JP2019534034A5 - - Google Patents
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- JP2019534034A5 JP2019534034A5 JP2019531512A JP2019531512A JP2019534034A5 JP 2019534034 A5 JP2019534034 A5 JP 2019534034A5 JP 2019531512 A JP2019531512 A JP 2019531512A JP 2019531512 A JP2019531512 A JP 2019531512A JP 2019534034 A5 JP2019534034 A5 JP 2019534034A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- antigen
- binding fragment
- seq
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610705763.5 | 2016-08-23 | ||
| CN201610705763.5A CN106977602B (zh) | 2016-08-23 | 2016-08-23 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
| PCT/CN2017/098465 WO2018036472A1 (zh) | 2016-08-23 | 2017-08-22 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019534034A JP2019534034A (ja) | 2019-11-28 |
| JP2019534034A5 true JP2019534034A5 (https=) | 2020-07-16 |
| JP7082620B2 JP7082620B2 (ja) | 2022-06-08 |
Family
ID=59340342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531512A Active JP7082620B2 (ja) | 2016-08-23 | 2017-08-22 | 抗ｐｄ１モノクローナル抗体、その医薬組成物およびその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US12076398B2 (https=) |
| EP (2) | EP4509186A3 (https=) |
| JP (1) | JP7082620B2 (https=) |
| KR (1) | KR102469286B1 (https=) |
| CN (1) | CN106977602B (https=) |
| AU (2) | AU2017316255C1 (https=) |
| BR (1) | BR112019003775A2 (https=) |
| EA (1) | EA201990570A1 (https=) |
| ES (1) | ES3001154T3 (https=) |
| FI (1) | FI3505535T3 (https=) |
| HU (1) | HUE069593T2 (https=) |
| IL (1) | IL264956B2 (https=) |
| LT (1) | LT3505535T (https=) |
| MX (1) | MX2019002268A (https=) |
| NZ (1) | NZ751902A (https=) |
| PL (1) | PL3505535T3 (https=) |
| PT (1) | PT3505535T (https=) |
| RS (1) | RS66372B1 (https=) |
| SG (1) | SG11201901584UA (https=) |
| SI (1) | SI3505535T1 (https=) |
| WO (1) | WO2018036472A1 (https=) |
| ZA (1) | ZA201901781B (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108112254B (zh) | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| CN114591433A (zh) | 2015-07-13 | 2022-06-07 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
| EP3370768B9 (en) | 2015-11-03 | 2022-03-16 | Janssen Biotech, Inc. | Antibodies specifically binding pd-1 and their uses |
| CN106967172B (zh) | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
| WO2018035710A1 (en) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anti-ctla4 antibodies |
| CN106977602B (zh) * | 2016-08-23 | 2018-09-25 | 中山康方生物医药有限公司 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
| JP2020522486A (ja) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | 活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
| SG11202000198QA (en) | 2017-08-04 | 2020-02-27 | Genmab As | Binding agents binding to pd-l1 and cd137 and use thereof |
| CN109425736B (zh) * | 2017-08-25 | 2021-04-09 | 北京百普赛斯生物科技股份有限公司 | 一种检测pd-1抗体血药浓度的方法及试剂盒 |
| MX2020003204A (es) * | 2017-09-20 | 2020-07-20 | Regeneron Pharma | Metodos de inmunoterapia para pacientes cuyos tumores portan una carga mutacional alta de un gen pasajero. |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法 |
| EP3773916A4 (en) * | 2018-04-04 | 2021-12-15 | TrueBinding, Inc. | PROCEDURES AND COMPOSITIONS FOR BLOCKING THE INTERACTION BETWEEN NON-GLYCOSYLATED PD-1 POLYPEPTIDES |
| WO2019217455A1 (en) | 2018-05-07 | 2019-11-14 | Genmab A/S | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate |
| WO2019217457A1 (en) | 2018-05-07 | 2019-11-14 | Genmab A/S | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate |
| EP3842070A4 (en) * | 2018-07-18 | 2022-04-20 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | DRUG COMBINATION OF QUINOLINE DERIVATIVE AND ANTIBODY |
| CN109053889B (zh) * | 2018-07-25 | 2019-06-21 | 博奥信生物技术（南京）有限公司 | 一种抗人pd1单克隆抗体及用途 |
