JP2019531474A5 - - Google Patents
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- Publication number
- JP2019531474A5 JP2019531474A5 JP2019512260A JP2019512260A JP2019531474A5 JP 2019531474 A5 JP2019531474 A5 JP 2019531474A5 JP 2019512260 A JP2019512260 A JP 2019512260A JP 2019512260 A JP2019512260 A JP 2019512260A JP 2019531474 A5 JP2019531474 A5 JP 2019531474A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- group
- spacer molecule
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 30
- 125000006850 spacer group Chemical group 0.000 claims 25
- 229920001223 polyethylene glycol Polymers 0.000 claims 18
- 125000000304 alkynyl group Chemical group 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 239000002202 Polyethylene glycol Substances 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 239000007850 fluorescent dye Substances 0.000 claims 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000004429 atom Chemical group 0.000 claims 6
- 125000001589 carboacyl group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 125000003827 glycol group Chemical group 0.000 claims 6
- 125000005496 phosphonium group Chemical group 0.000 claims 6
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 238000010791 quenching Methods 0.000 claims 4
- 230000000171 quenching effect Effects 0.000 claims 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 3
- -1 alkenoyl Chemical group 0.000 claims 3
- 229960003237 betaine Drugs 0.000 claims 3
- 150000007942 carboxylates Chemical group 0.000 claims 3
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 3
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 3
- 230000001268 conjugating effect Effects 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 238000001215 fluorescent labelling Methods 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022179386A JP2023025018A (ja) | 2016-09-01 | 2022-11-09 | 増強された蛍光のための組成物および方法 |
| JP2024196507A JP2025028883A (ja) | 2016-09-01 | 2024-11-11 | 増強された蛍光のための組成物および方法 |
| JP2025264130A JP2026071206A (ja) | 2016-09-01 | 2025-12-18 | 増強された蛍光のための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662382594P | 2016-09-01 | 2016-09-01 | |
| US62/382,594 | 2016-09-01 | ||
| PCT/US2017/049838 WO2018045278A1 (en) | 2016-09-01 | 2017-09-01 | Compositions and methods for enhanced fluorescence |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022179386A Division JP2023025018A (ja) | 2016-09-01 | 2022-11-09 | 増強された蛍光のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531474A JP2019531474A (ja) | 2019-10-31 |
| JP2019531474A5 true JP2019531474A5 (cg-RX-API-DMAC7.html) | 2020-10-15 |
| JP7216638B2 JP7216638B2 (ja) | 2023-02-01 |
Family
ID=59846737
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512260A Active JP7216638B2 (ja) | 2016-09-01 | 2017-09-01 | 増強された蛍光のための組成物および方法 |
| JP2022179386A Pending JP2023025018A (ja) | 2016-09-01 | 2022-11-09 | 増強された蛍光のための組成物および方法 |
| JP2024196507A Pending JP2025028883A (ja) | 2016-09-01 | 2024-11-11 | 増強された蛍光のための組成物および方法 |
| JP2025264130A Pending JP2026071206A (ja) | 2016-09-01 | 2025-12-18 | 増強された蛍光のための組成物および方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022179386A Pending JP2023025018A (ja) | 2016-09-01 | 2022-11-09 | 増強された蛍光のための組成物および方法 |
| JP2024196507A Pending JP2025028883A (ja) | 2016-09-01 | 2024-11-11 | 増強された蛍光のための組成物および方法 |
