JP2019533803A5 - - Google Patents
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- Publication number
- JP2019533803A5 JP2019533803A5 JP2019508235A JP2019508235A JP2019533803A5 JP 2019533803 A5 JP2019533803 A5 JP 2019533803A5 JP 2019508235 A JP2019508235 A JP 2019508235A JP 2019508235 A JP2019508235 A JP 2019508235A JP 2019533803 A5 JP2019533803 A5 JP 2019533803A5
- Authority
- JP
- Japan
- Prior art keywords
- capsid
- aav
- particles
- amino acid
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022014629A JP2022064980A (ja) | 2016-08-15 | 2022-02-02 | Ａａｖを検出するための方法 |
| JP2023202414A JP2024023460A (ja) | 2016-08-15 | 2023-11-30 | Ａａｖを検出するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662375314P | 2016-08-15 | 2016-08-15 | |
| US62/375,314 | 2016-08-15 | ||
| PCT/US2017/046814 WO2018035059A1 (en) | 2016-08-15 | 2017-08-14 | Methods for detecting aav |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022014629A Division JP2022064980A (ja) | 2016-08-15 | 2022-02-02 | Ａａｖを検出するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019533803A JP2019533803A (ja) | 2019-11-21 |
| JP2019533803A5 true JP2019533803A5 (enExample) | 2020-09-24 |
| JP7021191B2 JP7021191B2 (ja) | 2022-02-16 |
Family
ID=59762045
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508235A Active JP7021191B2 (ja) | 2016-08-15 | 2017-08-14 | Ａａｖを検出するための方法 |
| JP2022014629A Pending JP2022064980A (ja) | 2016-08-15 | 2022-02-02 | Ａａｖを検出するための方法 |
| JP2023202414A Pending JP2024023460A (ja) | 2016-08-15 | 2023-11-30 | Ａａｖを検出するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022014629A Pending JP2022064980A (ja) | 2016-08-15 | 2022-02-02 | Ａａｖを検出するための方法 |
| JP2023202414A Pending JP2024023460A (ja) | 2016-08-15 | 2023-11-30 | Ａａｖを検出するための方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US11698377B2 (enExample) |
| EP (2) | EP3497207B1 (enExample) |
| JP (3) | JP7021191B2 (enExample) |
| KR (5) | KR102922101B1 (enExample) |
| CN (2) | CN110168080B (enExample) |
| AU (2) | AU2017312951B2 (enExample) |
| CA (1) | CA3033856A1 (enExample) |
| CL (2) | CL2019000392A1 (enExample) |
| CR (1) | CR20190127A (enExample) |
| CY (1) | CY1124364T1 (enExample) |
| DK (1) | DK3497207T3 (enExample) |
| ES (1) | ES2863674T3 (enExample) |
| HU (1) | HUE053747T2 (enExample) |
| IL (3) | IL264819B2 (enExample) |
| MA (1) | MA55748A (enExample) |
| MX (2) | MX2019001938A (enExample) |
| NZ (3) | NZ751711A (enExample) |
| PH (1) | PH12019500316A1 (enExample) |
| SG (2) | SG10201913002QA (enExample) |
| TN (1) | TN2019000047A1 (enExample) |
| TW (2) | TW202309068A (enExample) |
| WO (1) | WO2018035059A1 (enExample) |
| ZA (2) | ZA201900945B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201508026D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
| CA3033856A1 (en) | 2016-08-15 | 2018-02-22 | Genzyme Corporation | Methods for detecting aav |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| PT3589730T (pt) | 2017-02-28 | 2024-02-28 | Univ Pennsylvania | Vetor de vírus adenoassociado (aav) de clado f e suas utilizações |
| IL276859B2 (en) * | 2018-02-27 | 2025-12-01 | Univ Pennsylvania | Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor |
| EP3768695A4 (en) * | 2018-02-27 | 2022-04-06 | The Trustees of the University of Pennsylvania | NOVEL ADENO-ASSOCIATED VIRUS (AAV) VECTORS, AAV VECTORS WITH REDUCED CAPSIID DEAMIDATION AND USES THEREOF |
| EP3762500A1 (en) * | 2018-03-06 | 2021-01-13 | Voyager Therapeutics, Inc. | Insect cell manufactured partial self-complementary aav genomes |
| EP4509831A3 (en) * | 2018-07-27 | 2025-03-19 | Waters Technologies Corporation | Liquid chromatography/mass spectrometry methods for the analysis of polar molecules |
| WO2020041498A1 (en) * | 2018-08-21 | 2020-02-27 | Massachusetts Eye And Ear Infirmary | Compositions and methods for modulating transduction efficiency of adeno-associated viruses |
| IL282411B2 (en) * | 2018-10-25 | 2025-09-01 | Regeneron Pharma | Methods for analyzing viral capsid protein composition |
| FI3953483T3 (fi) * | 2019-04-11 | 2023-11-30 | Regenxbio Inc | Kokoekskluusiokromatografiamenetelmiä rekombinanttien adenoassosioituneiden viruskoostumusten karakterisoimiseksi |
| US11841352B2 (en) * | 2019-07-31 | 2023-12-12 | Thermo Finnigan Llc | Determination and correction of retention time and mass/charge shifts in LC-MS experiments |
| CN114902051B (zh) * | 2020-01-03 | 2026-04-17 | 萨勒普塔医疗公司 | 用于分析aav衣壳蛋白的方法 |
| EP4097121A1 (en) | 2020-01-29 | 2022-12-07 | Genzyme Corporation | Modified adeno-associated viral capsid proteins for ocular gene therapy and methods of use thereof |
| CN111517359B (zh) * | 2020-04-23 | 2021-08-20 | 江南大学 | 一种手性硫化铜超粒子的合成方法 |
| RU2748540C1 (ru) * | 2021-02-08 | 2021-05-26 | Автономная некоммерческая образовательная организация высшего образования "Сколковский институт науки и технологий" | Способ детектирования вируса SARS-CoV-2 методом масс-спектрометрии |
| WO2022175728A1 (en) * | 2021-02-19 | 2022-08-25 | Waters Technologies Corporation | Methods for peptide mapping of adeno-associated virus (aav) proteins |
| US20240382966A1 (en) * | 2021-04-20 | 2024-11-21 | Universal Bio-Sampling Inc. | Specimen retention card and specimen inspection method using same |
| AU2022309726A1 (en) * | 2021-07-12 | 2024-01-25 | Regeneron Pharmaceuticals, Inc. | Liquid chromatography assay for determining aav capsid ratio |
| TW202321691A (zh) * | 2021-07-12 | 2023-06-01 | 美商再生元醫藥公司 | 用於分析病毒粒子之線上原生質譜方法 |
| CN113552349B (zh) * | 2021-07-30 | 2022-07-19 | 上海勉亦生物科技有限公司 | Aav蛋白外壳的检测方法 |
| JPWO2023132338A1 (enExample) * | 2022-01-06 | 2023-07-13 | ||
| US20250110119A1 (en) * | 2023-03-03 | 2025-04-03 | Sartorius Bioanalytical Instruments, Inc. | Methods for quantitating viral capsids |
| WO2024263520A1 (en) * | 2023-06-19 | 2024-12-26 | Regeneron Pharmaceuticals, Inc. | Host cell protein analysis for adeno-associated virus (aav)-based gene therapy |
| WO2025101795A1 (en) * | 2023-11-08 | 2025-05-15 | Oxford Biomedica (Us) Llc | Deamidation depleted adeno-associated virus product |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5540931A (en) | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
| US6204059B1 (en) * | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
| EP0931158A1 (en) | 1996-09-06 | 1999-07-28 | The Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