| CN109053895B (zh) * | 2018-08-30 | 2020-06-09 | 中山康方生物医药有限公司 | 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途 |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| EP3946377B1 (en) | 2019-04-03 | 2025-12-10 | Orega Biotech | Combination therapies based on pd1 and il-17b inhibitors |
| CN110373415B (zh) * | 2019-06-12 | 2023-06-09 | 安徽省昂普拓迈生物科技有限责任公司 | 特异性结合pd-l1蛋白的核酸适配体及其用途 |
| WO2021006199A1 (ja) | 2019-07-05 | 2021-01-14 | 小野薬品工業株式会社 | Ｐｄ－１／ｃｄ３二重特異性タンパク質による血液がん治療 |
| WO2021023117A1 (zh) * | 2019-08-02 | 2021-02-11 | 康方药业有限公司 | 抗ctla4-抗pd-1双特异性抗体及其用途 |
| AU2020324185A1 (en) | 2019-08-02 | 2022-03-03 | CTTQ-Akeso (ShangHai) Biomed. Tech. Co., Ltd. | Anti-PD-1 antibody and medical use thereof |
| EP4011918A4 (en) | 2019-08-08 | 2023-08-23 | ONO Pharmaceutical Co., Ltd. | DUAL SPECIFIC PROTEIN |
| CN110903391B (zh) * | 2019-10-25 | 2021-05-28 | 东大生物技术(苏州)有限公司 | 一组pd-l1单克隆抗体及其医药用途 |
| CN112915202B (zh) * | 2019-12-06 | 2025-08-01 | 正大天晴药业集团股份有限公司 | 喹啉衍生物与pd-1单抗的药物组合 |
| US20230044381A1 (en) * | 2019-12-20 | 2023-02-09 | Guangdong Feipeng Pharmaceutical Co., Ltd | Anti-human programmed death-1 monoclonal antibody |
| CN113117072A (zh) * | 2020-01-14 | 2021-07-16 | 正大天晴药业集团股份有限公司 | 喹啉衍生物与pd-1单抗的药物组合 |
| WO2021170750A1 (en) | 2020-02-28 | 2021-09-02 | Orega Biotech | Combination therapies based on ctla4 and il-17b inhibitors |
| KR20230004726A (ko) * | 2020-04-22 | 2023-01-06 | 아케소 바이오파마, 인크. | 항-cd73/항-pd-1 이중특이항체 및 이의 용도 |
| US20230235057A1 (en) | 2020-04-29 | 2023-07-27 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Bifunctional protein against pd-1 and tgf-beta |
| CN113754767A (zh) * | 2020-06-03 | 2021-12-07 | 上海恒润达生生物科技股份有限公司 | 抗人pd-1抗体及其用途 |
| WO2022068891A1 (zh) * | 2020-09-30 | 2022-04-07 | 苏州沙砾生物科技有限公司 | Pd-1抗体及其制备方法与应用 |
| WO2022108931A2 (en) | 2020-11-17 | 2022-05-27 | Seagen Inc. | Methods of treating cancer with a combination of tucatinib and an anti-pd-1/anti-pd-l1 antibody |
| CN113336848B (zh) * | 2021-02-03 | 2022-08-19 | 上海莱馥医疗科技有限公司 | 一种抗pd-1抗体及其用途 |
| EP4190819A4 (en) * | 2021-03-12 | 2024-08-14 | Akeso Biopharma, Inc. | PHARMACEUTICAL COMBINATION CONTAINING BISPECIFIC ANTI-PD-1-ANTI-VEGFA ANTIBODY, AND USE THEREOF |
| JP2024525758A (ja) | 2021-07-13 | 2024-07-12 | ビオンテック・ソシエタス・エウロパエア | がんのための併用療法におけるｃｄ４０およびｃｄ１３７に対する多重特異性結合剤 |
| CA3233205A1 (en) | 2021-09-29 | 2023-04-06 | Yu Xia | Anti-lag3 antibody, pharmaceutical composition and use |
| US20250002600A1 (en) | 2021-10-06 | 2025-01-02 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 in combination therapy |
| WO2023083439A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Tlr7 agonist and combinations for cancer treatment |
| CN113912710B (zh) * | 2021-11-17 | 2023-05-26 | 杭州旭科生物技术有限公司 | 抗新型冠状病毒n蛋白的单克隆抗体及其应用 |
| CN114316053B (zh) * | 2021-12-20 | 2023-09-29 | 南京诺唯赞检测技术有限公司 | 一种vce的单克隆抗体及其制备方法 |
| EP4257609A1 (en) | 2022-04-08 | 2023-10-11 | iOmx Therapeutics AG | Combination therapies based on pd-1 inhibitors and sik3 inhibitors |
| WO2023198060A1 (zh) * | 2022-04-12 | 2023-10-19 | 正大天晴药业集团股份有限公司 | 蛋白酶体抑制剂与抗pd-1抗体的药物组合 |
| US11932693B2 (en) | 2022-05-12 | 2024-03-19 | BioNTech SE | Monoclonal antibodies directed against programmed death-1 protein and their use in medicine |
| TW202413412A (zh) | 2022-05-12 | 2024-04-01 | 丹麥商珍美寶股份有限公司 | 在組合療法中能夠結合到ｃｄ２７之結合劑 |
| US20250282873A1 (en) | 2022-05-13 | 2025-09-11 | Nanjing Shunxin Pharmaceuticals Co., Ltd. Of Chiatai Tianqing Pharmaceutical Group | Drug combination of anti-tim-3 antibody and anti-pd-1 antibody |
| CN119789867A (zh) * | 2022-09-06 | 2025-04-08 | 正大天晴药业集团股份有限公司 | 结合tim-3的抗体与结合pd-1的抗体的药物组合 |
| EP4598960A1 (en) * | 2022-10-05 | 2025-08-13 | Chulalongkorn University | Monoclonal antibodies against human programmed cell death protein 1 (pd-1) |
