JP2019533803A5 - - Google Patents
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- Publication number
- JP2019533803A5 JP2019533803A5 JP2019508235A JP2019508235A JP2019533803A5 JP 2019533803 A5 JP2019533803 A5 JP 2019533803A5 JP 2019508235 A JP2019508235 A JP 2019508235A JP 2019508235 A JP2019508235 A JP 2019508235A JP 2019533803 A5 JP2019533803 A5 JP 2019533803A5
- Authority
- JP
- Japan
- Prior art keywords
- capsid
- aav
- particles
- amino acid
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022014629A JP2022064980A (ja) | 2016-08-15 | 2022-02-02 | Ａａｖを検出するための方法 |
| JP2023202414A JP2024023460A (ja) | 2016-08-15 | 2023-11-30 | Ａａｖを検出するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662375314P | 2016-08-15 | 2016-08-15 | |
| US62/375,314 | 2016-08-15 | ||
| PCT/US2017/046814 WO2018035059A1 (en) | 2016-08-15 | 2017-08-14 | Methods for detecting aav |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022014629A Division JP2022064980A (ja) | 2016-08-15 | 2022-02-02 | Ａａｖを検出するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019533803A JP2019533803A (ja) | 2019-11-21 |
| JP2019533803A5 true JP2019533803A5 (enExample) | 2020-09-24 |
| JP7021191B2 JP7021191B2 (ja) | 2022-02-16 |
Family
ID=59762045
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508235A Active JP7021191B2 (ja) | 2016-08-15 | 2017-08-14 | Ａａｖを検出するための方法 |
| JP2022014629A Pending JP2022064980A (ja) | 2016-08-15 | 2022-02-02 | Ａａｖを検出するための方法 |
| JP2023202414A Pending JP2024023460A (ja) | 2016-08-15 | 2023-11-30 | Ａａｖを検出するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022014629A Pending JP2022064980A (ja) | 2016-08-15 | 2022-02-02 | Ａａｖを検出するための方法 |
| JP2023202414A Pending JP2024023460A (ja) | 2016-08-15 | 2023-11-30 | Ａａｖを検出するための方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US11698377B2 (enExample) |
| EP (2) | EP3851449A1 (enExample) |
| JP (3) | JP7021191B2 (enExample) |
| KR (5) | KR102922101B1 (enExample) |
| CN (2) | CN118688363A (enExample) |
| AU (2) | AU2017312951B2 (enExample) |
| CA (1) | CA3033856A1 (enExample) |
| CL (2) | CL2019000392A1 (enExample) |
| CR (1) | CR20190127A (enExample) |
| CY (1) | CY1124364T1 (enExample) |
| DK (1) | DK3497207T3 (enExample) |
| ES (1) | ES2863674T3 (enExample) |
| HU (1) | HUE053747T2 (enExample) |
| IL (3) | IL264819B2 (enExample) |
| MA (1) | MA55748A (enExample) |
| MX (2) | MX2019001938A (enExample) |
| PH (1) | PH12019500316A1 (enExample) |
| SG (2) | SG10201913002QA (enExample) |
| TN (1) | TN2019000047A1 (enExample) |
| TW (2) | TW202309068A (enExample) |
| WO (1) | WO2018035059A1 (enExample) |
| ZA (2) | ZA201900945B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201508026D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
| HUE053747T2 (hu) | 2016-08-15 | 2021-07-28 | Genzyme Corp | Eljárások AAV kimutatására |
| RS65241B1 (sr) * | 2017-02-28 | 2024-03-29 | Univ Pennsylvania | Vektor adeno-asociranih virusa (aav) iz podgrupe f i njegove upotrebe |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| EP3768695A4 (en) * | 2018-02-27 | 2022-04-06 | The Trustees of the University of Pennsylvania | NOVEL ADENO-ASSOCIATED VIRUS (AAV) VECTORS, AAV VECTORS WITH REDUCED CAPSIID DEAMIDATION AND USES THEREOF |
| IL276859B2 (en) * | 2018-02-27 | 2025-12-01 | Univ Pennsylvania | Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor |
| EP3762500A1 (en) * | 2018-03-06 | 2021-01-13 | Voyager Therapeutics, Inc. | Insect cell manufactured partial self-complementary aav genomes |
| US11391707B2 (en) * | 2018-07-27 | 2022-07-19 | Waters Technologies Corporation | Liquid chromatography/mass spectrometry methods for the analysis of polar molecules |
| US12195745B2 (en) * | 2018-08-21 | 2025-01-14 | Massachusetts Eye And Ear Infirmary | Compositions and methods for modulating transduction efficiency of adeno-associated viruses |
| WO2020086893A1 (en) | 2018-10-25 | 2020-04-30 | Regeneron Pharmaceuticals, Inc. | Methods for analysis of viral capsid protein composition |
| ES2965341T3 (es) * | 2019-04-11 | 2024-04-12 | Regenxbio Inc | Métodos de cromatografía de exclusión por tamaño para la caracterización de composiciones de virus adenoasociados recombinantes |
