 2017-10-19 | Intuitive Surgical Operations, Inc. | Compositions of Near IR Closed Chain, Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands |
| ES2944610T3 (es) | 2016-09-09 | 2023-06-22 | On Target Laboratories Llc | Colorantes NIR dirigidos a PSMA y sus usos |
| AU2017345479B2 (en) | 2016-10-19 | 2024-03-21 | The Scripps Research Institute | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof |
| WO2018086139A1 (en) | 2016-11-14 | 2018-05-17 | Hangzhou Dac Biotech Co., Ltd | Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers |
| CN118453888A (zh) * | 2016-11-16 | 2024-08-09 | 普渡研究基金会 | 配体离子载体共轭物 |
| JP7162592B2 (ja) | 2016-12-14 | 2022-10-28 | パーデュー・リサーチ・ファウンデイション | 線維芽細胞活性化タンパク質（ｆａｐ）標的イメージングおよび治療 |
| KR102085798B1 (ko) | 2016-12-28 | 2020-03-06 | 주식회사 인투셀 | 베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물 |
| US11524082B2 (en) * | 2017-08-22 | 2022-12-13 | Purdue Research Foundation | FBSA-based therapeutic and radioimaging conjugates targeting carbonic anhydrase positive cancers |
| WO2019057964A1 (en) * | 2017-09-22 | 2019-03-28 | Heidelberg Pharma Research Gmbh | AMANITINE CONJUGATES TARGETING PSMA |
| EP3498308B1 (en) | 2017-12-13 | 2024-11-27 | Sciencons AS | Complex comprising a psma-targeting compound linked to a lead or thorium radionuclide |
| IL276528B2 (en) | 2018-02-06 | 2024-11-01 | Univ Johns Hopkins | PSMA Targeted Radiohalogenated Urea-Polyaminocarboxylates For Cancer Radiotherapy |
| WO2019183633A1 (en) * | 2018-03-23 | 2019-09-26 | Case Western Reserve Univeristy | Psma targeted conjugate compounds and uses thereof |
| CA3097381A1 (en) | 2018-04-17 | 2019-10-24 | Endocyte, Inc. | Methods of treating cancer |
| WO2019246445A1 (en) * | 2018-06-20 | 2019-12-26 | The Research Foundation For The State University Of New York | Triazamacrocycle-derived chelator compositions for coordination of imaging and therapy metal ions and methods of using same |
| CN110922450B (zh) * | 2018-09-19 | 2021-11-02 | 薪火炙药(北京)科技有限公司 | Psma激活式抗肿瘤前药cpt-x及其制备方法和应用 |
| US20210323985A1 (en) | 2018-09-21 | 2021-10-21 | Endocyte, Inc. | Shielding agents and their use |
| RU2697519C1 (ru) * | 2018-10-15 | 2019-08-15 | Общество с ограниченной ответственностью "Изварино Фарма" | Средство пептидной природы, включающее псма-связывающий лиганд на основе производного мочевины, способ его получения и применение для получения конъюгата с лекарственным и диагностическим агентом |
| WO2020108753A1 (en) * | 2018-11-28 | 2020-06-04 | ITM Isotopen Technologien München AG | Novel tumor antigen binding agents and uses thereof |
| WO2020123975A1 (en) * | 2018-12-14 | 2020-06-18 | The Johns Hopkins University | Psma-targeted pamam dendrimers for specific delivery of imaging, contrast and therapeutic agents |
| US12133901B2 (en) | 2019-01-18 | 2024-11-05 | Case Western Reserve University | PSMA ligand targeted compounds and uses thereof |
| US20220096669A1 (en) * | 2019-01-30 | 2022-03-31 | Technische Universität München | Silicon-fluoride acceptor substituted radiopharmaceuticals and precursors thereof |
| EP3972627A4 (en) | 2019-05-20 | 2023-06-21 | Endocyte, Inc. | Methods for preparing psma conjugates |
| CN110305187B (zh) * | 2019-06-06 | 2021-02-23 | 原子高科股份有限公司 | 前列腺癌PET诊断试剂68Ga-NOTA-ANCP-PSMA及其制备方法和应用 |
| CN110305186B (zh) * | 2019-06-06 | 2021-02-23 | 原子高科股份有限公司 | 前列腺癌PET诊断试剂68Ga-DOTA-ANCP-PSMA及其制备方法和应用 |
| KR20220029725A (ko) | 2019-06-29 | 2022-03-08 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 세포-결합 분자-튜불리신 유도체 접합체 및 이의 제조 방법 |
| RU2713151C1 (ru) * | 2019-07-02 | 2020-02-04 | Общество с ограниченной ответственностью "Изварино Фарма" | Конъюгат флуоресцентного красителя с веществом пептидной природы, включающим псма-связывающий лиганд на основе производного мочевины для визуализации клеток, экспрессирующих псма, способ его получения и применения |
| JP7675060B2 (ja) | 2019-07-10 | 2025-05-12 | サイブレクサ ３，インコーポレイテッド | 治療薬としての微小管標的化剤のペプチドコンジュゲート |
| CR20220058A (es) * | 2019-07-10 | 2022-07-19 | Cybrexa 2 Inc | Conjugados peptídicos de citotoxinas como terapéuticos |
| US20240115744A1 (en) * | 2019-10-23 | 2024-04-11 | Peter Caravan | Fibrin-binding compounds for imaging and treatment |
| DE102019135564B4 (de) * | 2019-12-20 | 2022-05-19 | Johannes-Gutenberg-Universität Mainz | Verbindung für Smart-Drug-Delivery und pharmazeutisches Kit für duale nuklearmedizinisch-cytotoxische Theranostik |
| EP4114415A1 (en) | 2020-03-06 | 2023-01-11 | Sorrento Therapeutics, Inc. | Innate immunity killer cells targeting psma positive tumor cells |
| WO2021250240A1 (en) | 2020-06-12 | 2021-12-16 | Orano | Diaza-18-crown-6 derivative useful for chelating radium, conjugate and radium chelate comprising the same, and uses thereof |
| US20230372384A1 (en) | 2020-10-08 | 2023-11-23 | Targimmune Therapeutics Ag | Immunotherapy for the treatment of cancer |