| CN117986356B (zh) * | 2022-10-27 | 2025-07-22 | 纽迈生物科技(苏州)有限公司 | 一种制备抗体的方法 |
| JP2025541738A (ja) | 2022-12-01 | 2025-12-23 | ビオンテック・ソシエタス・エウロパエア | 抗ｐｄ１ａｂと化学療法での併用療法におけるｃｄ４０およびｃｄ１３７に対する多重特異性抗体 |
| CN121620391A (zh) | 2023-04-06 | 2026-03-06 | 金麦安博股份有限公司 | 用于治疗癌症的针对pd-l1和cd137的多特异性结合剂 |
| CN121285385A (zh) | 2023-05-12 | 2026-01-06 | 金麦安博股份有限公司 | 能够与ox40结合的抗体、其变体及其用途 |
| WO2025056011A1 (zh) * | 2023-09-13 | 2025-03-20 | 正大天晴药业集团股份有限公司 | 包含抗pd-1抗体和第二抗体的药物组合物 |
| WO2025056014A1 (zh) * | 2023-09-13 | 2025-03-20 | 正大天晴药业集团股份有限公司 | 包含抗pd-1抗体和第二抗体的药物组合物 |
| TW202540189A (zh) | 2023-11-30 | 2025-10-16 | 德商生物新技術公司 | 在組合療法中能夠結合ｏｘ４０之抗體 |
| CN118652343B (zh) * | 2024-07-08 | 2025-05-09 | 吉林省医菲尼迪生物医药有限公司 | 一种临床血液免疫细胞以及在治疗疾病中的应用 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| ES2350687T3 (es) | 2002-07-03 | 2011-01-26 | Ono Pharmaceutical Co., Ltd. | Composiciones de inmunopotenciación. |
| CN1753912B (zh) * | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| RU2494107C2 (ru) | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| BRPI0910482A2 (pt) | 2008-04-29 | 2019-09-24 | Abbott Lab | imunoglobinas de domínio variável duplo e usos das mesmas |
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| MY184154A (en) * | 2013-12-12 | 2021-03-23 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
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| CN105296433B (zh) | 2014-08-01 | 2018-02-09 | 中山康方生物医药有限公司 | 一种ctla4抗体、其药物组合物及其用途 |
| CN104987421A (zh) | 2015-05-13 | 2015-10-21 | 北京比洋生物技术有限公司 | 抗ctla-4和pd-1的双重可变结构域免疫球蛋白 |
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| CN105175544B (zh) | 2015-10-20 | 2021-04-09 | 安徽瀚海博兴生物技术有限公司 | 一种抗pd-1人源化单克隆抗体及其应用 |
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| WO2018035710A1 (en) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anti-ctla4 antibodies |
| CN106977602B (zh) | 2016-08-23 | 2018-09-25 | 中山康方生物医药有限公司 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
| CN106967172B (zh) | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
-
2016
- 2016-08-23 CN CN201610705763.5A patent/CN106977602B/zh active Active
-
2017
- 2017-08-22 HU HUE17842895A patent/HUE069593T2/hu unknown
- 2017-08-22 BR BR112019003775-6A patent/BR112019003775A2/pt active Search and Examination
- 2017-08-22 EA EA201990570A patent/EA201990570A1/ru unknown
- 2017-08-22 SI SI201731577T patent/SI3505535T1/sl unknown
- 2017-08-22 MX MX2019002268A patent/MX2019002268A/es unknown
- 2017-08-22 JP JP2019531512A patent/JP7082620B2/ja active Active
- 2017-08-22 FI FIEP17842895.9T patent/FI3505535T3/fi active
- 2017-08-22 NZ NZ751902A patent/NZ751902A/en unknown
- 2017-08-22 AU AU2017316255A patent/AU2017316255C1/en active Active
- 2017-08-22 SG SG11201901584UA patent/SG11201901584UA/en unknown
- 2017-08-22 EP EP24206755.1A patent/EP4509186A3/en active Pending
- 2017-08-22 WO PCT/CN2017/098465 patent/WO2018036472A1/zh not_active Ceased
- 2017-08-22 LT LTEPPCT/CN2017/098465T patent/LT3505535T/lt unknown
- 2017-08-22 PL PL17842895.9T patent/PL3505535T3/pl unknown
- 2017-08-22 US US16/327,083 patent/US12076398B2/en active Active
- 2017-08-22 PT PT178428959T patent/PT3505535T/pt unknown
- 2017-08-22 RS RS20250001A patent/RS66372B1/sr unknown
- 2017-08-22 ES ES17842895T patent/ES3001154T3/es active Active
- 2017-08-22 KR KR1020197008464A patent/KR102469286B1/ko active Active
- 2017-08-22 EP EP17842895.9A patent/EP3505535B1/en active Active
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2019
- 2019-02-21 IL IL264956A patent/IL264956B2/en unknown
- 2019-03-22 ZA ZA2019/01781A patent/ZA201901781B/en unknown
-
2024
- 2024-04-17 AU AU2024202527A patent/AU2024202527B2/en active Active
- 2024-07-22 US US18/780,086 patent/US20250041409A1/en active Pending
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