JP2019531697A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019531697A5 JP2019531697A5 JP2018567883A JP2018567883A JP2019531697A5 JP 2019531697 A5 JP2019531697 A5 JP 2019531697A5 JP 2018567883 A JP2018567883 A JP 2018567883A JP 2018567883 A JP2018567883 A JP 2018567883A JP 2019531697 A5 JP2019531697 A5 JP 2019531697A5
- Authority
- JP
- Japan
- Prior art keywords
- complex
- sialidase
- surface molecule
- cell surface
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 16
- 108010006232 Neuraminidase Proteins 0.000 claims 11
- 102000005348 Neuraminidase Human genes 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 101001123859 Homo sapiens Sialidase-1 Proteins 0.000 claims 1
- 101001123851 Homo sapiens Sialidase-2 Proteins 0.000 claims 1
- 101001123847 Homo sapiens Sialidase-3 Proteins 0.000 claims 1
- 101000601384 Homo sapiens Sialidase-4 Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 101900324552 Salmonella typhimurium Sialidase Proteins 0.000 claims 1
- 102100028760 Sialidase-1 Human genes 0.000 claims 1
- 102100028755 Sialidase-2 Human genes 0.000 claims 1
- 102100028756 Sialidase-3 Human genes 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 241000607626 Vibrio cholerae Species 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 102000047925 human NEU4 Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 229940118696 vibrio cholerae Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022131521A JP7496629B2 (ja) | 2016-07-01 | 2022-08-22 | 標的化された細胞表面編集のための複合体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662357645P | 2016-07-01 | 2016-07-01 | |
| US62/357,645 | 2016-07-01 | ||
| PCT/US2017/040411 WO2018006034A1 (en) | 2016-07-01 | 2017-06-30 | Conjugates for targeted cell surface editing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022131521A Division JP7496629B2 (ja) | 2016-07-01 | 2022-08-22 | 標的化された細胞表面編集のための複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531697A JP2019531697A (ja) | 2019-11-07 |
| JP2019531697A5 true JP2019531697A5 (https=) | 2020-08-06 |
| JP7187024B2 JP7187024B2 (ja) | 2022-12-12 |
Family
ID=60787043
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567883A Active JP7187024B2 (ja) | 2016-07-01 | 2017-06-30 | 標的化された細胞表面編集のための複合体 |
| JP2022131521A Active JP7496629B2 (ja) | 2016-07-01 | 2022-08-22 | 標的化された細胞表面編集のための複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022131521A Active JP7496629B2 (ja) | 2016-07-01 | 2022-08-22 | 標的化された細胞表面編集のための複合体 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11459398B2 (https=) |
| EP (2) | EP4218802A3 (https=) |
| JP (2) | JP7187024B2 (https=) |
| KR (2) | KR102822525B1 (https=) |
| CN (1) | CN109641038A (https=) |
| AU (2) | AU2017290554B2 (https=) |
| BR (1) | BR112018077362A2 (https=) |
| CA (1) | CA3027234A1 (https=) |
| DK (1) | DK3478314T5 (https=) |
| ES (1) | ES2947312T3 (https=) |
| IL (2) | IL263617B2 (https=) |
| MX (1) | MX2018016393A (https=) |
| SG (1) | SG11201811719RA (https=) |