| JP2025264130A Pending JP2026071206A (ja) | 2016-09-01 | 2025-12-18 | 増強された蛍光のための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20180092993A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3507603B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP7216638B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109844538A (cg-RX-API-DMAC7.html) |
| ES (1) | ES2979129T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018045278A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3019559A4 (en) | 2013-08-22 | 2017-04-05 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| BR112018070164B1 (pt) | 2016-04-01 | 2022-09-27 | Sony Corporation Of America | Corantes diméricos ou poliméricos ultrabrilhantes |
| CN109153860B (zh) | 2016-04-06 | 2021-04-23 | 索尼公司 | 具有间隔连接体基团的超高亮二聚体或聚合物染料 |
| BR112018073199A2 (pt) | 2016-05-11 | 2019-04-16 | Sony Corporation | corantes diméricos ou poliméricos ultrabrilhantes |
| WO2018022925A1 (en) | 2016-07-29 | 2018-02-01 | Sony Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
| EP3507603B1 (en) * | 2016-09-01 | 2024-03-06 | Life Technologies Corporation | Compositions and methods for enhanced fluorescence |
| KR102795781B1 (ko) | 2017-06-16 | 2025-04-15 | 듀크 유니버시티 | 개선된 라벨 검출, 계산, 분석물 감지, 및 조정 가능한 난수 생성을 위한 공진기 네트워크 |
| US12290571B2 (en) | 2017-10-05 | 2025-05-06 | Sony Group Corporation | Programmable dendritic drugs |
| KR20260011205A (ko) | 2017-10-05 | 2026-01-22 | 소니그룹주식회사 | 프로그램가능한 중합체성 약물 |
| CN111836645A (zh) | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| US20190154669A1 (en) * | 2017-11-20 | 2019-05-23 | Vector Laboratories, Inc. | Methods and systems for species-on-species immunoassay detection |
| EP3737417B1 (en) | 2018-01-12 | 2025-08-27 | Sony Group Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| US12076407B2 (en) | 2018-01-12 | 2024-09-03 | Sony Group Corporation | Polymers with rigid spacing groups comprising biologically active compounds |
| WO2019140128A1 (en) | 2018-01-12 | 2019-07-18 | Sony Corporation | Phosphoalkyl polymers comprising biologically active compounds |
| EP3769085B1 (en) * | 2018-03-19 | 2022-08-24 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
| KR102864292B1 (ko) | 2018-03-21 | 2025-09-26 | 소니그룹주식회사 | 링커 군을 갖는 중합체성 텐덤 염료 |
| CN112384573A (zh) | 2018-03-30 | 2021-02-19 | 贝克顿·迪金森公司 | 含侧基发色团的水溶性聚合染料 |
| JP7580689B2 (ja) | 2018-06-27 | 2024-11-12 | ソニーグループ株式会社 | デオキシリボースを含むリンカー基を有するポリマー色素 |
| CN109086566B (zh) * | 2018-07-12 | 2021-06-18 | 浙江工业大学 | 一种基于片段重采样的群体蛋白质结构预测方法 |
| US12578342B2 (en) | 2018-07-13 | 2026-03-17 | Sony Group Corporation | Polymeric dyes having a backbone comprising organophosphate units |
| JP2022533145A (ja) * | 2019-05-13 | 2022-07-21 | シャンハイ ポラリス バイオロジー カンパニー， リミテッド | 生体分子を標識するためのタグ |
| WO2020255906A1 (ja) * | 2019-06-20 | 2020-12-24 | コニカミノルタ株式会社 | 蛍光標識剤用連結体 |
| EP3861074A2 (en) | 2019-09-26 | 2021-08-11 | Sony Group Corporation | Polymeric tandem dyes with linker groups |
| EP4038081A1 (en) | 2019-09-30 | 2022-08-10 | Sony Group Corporation | Nucleotide probes |
| CN115023611A (zh) * | 2020-03-25 | 2022-09-06 | 积水医疗株式会社 | 免疫学分析方法和免疫学分析试剂盒 |
| CN113913404B (zh) * | 2020-07-10 | 2025-08-12 | 上海米然生物科技有限公司 | 一种荧光交联RNase H突变体缀合物及其应用 |
| US11408825B2 (en) | 2020-08-28 | 2022-08-09 | Hong Kong Applied Science and Technology Research Institute Company Limited | Forensic detector and the system thereof |
| US12203914B2 (en) | 2020-11-12 | 2025-01-21 | Sartorius Bioanalytical Instruments, Inc. | Viral clearance evaluation for biological medical product preparation processes |
