JP2019531728A5 - - Google Patents
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- JP2019531728A5 JP2019531728A5 JP2019516603A JP2019516603A JP2019531728A5 JP 2019531728 A5 JP2019531728 A5 JP 2019531728A5 JP 2019516603 A JP2019516603 A JP 2019516603A JP 2019516603 A JP2019516603 A JP 2019516603A JP 2019531728 A5 JP2019531728 A5 JP 2019531728A5
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- Prior art keywords
- seq
- cancer
- fusion protein
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- amino acid
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000037865 fusion proteins Human genes 0.000 claims 29
- 108020001507 fusion proteins Proteins 0.000 claims 29
- 239000013604 expression vector Substances 0.000 claims 15
- 239000002773 nucleotide Substances 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 241000701161 unidentified adenovirus Species 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 125000000539 amino acid group Chemical group 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 5
- 102000003675 cytokine receptors Human genes 0.000 claims 5
- 108010057085 cytokine receptors Proteins 0.000 claims 5
- 241001135569 Human adenovirus 5 Species 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 230000007547 defect Effects 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 238000003780 insertion Methods 0.000 claims 4
- 230000037431 insertion Effects 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000007812 deficiency Effects 0.000 claims 3
- 201000010536 head and neck cancer Diseases 0.000 claims 3
- 208000014829 head and neck neoplasm Diseases 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 230000004614 tumor growth Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
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- 102000003839 Human Proteins Human genes 0.000 claims 2
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- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
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- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 102000026898 cytokine binding proteins Human genes 0.000 claims 2
- 108091008470 cytokine binding proteins Proteins 0.000 claims 2
- 210000004602 germ cell Anatomy 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
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- 230000002401 inhibitory effect Effects 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
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- 244000309459 oncolytic virus Species 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
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- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 1
- 206010062878 Gastrooesophageal cancer Diseases 0.000 claims 1
- 241000701109 Human adenovirus 2 Species 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 101100012019 Mus musculus Etv4 gene Proteins 0.000 claims 1
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000000220 brain stem cancer Diseases 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000005018 casein Substances 0.000 claims 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
- 235000021240 caseins Nutrition 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000006974 gastroesophageal cancer Diseases 0.000 claims 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000026045 malignant tumor of parathyroid gland Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000008106 ocular cancer Diseases 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 201000003913 parathyroid carcinoma Diseases 0.000 claims 1
- 208000017954 parathyroid gland carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 201000010106 skin squamous cell carcinoma Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024003052A JP2024026738A (ja) | 2016-09-27 | 2024-01-12 | 免疫調節融合タンパク質 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662400338P | 2016-09-27 | 2016-09-27 | |
