JP2019531758A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019531758A5 JP2019531758A5 JP2019523137A JP2019523137A JP2019531758A5 JP 2019531758 A5 JP2019531758 A5 JP 2019531758A5 JP 2019523137 A JP2019523137 A JP 2019523137A JP 2019523137 A JP2019523137 A JP 2019523137A JP 2019531758 A5 JP2019531758 A5 JP 2019531758A5
- Authority
- JP
- Japan
- Prior art keywords
- microorganism
- target substance
- activity
- amino acid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 26
- 244000005700 microbiome Species 0.000 claims 19
- 239000013076 target substance Substances 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 230000000694 effects Effects 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- YQUVCSBJEUQKSH-UHFFFAOYSA-N 3,4-dihydroxybenzoic acid Chemical group OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims 6
- 235000018102 proteins Nutrition 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 150000001413 amino acids Chemical group 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 4
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 claims 4
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims 3
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims 3
- 235000012141 vanillin Nutrition 0.000 claims 3
- YOMSJEATGXXYPX-UHFFFAOYSA-N 2-methoxy-4-vinylphenol Chemical compound COC1=CC(C=C)=CC=C1O YOMSJEATGXXYPX-UHFFFAOYSA-N 0.000 claims 2
- IBGBGRVKPALMCQ-UHFFFAOYSA-N 3,4-dihydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1O IBGBGRVKPALMCQ-UHFFFAOYSA-N 0.000 claims 2
- CHWNEIVBYREQRF-UHFFFAOYSA-N 4-Ethyl-2-methoxyphenol Chemical compound CCC1=CC=C(O)C(OC)=C1 CHWNEIVBYREQRF-UHFFFAOYSA-N 0.000 claims 2
- 241000186216 Corynebacterium Species 0.000 claims 2
- 241000186226 Corynebacterium glutamicum Species 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 108050008280 Shikimate dehydrogenase Proteins 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 239000006227 byproduct Substances 0.000 claims 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims 1
- QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 claims 1
- 108010038550 3-dehydroquinate dehydratase Proteins 0.000 claims 1
- 108050006180 3-dehydroquinate synthase Proteins 0.000 claims 1
- SLWWJZMPHJJOPH-PHDIDXHHSA-N 3-dehydroshikimic acid Chemical compound O[C@@H]1CC(C(O)=O)=CC(=O)[C@H]1O SLWWJZMPHJJOPH-PHDIDXHHSA-N 0.000 claims 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 1
- 102000008170 Aldehyde Oxidoreductases Human genes 0.000 claims 1
- 108010060441 Aldehyde Oxidoreductases Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 claims 1
- SLWWJZMPHJJOPH-UHFFFAOYSA-N DHS Natural products OC1CC(C(O)=O)=CC(=O)C1O SLWWJZMPHJJOPH-UHFFFAOYSA-N 0.000 claims 1
- 241000588921 Enterobacteriaceae Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims 1
- 108090001042 Hydro-Lyases Proteins 0.000 claims 1
- 102000004867 Hydro-Lyases Human genes 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 229930064664 L-arginine Natural products 0.000 claims 1
- 235000014852 L-arginine Nutrition 0.000 claims 1
- SSISHJJTAXXQAX-ZETCQYMHSA-N L-ergothioneine Chemical compound C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC(=S)N1 SSISHJJTAXXQAX-ZETCQYMHSA-N 0.000 claims 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims 1
- 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 102000055027 Protein Methyltransferases Human genes 0.000 claims 1
- 108700040121 Protein Methyltransferases Proteins 0.000 claims 1
- 108010016080 Protocatechuate-3,4-Dioxygenase Proteins 0.000 claims 1
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 229960001570 ademetionine Drugs 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000003934 aromatic aldehydes Chemical class 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 241000186254 coryneform bacterium Species 0.000 claims 1
- 229960003624 creatine Drugs 0.000 claims 1