| WO2022101352A1 (en) | 2020-11-12 | 2022-05-19 | Abx Advanced Biochemical Compounds Gmbh | Ligands of prostate specific membrane antigen (psma) containing heteroaromatic linker building blocks |
| US20230414762A1 (en) * | 2020-11-17 | 2023-12-28 | The Johns Hopkins University | Prostate-specific membrane antigen (psma)-targeted prodrug for selective killing of cells expressing psma |
| EP4326246A1 (en) * | 2021-04-23 | 2024-02-28 | Wisconsin Alumni Research Foundation | Psma-targeting ligands with optimal properties for imaging and therapy |
| CN115745903B (zh) | 2021-09-03 | 2024-07-23 | 晶核生物医药科技(南京)有限公司 | 一种肽脲素衍生物、含其的药物组合物及其应用 |
| JP2024541058A (ja) | 2021-11-03 | 2024-11-06 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． | 抗体の特異的共役 |
| WO2023079142A2 (en) | 2021-11-05 | 2023-05-11 | Targimmune Therapeutics Ag | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| WO2023086833A1 (en) | 2021-11-09 | 2023-05-19 | Case Western Reserve University | Psma targeted conjugate compounds and uses thereof |
| TW202426433A (zh) | 2022-09-23 | 2024-07-01 | 瑞士商紐利迪姆股份公司 | 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途 |
| WO2024100044A1 (en) | 2022-11-07 | 2024-05-16 | Targimmune Therapeutics Ag | Polyplexes of nucleic acids and targeted conjugates comprising polyethyleneimine and polyethylene glycol |
| IL320615A (en) | 2022-11-07 | 2025-07-01 | Targimmune Therapeutics Ag | PSMA-targeting linear conjugates containing polyethyleneimine and polyethylene glycol and polyplexes containing the same materials |
| EP4615511A1 (en) | 2022-11-07 | 2025-09-17 | TargImmune Therapeutics AG | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| AU2024208501A1 (en) | 2023-01-10 | 2025-07-24 | Sun Pharma Advanced Research Company Limited | Ligand-drug conjugates |
| WO2024206482A1 (en) * | 2023-03-27 | 2024-10-03 | Yale University | Methods and kits for delivery of compounds into cells |
| US20250041461A1 (en) | 2023-07-31 | 2025-02-06 | Curium Us Llc | [177lu] lutetium-psma i&t composition and dosimetry, kit, method of making, and method of using thereof |
| US20250213705A1 (en) | 2023-08-23 | 2025-07-03 | Bright Peak Therapeutics Ag | Psma targeting ligands and methods of use |
| WO2025119908A1 (en) | 2023-12-06 | 2025-06-12 | Bracco Imaging Spa | Psma-targeting fluorescent probes |
| WO2025238236A1 (en) | 2024-05-16 | 2025-11-20 | Targimmune Therapeutics Ag | Polyplexes of nucleic acids and targeted conjugates comprising polyethyleneimine and polyethylene glycol |
Family Cites Families (232)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713249A (en) | 1981-11-12 | 1987-12-15 | Schroeder Ulf | Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof |
| DE116208T1 (de) | 1982-12-07 | 1985-02-28 | Kyowa Hakko Kogyo Co., Ltd., Tokio/Tokyo | Mitomycin-analoge. |
| JPS60255789A (ja) | 1984-06-01 | 1985-12-17 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体，その製造法および抗腫瘍剤 |
| US5266333A (en) | 1985-03-06 | 1993-11-30 | American Cyanamid Company | Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration of growth hormone |
| US5103018A (en) * | 1986-08-26 | 1992-04-07 | Kyowa Hakko Kogyo Kabushiki Kaisha | Mitomycin derivatives |
| CA2044590A1 (en) | 1989-11-13 | 1991-05-14 | Marc D. Better | Chimeric mouse-human a10 antibody with specificity to a human tumor cell antigen |
| US5627165A (en) * | 1990-06-13 | 1997-05-06 | Drug Innovation & Design, Inc. | Phosphorous prodrugs and therapeutic delivery systems using same |
| AU653565B2 (en) * | 1990-12-21 | 1994-10-06 | Nikken Corporation | Raw sewage disposal apparatus and prefab for accomodating the same |
| US6291196B1 (en) | 1992-01-31 | 2001-09-18 | Research Corporation Technologies, Inc. | Melanoma and prostate cancer specific antibodies for immunodetection and immunotherapy |
| US7070782B1 (en) * | 1992-11-05 | 2006-07-04 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
| US6569432B1 (en) * | 1995-02-24 | 2003-05-27 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
| JP3538221B2 (ja) | 1993-11-19 | 2004-06-14 | 富士写真フイルム株式会社 | 定着濃厚液およびそれを用いたハロゲン化銀写真感光材料の処理方法 |
| US5417982A (en) | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| US5866679A (en) | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
| US6946133B1 (en) | 1996-03-20 | 2005-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Prostate specific antigen oligo-epitope peptide |
| IL125895A (en) | 1996-04-01 | 2001-09-13 | Epix Medical Inc | Use of an image-enhancing moiety in the preparation of a bioactivated nmr or optical imaging contrast agent from a prodrug |
| CN1153064C (zh) | 1996-04-05 | 2004-06-09 | 约翰斯·霍普金斯大学 | 富集稀少细胞的方法 |
| US5795877A (en) | 1996-12-31 | 1998-08-18 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
