|
US5410017A
(en)
*
|
1993-05-21 |
1995-04-25 |
Rohm And Haas Company |
Continuous thermal polycondensation process for preparing polypeptide polymers
|
|
US9725485B2
(en)
|
2012-05-15 |
2017-08-08 |
University Of Florida Research Foundation, Inc. |
AAV vectors with high transduction efficiency and uses thereof for gene therapy
|
|
ES2714007T3
(es)
|
2007-04-09 |
2019-05-24 |
Univ Florida |
Composiciones de vectores rAAV que tienen proteínas de la cápside modificadas en tirosina y métodos para su uso
|
|
US10294281B2
(en)
|
2012-05-15 |
2019-05-21 |
University Of Florida Research Foundation, Incorporated |
High-transduction-efficiency rAAV vectors, compositions, and methods of use
|
|
US12358954B2
(en)
|
2012-05-15 |
2025-07-15 |
University Of Florida Research Foundation, Incorporated |
Capsid-modified rAAV vector compositions and methods therefor
|
|
WO2015048534A1
(en)
|
2013-09-26 |
2015-04-02 |
University Of Florida Research Foundation, Inc. |
Synthetic combinatorial aav capsid library for targeted gene therapy
|
|
EP3151866B1
(en)
|
2014-06-09 |
2023-03-08 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
GB201420139D0
(en)
|
2014-11-12 |
2014-12-24 |
Ucl Business Plc |
Factor IX gene therapy
|
|
US20180030096A1
(en)
|
2015-02-03 |
2018-02-01 |
University Of Florida Research Foundation, Inc. |
Recombinant aav1, aav5, and aav6 capsid mutants and uses thereof
|
|
GB201508026D0
(en)
|
2015-05-11 |
2015-06-24 |
Ucl Business Plc |
Capsid
|
|
ES2865487T3
(es)
|
2015-09-28 |
2021-10-15 |
Univ North Carolina Chapel Hill |
Métodos y composiciones para vectores virales que evaden los anticuerpos
|
|
US12188037B2
(en)
|
2015-10-22 |
2025-01-07 |
University Of Florida Research Foundation, Incorporated |
Synthetic combinatorial AAV3 capsid library
|
|
JP7406783B2
(ja)
*
|
2015-12-14 |
2023-12-28 |
ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
パルボウイルスベクターの高められた送達のための改変キャプシドタンパク質
|
|
US20190262373A1
(en)
*
|
2016-08-16 |
2019-08-29 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for targeted gene transfer
|
|
IL315358A
(en)
*
|
2016-08-18 |
2024-11-01 |
Univ California |
CRISPR-CAS genome engineering using a modular AAV delivery system
|
|
EP3585883A4
(en)
*
|
2017-02-21 |
2021-04-14 |
University of Florida Research Foundation, Incorporated |
MODIFIED AAV CAPSID PROTEINS AND USES THEREOF
|
|
KR102606810B1
(ko)
|
2017-05-05 |
2023-11-27 |
유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 |
오토펄린을 발현시키기 위한 조성물 및 방법
|
|
PE20200488A1
(es)
*
|
2017-06-27 |
2020-03-03 |
Regeneron Pharma |
Vectores virales recombinantes con tropismo modificado y usos de estos para la introduccion dirigida de material genetico a celulas humanas
|
|