- 239000006046 creatine Substances 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 229940093497 ergothioneine Drugs 0.000 claims 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims 1
- 229940114124 ferulic acid Drugs 0.000 claims 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims 1
- 235000001785 ferulic acid Nutrition 0.000 claims 1
- 229960001867 guaiacol Drugs 0.000 claims 1
- 229960002885 histidine Drugs 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- GJRGEVKCJPPZIT-UHFFFAOYSA-N isomugineic acid Natural products OC(=O)C(O)CCNC(C(O)=O)C(O)CN1CCC1C(O)=O GJRGEVKCJPPZIT-UHFFFAOYSA-N 0.000 claims 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims 1
- 229960003987 melatonin Drugs 0.000 claims 1
- GJRGEVKCJPPZIT-JBDRJPRFSA-N mugineic acid Chemical compound OC(=O)[C@@H](O)CCN[C@H](C(O)=O)[C@@H](O)CN1CC[C@H]1C(O)=O GJRGEVKCJPPZIT-JBDRJPRFSA-N 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 229960003371 protocatechualdehyde Drugs 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims 1
- 229960004441 tyrosine Drugs 0.000 claims 1
- 230000003313 weakening effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413044P | 2016-10-26 | 2016-10-26 | |
| US62/413,044 | 2016-10-26 | ||
| US201662417609P | 2016-11-04 | 2016-11-04 | |
| US62/417,609 | 2016-11-04 | ||
| PCT/JP2017/038798 WO2018079686A1 (en) | 2016-10-26 | 2017-10-26 | Method for producing l-methionine or metabolites requiring s-adenosylmethionine for synthesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531758A JP2019531758A (ja) | 2019-11-07 |
| JP2019531758A5 true JP2019531758A5 (enExample) | 2020-12-03 |
| JP7188385B2 JP7188385B2 (ja) | 2022-12-13 |
Family
ID=60302430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523137A Active JP7188385B2 (ja) | 2016-10-26 | 2017-10-26 | Ｌ－メチオニンまたは合成にｓ－アデノシルメチオニンを要求する代謝物の製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190241914A1 (enExample) |
| EP (1) | EP3532631A1 (enExample) |
| JP (1) | JP7188385B2 (enExample) |
| CN (1) | CN109963947B (enExample) |
| WO (1) | WO2018079686A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112021019284A2 (pt) | 2019-03-29 | 2022-02-01 | Ajinomoto Kk | Métodos para produzir alolactose e para produzir um indutor de expressão gênica |
| WO2020226087A1 (ja) | 2019-05-08 | 2020-11-12 | 味の素株式会社 | バニリンの製造方法 |
| JPWO2021177392A1 (enExample) | 2020-03-04 | 2021-09-10 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5089592A (enExample) | 1973-12-13 | 1975-07-18 | ||
| JPS57134500A (en) | 1981-02-12 | 1982-08-19 | Kyowa Hakko Kogyo Co Ltd | Plasmid pcg1 |
| JPS57183799A (en) | 1981-04-17 | 1982-11-12 | Kyowa Hakko Kogyo Co Ltd | Novel plasmid |
| JPS5835197A (ja) | 1981-08-26 | 1983-03-01 | Kyowa Hakko Kogyo Co Ltd | プラスミドｐｃｇ２ |
| JPS58192900A (ja) | 1982-05-04 | 1983-11-10 | Ajinomoto Co Inc | 複合プラスミド |
| JPH01191686A (ja) | 1988-01-26 | 1989-08-01 | Mitsubishi Petrochem Co Ltd | 複合プラスミド |
| FR2627508B1 (fr) | 1988-02-22 | 1990-10-05 | Eurolysine | Procede pour l'integration d'un gene choisi sur le chromosome d'une bacterie et bacterie obtenue par ledit procede |
| US5185262A (en) | 1988-07-27 | 1993-02-09 | Mitsubishi Petrochemical Co., Ltd. | DNA fragment containing gene which encodes the function of stabilizing plasmid in host microorganism |
| JP2678995B2 (ja) | 1988-09-08 | 1997-11-19 | 三菱化学株式会社 | トリプトフアンシンターゼの製造法 |
| JPH02207791A (ja) | 1989-02-07 | 1990-08-17 | Ajinomoto Co Inc | 微生物の形質転換法 |
| JP2973446B2 (ja) | 1990-01-11 | 1999-11-08 | 三菱化学株式会社 | 新規プラスミドベクター |
| JPH07108228B2 (ja) | 1990-10-15 | 1995-11-22 | 味の素株式会社 | 温度感受性プラスミド |
| JPH05244941A (ja) | 1992-03-03 | 1993-09-24 | Toyo Ink Mfg Co Ltd | Ｎａｄｈ依存性パラヒドロキシ安息香酸ヒドロキシラーゼ及びその製造方法 |
| US5272073A (en) | 1992-06-30 | 1993-12-21 | Purdue Research Foundation | Biocatalytic synthesis of catechol from glucose |
| JPH0775589A (ja) | 1993-09-08 | 1995-03-20 | Kawasaki Steel Corp | プロトカテキュ酸の製造方法 |