| US5672592A (en) | 1996-06-17 | 1997-09-30 | Guilford Pharmaceuticals Inc. | Certain phosphonomethyl-pentanedioic acid derivatives thereof |
| US5902817A (en) | 1997-04-09 | 1999-05-11 | Guilford Pharmaceuticals Inc. | Certain sulfoxide and sulfone derivatives |
| US5863536A (en) | 1996-12-31 | 1999-01-26 | Guilford Pharmaceuticals Inc. | Phosphoramidate derivatives |
| US6054444A (en) * | 1997-04-24 | 2000-04-25 | Guilford Pharmaceuticals Inc. | Phosphonic acid derivatives |
| US5998362A (en) | 1996-09-12 | 1999-12-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US6368598B1 (en) * | 1996-09-16 | 2002-04-09 | Jcrt Radiation Oncology Support Services, Inc. | Drug complex for treatment of metastatic prostate cancer |
| US5962521A (en) | 1997-04-04 | 1999-10-05 | Guilford Pharmaceuticals Inc. | Hydroxamic acid derivatives |
| US6177404B1 (en) | 1996-10-15 | 2001-01-23 | Merck & Co., Inc. | Conjugates useful in the treatment of benign prostatic hyperplasia |
| US5948750A (en) | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| JP3981416B2 (ja) | 1997-04-10 | 2007-09-26 | ユニバーシティ メディカル センター ナイメーヘン | Ｐｃａ３タンパク質、ｐｃａ３遺伝子、及びこれらの用途 |
| US6127333A (en) | 1997-07-10 | 2000-10-03 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US6391305B1 (en) | 1997-09-10 | 2002-05-21 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US20020115596A1 (en) | 1997-10-27 | 2002-08-22 | Merk & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| CA2311615A1 (en) | 1997-12-02 | 1999-06-10 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| ZA9810974B (en) * | 1997-12-02 | 1999-06-03 | Merck & Co Inc | Conjugates useful in the treatment of prostate cancer |
| US20040081659A1 (en) | 1997-12-02 | 2004-04-29 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| JP2002506204A (ja) * | 1998-03-03 | 2002-02-26 | モザイク テクノロジーズ | 可逆的アフィニティー電気泳動を用いる精製および検出プロセス |
| US20020103136A1 (en) | 1998-03-05 | 2002-08-01 | Dong-Mei Feng | Conjugates useful in the treatment of prostate cancer |
| US6232287B1 (en) | 1998-03-13 | 2001-05-15 | The Burnham Institute | Molecules that home to various selected organs or tissues |
| US6093382A (en) | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
| US6833438B1 (en) | 1999-06-01 | 2004-12-21 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| JP4855577B2 (ja) | 1998-06-01 | 2012-01-18 | アジェンシス，インコーポレイテッド | ヒト癌で発現される新規蛇行性膜貫通抗原およびその使用 |
| US20070020327A1 (en) | 1998-11-10 | 2007-01-25 | John Fikes | Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions |
| US6174858B1 (en) | 1998-11-17 | 2001-01-16 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US20030207808A1 (en) | 1999-02-18 | 2003-11-06 | Kinneret Savitzky | Novel nucleic acid and amino acid sequences |
| AU4063600A (en) | 1999-04-05 | 2000-10-23 | Merck & Co., Inc. | A method of treating cancer |
| US6528499B1 (en) * | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
| US6479470B1 (en) * | 1999-04-28 | 2002-11-12 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALAdase |
| AUPQ014799A0 (en) | 1999-05-04 | 1999-05-27 | Access Pharmaceuticals Australia Pty Limited | Amplification of folate-mediated targeting to tumor cells using polymers |
| US7166573B1 (en) | 1999-05-28 | 2007-01-23 | Ludwig Institute For Cancer Research | Breast, gastric and prostate cancer associated antigens and uses therefor |
| US20040146516A1 (en) * | 1999-06-17 | 2004-07-29 | Utah Ventures Ii L.P. | Lumen-exposed molecules and methods for targeted delivery |
| US7361338B2 (en) | 1999-10-05 | 2008-04-22 | Agensys, Inc. | Methods to inhibit growth of prostate cancer cells |
| US6692724B1 (en) | 1999-10-25 | 2004-02-17 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
| US6428785B1 (en) | 1999-10-28 | 2002-08-06 | Immunolytics Inc. | Method and composition for treating prostate cancer |
| CA2391534A1 (en) * | 1999-11-15 | 2001-05-25 | Drug Innovation & Design, Inc. | Selective cellular targeting: multifunctional delivery vehicles |
| CN102805868A (zh) | 2000-03-31 | 2012-12-05 | 普渡研究基金会 | 用配体-免疫原缀合物治疗的方法 |
| US20030072794A1 (en) | 2000-06-09 | 2003-04-17 | Teni Boulikas | Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes |
| AU2002224401B2 (en) * | 2000-10-16 | 2007-12-06 | Gilead Sciences, Inc. | Nucleic acid ligands to the prostate specific membrane antigen |
| US20020132983A1 (en) | 2000-11-30 | 2002-09-19 | Junghans Richard P. | Antibodies as chimeric effector cell receptors against tumor antigens |
| US7468354B2 (en) * | 2000-12-01 | 2008-12-23 | Genspera, Inc. | Tissue specific prodrugs |
| AU2002249935A1 (en) | 2001-01-08 | 2002-08-19 | Neorx Corporation | Radioactively labelled conjugates of phosphonates |
| ATE337011T1 (de) * | 2001-02-07 | 2006-09-15 | Beth Israel Hospital | Modifizierte psma-liganden und deren verwendung |