| WO (1) | WO2018006034A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2996059A1 (en) | 2015-08-28 | 2017-03-09 | Alector Llc | Anti-siglec-7 antibodies and methods of use thereof |
| GB201616006D0 (en) * | 2016-09-20 | 2016-11-02 | Univ Court Of The Univ Of St Andrews The | Cell modulation |
| WO2018231661A1 (en) * | 2017-06-12 | 2018-12-20 | Tianxin Wang | Methods and reagents to treat tumor and cancer |
| KR102914621B1 (ko) | 2018-01-03 | 2026-01-21 | 팔레온 파마슈티칼스 인크. | 재조합 인간 시알리다제, 시알리다제 융합 단백질, 및 이를 사용하는 방법 |
| US20210395333A1 (en) * | 2018-06-07 | 2021-12-23 | Palleon Pharmaceuticals Inc. | Multimeric proteins for detecting a carbohydrate and/or treating a siglec-mediated disorder |
| MX2020013172A (es) | 2018-06-08 | 2021-03-29 | Alector Llc | Anticuerpos anti-siglec-7 y sus metodos de uso. |
| GB201811291D0 (en) * | 2018-07-10 | 2018-08-29 | Univ Dublin City | A method of predicting response to treatment in cancer patients |
| EP3604551A1 (en) * | 2018-07-31 | 2020-02-05 | Université de Bretagne Occidentale | Complement-dependent cytotoxicity and sialylation as biomarkers for predicting clinical response to cancer treatment with antibody or derivative mediating complement activation |
| GB201819920D0 (en) * | 2018-12-06 | 2019-01-23 | Pneumagen Ltd | Cancer treatment |
| WO2020142727A1 (en) * | 2019-01-03 | 2020-07-09 | Palleon Pharmaceuticals Inc. | Methods and compositions for treating cancer with immune cells |
| WO2020172072A1 (en) * | 2019-02-21 | 2020-08-27 | The General Hospital Corporation | Glycoengineering immunoglobulin e |
| BR112021026852A2 (pt) * | 2019-07-03 | 2022-02-22 | Palleon Pharmaceuticals Inc | Sialidases recombinantes e métodos de uso das mesmas |
| WO2021003464A1 (en) * | 2019-07-03 | 2021-01-07 | Palleon Pharmaceuticals Inc. | Sialidase-pd-l1-antibody fusion proteins and methods of use thereof |
| US20220387616A1 (en) * | 2019-07-03 | 2022-12-08 | Palleon Pharmaceuticals Inc. | Sialidase-her2-antibody fusion proteins and methods of use thereof |
| JP7777988B2 (ja) * | 2019-07-03 | 2025-12-01 | パレオン ファーマシューティカルズ インコーポレイテッド | 組換えヒトシアリダーゼ、シアリダーゼ融合タンパク質およびその使用方法 |
| US20220380742A1 (en) * | 2019-07-03 | 2022-12-01 | Palleon Pharmaceuticals Inc. | Sialidase-cd20-antibody fusion proteins and methods of use thereof |
| JP2023526277A (ja) * | 2020-05-13 | 2023-06-21 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 核酸リガンドコンジュゲートおよび細胞への送達のためのその使用 |
| CN116368222A (zh) * | 2020-07-21 | 2023-06-30 | 斯克里普斯研究学院 | 破坏cd28-唾液酸糖苷配体复合物以增强t细胞活化 |
| US20240100177A1 (en) * | 2020-12-04 | 2024-03-28 | Dyne Therapeutics, Inc. | Antibody-oligonucleotide complexes and uses thereof |
| JP2024512645A (ja) * | 2021-04-02 | 2024-03-19 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 二重特異性分子並びに関連する組成物及び方法 |
| AU2022262794A1 (en) | 2021-04-23 | 2023-11-02 | Beth Israel Deaconess Medical Center, Inc. | Glycan modified nucleic acids, methods of preparation, and therapeutic uses |
| US20250064921A1 (en) * | 2021-12-28 | 2025-02-27 | Cz Biohub Sf, Llc | Chemically modified bacterial peptidoglycan compositions and uses thereof |