| US6989264B2 (en) | 1997-09-05 | 2006-01-24 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| CA2379166C (en) | 1999-08-09 | 2013-03-26 | Targeted Genetics Corporation | Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms instrastrand base pairs |
| ATE318923T1 (de) | 2000-06-01 | 2006-03-15 | Univ North Carolina | Doppelsträngige parvovirus-vektoren |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| MX359371B (es) | 2001-11-13 | 2018-09-25 | Univ Pennsylvania | Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo. |
| SI1496944T1 (sl) | 2002-05-01 | 2009-02-28 | Univ Florida | Izboljšani sistemi ekspresije RAAV za genetsko modifikacijo specifičnih kapsidnih proteinov |
| US20040172200A1 (en) * | 2002-11-22 | 2004-09-02 | Kearney Paul Edward | Constellation mapping and uses thereof |
| US7510872B2 (en) | 2003-02-26 | 2009-03-31 | Nationwide Children's Hospital | Recombinant adeno-associated virus production |
| US7261544B2 (en) | 2003-05-21 | 2007-08-28 | Genzyme Corporation | Methods for producing preparations of recombinant AAV virions substantially free of empty capsids |
| EP1486567A1 (en) | 2003-06-11 | 2004-12-15 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Improved adeno-associated virus (AAV) vector for gene therapy |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| WO2006119432A2 (en) | 2005-04-29 | 2006-11-09 | The Government Of The U.S.A., As Rep. By The Sec., Dept. Of Health & Human Services | Isolation, cloning and characterization of new adeno-associated virus (aav) serotypes |
| EP2311966A3 (en) * | 2005-10-20 | 2012-09-05 | Amsterdam Molecular Therapeutics (AMT) B.V. | Improved AAV vectors produced in insect cells |
| US7588772B2 (en) | 2006-03-30 | 2009-09-15 | Board Of Trustees Of The Leland Stamford Junior University | AAV capsid library and AAV capsid proteins |
| US20110275529A1 (en) | 2008-09-19 | 2011-11-10 | Charite Universitatsmedizin Berlin | Identification and characterisation of recombinant viral gene therapy vectors |
| WO2010093784A2 (en) | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| KR20180000341A (ko) | 2009-06-16 | 2018-01-02 | 젠자임 코포레이션 | 재조합 ａａｖ 벡터에 대한 개선된 정제 방법 |
| EP2561073B1 (en) | 2010-04-23 | 2016-08-24 | University of Massachusetts | Cns targeting aav vectors and methods of use thereof |
| WO2012031245A1 (en) * | 2010-09-03 | 2012-03-08 | North Carolina Central University | Biodegradable liquogel and ph sensitive nanocarriers |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| TR201908020T4 (tr) | 2011-02-17 | 2019-06-21 | Univ Pennsylvania | Doku özgüllüğünü değiştirmek ve aav9-aracılı gen transferini geliştirmek için bileşimler ve yöntemler. |
| ES2857773T5 (es) | 2011-08-24 | 2024-06-04 | Univ Leland Stanford Junior | Nuevas proteínas de la cápside de AAV para la transferencia de ácidos nucleicos |
| NZ701693A (en) * | 2012-04-18 | 2017-02-24 | The Children’S Hospital Of Philadelphia | Composition and methods for highly efficient gene transfer using aav capsid variants |
| US20140017716A1 (en) * | 2012-07-11 | 2014-01-16 | Siscapa Assay Technologies, Inc. | Proteolytic digestion kit with dried reagents |
| GB201401707D0 (en) | 2014-01-31 | 2014-03-19 | Sec Dep For Health The | Adeno-associated viral vectors |