| AU2002306766A1 (en) | 2001-03-16 | 2002-10-03 | Johns Hopkins University School Of Medicine | Immune modulation by transduced hematopoietic stem cells expressing antigens and antigen-presenting cell regulatory molecules |
| DE60231868D1 (de) * | 2001-04-24 | 2009-05-20 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
| RU2316349C2 (ru) | 2001-05-02 | 2008-02-10 | Пердью Рисерч Фаундейшн | Лечение и диагностика заболеваний, опосредованных макрофагами |
| US7109165B2 (en) * | 2001-05-18 | 2006-09-19 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| US7514078B2 (en) | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
| EP2277542B1 (en) | 2001-06-01 | 2014-04-16 | Cornell Research Foundation Inc. | Modified antibodies to prostrate-specific membrane antigen and uses thereof |
| US20040018203A1 (en) * | 2001-06-08 | 2004-01-29 | Ira Pastan | Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates |
| EP1410022B1 (en) | 2001-06-21 | 2009-05-06 | GlycoMimetics, Inc. | Detection and treatment of prostate cancer |
| CA2451188A1 (en) * | 2001-06-25 | 2003-01-03 | Drug Innovation & Design, Incorporated | Exponential pattern recognition based cellular targeting, compositions, methods and anticancer applications |
| US7755757B2 (en) | 2007-02-14 | 2010-07-13 | Chemimage Corporation | Distinguishing between renal oncocytoma and chromophobe renal cell carcinoma using raman molecular imaging |
| US7893223B2 (en) | 2001-07-17 | 2011-02-22 | Bracco Imaging S.P.A. | Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy |
| AU2002331720B2 (en) | 2001-08-24 | 2007-10-11 | Johns Hopkins University | Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer |
| CA2452288A1 (en) | 2001-09-20 | 2003-03-27 | Cornell Research Foundation, Inc. | Methods and compositions for treating and preventing skin disorders using binding agents specific for psma |
| US20030232760A1 (en) | 2001-09-21 | 2003-12-18 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| KR20040053136A (ko) | 2001-09-28 | 2004-06-23 | 펄듀 리서치 파운데이션 | 리간드-면역원 공액체를 이용한 치료 방법 |
| US20030215456A1 (en) | 2001-10-02 | 2003-11-20 | Sui-Long Yao | Method of treating cancer |
| US20030133927A1 (en) | 2001-10-10 | 2003-07-17 | Defeo-Jones Deborah | Conjugates useful in the treatment of prostate cancer |
| US20040058857A1 (en) | 2001-11-29 | 2004-03-25 | Siu-Long Yao | Method of treating cancer |
| US20070031438A1 (en) | 2001-12-10 | 2007-02-08 | Junghans Richard P | Antibodies as chimeric effector cell receptors against tumor antigens |
| PT1472541E (pt) | 2002-01-10 | 2009-12-21 | Univ Johns Hopkins | Agentes de imagiologia e métodos de imagiologia de naaladase de psma |
| WO2003074450A2 (en) * | 2002-02-28 | 2003-09-12 | The University Of Tennessee Research Corporation | Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy |
| CA2478592A1 (en) | 2002-03-07 | 2003-09-18 | The Johns Hopkins University School Of Medicine | Genomic screen for epigenetically silenced genes associated with cancer |
| US7534580B2 (en) | 2002-05-01 | 2009-05-19 | Ambrilia Biopharma Inc. | PSP94 diagnostic reagents and assays |
| SI2151250T1 (sl) | 2002-05-06 | 2014-02-28 | Endocyte, Inc. | Z vitamini ciljana sredstva za slikanje |
| JP4814520B2 (ja) | 2002-05-15 | 2011-11-16 | エンドサイト，インコーポレイテッド | ビタミン−マイトマイシン結合体 |
| US7767803B2 (en) * | 2002-06-18 | 2010-08-03 | Archemix Corp. | Stabilized aptamers to PSMA and their use as prostate cancer therapeutics |
| AR040956A1 (es) * | 2002-07-31 | 2005-04-27 | Schering Ag | Nuevos conjugados de efectores, procedimientos para su preparacion y su uso farmaceutico |
| EP2353611B1 (en) | 2002-07-31 | 2015-05-13 | Seattle Genetics, Inc. | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
| JP2004064945A (ja) | 2002-07-31 | 2004-02-26 | Hitachi Koki Co Ltd | 回転体駆動装置 |
| US7749968B2 (en) * | 2002-08-05 | 2010-07-06 | The Johns Hopkins University | Peptides for targeting the prostate specific membrane antigen |
| AU2003259761A1 (en) | 2002-08-08 | 2004-02-25 | Johns Hopkins University | Enhancement of adenoviral oncolytic activity in prostate cells by modification of the e1a gene product |
| US8487128B2 (en) | 2002-11-26 | 2013-07-16 | Chs Pharma, Inc. | Protection of normal cells |
| WO2004058158A2 (en) | 2002-12-20 | 2004-07-15 | The Johns Hopkins University | Treatment of metastatic cancer with the b-subunit of shiga toxin |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US20080008649A1 (en) | 2003-01-13 | 2008-01-10 | Bracco Imaging S.P.A. | Gastrin Releasing Peptide Compounds |
| EP2529758A3 (en) | 2003-01-27 | 2013-01-02 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| CA2514419A1 (en) | 2003-01-28 | 2004-08-12 | Proscan Rx Pharma Inc. | Prostate cancer diagnosis and treatment |
| US7638122B2 (en) | 2003-03-07 | 2009-12-29 | University Of South Florida | Stat3 antagonists and their use as vaccines against cancer |