| WO2026037175A1 (zh) | 2024-08-16 | 2026-02-19 | 上海宝济药业股份有限公司 | 靶向靶细胞的复合物及其应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2620649C3 (de) | 1976-05-11 | 1980-11-06 | Behringwerke Ag, 3550 Marburg | Immunologisches Adjuvans |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| FR2828386B1 (fr) | 2001-08-10 | 2004-06-11 | Jean Noel Acquaviva | Ecran de vision coupe-vent |
| WO2004047735A2 (en) | 2002-11-22 | 2004-06-10 | Mang Yu | Broad spectrum anti-viral therapeutics and prophylaxis |
| US8512710B2 (en) | 2002-11-22 | 2013-08-20 | Ansun Biopharma, Inc. | Class of therapeutic protein based molecules |
| US7807174B2 (en) | 2002-11-22 | 2010-10-05 | Nexbio, Inc. | Class of therapeutic protein based molecules |
| KR101501780B1 (ko) | 2006-01-24 | 2015-03-16 | 넥스바이오, 인코퍼레이티드 | 고분자 미소 구체들의 조제를 위한 기술 |
| EP2389947A1 (en) | 2006-03-23 | 2011-11-30 | Novartis AG | Anti-tumor cell antigen antibody therapeutics |
| EP1938835A1 (en) | 2006-12-29 | 2008-07-02 | Pevion Biotech AG | Non-specific immunostimulating agents |
| JP2013510169A (ja) | 2009-11-06 | 2013-03-21 | ネクスバイオ，インク． | 呼吸器管の治療及び予防のための方法、化合物、及び組成物 |
| JP2015521602A (ja) * | 2012-06-14 | 2015-07-30 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 核受容体リガンドポリペプチドに対して複合化されている抗ｐｓｍａ抗体 |
| CN112587671A (zh) * | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| UA105278C2 (ru) * | 2012-09-06 | 2014-04-25 | Інститут Біології Клітини Нан України | Способ получения каталитически активных антител (абзимов) с сиалидазной активностью |
| EP2970857A4 (en) | 2013-03-15 | 2016-11-02 | Ansun Biopharma Inc | NEW PROTEIN CLEANING PROCESS |
| WO2014201027A2 (en) | 2013-06-10 | 2014-12-18 | Ansun Biopharma, Inc. | Treatment of merkel cell polyomavirus infection |
| US10300116B2 (en) | 2013-06-10 | 2019-05-28 | Ansun Biopharma, Inc. | Treatment for BK polyomavirus infection |
| US20160229882A1 (en) | 2013-09-17 | 2016-08-11 | The Regents Of The University Of California | Non-enzymatic, salt-mediated synthesis of polynucleic acids |
| US20170165334A1 (en) | 2015-12-11 | 2017-06-15 | Tianxin Wang | Methods to Treat Diseases with Protein, Peptide, Antigen Modification and Hemopurification |
| WO2015184356A1 (en) | 2014-05-30 | 2015-12-03 | Ansun Biopharma, Inc. | Treatment of middle east respiratory syndrome coronavirus |
| JP2017532025A (ja) * | 2014-09-10 | 2017-11-02 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | 交差反応性ｓｉｇｌｅｃ抗体 |
| WO2016044656A1 (en) | 2014-09-17 | 2016-03-24 | Ansun Biopharma, Inc. | Treatment of infection by human enterovirus d68 |
| US20180177852A1 (en) | 2015-06-08 | 2018-06-28 | Ansun Biopharma, Inc. | Treatment of human metapneumovirus |
| AR107483A1 (es) | 2016-01-29 | 2018-05-02 | Hanmi Pharm Ind Co Ltd | Conjugado de enzimas terapéuticas |
| US20180271997A1 (en) | 2016-05-31 | 2018-09-27 | Tianxin Wang | Methods and Reagents to Treat Tumor and Cancer |
| GB201616006D0 (en) | 2016-09-20 | 2016-11-02 | Univ Court Of The Univ Of St Andrews The | Cell modulation |