KR102696307B1
(ko)
*
|
2017-09-08 |
2024-08-16 |
제너레이션 바이오 컴퍼니 |
비-바이러스성 캡시드-비함유 dna 벡터의 지질 나노입자 제형
|
|
AU2019209770B2
(en)
*
|
2018-01-16 |
2025-07-31 |
Cls Therapeutics Limited |
Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (DNase) activity
|
|
SI3740222T1
(sl)
*
|
2018-01-17 |
2023-11-30 |
Meiragtx Uk Ii Limited |
Modificiran kapsidni protein raav za gensko terapijo
|
|
US10610606B2
(en)
|
2018-02-01 |
2020-04-07 |
Homology Medicines, Inc. |
Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
|
|
US20190256867A1
(en)
|
2018-02-01 |
2019-08-22 |
Homology Medicines, Inc. |
Adeno-associated virus compositions for restoring pah gene function and methods of use thereof
|
|
CN111902539B
(zh)
*
|
2018-02-07 |
2025-05-16 |
吉尼松公司 |
杂合调控元件
|
|
JP7244547B2
(ja)
|
2018-02-19 |
2023-03-22 |
ホモロジー・メディシンズ・インコーポレイテッド |
F8遺伝子機能を回復させるためのアデノ随伴ウイルス組成物及びその使用の方法
|
|
JP2021519612A
(ja)
*
|
2018-03-29 |
2021-08-12 |
アスクレピオス バイオファーマシューティカル, インコーポレイテッド |
中和を回避する肝臓向性組換えaav6ベクター
|
|
AU2019247748A1
(en)
|
2018-04-03 |
2020-10-08 |
Ginkgo Bioworks, Inc. |
Antibody-evading virus vectors
|
|
EP3774852A1
(en)
|
2018-04-03 |
2021-02-17 |
Stridebio, Inc. |
Antibody-evading virus vectors
|
|
MX2020010465A
(es)
|
2018-04-03 |
2021-01-08 |
|
Vectores de virus para direccionamiento a tejidos oftalmicos.
|
|
CN112703016B
(zh)
|
2018-04-27 |
2024-11-22 |
分贝治疗公司 |
肌球蛋白15启动子及其用途
|
|
EP3784697A4
(en)
*
|
2018-04-27 |
2022-07-06 |
Spark Therapeutics, Inc. |
GMO AAV CAPSIDS WITH INCREASED TROPISM AND AAV VECTORS CONTAINING THE GMO CAPSIDS, AND METHODS FOR THEIR MANUFACTURE AND USE
|
|
JP7142815B2
(ja)
*
|
2018-06-21 |
2022-09-28 |
株式会社遺伝子治療研究所 |
ヒト肝臓への遺伝子導入のためのアデノ随伴ウイルスビリオン
|
|
WO2020014471A1
(en)
|
2018-07-11 |
2020-01-16 |
The Brigham And Women's Hospital, Inc. |
Methods and compositions for delivery of agents across the blood-brain barrier
|
|
US10842885B2
(en)
|
2018-08-20 |
2020-11-24 |
Ucl Business Ltd |
Factor IX encoding nucleotides
|
|
GB201813528D0
(en)
|
2018-08-20 |
2018-10-03 |
Ucl Business Plc |
Factor IX encoding nucleotides
|
|
WO2020079256A1
(en)
*
|
2018-10-19 |
2020-04-23 |
Genethon |
Modulation, monitoring and prediction of the immune response directed against aav gene therapy vectors
|
|
EP4295913A3
(en)
*
|
2019-01-18 |
2024-03-06 |
Institut Pasteur |
Aav-mediated gene therapy restoring the otoferlin gene
|
|
CA3129422A1
(en)
|
2019-02-08 |
2020-08-13 |
Decibel Therapeutics, Inc. |
Myosin 15 promoters and uses thereof
|
|
EP3921032A4
(en)
|
2019-02-08 |
2022-11-30 |
Decibel Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS
|
|
AR118465A1
(es)
|
2019-03-21 |
2021-10-06 |
Stridebio Inc |
Vectores de virus adenoasociados recombinantes
|
|
EP3736330A1