| WO1996023073A1 (en) | 1995-01-23 | 1996-08-01 | Novo Nordisk A/S | Dna integration by transposition |
| JPH0970291A (ja) | 1995-06-30 | 1997-03-18 | Ajinomoto Co Inc | 人工トランスポゾンを用いた遺伝子増幅方法 |
| JP4168463B2 (ja) | 1996-12-05 | 2008-10-22 | 味の素株式会社 | Ｌ−リジンの製造法 |
| AU756507B2 (en) | 1998-03-18 | 2003-01-16 | Ajinomoto Co., Inc. | L-glutamic acid-producing bacterium and method for producing L-glutamic acid |
| US6372461B1 (en) | 1998-09-18 | 2002-04-16 | Board Of Directors Operating Michigan State University | Synthesis of vanillin from a carbon source |
| JP2000262288A (ja) | 1999-03-16 | 2000-09-26 | Ajinomoto Co Inc | コリネ型細菌の温度感受性プラスミド |
| US7846697B2 (en) | 2003-06-19 | 2010-12-07 | BLMaps | Method of producing a low molecular weight organic compound in a cell |
| PL1651758T3 (pl) | 2003-07-29 | 2009-04-30 | Ajinomoto Kk | Sposób wytwarzania L-lizyny lub L-treoniny przy użyciu bakterii Escherichia o atenuowanej aktywności enzymu jabłczanowego |
| KR20080028940A (ko) | 2005-06-17 | 2008-04-02 | 마이크로비아 인코포레이티드 | 아미노산 및 대사산물의 개선된 생합성 방법 |
| JP2009501548A (ja) | 2005-07-18 | 2009-01-22 | ビーエーエスエフ ソシエタス・ヨーロピア | 微生物におけるメチオニン生産のためのジメチルジスルフィドの使用 |
| JP4882063B2 (ja) | 2005-10-12 | 2012-02-22 | 国立大学法人東京農工大学 | テレフタル酸の代謝に関与する新規遺伝子 |
| EP1947190B1 (en) | 2005-10-18 | 2017-11-29 | Ajinomoto Co., Inc. | Process for production of succinic acid |
| RU2418069C2 (ru) | 2006-09-29 | 2011-05-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ конструирования рекомбинантных бактерий, принадлежащих к роду pantoea, и способ продукции l-аминокислот с использованием бактерий, принадлежащих к роду pantoea |
| JP2010207094A (ja) | 2009-03-06 | 2010-09-24 | Genaris Inc | プロトカテク酸の製造法 |
| CN103987840A (zh) | 2011-08-08 | 2014-08-13 | 国际香料香精公司 | 用于香草醛或香草醛β-D-葡萄糖苷的生物合成的组合物和方法 |
| BR112013016373B1 (pt) | 2011-11-11 | 2021-05-18 | Ajinomoto Co., Inc | método para produzir uma substância alvo |
| KR101944150B1 (ko) | 2012-06-18 | 2019-01-30 | 에보니크 데구사 게엠베하 | 메티오닌의 발효적 생산을 위한 재조합 미생물 |
| CA2888636C (en) | 2012-11-05 | 2022-11-29 | Evolva Sa | Vanillin synthase |
-
2017
- 2017-10-26 EP EP17797450.8A patent/EP3532631A1/en active Pending
- 2017-10-26 WO PCT/JP2017/038798 patent/WO2018079686A1/en not_active Ceased
- 2017-10-26 JP JP2019523137A patent/JP7188385B2/ja active Active
- 2017-10-26 CN CN201780066783.5A patent/CN109963947B/zh active Active
-
2019
- 2019-04-24 US US16/392,776 patent/US20190241914A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019531757A5 (enExample) | ||
| JP2019531759A5 (enExample) | ||
| JP2019536449A5 (enExample) | ||
| Song et al. | Biotechnological production of alpha-keto acids: current status and perspectives | |
| JP5805202B2 (ja) | Ｏ−ホスホセリンを生産する微生物およびそれを用いてｏ−ホスホセリンからｌ−システインまたはその誘導体を生産する方法 | |
| TWI486453B (zh) | 乳酸生產細菌及乳酸生產方法 | |
| TWI573869B (zh) | 導入有二氧化碳固定循環之微生物 | |
| JP7380768B2 (ja) | アルデヒドの製造方法 | |
| JP7074133B2 (ja) | 目的物質の製造方法 | |
| CN104718292B (zh) | 导入了二氧化碳固定循环的微生物 | |
| CN112888776B (zh) | 生产目标物质的方法 | |
| JP2022093626A5 (enExample) | ||
| JP2019134700A5 (enExample) | ||
| JP7359248B2 (ja) | 目的物質の製造方法 | |
| JPWO2020208842A5 (enExample) | ||
| JP2022093626A (ja) | 目的物質の製造方法 | |
| JP2019531758A5 (enExample) | ||
| Cheng et al. | A high-efficiency artificial synthetic pathway for 5-aminovalerate production from biobased L-lysine in Escherichia coli | |
| JP6596105B2 (ja) | Ｌ−トリプトファンを産生するエシェリキア属の微生物及びそれを用いたｌ−トリプトファンの製造方法 | |
| RU2678139C2 (ru) | Микроорганизм рода Escherichia, продуцирующий L-триптофан, и способ продуцирования L-триптофана с использованием данного микроорганизма | |
| JP6412147B2 (ja) | Ｌ−スレオニン産生能を有する組み換えエシェリキア属微生物およびこれを用いたｌ−スレオニンの産生方法 | |
| JPWO2008047656A1 (ja) | Ｌ−アミノ酸の製造方法 | |
| JP2012528577A5 (enExample) | ||
| WO2017036740A1 (en) | Biological preparation of 5-aminovalerate | |
| CN103534350A (zh) | 对于谷氨酸显示高活性的新型氨基转移酶、编码该酶的基因和它们的利用法 |