| CA2942289C (en) | 2014-03-10 | 2024-05-21 | Uniqure Ip B.V. | Further improved aav vectors produced in insect cells |
| CA3033856A1 (en) | 2016-08-15 | 2018-02-22 | Genzyme Corporation | Methods for detecting aav |
-
2017
- 2017-08-14 CA CA3033856A patent/CA3033856A1/en active Pending
- 2017-08-14 DK DK17761362.7T patent/DK3497207T3/da active
- 2017-08-14 SG SG10201913002QA patent/SG10201913002QA/en unknown
- 2017-08-14 MA MA055748A patent/MA55748A/fr unknown
- 2017-08-14 EP EP17761362.7A patent/EP3497207B1/en active Active
- 2017-08-14 JP JP2019508235A patent/JP7021191B2/ja active Active
- 2017-08-14 EP EP20210237.2A patent/EP3851449A1/en active Pending
- 2017-08-14 NZ NZ751711A patent/NZ751711A/en unknown
- 2017-08-14 MX MX2019001938A patent/MX2019001938A/es unknown
- 2017-08-14 NZ NZ791263A patent/NZ791263A/en unknown
- 2017-08-14 TN TNP/2019/000047A patent/TN2019000047A1/en unknown
- 2017-08-14 KR KR1020247039853A patent/KR102922101B1/ko active Active
- 2017-08-14 US US16/325,653 patent/US11698377B2/en active Active
- 2017-08-14 SG SG11201901221YA patent/SG11201901221YA/en unknown
- 2017-08-14 CN CN201780063531.7A patent/CN110168080B/zh active Active
- 2017-08-14 KR KR1020227025409A patent/KR102538037B1/ko active Active
- 2017-08-14 CR CR20190127A patent/CR20190127A/es unknown
- 2017-08-14 AU AU2017312951A patent/AU2017312951B2/en active Active
- 2017-08-14 KR KR1020267003039A patent/KR20260036296A/ko active Pending
- 2017-08-14 IL IL264819A patent/IL264819B2/en unknown
- 2017-08-14 WO PCT/US2017/046814 patent/WO2018035059A1/en not_active Ceased
- 2017-08-14 KR KR1020197007381A patent/KR102425289B1/ko active Active
- 2017-08-14 CN CN202410630268.7A patent/CN118688363A/zh active Pending
- 2017-08-14 NZ NZ791267A patent/NZ791267A/en unknown
- 2017-08-14 KR KR1020237017707A patent/KR102738219B1/ko active Active
- 2017-08-14 ES ES17761362T patent/ES2863674T3/es active Active
- 2017-08-14 IL IL312792A patent/IL312792B2/en unknown
- 2017-08-14 HU HUE17761362A patent/HUE053747T2/hu unknown
- 2017-08-15 TW TW111138258A patent/TW202309068A/zh unknown
- 2017-08-15 TW TW106127648A patent/TWI781953B/zh active
-
2019
- 2019-02-13 CL CL2019000392A patent/CL2019000392A1/es unknown
- 2019-02-14 ZA ZA2019/00945A patent/ZA201900945B/en unknown
- 2019-02-14 PH PH12019500316A patent/PH12019500316A1/en unknown
- 2019-02-15 MX MX2023009081A patent/MX2023009081A/es unknown
- 2019-10-14 CL CL2019002912A patent/CL2019002912A1/es unknown
-
2021
- 2021-02-15 ZA ZA2021/01002A patent/ZA202101002B/en unknown
- 2021-03-24 CY CY20211100262T patent/CY1124364T1/el unknown
-
2022
- 2022-02-02 JP JP2022014629A patent/JP2022064980A/ja active Pending
-
2023
- 2023-05-22 US US18/321,542 patent/US12123880B2/en active Active
- 2023-11-30 JP JP2023202414A patent/JP2024023460A/ja active Pending
-
2024
- 2024-01-18 AU AU2024200349A patent/AU2024200349A1/en active Pending
- 2024-08-12 US US18/801,293 patent/US20250027951A1/en active Pending
-
2025
- 2025-01-08 US US19/013,836 patent/US20250147042A1/en active Pending
- 2025-01-08 US US19/013,863 patent/US12298313B1/en active Active
- 2025-10-15 IL IL323969A patent/IL323969A/en unknown
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