(en)
*
|
2019-05-08 |
2020-11-11 |
European Molecular Biology Laboratory |
Modified adeno-associated virus (aav) particles for gene therapy
|
|
AU2020299026A1
(en)
*
|
2019-07-04 |
2022-01-20 |
Children's Medical Research Institute |
Methods and AAV vectors for in vivo transduction
|
|
EP3997214B1
(en)
*
|
2019-07-11 |
2023-08-02 |
Centre National de la Recherche Scientifique |
Chemically-modified adeno-associated virus
|
|
EP4028064A1
(en)
*
|
2019-09-12 |
2022-07-20 |
The Broad Institute, Inc. |
Engineered adeno-associated virus capsids
|
|
US12611436B2
(en)
|
2019-10-17 |
2026-04-28 |
Sarepta Therapeutics, Inc. |
AAV transfer cassette
|
|
JP2022551739A
(ja)
|
2019-10-17 |
2022-12-13 |
ストライドバイオ,インコーポレイテッド |
ニーマン・ピック病c型の治療のためのアデノ随伴ウイルスベクター
|
|
KR20220130093A
(ko)
|
2019-10-30 |
2022-09-26 |
데시벨 테라퓨틱스, 인크. |
오토펄린 듀얼 벡터 시스템을 사용한 감각신경성 난청을 치료하기 위한 조성물 및 방법
|
|
US20230340526A1
(en)
*
|
2019-11-25 |
2023-10-26 |
University Of Florida Research Foundation, Incorporated |
Novel aav3b variants that target hepatocytes and evade the humoral immune response
|
|
WO2021108468A1
(en)
*
|
2019-11-25 |
2021-06-03 |
University Of Florida Research Foundation, Incorporated |
Novel aav3b variants that target human hepatocytes in the liver of humanized mice
|
|
CN115279400B
(zh)
*
|
2020-01-10 |
2026-04-28 |
布里格姆妇女医院 |
用于跨血脑屏障递送免疫治疗剂以治疗脑癌的方法和组合物
|
|
TW202140791A
(zh)
|
2020-01-13 |
2021-11-01 |
美商霍蒙拉奇醫藥公司 |
治療苯酮尿症之方法
|
|
CN115666658A
(zh)
|
2020-04-01 |
2023-01-31 |
佛罗里达州大学研究基金会 |
具有提高的治疗ush1b的安全性的双aav-myo7a载体
|
|
JP2023524577A
(ja)
*
|
2020-05-05 |
2023-06-12 |
ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル |
改変アデノ随伴ウイルス5カプシドおよびその使用
|
|
TW202208632A
(zh)
|
2020-05-27 |
2022-03-01 |
美商同源醫藥公司 |
用於恢復pah基因功能的腺相關病毒組成物及其使用方法
|
|
AU2021328475A1
(en)
|
2020-08-19 |
2023-03-16 |
Sarepta Therapeutics, Inc. |
Adeno-associated virus vectors for treatment of Rett syndrome
|
|
AU2021378075B2
(en)
|
2020-11-11 |
2025-03-27 |
Borea Therapeutics S.R.L. |
Modified viral particles for gene therapy
|
|
CN113647359A
(zh)
*
|
2021-08-15 |
2021-11-16 |
芜湖职业技术学院 |
注射衣霉素诱导急性肝损伤小鼠模型的构建方法
|
|
CN118201947B
(zh)
*
|
2021-10-28 |
2025-03-21 |
上海天泽云泰生物医药有限公司 |
腺相关病毒衣壳
|
|
EP4508065A2
(en)
*
|
2022-04-15 |
2025-02-19 |
Dyno Therapeutics, Inc. |
Capsid variants and methods of using the same
|
|
GB202407863D0
(en)
|
2024-06-03 |
2024-07-17 |
Purespring Therapeutics Ltd |
Methods
|
|
WO2026001958A1
(zh)
*
|
2024-06-24 |
2026-01-02 |
黄菁 |
Aav载体、aav载体的组合、构建aml pdx和mm pdx非人动物的方法及构建免疫系统人源化非人动物的方法
|
|
KR20260014488A
(ko)
*
|
2024-07-22 |
2026-01-30 |
한국생명공학연구원 |
변이체 캡시드를 포함하는 아데노-연관 바이러스 및 이의 용도
|
|
CN119380820B
(zh)
*
|
2024-10-10 |
2025-06-17 |
四川大学华西医院 |
一种aav2衣壳蛋白变体设计方法、系统和存储介质
|