| WO2004080412A2 (en) * | 2003-03-07 | 2004-09-23 | The University Of Toledo | Paclitaxel hybrid derivatives |
| US20070179100A1 (en) | 2003-04-09 | 2007-08-02 | Muthiah Manoharan | Protected monomers |
| DK1620544T3 (en) * | 2003-04-17 | 2019-01-14 | Alnylam Pharmaceuticals Inc | MODIFIED iRNA AGENTS |
| WO2004096120A2 (en) | 2003-05-01 | 2004-11-11 | Nst Neurosurvival Technologies Ltd. | Compounds that selectively bind to membranes of apoptotic cells |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| JP4937751B2 (ja) * | 2003-06-13 | 2012-05-23 | イミューノメディクス、インコーポレイテッド | Ｄ−アミノ酸ペプチド |
| US7232805B2 (en) * | 2003-09-10 | 2007-06-19 | Inflabloc Pharmaceuticals, Inc. | Cobalamin conjugates for anti-tumor therapy |
| US20050255042A1 (en) | 2003-11-24 | 2005-11-17 | The Regents Of The University Of California Office Of Technology Transfer, University Of California | On-demand cleavable linkers for radioconjugates for cancer imaging and therapy |
| FR2864546A1 (fr) * | 2003-12-24 | 2005-07-01 | Assist Publ Hopitaux De Paris | Methode d'identification et de preparation de lymphocytes t regulateurs/suppresseurs, compositions et utilisations |
| US8586932B2 (en) | 2004-11-09 | 2013-11-19 | Spectrum Dynamics Llc | System and method for radioactive emission measurement |
| WO2007010534A2 (en) | 2005-07-19 | 2007-01-25 | Spectrum Dynamics Llc | Imaging protocols |
| DE102004004787A1 (de) * | 2004-01-30 | 2005-08-18 | Schering Ag | Neue Effektor-Konjugate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| AU2005216251B2 (en) | 2004-02-23 | 2011-03-10 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| EP1610818A4 (en) | 2004-03-03 | 2007-09-19 | Millennium Pharm Inc | MODIFIED ANTIBODIES AGAINST A PROSTATE-SPECIFIC MEMBRANE-ANTIGEN AND USE THEREOF |
| US20070254317A1 (en) | 2004-03-03 | 2007-11-01 | Biomerieux | Method for Detecting the Activatable Free Form of Psa and the Use Thereof for Diagnosing Benign Pathologies of the Prostate and Adenocarcinoma of the Prostate |
| EP1577673B1 (en) * | 2004-03-15 | 2008-07-30 | F. Hoffmann-La Roche Ag | The use of BNP-type peptides and ANP-type peptides for assessing the risk of suffering from a cardiovascular complication as a consequence of volume overload |
| WO2005100404A1 (en) | 2004-04-19 | 2005-10-27 | Proscan Rx Pharma | Prostate cancer diagnosis and treatment |
| US20060105975A1 (en) * | 2004-04-19 | 2006-05-18 | Shannon Pendergrast | Aptamer-mediated intracellular delivery of therapeutic oligonucleotides |
| RU2402548C2 (ru) | 2004-05-19 | 2010-10-27 | Медарекс, Инк. | Химические линкеры и их конъюгаты |
| JP4806680B2 (ja) * | 2004-05-19 | 2011-11-02 | メダレックス インコーポレイテッド | 自己犠牲リンカー及び薬剤複合体 |
| US20080008719A1 (en) | 2004-07-10 | 2008-01-10 | Bowdish Katherine S | Methods and compositions for the treatment of prostate cancer |
| EP1789391B1 (en) | 2004-07-23 | 2017-06-28 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| AU2005274905B2 (en) | 2004-08-04 | 2010-12-23 | Mentrik Biotech, Llc | Variant Fc regions |
| CA2577398A1 (en) | 2004-08-30 | 2006-03-09 | Neuromed Pharmaceuticals Ltd. | Urea derivatives as calcium channel blockers |
| US7713944B2 (en) * | 2004-10-13 | 2010-05-11 | Isis Pharmaceuticals, Inc. | Oligomers comprising activated disulfides which bind to plasma proteins and their use for delivery to cells |
| EP1807420B1 (en) | 2004-10-27 | 2010-03-10 | Janssen Pharmaceutica N.V. | Trisubstituted thiophenes as progesterone receptor modulators |
| US8000773B2 (en) | 2004-11-09 | 2011-08-16 | Spectrum Dynamics Llc | Radioimaging |
| EP1827505A4 (en) | 2004-11-09 | 2017-07-12 | Biosensors International Group, Ltd. | Radioimaging |
| US20060140871A1 (en) | 2004-11-30 | 2006-06-29 | Sillerud Laurel O | Magnetic resonance imaging of prostate cancer |
| EP1844351A4 (en) | 2005-01-13 | 2017-07-05 | Biosensors International Group, Ltd. | Multi-dimensional image reconstruction and analysis for expert-system diagnosis |
| US20060155021A1 (en) | 2005-01-13 | 2006-07-13 | Lenges Christian P | Coating compositions containing rheology control agents |
| US7741510B2 (en) | 2005-01-13 | 2010-06-22 | E. I. Du Pont De Nemours And Company | Rheology control agents |
| US20090258002A1 (en) | 2005-02-01 | 2009-10-15 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Biomarkers for Tissue Status |
| WO2006093991A1 (en) | 2005-03-02 | 2006-09-08 | The Cleveland Clinic Foundation | Compounds which bind psma and uses thereof |
| US20090105172A1 (en) | 2005-03-07 | 2009-04-23 | Diener John L | Stabilized Aptamers to PSMA and Their Use as Prostate Cancer Therapeutics |
| US8088908B2 (en) | 2005-05-10 | 2012-01-03 | City Of Hope | Humanized anti-prostate stem cell antigen monoclonal antibody |
| KR101068612B1 (ko) | 2005-05-24 | 2011-09-30 | 휴마시스 주식회사 | 유사구조 단백질 비율 측정을 이용한 진단장치 |