| US11841352B2 (en) * | 2019-07-31 | 2023-12-12 | Thermo Finnigan Llc | Determination and correction of retention time and mass/charge shifts in LC-MS experiments |
| EP4085255A1 (en) * | 2020-01-03 | 2022-11-09 | Sarepta Therapeutics, Inc. | Methods for analyzing aav capsid proteins |
| WO2021155137A1 (en) | 2020-01-29 | 2021-08-05 | Genzyme Corporation | Modified adeno-associated viral capsid proteins for ocular gene therapy and methods of use thereof |
| CN111517359B (zh) * | 2020-04-23 | 2021-08-20 | 江南大学 | 一种手性硫化铜超粒子的合成方法 |
| RU2748540C1 (ru) * | 2021-02-08 | 2021-05-26 | Автономная некоммерческая образовательная организация высшего образования "Сколковский институт науки и технологий" | Способ детектирования вируса SARS-CoV-2 методом масс-спектрометрии |
| US20220268783A1 (en) * | 2021-02-19 | 2022-08-25 | Waters Technologies Corporation | Methods for peptide mapping of adeno-associated virus (aav) proteins |
| WO2022224965A1 (ja) * | 2021-04-20 | 2022-10-27 | 株式会社ユニバーサル・バイオサンプリング | 検体保持カード及びそれを用いた検体の検査方法 |
| JP2024525686A (ja) * | 2021-07-12 | 2024-07-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ａａｖカプシド比を決定するための液体クロマトグラフィーアッセイ |
| CA3225360A1 (en) * | 2021-07-12 | 2023-01-19 | Victoria COTHAM | Online native mass spectrometry methods for assaying viral particles |
| CN113552349B (zh) * | 2021-07-30 | 2022-07-19 | 上海勉亦生物科技有限公司 | Aav蛋白外壳的检测方法 |
| EP4462114A4 (en) * | 2022-01-06 | 2025-04-16 | FUJIFILM Corporation | Method and kit for identifying sugar-bound amino acid site in protein |
| US20250110119A1 (en) * | 2023-03-03 | 2025-04-03 | Sartorius Bioanalytical Instruments, Inc. | Methods for quantitating viral capsids |
| WO2024263520A1 (en) * | 2023-06-19 | 2024-12-26 | Regeneron Pharmaceuticals, Inc. | Host cell protein analysis for adeno-associated virus (aav)-based gene therapy |
| AU2024378556A1 (en) * | 2023-11-08 | 2026-05-21 | Oxford Biomedica (Us) Llc | Deamidation depleted adeno-associated virus product |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5540931A (en) | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
| US6204059B1 (en) * | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
| CA2264482A1 (en) | 1996-09-06 | 1998-03-12 | The Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6995006B2 (en) | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6596535B1 (en) | 1999-08-09 | 2003-07-22 | Targeted Genetics Corporation | Metabolically activated recombinant viral vectors and methods for the preparation and use |
| US7465583B2 (en) | 2000-06-01 | 2008-12-16 | The University Of North Carolina At Chapel Hill | Duplexed parvovirus vectors |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| CN103589692B (zh) | 2001-11-13 | 2018-07-24 | 宾夕法尼亚大学托管会 | 检测和/或鉴定腺伴随病毒(aav)序列以及分离所鉴定的新型序列的方法 |
| SI1496944T1 (sl) | 2002-05-01 | 2009-02-28 | Univ Florida | Izboljšani sistemi ekspresije RAAV za genetsko modifikacijo specifičnih kapsidnih proteinov |
| WO2004049385A2 (en) | 2002-11-22 | 2004-06-10 | Caprion Pharmaceuticals, Inc. | Constellation mapping and uses thereof |
| US7510872B2 (en) | 2003-02-26 | 2009-03-31 | Nationwide Children's Hospital | Recombinant adeno-associated virus production |
| JP4559429B2 (ja) | 2003-05-21 | 2010-10-06 | ジェンザイム・コーポレーション | 空キャプシドを実質的に含まない組換えａａｖビリオン調製物を生成するための方法 |
| EP1486567A1 (en) | 2003-06-11 | 2004-12-15 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Improved adeno-associated virus (AAV) vector for gene therapy |
| US9441244B2 (en) * | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US8283151B2 (en) | 2005-04-29 | 2012-10-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes |
| PT3272872T (pt) | 2005-10-20 | 2020-06-26 | Uniqure Ip Bv | Vetores aav melhorados produzidos em células de insetos |
| US7588772B2 (en) | 2006-03-30 | 2009-09-15 | Board Of Trustees Of The Leland Stamford Junior University | AAV capsid library and AAV capsid proteins |
| EP2342567A1 (en) | 2008-09-19 | 2011-07-13 | Charité Universitätsmedizin Berlin | Identification and characterisation of recombinant viral gene therapy vectors |
