JP2022093626A5 - - Google Patents
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- Publication number
- JP2022093626A5 JP2022093626A5 JP2022075719A JP2022075719A JP2022093626A5 JP 2022093626 A5 JP2022093626 A5 JP 2022093626A5 JP 2022075719 A JP2022075719 A JP 2022075719A JP 2022075719 A JP2022075719 A JP 2022075719A JP 2022093626 A5 JP2022093626 A5 JP 2022093626A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- protein
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001413 amino acids Chemical group 0.000 claims 55
- 108090000623 proteins and genes Proteins 0.000 claims 46
- 102000004169 proteins and genes Human genes 0.000 claims 40
- 238000000034 method Methods 0.000 claims 25
- 244000005700 microbiome Species 0.000 claims 17
- 230000014233 sulfur utilization Effects 0.000 claims 16
- 239000013076 target substance Substances 0.000 claims 14
- 238000007792 addition Methods 0.000 claims 11
- 125000000539 amino acid group Chemical group 0.000 claims 11
- 238000012217 deletion Methods 0.000 claims 11
- 230000037430 deletion Effects 0.000 claims 11
- 230000000694 effects Effects 0.000 claims 11
- 238000003780 insertion Methods 0.000 claims 11
- 230000037431 insertion Effects 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 11
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 8
- 102000004190 Enzymes Human genes 0.000 claims 7
- 108090000790 Enzymes Proteins 0.000 claims 7
- 101150094831 cysK gene Proteins 0.000 claims 7
- 101150075677 cysR gene Proteins 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 230000001580 bacterial effect Effects 0.000 claims 5
- YQUVCSBJEUQKSH-UHFFFAOYSA-N protochatechuic acid Natural products OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims 5
- 235000013878 L-cysteine Nutrition 0.000 claims 4
- 239000004201 L-cysteine Substances 0.000 claims 4
- 108700027408 O-acetylhomoserine (thiol)-lyase Proteins 0.000 claims 4
- 230000001851 biosynthetic effect Effects 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 4
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical group COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 claims 3
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 claims 3
- 241000186216 Corynebacterium Species 0.000 claims 2
- 241000186226 Corynebacterium glutamicum Species 0.000 claims 2
- 101150103751 FPR2 gene Proteins 0.000 claims 2
- 108050008280 Shikimate dehydrogenase Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 241000186254 coryneform bacterium Species 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 101150052442 cysD gene Proteins 0.000 claims 2
- 101150041643 cysH gene Proteins 0.000 claims 2
- 101150100268 cysI gene Proteins 0.000 claims 2
- 101150086660 cysN gene Proteins 0.000 claims 2
- 101150118721 cysX gene Proteins 0.000 claims 2
- 101150111924 cysZ gene Proteins 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims 2
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims 2
- 235000012141 vanillin Nutrition 0.000 claims 2
- 108010080376 3-Deoxy-7-Phosphoheptulonate Synthase Proteins 0.000 claims 1
- 108010038550 3-dehydroquinate dehydratase Proteins 0.000 claims 1
- 108050006180 3-dehydroquinate synthase Proteins 0.000 claims 1
- 108010055053 3-dehydroshikimate dehydratase Proteins 0.000 claims 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 1
- 102000008170 Aldehyde Oxidoreductases Human genes 0.000 claims 1
- 108010060441 Aldehyde Oxidoreductases Proteins 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000055027 Protein Methyltransferases Human genes 0.000 claims 1
- 108700040121 Protein Methyltransferases Proteins 0.000 claims 1