| WO2006133553A1 (en) | 2005-06-14 | 2006-12-21 | Protox Therapeutics Incorporated | Method of treating or preventing benign prostatic hyperplasia using modified pore-forming proteins |
| CN101287498B (zh) | 2005-06-20 | 2013-03-27 | Psma开发有限公司 | Psma抗体-药物缀合物 |
| US7403088B2 (en) | 2005-06-29 | 2008-07-22 | Eaton Corporation | Handle apparatus and electrical switching apparartus employing the same |
| WO2007006041A2 (en) | 2005-07-05 | 2007-01-11 | Purdue Research Foundation | Imaging and therapeutic method using monocytes |
| US20070010014A1 (en) * | 2005-07-06 | 2007-01-11 | General Electric Company | Compositions and methods for enhanced delivery to target sites |
| JP5475992B2 (ja) | 2005-08-19 | 2014-04-16 | エンドサイト，インコーポレイテッド | 多剤リガンド結合体 |
| WO2007022493A2 (en) | 2005-08-19 | 2007-02-22 | Endocyte, Inc. | Ligand conjugates of vinca alkaloids, analogs, and derivatives |
| WO2007033215A2 (en) | 2005-09-12 | 2007-03-22 | The Johns Hopkins University | Compositions having antiangiogenic activity and uses thereof |
| JP5368099B2 (ja) | 2005-10-07 | 2013-12-18 | ゲルベ | ガリウムと錯体形成することが可能なシグナル部分にカップリングされた、生物学的標的の認識のための部分を含んでなる化合物 |
| WO2008048298A2 (en) * | 2005-11-21 | 2008-04-24 | Medivas, Llc | Polymer particles for delivery of macromolecules and methods of use |
| EP1951316B1 (en) * | 2005-11-23 | 2015-08-19 | Ventana Medical Systems, Inc. | Molecular conjugate |
| WO2007081751A2 (en) | 2006-01-05 | 2007-07-19 | The Johns Hopkins University | Compositions and methods for the treatment of cancer |
| US7635682B2 (en) | 2006-01-06 | 2009-12-22 | Genspera, Inc. | Tumor activated prodrugs |
| CA2645809C (en) * | 2006-03-14 | 2015-05-26 | Cancer Targeted Technology Llc | Peptidomimetic inhibitors of psma, compounds comprising them, and methods of use |
| JP2009531324A (ja) | 2006-03-20 | 2009-09-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 癌標的化のための操作された抗前立腺幹細胞抗原（ｐｓｃａ）抗体 |
| US20070225213A1 (en) | 2006-03-23 | 2007-09-27 | Kosak Matthew K | Nucleic acid carriers for delivery of therapeutic agents |
| US20140314864A1 (en) | 2006-03-31 | 2014-10-23 | Massachusetts Institute Of Technology | System for Targeted Delivery of Therapeutic Agents |
| JP2009534309A (ja) | 2006-03-31 | 2009-09-24 | マサチューセッツ インスティテュート オブ テクノロジー | 治療剤の標的化送達のためのシステム |
| US7842280B2 (en) * | 2006-09-06 | 2010-11-30 | Case Western Reserve University | Flexibly labeling peptides |
| US8685752B2 (en) * | 2006-11-03 | 2014-04-01 | Purdue Research Foundation | Ex vivo flow cytometry method and device |
| PL3699162T3 (pl) | 2006-11-08 | 2022-10-31 | Molecular Insight Pharmaceuticals, Inc. | Heterodimery kwasu glutaminowego |
| US20100210792A1 (en) * | 2006-12-05 | 2010-08-19 | David Taft | Drug delivery |
| US8507434B2 (en) | 2007-01-03 | 2013-08-13 | The Johns Hopkins University | Peptide modulators of angiogenesis and use thereof |
| EP2117604B1 (en) | 2007-01-11 | 2017-07-26 | Immunomedics, Inc. | Methods and compositions for improved f-18 labeling of proteins, peptides and other molecules |
| US20080214436A1 (en) * | 2007-01-26 | 2008-09-04 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| JP5869205B2 (ja) | 2007-02-07 | 2016-02-24 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | ポジトロン放射断層画像法 |
| WO2008101231A2 (en) | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| CN101678124A (zh) * | 2007-03-14 | 2010-03-24 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| WO2008124197A1 (en) | 2007-04-10 | 2008-10-16 | The Johns Hopkins University | Imaging and therapy of virus-associated tumors |
| EP3569251A1 (en) | 2007-06-25 | 2019-11-20 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
| EP2921482B1 (en) | 2007-06-26 | 2018-09-05 | The Johns Hopkins University | Labeled inhibitors of prostate-specific membrane antigen (psma), biological evaluation, and use as imaging agents |
| GB0723246D0 (en) | 2007-07-03 | 2008-01-09 | Barton Michelle | p53 modulator |
| US8153595B2 (en) | 2007-07-13 | 2012-04-10 | The Johns Hopkins University | B7-DC variants immunogenic compositions and methods of use thereof |
| KR20100063048A (ko) | 2007-07-31 | 2010-06-10 | 더 존스 홉킨스 유니버시티 | 신생물성 또는 감염성 장애의 면역예방 또는 면역치료를 위한 폴리펩티드-핵산 접합체 |
| US9193763B2 (en) | 2007-08-17 | 2015-11-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| CA2891005A1 (en) | 2007-09-28 | 2008-10-09 | Bind Therapeutics, Inc. | Cancer cell targeting using nanoparticles |
| CN101909441B (zh) * | 2007-10-25 | 2015-05-13 | 恩多塞特公司 | 微管蛋白抑制剂及其制备方法 |
| US8450290B2 (en) | 2007-11-26 | 2013-05-28 | Enzon Pharmaceuticals, Inc. | Methods for treating androgen receptor dependent disorders including cancers |
| WO2009070302A1 (en) | 2007-11-30 | 2009-06-04 | The Johns Hopkins University | Prostate specific membrane antigen (psma) targeted nanoparticles for therapy of prostate cancer |