| US62/400,338 | 2016-09-27 | ||
| US201762484841P | 2017-04-12 | 2017-04-12 | |
| US62/484,841 | 2017-04-12 | ||
| PCT/US2017/053765 WO2018064190A1 (en) | 2016-09-27 | 2017-09-27 | Immunomodulatory fusion proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024003052A Division JP2024026738A (ja) | 2016-09-27 | 2024-01-12 | 免疫調節融合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531728A JP2019531728A (ja) | 2019-11-07 |
| JP2019531728A5 true JP2019531728A5 (https=) | 2020-11-12 |
| JP7421338B2 JP7421338B2 (ja) | 2024-01-24 |
Family
ID=61763625
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019516603A Active JP7421338B2 (ja) | 2016-09-27 | 2017-09-27 | 免疫調節融合タンパク質 |
| JP2024003052A Pending JP2024026738A (ja) | 2016-09-27 | 2024-01-12 | 免疫調節融合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024003052A Pending JP2024026738A (ja) | 2016-09-27 | 2024-01-12 | 免疫調節融合タンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10906957B2 (https=) |
| EP (1) | EP3519442A4 (https=) |
| JP (2) | JP7421338B2 (https=) |
| KR (2) | KR20240014617A (https=) |
| CN (2) | CN110546168B (https=) |
| AU (1) | AU2017336546C1 (https=) |
| BR (1) | BR112019005964A2 (https=) |
| CA (1) | CA3038526A1 (https=) |
| IL (1) | IL265657A (https=) |
| MX (1) | MX2019003445A (https=) |
| WO (1) | WO2018064190A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1225740A1 (zh) | 2013-08-22 | 2017-09-15 | Acceleron Pharma Inc. | TGF-β受体II型变体及其用途 |
| CN108348578B (zh) | 2015-08-04 | 2022-08-09 | 阿塞勒隆制药公司 | 用于治疗骨髓增生性病症的方法 |
| US10273281B2 (en) | 2015-11-02 | 2019-04-30 | Five Prime Therapeutics, Inc. | CD80 extracellular domain polypeptides and their use in cancer treatment |
| BR112019005964A2 (pt) | 2016-09-27 | 2019-06-18 | Epicentrx, Inc. | proteínas de fusão imunomoduladoras |
| JP7657548B2 (ja) | 2017-04-21 | 2025-04-07 | エランコ・ユーエス・インコーポレイテッド | 獣医学的使用のためのｉｌ４／ｉｌ１３受容体分子 |
| KR20190139216A (ko) | 2017-04-28 | 2019-12-17 | 파이브 프라임 테라퓨틱스, 인크. | Cd80 세포외 도메인 폴리펩티드를 이용한 치료 방법 |
| ES2948647T3 (es) | 2017-05-04 | 2023-09-15 | Acceleron Pharma Inc | Proteínas de fusión del receptor TGF-beta tipo II y usos de las mismas |
| NZ762376A (en) * | 2017-09-19 | 2022-08-26 | Scherrer Inst Paul | Transglutaminase conjugation method and linker |
| JP2020536518A (ja) | 2017-09-27 | 2020-12-17 | エピセントアールエックス，インコーポレイテッド | 免疫調節融合タンパク質 |
| CN112566650A (zh) | 2018-06-21 | 2021-03-26 | 沙塔克实验室有限公司 | 异二聚体蛋白及其用途 |
| KR20210022680A (ko) * | 2018-06-22 | 2021-03-03 | 메르크 파텐트 게엠베하 | 담도암의 치료에 사용하기 위한 표적화된 TGF-β 억제를 위한 투약 레지멘 |
| AU2019301070B2 (en) | 2018-07-09 | 2025-09-11 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| JP7241161B2 (ja) | 2018-08-01 | 2023-03-16 | イミュニティーバイオ、インコーポレイテッド | 細胞免疫療法の安定した遺伝子改変のための、ホーミング受容体又はサイトカインとキメラ抗原受容体とを含むクアドリシストロニックシステム |
| EP3870601A4 (en) * | 2018-10-25 | 2022-07-13 | Kindred Biosciences, Inc. | IL4/IL13 RECEPTOR MOLECULE FOR USE IN VETERINARY MEDICINE |
| US12589132B2 (en) | 2019-02-22 | 2026-03-31 | Five Prime Therapeutics, Inc. | CD80 extracellular domain Fc fusion proteins for treating PD-L1 negative tumors |
| CN113710229B (zh) | 2019-02-25 | 2026-01-06 | 芝加哥大学 | 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物 |
| JP2022532430A (ja) * | 2019-05-16 | 2022-07-14 | シャタック ラボ，インコーポレイテッド | Ｎｋ細胞指向性キメラタンパク質 |
| BR112022001320A2 (pt) * | 2019-07-25 | 2022-04-12 | Univ Chicago | Composições e métodos compreendendo agentes terapêuticos ativados por protease |
| CN112574314A (zh) * | 2019-09-30 | 2021-03-30 | 和铂医药(苏州)有限公司 | 一种融合蛋白及其应用 |
| CN111000982A (zh) * | 2019-12-25 | 2020-04-14 | 沣潮医药科技（上海）有限公司 | Amhr2重组蛋白或融合蛋白在制备amh信号轴异常活化相关疾病治疗药物中的用途 |
| CN111154806A (zh) * | 2020-01-08 | 2020-05-15 | 深圳普菲科生命科技有限公司 | 一种嵌合外源超级细胞因子的溶瘤病毒载体系统及其在药物中的应用 |
| CN115315510A (zh) * | 2020-01-28 | 2022-11-08 | 免疫生物公司 | 靶向egfr超家族受体的嵌合抗原受体修饰的nk-92细胞 |
| US11230699B2 (en) | 2020-01-28 | 2022-01-25 | Immunitybio, Inc. | Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors |
| JP7773991B2 (ja) * | 2020-03-23 | 2025-11-20 | ザイムワークス ビーシー インコーポレイテッド | マスクされたｉｌ１２融合タンパク質及びその使用方法 |
| CN111690070A (zh) * | 2020-05-13 | 2020-09-22 | 深圳市众循精准医学研究院 | 一种sPD-1-Fc-sTGFβRII融合蛋白及其应用 |
| IL298136A (en) | 2020-05-13 | 2023-01-01 | Bonum Therapeutics Inc | Preparations of protein complexes and methods of using them |
| WO2022007804A1 (zh) * | 2020-07-07 | 2022-01-13 | 深圳市菲鹏生物治疗股份有限公司 | T淋巴细胞及其应用 |
| WO2022011256A1 (en) | 2020-07-10 | 2022-01-13 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| KR20230048046A (ko) * | 2020-08-12 | 2023-04-10 | 유니버시티 오브 센트럴 플로리다 리서치 파운데이션, 인코포레이티드 | 감마 델타 t 세포를 자극하기 위한 방법 및 조성물 |
| WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| KR20230096052A (ko) | 2020-10-25 | 2023-06-29 | 아라리스 바이오테크 아게 | 항체-링커 접합체를 생성하기 위한 수단 및 방법 |
| CN112375149B (zh) * | 2020-10-30 | 2023-04-18 | 沣潮医药科技（上海）有限公司 | Ace2免疫融合蛋白及其应用 |
| WO2022105751A1 (zh) * | 2020-11-19 | 2022-05-27 | 信达生物制药(苏州)有限公司 | TGFβRII融合蛋白以及其用途 |
| WO2024158813A2 (en) * | 2023-01-24 | 2024-08-02 | Providence Health & Services - Oregon | Pet tracer for detection of transforming growth factor beta |
| WO2024179553A1 (zh) * | 2023-03-01 | 2024-09-06 | 广东菲鹏制药股份有限公司 | 靶向TGFβ的融合蛋白及其应用 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5525491A (en) | 1991-02-27 | 1996-06-11 | Creative Biomolecules, Inc. | Serine-rich peptide linkers |
| US5262522A (en) | 1991-11-22 | 1993-11-16 | Immunex Corporation | Receptor for oncostatin M and leukemia inhibitory factor |
| WO1996011213A1 (en) | 1994-10-07 | 1996-04-18 | Amgen Boulder Inc. | Dimeric il-4 inhibitors |
| AUPN477695A0 (en) | 1995-08-14 | 1995-09-07 | Commonwealth Scientific And Industrial Research Organisation | Gene therapy |
| US5672508A (en) | 1996-01-23 | 1997-09-30 | Mitotix, Inc. | Inhibitors of cell-cycle progression, and uses related thereto |
| GB9626029D0 (en) | 1996-12-14 | 1997-01-29 | Univ Leeds | EVH-1 vectors |
| US5998598A (en) | 1997-03-10 | 1999-12-07 | The United States Of America, As Represented By The Department Of Health And Human Services | Immunoadhesins and methods of production and use thereof |
| NZ500284A (en) | 1997-04-18 | 2001-09-28 | Biogen Inc | Type II TGF-beta receptor fusion proteins |
| AU4572899A (en) | 1998-06-16 | 2000-01-05 | Biogen, Inc. | Variant type ii tgf-beta receptor fusion proteins and methods |
| US7083950B2 (en) | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | High affinity fusion proteins and therapeutic and diagnostic methods for use |
| US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| US7754855B1 (en) * | 1999-07-13 | 2010-07-13 | Bolder Biotechnology, Inc. | Immunoglobulin fusion proteins |
| MXPA02001417A (es) * | 1999-08-09 | 2002-08-12 | Lexigen Pharm Corp | Complejos multiples de citosina-anticuerpo. |
| US7638604B2 (en) | 2001-02-23 | 2009-12-29 | Genetics Institute, Llc | Monoclonal antibodies against interleukin-22 |
| US20030125251A1 (en) | 2001-06-21 | 2003-07-03 | Wakefield Lalage M. | Transforming growth factor beta (TGF-beta) antagonist selectively neutralizes "pathological" TGF-beta |
| WO2003066002A2 (en) | 2002-02-08 | 2003-08-14 | University Of Medicine And Dentistry Of New Jersey | IFN-a/b-INDEPENDENT MECHANISM OF ANTIVIRAL PROTECTION |
| WO2005028517A2 (en) | 2003-05-09 | 2005-03-31 | The General Hospital Corporation | SOLUBLE TGF-β TYPE III RECEPTOR FUSION PROTEINS |
| US20090111146A1 (en) | 2003-09-02 | 2009-04-30 | National Institute Of Advanced Industrial Science | Antibody Drug |
| US20090232800A1 (en) | 2004-12-31 | 2009-09-17 | Per Sonne Holm | E1-minus adenoviruses and use thereof |
| US20090155267A1 (en) | 2005-02-09 | 2009-06-18 | Apollo Life Sciences Limited | Molecule and chimeric molecules thereof |
| JP2008536477A (ja) | 2005-02-14 | 2008-09-11 | アポロ ライフ サイエンシズ リミテッド | 分子およびそのキメラ分子 |