- 108010016080 Protocatechuate-3,4-Dioxygenase Proteins 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 150000003934 aromatic aldehydes Chemical class 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 108010001814 phosphopantetheinyl transferase Proteins 0.000 claims 1
- 108010070467 vanillate O-demethylase Proteins 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413030P | 2016-10-26 | 2016-10-26 | |
| US62/413,030 | 2016-10-26 | ||
| US201662417602P | 2016-11-04 | 2016-11-04 | |
| US62/417,602 | 2016-11-04 | ||
| JP2019523138A JP2019531759A (ja) | 2016-10-26 | 2017-10-26 | 目的物質の製造方法 |
| PCT/JP2017/038799 WO2018079687A1 (en) | 2016-10-26 | 2017-10-26 | Method for producing objective substance |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523138A Division JP2019531759A (ja) | 2016-10-26 | 2017-10-26 | 目的物質の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022093626A JP2022093626A (ja) | 2022-06-23 |
| JP2022093626A5 true JP2022093626A5 (enExample) | 2022-08-25 |
| JP7331985B2 JP7331985B2 (ja) | 2023-08-23 |
Family
ID=61226628
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523138A Pending JP2019531759A (ja) | 2016-10-26 | 2017-10-26 | 目的物質の製造方法 |
| JP2022075719A Active JP7331985B2 (ja) | 2016-10-26 | 2022-05-02 | 目的物質の製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523138A Pending JP2019531759A (ja) | 2016-10-26 | 2017-10-26 | 目的物質の製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190249205A1 (enExample) |
| EP (1) | EP3532627A1 (enExample) |
| JP (2) | JP2019531759A (enExample) |
| CN (1) | CN109952380B (enExample) |
| WO (1) | WO2018079687A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111748506B (zh) * | 2019-03-29 | 2022-07-05 | 中国科学院微生物研究所 | 产胍基乙酸的工程菌及其构建方法与应用 |
| WO2020203885A1 (ja) | 2019-03-29 | 2020-10-08 | 味の素株式会社 | アロラクトースの製造法 |
| EP3967676A4 (en) | 2019-05-08 | 2023-02-08 | Ajinomoto Co., Inc. | PROCESS FOR PRODUCTION OF VANILLIN |
| EP3839051A1 (en) | 2019-12-19 | 2021-06-23 | Evonik Operations GmbH | Method for the fermentative production of guanidinoacetic acid |
| WO2021177392A1 (ja) | 2020-03-04 | 2021-09-10 | 味の素株式会社 | 変異型トランスグルタミナーゼ |
| PH12023550036A1 (en) * | 2020-07-09 | 2024-03-11 | Evonik Operations Gmbh | Method for the fermentative production of guanidinoacetic acid |
| AU2021303704A1 (en) * | 2020-07-09 | 2023-03-09 | Evonik Operations Gmbh | Method for the fermentative production of guanidinoacetic acid |
| CN114276947B (zh) * | 2021-10-12 | 2024-07-23 | 湖北远大生物技术有限公司 | 酶促转化制备l-半胱氨酸的方法和用途 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5089592A (enExample) | 1973-12-13 | 1975-07-18 | ||
| JPS57134500A (en) | 1981-02-12 | 1982-08-19 | Kyowa Hakko Kogyo Co Ltd | Plasmid pcg1 |
| JPS57183799A (en) | 1981-04-17 | 1982-11-12 | Kyowa Hakko Kogyo Co Ltd | Novel plasmid |
| JPS5835197A (ja) | 1981-08-26 | 1983-03-01 | Kyowa Hakko Kogyo Co Ltd | プラスミドｐｃｇ２ |
| JPS58192900A (ja) | 1982-05-04 | 1983-11-10 | Ajinomoto Co Inc | 複合プラスミド |
| JPH01191686A (ja) | 1988-01-26 | 1989-08-01 | Mitsubishi Petrochem Co Ltd | 複合プラスミド |
| FR2627508B1 (fr) | 1988-02-22 | 1990-10-05 | Eurolysine | Procede pour l'integration d'un gene choisi sur le chromosome d'une bacterie et bacterie obtenue par ledit procede |
| JP2678995B2 (ja) | 1988-09-08 | 1997-11-19 | 三菱化学株式会社 | トリプトフアンシンターゼの製造法 |
| US5185262A (en) | 1988-07-27 | 1993-02-09 | Mitsubishi Petrochemical Co., Ltd. | DNA fragment containing gene which encodes the function of stabilizing plasmid in host microorganism |
| JPH02207791A (ja) | 1989-02-07 | 1990-08-17 | Ajinomoto Co Inc | 微生物の形質転換法 |
| JP2973446B2 (ja) | 1990-01-11 | 1999-11-08 | 三菱化学株式会社 | 新規プラスミドベクター |