| WO2009082606A2 (en) | 2007-12-04 | 2009-07-02 | Alnylam Pharmaceuticals, Inc. | Folate conjugates |
| US20090180951A1 (en) | 2007-12-12 | 2009-07-16 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of integrin vla-4 |
| WO2009089383A2 (en) | 2008-01-09 | 2009-07-16 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of carbonic anhydrase ix |
| ITTO20080313A1 (it) | 2008-04-22 | 2009-10-23 | Marco Colombatti | Anticorpo monoclonale isolato o suo frammento legante l'antigene specifico di membrana della prostata, suoi coniugati e suoi usi |
| EP2990487A1 (en) | 2008-05-08 | 2016-03-02 | Asuragen, INC. | Compositions and methods related to mirna modulation of neovascularization or angiogenesis |
| PL2291659T3 (pl) | 2008-05-13 | 2016-04-29 | Univ Yale | Małe cząsteczki chimerowe do rekrutacji przeciwciał do komórek nowotworowych |
| US8852630B2 (en) | 2008-05-13 | 2014-10-07 | Yale University | Chimeric small molecules for the recruitment of antibodies to cancer cells |
| EP2309990B2 (en) * | 2008-06-16 | 2017-03-15 | Pfizer Inc. | Drug loaded polymeric nanoparticles and methods of making and using same |
| PL2318366T3 (pl) | 2008-08-01 | 2017-10-31 | Univ Johns Hopkins | Środki wiążące PSMA i ich zastosowania |
| US8816095B2 (en) | 2008-08-15 | 2014-08-26 | Georgetown University | Na channels, disease, and related assays and compositions |
| EP2727606A3 (en) | 2008-09-08 | 2015-09-23 | Psma Development Company, L.L.C. | Compounds for killing psma-expressing, taxane-resistant cancer cells |
| EP2166021A1 (en) | 2008-09-16 | 2010-03-24 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
| PL2349274T3 (pl) | 2008-09-17 | 2025-09-22 | Endocyte, Inc. | Koniugaty antyfolianów wiążące się z receptorem folianów |
| WO2010045598A2 (en) | 2008-10-17 | 2010-04-22 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| WO2010065899A2 (en) | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof |
| HUE029940T2 (en) | 2008-12-05 | 2017-04-28 | Molecular Insight Pharm Inc | Bis (imidazolyl) compounds and radionuclide complexes |
| US8211402B2 (en) | 2008-12-05 | 2012-07-03 | Molecular Insight Pharmaceuticals, Inc. | CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer |
| EP2398504B1 (en) | 2009-02-17 | 2018-11-28 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| EP2408465A4 (en) | 2009-03-17 | 2012-11-28 | Univ Johns Hopkins | METHODS AND COMPOSITIONS FOR CANCER SCREENING |
| EP4420730A3 (en) | 2009-03-19 | 2024-11-13 | The Johns Hopkins University | Psma-targeting compounds and uses thereof |
| BR112012000209B8 (pt) | 2009-06-15 | 2021-07-27 | Molecular Insight Pharm Inc | heterodímeros de ácido glutâmico e seus processos de preparação |
| CN102549434A (zh) | 2009-07-31 | 2012-07-04 | 恩多塞特公司 | 叶酸盐靶向的诊断和治疗 |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| US8313128B2 (en) | 2009-08-20 | 2012-11-20 | Rhoost, Llc. | Safety locking mechanism for doors |
| WO2011031517A1 (en) | 2009-08-27 | 2011-03-17 | Nuclea Biotechnologies, LLC | Method and assay for determining fas expression |
| BR112012012887A2 (pt) | 2009-12-02 | 2017-05-02 | Imaginab Inc | minicorpo e cys-diabody (cysdb) codificados por sequência de nucleótidos, respectivo uso e métodos de diagnósticos e de tratamento de câncer associado com a expressão de psma num sujeito. |
| EP2509634B1 (en) | 2009-12-11 | 2019-03-06 | Pfizer Inc | Stable formulations for lyophilizing therapeutic particles |
| AU2011212813B2 (en) | 2010-02-04 | 2014-10-23 | Radius Health, Inc. | Selective androgen receptor modulators |
| WO2011106639A1 (en) | 2010-02-25 | 2011-09-01 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| CN101863924B (zh) | 2010-05-17 | 2012-06-27 | 北京师范大学 | 99mTc标记肼基烟酰胺基-二氧辛酰-叶酸配合物及制备方法 |
| JP6275484B2 (ja) | 2010-12-06 | 2018-02-07 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | Ｐｓｍａ標的化デンドリマー |
| WO2012166923A2 (en) | 2011-05-31 | 2012-12-06 | Bind Biosciences | Drug loaded polymeric nanoparticles and methods of making and using same |
| CA2844151C (en) | 2011-08-05 | 2022-11-29 | John W. Babich | Radiolabeled prostate specific membrane antigen inhibitors |
| US10011632B2 (en) | 2011-08-22 | 2018-07-03 | Siemens Medical Solutions Usa, Inc. | PSMA imaging agents |
| US9629918B2 (en) | 2012-02-29 | 2017-04-25 | Purdue Research Foundation | Folate receptor alpha binding ligands |
| KR20150070318A (ko) | 2012-10-16 | 2015-06-24 | 엔도사이트, 인코포레이티드 | 비천연 아미노산을 함유하는 약물 전달 컨쥬게이트 및 사용 방법 |
| US20140107316A1 (en) * | 2012-10-16 | 2014-04-17 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
| EP3858341A1 (en) | 2012-11-15 | 2021-08-04 | Endocyte, Inc. | Psma ligand-containing conjugates for the treatment of prostate cancer |
| US20140154702A1 (en) | 2012-11-30 | 2014-06-05 | Endocyte, Inc. | Methods For Treating Cancer Using Combination Therapies |