| US10940185B2 (en) | 2016-12-28 | 2021-03-09 | Jcr Pharmaceuticals Co., Ltd. | Lyophilized preparation |
| WO2018231661A1 (en) | 2017-06-12 | 2018-12-20 | Tianxin Wang | Methods and reagents to treat tumor and cancer |
| WO2020018996A2 (en) | 2018-07-20 | 2020-01-23 | Ansun Biopharma, Inc. | Delivery of sialidase to cancer cells, immune cells and the tumor microenvironment |
-
2017
- 2017-06-30 MX MX2018016393A patent/MX2018016393A/es unknown
- 2017-06-30 WO PCT/US2017/040411 patent/WO2018006034A1/en not_active Ceased
- 2017-06-30 BR BR112018077362-0A patent/BR112018077362A2/pt not_active Application Discontinuation
- 2017-06-30 SG SG11201811719RA patent/SG11201811719RA/en unknown
- 2017-06-30 CN CN201780040962.1A patent/CN109641038A/zh active Pending
- 2017-06-30 AU AU2017290554A patent/AU2017290554B2/en active Active
- 2017-06-30 DK DK17821402.9T patent/DK3478314T5/da active
- 2017-06-30 US US16/308,732 patent/US11459398B2/en active Active
- 2017-06-30 KR KR1020237031968A patent/KR102822525B1/ko active Active
- 2017-06-30 IL IL263617A patent/IL263617B2/en unknown
- 2017-06-30 EP EP23155976.6A patent/EP4218802A3/en active Pending
- 2017-06-30 IL IL305907A patent/IL305907A/en unknown
- 2017-06-30 EP EP17821402.9A patent/EP3478314B1/en active Active
- 2017-06-30 ES ES17821402T patent/ES2947312T3/es active Active
- 2017-06-30 KR KR1020197002051A patent/KR102581747B1/ko active Active
- 2017-06-30 CA CA3027234A patent/CA3027234A1/en active Pending
- 2017-06-30 JP JP2018567883A patent/JP7187024B2/ja active Active
-
2020
- 2020-12-15 AU AU2020289739A patent/AU2020289739B2/en active Active
-
2022
- 2022-08-22 JP JP2022131521A patent/JP7496629B2/ja active Active
- 2022-08-26 US US17/822,638 patent/US12404342B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019531697A5 (https=) | ||
| JP7335290B2 (ja) | 二重特異性四価抗体並びにその製作及び使用方法 | |
| Hudson et al. | High avidity scFv multimers; diabodies and triabodies | |
| JP2020531043A5 (https=) | ||
| JP7209464B2 (ja) | ヒトインターロイキン－２に対する免疫刺激性モノクローナル抗体 | |
| JP2020063262A5 (https=) | ||
| Maleki et al. | Future prospects of monoclonal antibodies as magic bullets in immunotherapy | |
| JP7399852B2 (ja) | 多重特異性抗体とその作製及び使用方法 | |
| RU2017115315A (ru) | Антитела к рецептору глюкокортикоид-индуцированного фактора некроза опухоли (gitr) и способы их применения | |
| JP2021502810A5 (https=) | ||
| JP2013502913A5 (https=) | ||
| FI3348571T3 (fi) | Yksidomeeninen vasta-aine ohjelmoitu solukuolema -ligandille (pd-l1) ja siitä peräisin oleva proteiini | |
| JP2019533475A5 (https=) | ||
| RU2014101669A (ru) | Агенты, связывающие белки r-спондины (rspo), и способы их применения | |
| JP2017531427A5 (https=) | ||
| JP2018527919A5 (https=) | ||
| JP2011505146A5 (https=) | ||
| JP2014518615A5 (https=) | ||
| CN117946277A (zh) | 多特异性抗体及其制备和使用方法 | |
| JP2010535713A5 (https=) | ||
| JP2014166186A5 (https=) | ||
| RS58448B1 (sr) | Antitela protiv antigena matičnih ćelija specifičan za prostatu i njihova upotreba | |
| JP2021512151A5 (https=) | ||
| JP2017521054A5 (https=) | ||
| JP2021512604A5 (https=) |