| JPH07108228B2 (ja) | 1990-10-15 | 1995-11-22 | 味の素株式会社 | 温度感受性プラスミド |
| US5128253A (en) * | 1991-05-31 | 1992-07-07 | Kraft General Foods, Inc. | Bioconversion process for the production of vanillin |
| JPH05244941A (ja) | 1992-03-03 | 1993-09-24 | Toyo Ink Mfg Co Ltd | Ｎａｄｈ依存性パラヒドロキシ安息香酸ヒドロキシラーゼ及びその製造方法 |
| US5272073A (en) | 1992-06-30 | 1993-12-21 | Purdue Research Foundation | Biocatalytic synthesis of catechol from glucose |
| JPH0775589A (ja) | 1993-09-08 | 1995-03-20 | Kawasaki Steel Corp | プロトカテキュ酸の製造方法 |
| AU4431196A (en) | 1995-01-23 | 1996-08-14 | Novo Nordisk A/S | Dna integration by transposition |
| JPH0970291A (ja) | 1995-06-30 | 1997-03-18 | Ajinomoto Co Inc | 人工トランスポゾンを用いた遺伝子増幅方法 |
| JP4168463B2 (ja) | 1996-12-05 | 2008-10-22 | 味の素株式会社 | Ｌ−リジンの製造法 |
| AU756507B2 (en) | 1998-03-18 | 2003-01-16 | Ajinomoto Co., Inc. | L-glutamic acid-producing bacterium and method for producing L-glutamic acid |
| AU6043399A (en) | 1998-09-18 | 2000-04-10 | Board Of Trustees Of Michigan State University | Synthesis of vanillin from a carbon source |
| JP2000262288A (ja) | 1999-03-16 | 2000-09-26 | Ajinomoto Co Inc | コリネ型細菌の温度感受性プラスミド |
| MXPA02008710A (es) * | 2000-03-09 | 2003-02-24 | Basf Ag | Genes de corynebacterium glutamicum que codifican proteinas de via metabolica. |
| US7846697B2 (en) | 2003-06-19 | 2010-12-07 | BLMaps | Method of producing a low molecular weight organic compound in a cell |
| WO2005010794A2 (en) | 2003-07-29 | 2005-02-03 | Ajinomoto Co., Inc. | Method for determining metabolic flux affecting substance production |
| JP4882063B2 (ja) | 2005-10-12 | 2012-02-22 | 国立大学法人東京農工大学 | テレフタル酸の代謝に関与する新規遺伝子 |
| BRPI0617491B1 (pt) | 2005-10-18 | 2021-04-27 | Ajinomoto Co., Inc | Processo para produção de ácido succínico |
| RU2418069C2 (ru) | 2006-09-29 | 2011-05-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ конструирования рекомбинантных бактерий, принадлежащих к роду pantoea, и способ продукции l-аминокислот с использованием бактерий, принадлежащих к роду pantoea |
| JP2010130899A (ja) * | 2007-03-14 | 2010-06-17 | Ajinomoto Co Inc | Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法 |
| JP2010207094A (ja) | 2009-03-06 | 2010-09-24 | Genaris Inc | プロトカテク酸の製造法 |
| MX392155B (es) | 2011-08-08 | 2025-03-21 | Int Flavors & Fragrances Inc | Composiciones y metodos para la biosintesis de vainillina o de beta-d-glucosido de vainillina. |
| PE20141569A1 (es) | 2011-11-11 | 2014-11-08 | Ajinomoto Kk | Metodo para producir una sustancia diana mediante fermentacion |
| EP2914733A1 (en) | 2012-11-05 | 2015-09-09 | Evolva SA | Vanillin synthase |
| US10000782B2 (en) * | 2013-07-16 | 2018-06-19 | International Flavors & Fragrances Inc. | Recombinant host cell for the biosynthesis of vanillin or vanillin beta-D-glucoside |
| MY194223A (en) * | 2014-09-01 | 2022-11-22 | Evonik Operations Gmbh | Method and microorganism for methionine production by fermentation with improved methionine efflux |
| EP3331998B1 (en) * | 2015-08-07 | 2020-06-24 | Evonik Operations GmbH | Protein thiocarboxylate-dependent l-methionine production by fermentation |
| JP6881448B2 (ja) * | 2015-10-27 | 2021-06-02 | 味の素株式会社 | アルデヒドの製造方法 |
-
2017
- 2017-10-26 WO PCT/JP2017/038799 patent/WO2018079687A1/en not_active Ceased
- 2017-10-26 JP JP2019523138A patent/JP2019531759A/ja active Pending
- 2017-10-26 EP EP17842339.8A patent/EP3532627A1/en active Pending
- 2017-10-26 CN CN201780066784.XA patent/CN109952380B/zh active Active
-
2019
- 2019-04-24 US US16/392,756 patent/US20190249205A1/en not_active Abandoned
-
2022
- 2022-05-02 JP JP2022075719A patent/JP7331985B2/ja active Active
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