| EP2396343B1 (en) | 2009-02-11 | 2017-05-17 | The University of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| JP5956331B2 (ja) | 2009-06-16 | 2016-07-27 | ジェンザイム・コーポレーション | 組換えａａｖベクターの改良された精製方法 |
| DK2561073T3 (en) | 2010-04-23 | 2016-12-12 | Univ Massachusetts | Aav vectors targeted to central nervous system and methods of use thereof |
| US20130217789A1 (en) * | 2010-09-03 | 2013-08-22 | North Carolina Central University | Biodegradable liquogel and ph sensitive nanocarriers |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| CN103502458B (zh) | 2011-02-17 | 2016-11-16 | 宾夕法尼亚大学托管会 | 用于改变组织特异性和改善aav9-介导的基因转移的组合物和方法 |
| EP3795581A3 (en) | 2011-08-24 | 2021-06-09 | The Board of Trustees of the Leland Stanford Junior University | New avv capsid proteins for nucleic acid transfer |
| JP6342886B2 (ja) * | 2012-04-18 | 2018-06-13 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ | Ａａｖカプシドバリアントを使用した高効率な遺伝子導入のための組成物及び方法 |
| US20140017716A1 (en) * | 2012-07-11 | 2014-01-16 | Siscapa Assay Technologies, Inc. | Proteolytic digestion kit with dried reagents |
| GB201401707D0 (en) | 2014-01-31 | 2014-03-19 | Sec Dep For Health The | Adeno-associated viral vectors |
| WO2015137802A1 (en) * | 2014-03-10 | 2015-09-17 | Uniqure Ip B.V. | Further improved aav vectors produced in insect cells |
| HUE053747T2 (hu) | 2016-08-15 | 2021-07-28 | Genzyme Corp | Eljárások AAV kimutatására |
-
2017
- 2017-08-14 HU HUE17761362A patent/HUE053747T2/hu unknown
- 2017-08-14 SG SG10201913002QA patent/SG10201913002QA/en unknown
- 2017-08-14 CR CR20190127A patent/CR20190127A/es unknown
- 2017-08-14 EP EP20210237.2A patent/EP3851449A1/en active Pending
- 2017-08-14 KR KR1020247039853A patent/KR102922101B1/ko active Active
- 2017-08-14 CN CN202410630268.7A patent/CN118688363A/zh active Pending
- 2017-08-14 KR KR1020267003039A patent/KR20260036296A/ko active Pending
- 2017-08-14 KR KR1020237017707A patent/KR102738219B1/ko active Active
- 2017-08-14 ES ES17761362T patent/ES2863674T3/es active Active
- 2017-08-14 SG SG11201901221YA patent/SG11201901221YA/en unknown
- 2017-08-14 KR KR1020227025409A patent/KR102538037B1/ko active Active
- 2017-08-14 US US16/325,653 patent/US11698377B2/en active Active
- 2017-08-14 AU AU2017312951A patent/AU2017312951B2/en active Active
- 2017-08-14 MA MA055748A patent/MA55748A/fr unknown
- 2017-08-14 DK DK17761362.7T patent/DK3497207T3/da active
- 2017-08-14 EP EP17761362.7A patent/EP3497207B1/en active Active
- 2017-08-14 MX MX2019001938A patent/MX2019001938A/es unknown
- 2017-08-14 CN CN201780063531.7A patent/CN110168080B/zh active Active
- 2017-08-14 CA CA3033856A patent/CA3033856A1/en active Pending
- 2017-08-14 JP JP2019508235A patent/JP7021191B2/ja active Active
- 2017-08-14 IL IL264819A patent/IL264819B2/en unknown
- 2017-08-14 WO PCT/US2017/046814 patent/WO2018035059A1/en not_active Ceased
- 2017-08-14 TN TNP/2019/000047A patent/TN2019000047A1/en unknown
- 2017-08-14 KR KR1020197007381A patent/KR102425289B1/ko active Active
- 2017-08-14 IL IL312792A patent/IL312792B2/en unknown
- 2017-08-15 TW TW111138258A patent/TW202309068A/zh unknown
- 2017-08-15 TW TW106127648A patent/TWI781953B/zh active
-
2019
- 2019-02-13 CL CL2019000392A patent/CL2019000392A1/es unknown
- 2019-02-14 PH PH12019500316A patent/PH12019500316A1/en unknown
- 2019-02-14 ZA ZA2019/00945A patent/ZA201900945B/en unknown
- 2019-02-15 MX MX2023009081A patent/MX2023009081A/es unknown
- 2019-10-14 CL CL2019002912A patent/CL2019002912A1/es unknown
-
2021
- 2021-02-15 ZA ZA2021/01002A patent/ZA202101002B/en unknown
- 2021-03-24 CY CY20211100262T patent/CY1124364T1/el unknown
-
2022
- 2022-02-02 JP JP2022014629A patent/JP2022064980A/ja active Pending
-
2023
- 2023-05-22 US US18/321,542 patent/US12123880B2/en active Active
- 2023-11-30 JP JP2023202414A patent/JP2024023460A/ja active Pending
-
2024
- 2024-01-18 AU AU2024200349A patent/AU2024200349B2/en active Active
- 2024-08-12 US US18/801,293 patent/US20250027951A1/en active Pending
-
2025
- 2025-01-08 US US19/013,836 patent/US20250147042A1/en active Pending
- 2025-01-08 US US19/013,863 patent/US12298313B1/en active Active
- 2025-10-15 IL IL323969A patent/IL323969A/en unknown
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