| JP2012228248A (ja) * | 2005-08-19 | 2012-11-22 | Abbott Lab | 二重可変ドメイン免疫グロブリン及びその使用 |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US20090175819A1 (en) | 2005-11-15 | 2009-07-09 | Apollo Life Sciences Limited | Molecule and chimeric molecules thereof |
| ES2623925T3 (es) | 2007-05-30 | 2017-07-12 | Postech Academy-Industry- Foundation | Proteínas de fusión de inmunoglobulina |
| WO2008157367A1 (en) | 2007-06-15 | 2008-12-24 | Genzyme Corporation | Fusion proteins containing two tgf-beta binding domains of tgf-beta type ii receptor |
| WO2009154995A2 (en) | 2008-05-27 | 2009-12-23 | Kyowa Hakko Kirin Co., Ltd. | Interleukin 10 receptor (il-10r) antibodies and methods of use |
| NZ590667A (en) | 2008-07-02 | 2013-01-25 | Emergent Product Dev Seattle | Tgf-b antagonist multi-target binding proteins |
| EP2326670A4 (en) | 2008-09-17 | 2014-04-16 | Nat Res Council Canada | HETERO MULTIVALENT BINDING AGENT FOR ELEMENTS OF THE TGF-BETA SUPERFAMILY |
| HUE026386T2 (en) | 2009-03-02 | 2016-06-28 | Univ California | Tumor-selective adenovirus e1a and e1b mutants |
| CA3253628A1 (en) | 2010-03-05 | 2025-11-29 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| AU2011333738A1 (en) * | 2010-11-24 | 2013-07-11 | Glaxo Group Limited | Multispecific antigen binding proteins targeting HGF |
| PL3489254T3 (pl) | 2012-04-30 | 2023-01-30 | Biocon Limited | Ukierunkowujące/immunomodulujące białko fuzyjne i sposoby jego otrzymywania |
| CA2902830C (en) | 2013-03-12 | 2023-09-19 | Biocon Ltd. | Fusion immunomodulatory proteins and methods for making same |
| HK1225740A1 (zh) | 2013-08-22 | 2017-09-15 | Acceleron Pharma Inc. | TGF-β受体II型变体及其用途 |
| ES2902533T3 (es) * | 2013-11-21 | 2022-03-28 | Brigham & Womens Hospital Inc | Composiciones y métodos para tratar la hipertensión pulmonar |
| BR112016014952A2 (pt) | 2014-02-10 | 2017-09-19 | Merck Patent Gmbh | Inibição direcionada de tgfbeta |
| AU2015364396B2 (en) | 2014-12-19 | 2018-08-09 | Alkermes, Inc. | Single chain Fc fusion proteins |
| JP2018518945A (ja) | 2015-04-29 | 2018-07-19 | メディオラヌム・ファルマチェウティチ・ソチエタ・ペル・アツィオーニ | 可溶性キメラインターロイキン−１０受容体およびその療法使用 |
| US20200231652A1 (en) * | 2015-08-31 | 2020-07-23 | National Research Council Of Canada | Tgf-b-receptor ectodomain fusion molecules and uses thereof |
| BR112019005964A2 (pt) | 2016-09-27 | 2019-06-18 | Epicentrx, Inc. | proteínas de fusão imunomoduladoras |
| US10232053B2 (en) | 2016-12-30 | 2019-03-19 | Trieza Therapeutics, Inc. | Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer |
| JP2020536518A (ja) | 2017-09-27 | 2020-12-17 | エピセントアールエックス，インコーポレイテッド | 免疫調節融合タンパク質 |
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2017
- 2017-09-27 BR BR112019005964-4A patent/BR112019005964A2/pt active Search and Examination
- 2017-09-27 KR KR1020247002333A patent/KR20240014617A/ko active Pending
- 2017-09-27 JP JP2019516603A patent/JP7421338B2/ja active Active
- 2017-09-27 WO PCT/US2017/053765 patent/WO2018064190A1/en not_active Ceased
- 2017-09-27 US US15/717,199 patent/US10906957B2/en active Active
- 2017-09-27 CA CA3038526A patent/CA3038526A1/en active Pending
- 2017-09-27 EP EP17857347.3A patent/EP3519442A4/en active Pending
- 2017-09-27 MX MX2019003445A patent/MX2019003445A/es unknown
- 2017-09-27 CN CN201780073371.4A patent/CN110546168B/zh active Active
- 2017-09-27 AU AU2017336546A patent/AU2017336546C1/en not_active Ceased
- 2017-09-27 KR KR1020197012132A patent/KR20190128618A/ko not_active Ceased
- 2017-09-27 CN CN202410281185.1A patent/CN118307682A/zh active Pending
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2019
- 2019-03-27 IL IL265657A patent/IL265657A/en unknown
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2021
- 2021-01-15 US US17/150,993 patent/US12054530B2/en active Active
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2024
- 2024-01-12 JP JP2024003052A patent/JP2024026738A/ja active Pending
- 2024-07-12 US US18/772,025 patent/US20250074967A1/en active Pending
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