JP2019535707A - 軟骨損傷および関節炎の処置のための方法および組成物 - Google Patents

軟骨損傷および関節炎の処置のための方法および組成物 Download PDF

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JP2019535707A
JP2019535707A JP2019524328A JP2019524328A JP2019535707A JP 2019535707 A JP2019535707 A JP 2019535707A JP 2019524328 A JP2019524328 A JP 2019524328A JP 2019524328 A JP2019524328 A JP 2019524328A JP 2019535707 A JP2019535707 A JP 2019535707A
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Prior art keywords
polypeptide
composition
amino acid
seq
intra
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JP2019535707A5 (https=
Inventor
ジョンソン，クリステン
ゴールドハーン，ヨルグ
スコッティ，セレステ
ボスティアー，イゴール
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ノバルティス アーゲー
ノバルティス アーゲー
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Publication of JP2019535707A publication Critical patent/JP2019535707A/ja
Publication of JP2019535707A5 publication Critical patent/JP2019535707A5/ja
Priority to JP2022193539A priority Critical patent/JP2023039962A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019524328A 2016-11-14 2017-11-13 軟骨損傷および関節炎の処置のための方法および組成物 Withdrawn JP2019535707A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022193539A JP2023039962A (ja) 2016-11-14 2022-12-02 軟骨損傷および関節炎の処置のための方法および組成物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662421534P 2016-11-14 2016-11-14
US62/421,534 2016-11-14
US201762560301P 2017-09-19 2017-09-19
US62/560,301 2017-09-19
PCT/IB2017/057081 WO2018087727A1 (en) 2016-11-14 2017-11-13 Methods and compositions for treatment of cartilage damage and arthritis

Related Child Applications (1)

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JP2022193539A Division JP2023039962A (ja) 2016-11-14 2022-12-02 軟骨損傷および関節炎の処置のための方法および組成物

Publications (2)

Publication Number Publication Date
JP2019535707A true JP2019535707A (ja) 2019-12-12
JP2019535707A5 JP2019535707A5 (https=) 2020-12-24

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JP2019524328A Withdrawn JP2019535707A (ja) 2016-11-14 2017-11-13 軟骨損傷および関節炎の処置のための方法および組成物
JP2022193539A Pending JP2023039962A (ja) 2016-11-14 2022-12-02 軟骨損傷および関節炎の処置のための方法および組成物

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Country Status (10)

Country Link
US (3) US11351223B2 (https=)
EP (1) EP3538127A1 (https=)
JP (2) JP2019535707A (https=)
KR (2) KR20190084287A (https=)
CN (2) CN109963579A (https=)
AU (2) AU2017357785A1 (https=)
CA (1) CA3043667A1 (https=)
IL (1) IL266361B2 (https=)
MX (2) MX2019005621A (https=)
WO (1) WO2018087727A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024519893A (ja) 2021-05-24 2024-05-21 ノバルティス アーゲー 変形性関節症の治療方法
TW202306970A (zh) 2021-05-24 2023-02-16 瑞士商諾華公司 用於治療骨關節炎之方法
CN118251594A (zh) * 2021-11-10 2024-06-25 诺华股份有限公司 用于确定angptl多肽的生物活性的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012533549A (ja) * 2009-07-14 2012-12-27 ザ スクリプス リサーチ インスティチュート 間葉幹細胞分化
JP2016510763A (ja) * 2013-03-08 2016-04-11 ノバルティス アーゲー 関節損傷の治療のためのペプチドおよび組成物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7083970B2 (en) 2001-04-19 2006-08-01 The Scripps Research Institute Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
MXPA05003978A (es) 2002-10-16 2005-06-22 Scripps Research Inst Sintesis de glicoproteinas.
ES2324608T3 (es) 2002-10-16 2009-08-11 The Scripps Research Institute Incorporacion especifica de sitio de cetoaminoacidos en proteinas.
WO2004094593A2 (en) 2003-04-17 2004-11-04 The Scripps Research Institute Expanding the eukaryotic genetic code
US20060160175A1 (en) 2003-07-07 2006-07-20 The Scripps Research Institute Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
WO2005007624A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof
WO2005019415A2 (en) 2003-07-07 2005-03-03 The Scripps Research Institute Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
CA2580840A1 (en) 2004-09-21 2006-03-30 The Scripps Research Institute In vivo incorporation of alkynyl amino acids into proteins in eubacteria
EP1807515A4 (en) 2004-10-27 2008-06-18 Scripps Research Inst Orthogonal translation components for the in vivo incorporation of unnatural amino acids
US7960141B2 (en) 2006-03-09 2011-06-14 The Scripps Research Institute Systems for the expression of orthogonal translation components in eubacterial host cells
EP2118150B1 (en) 2007-02-14 2015-09-23 Biocompatibles UK Limited Derivatisation of biological molecules
US8858940B2 (en) * 2008-12-10 2014-10-14 Ablynx N.V. Amino acid sequences directed against the Angiopoietin/Tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis
UY32979A (es) * 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
AU2013204754C1 (en) * 2012-05-16 2018-10-11 Takeda Pharmaceutical Company Limited Nucleophilic Catalysts for Oxime Linkage
US9301971B2 (en) * 2013-03-08 2016-04-05 Novartis Ag Peptides and compositions for treatment of joint damage
ES2900815T3 (es) * 2013-03-15 2022-03-18 Scripps Research Inst Compuestos y métodos para inducir la condrogénesis
EP3143026B1 (en) * 2014-05-13 2024-07-10 Novartis AG Compounds and compositions for inducing chondrogenesis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012533549A (ja) * 2009-07-14 2012-12-27 ザ スクリプス リサーチ インスティチュート 間葉幹細胞分化
JP2016510763A (ja) * 2013-03-08 2016-04-11 ノバルティス アーゲー 関節損傷の治療のためのペプチドおよび組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DEV. DYN. (2007) VOL.236, ISSUE 9, P.2643-2652, JPN6021039990, ISSN: 0004613302 *

Also Published As

Publication number Publication date
AU2020281098B2 (en) 2024-05-02
IL266361B1 (en) 2023-10-01
EP3538127A1 (en) 2019-09-18
JP2023039962A (ja) 2023-03-22
US20250302915A1 (en) 2025-10-02
CN109963579A (zh) 2019-07-02
WO2018087727A1 (en) 2018-05-17
KR20190084287A (ko) 2019-07-16
IL266361A (en) 2019-06-30
MX2022011897A (es) 2022-10-18
US11351223B2 (en) 2022-06-07
MX2019005621A (es) 2019-08-12
US20220331398A1 (en) 2022-10-20
CN117860868A (zh) 2024-04-12
CA3043667A1 (en) 2018-05-17
AU2020281098A1 (en) 2021-01-14
RU2019117884A (ru) 2020-12-14
IL266361B2 (en) 2024-02-01
RU2019117884A3 (https=) 2021-02-05
KR20240045351A (ko) 2024-04-05
AU2017357785A2 (en) 2019-05-02
AU2017357785A1 (en) 2019-04-11
US20190269754A1 (en) 2019-09-05

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