| AU2013366490B9 (en) | 2012-12-21 | 2018-02-01 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
| AU2013369982B2 (en) | 2012-12-28 | 2016-11-17 | Tva (Abc), Llc | Targeted conjugates encapsulated in particles and formulations thereof |
| US9889199B2 (en) | 2013-02-15 | 2018-02-13 | Case Western Reserve University | PSMA ligands and uses thereof |
| US20140249315A1 (en) | 2013-03-01 | 2014-09-04 | Endocyte, Inc. | Processes for preparing tubulysins |
| US20170232119A1 (en) * | 2013-03-15 | 2017-08-17 | Purdue Research Foundation | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
| US10406246B2 (en) | 2013-10-17 | 2019-09-10 | Deutsches Kresbsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
| KR101947053B1 (ko) | 2013-10-18 | 2019-02-12 | 도이체스 크렙스포르슝스첸트룸 | 전립선 특이적 막 항원（ｐｓｍａ）의 표지된 억제제, 조영제로서의 이의 용도 및 전립선암 치료용 약제 |
| US20150110814A1 (en) | 2013-10-18 | 2015-04-23 | Psma Development Company, Llc | Combination therapies with psma ligand conjugates |
| EP3533473A3 (en) | 2013-11-14 | 2019-12-18 | Endocyte, Inc. | Compounds for positron emission tomography |
| CN106660943B (zh) | 2014-05-06 | 2020-03-17 | 约翰霍普金斯大学 | 用于psma靶向的成像和放射疗法的金属/放射性金属标记的psma抑制物 |
| PL3183236T3 (pl) | 2014-08-24 | 2022-07-18 | Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften | Sposób wytwarzania 18f-znakowanych aktywnych estrów i ich zastosowanie na przykładzie wytwarzania znacznika pet specyficznego dla psma |
| EP3193914B1 (en) | 2014-09-08 | 2021-01-20 | Molecular Insight Pharmaceuticals, Inc. | Organ protection in psma-targeted radionuclide therapy of prostate cancer |
| WO2016183131A1 (en) * | 2015-05-11 | 2016-11-17 | Purdue Research Foundation | Ligand ionophore conjugates |
| US9808538B2 (en) * | 2015-09-09 | 2017-11-07 | On Target Laboratories, LLC | PSMA-targeted NIR dyes and their uses |
| US10842887B2 (en) * | 2015-09-09 | 2020-11-24 | On Target Laboratories, LLC | PSMA-targeted NIR dyes and their uses |
| FR3043970B1 (fr) | 2015-11-25 | 2019-06-21 | Medtech Sa | Systeme mecanique de stabilisation au sol pour vehicules a roulettes |
| JP6806471B2 (ja) | 2016-06-16 | 2021-01-06 | キヤノン株式会社 | 焦点検出装置及び方法、及び撮像装置 |
| ES2944610T3 (es) * | 2016-09-09 | 2023-06-22 | On Target Laboratories Llc | Colorantes NIR dirigidos a PSMA y sus usos |
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2016
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- 2016-03-09 JP JP2016046076A patent/JP2016153410A/ja active Pending
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2017
- 2017-05-26 US US15/606,913 patent/US10406240B2/en active Active
- 2017-11-21 JP JP2017223872A patent/JP6596479B2/ja active Active
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2018
- 2018-04-20 US US15/959,110 patent/US10624969B2/en active Active
- 2018-05-25 JP JP2018100343A patent/JP6625690B2/ja active Active
- 2018-05-25 US US15/990,111 patent/US10485878B2/en active Active
- 2018-05-25 US US15/990,144 patent/US10624971B2/en active Active
- 2018-05-25 US US15/990,095 patent/US10624970B2/en active Active
- 2018-05-25 US US15/990,136 patent/US10646581B2/en active Active
- 2018-05-25 US US15/990,152 patent/US10828282B2/en active Active
- 2018-05-25 US US15/990,083 patent/US10517956B2/en active Active
- 2018-06-04 US US15/997,451 patent/US10517957B2/en active Active
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2019
- 2019-07-10 US US16/507,713 patent/US11298341B2/en active Active
- 2019-09-30 JP JP2019179190A patent/JP6838118B2/ja active Active
- 2019-12-17 US US16/717,753 patent/US20200188523A1/en not_active Abandoned
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2020
- 2020-01-22 US US16/749,827 patent/US11083710B2/en active Active
- 2020-01-22 US US16/749,896 patent/US20200297701A1/en not_active Abandoned
- 2020-05-07 US US16/869,268 patent/US11504357B2/en active Active
- 2020-10-30 US US17/086,063 patent/US11717514B2/en active Active
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2021
- 2021-02-10 JP JP2021019732A patent/JP7079355B2/ja active Active
- 2021-06-25 US US17/359,314 patent/US11318121B2/en active Active
- 2021-06-25 US US17/358,726 patent/US12496292B2/en active Active
- 2021-06-25 US US17/359,277 patent/US11369590B2/en active Active
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2022
- 2022-01-11 US US17/573,304 patent/US20230000836A1/en active Pending
- 2022-05-19 JP JP2022082105A patent/JP7609824B2/ja active Active
- 2022-11-21 US US17/991,013 patent/US20230293497A1/en active Pending
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2023
- 2023-03-09 US US18/181,487 patent/US20230346752A1/en active Pending
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2024
- 2024-06-12 JP JP2024095014A patent/JP2024117783A/ja active Pending
- 2024-12-11 US US18/977,274 patent/US20250108039A1/en active Pending