| EP4256078A1 (en) | 2020-12-07 | 2023-10-11 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| WO2023032994A1 (ja) * | 2021-08-31 | 2023-03-09 | 富士フイルム株式会社 | 化合物及びこれを用いた標識生体物質 |
| CN116148462B (zh) * | 2021-11-22 | 2025-11-18 | 菲鹏生物股份有限公司 | 一种捕获法检测抗体的方法和应用 |
| CN115466960B (zh) * | 2022-09-15 | 2023-05-26 | 河北工业大学 | 一种含苯并噻唑基团改性聚天冬氨酸荧光缓蚀剂的制备方法和应用 |
| CN120380327A (zh) * | 2022-12-26 | 2025-07-25 | 富士胶片株式会社 | 荧光强度增强剂、经荧光标记的靶标生物物质的荧光强度增强方法及荧光检测用试剂盒 |
| CN117168937A (zh) * | 2023-09-01 | 2023-12-05 | 河南赛诺特生物技术有限公司 | 一种延缓荧光淬灭的封片组合物、封片剂及其应用 |
| WO2025182762A1 (ja) * | 2024-02-29 | 2025-09-04 | 富士レビオ株式会社 | 検出方法、並びに、これに用いる標識体及びキット |
| US20250341516A1 (en) * | 2024-05-01 | 2025-11-06 | BioLegend, Inc. | Compositions for use with multiple fluorophores and methods of using |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5459272A (en) | 1990-10-16 | 1995-10-17 | Research Corporation Technologies | Quinoline-2-(carboxaldehyde) reagents for detection of primary amines |
| US6706879B2 (en) | 2001-02-28 | 2004-03-16 | Stratagene | Fluorescent dye |
| US6972326B2 (en) | 2001-12-03 | 2005-12-06 | Molecular Probes, Inc. | Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes |
| CA2487944A1 (en) * | 2002-06-03 | 2003-12-11 | Pamgene B.V. | Biomolecular kinetics method using a flow-through microarray |
| PL1660134T3 (pl) * | 2003-08-08 | 2011-05-31 | Fresenius Kabi Deutschland Gmbh | Koniugaty hydroksyalkiloskrobi i G-CSF |
| WO2007120762A2 (en) * | 2006-04-14 | 2007-10-25 | Cambrios Technologies Corporation | Fluorescent particles bound to multifunctional scaffolds and their uses |
| US9127130B2 (en) | 2006-08-11 | 2015-09-08 | Starpharma Pty Ltd. | Polylysine dendrimer contrast agent |
| CN101827946A (zh) * | 2007-05-18 | 2010-09-08 | 茵维特罗根公司 | 快速蛋白质标记和分析 |
| GB0711560D0 (en) * | 2007-06-14 | 2007-07-25 | Innova Biosciences Ltd | Improvements in or relating to production of conjugates |
| JP2011506673A (ja) * | 2007-12-14 | 2011-03-03 | バイオティウム， インコーポレイテッド | 蛍光性化合物 |
| ES2977359T3 (es) * | 2010-01-19 | 2024-08-22 | Sirigen Ii Ltd | Nuevos reactivos para la amplificación dirigida de la señal de un biomarcador |
| JP5540964B2 (ja) | 2010-07-23 | 2014-07-02 | コニカミノルタ株式会社 | 蛍光標識剤、並びにこれを用いた結合体及びバイオアッセイ法 |
| US9448173B2 (en) | 2011-03-08 | 2016-09-20 | The Board Of Trustees Of The University Of Illinois | Dye-conjugated dendrimers |
| US20130052130A1 (en) | 2011-08-30 | 2013-02-28 | University Of Washington | Branched Discreet PEG Constructs |
| US8835000B2 (en) | 2011-12-23 | 2014-09-16 | General Electric Company | High-density fluorescent dye clusters |
| AU2013229631B2 (en) | 2012-03-05 | 2017-09-14 | Bracco Imaging Spa | Dynamic Contrast Enhanced MRI method and agents for the assessment of the macromolecular transport within pathologic tissues |
| CN102692508B (zh) * | 2012-04-28 | 2014-12-17 | 广州鸿琪光学仪器科技有限公司 | 一种快速定量检测肌钙蛋白t的免疫荧光试纸条组件及其制成的检测卡组件和制备方法 |
| US10107799B2 (en) * | 2012-09-18 | 2018-10-23 | Biotium, Inc. | Methods, compositions and kits for labeling of proteins |
| WO2014138186A1 (en) * | 2013-03-05 | 2014-09-12 | The Johns Hopkins University | Bioorthogonal two-component delivery systems for enhanced internalization of nanotherapeutics |
| US9670318B2 (en) | 2015-05-28 | 2017-06-06 | Miltenyi Biotec Gmbh | Bright fluorochromes based on multimerization of fluorescent dyes |
| EP3507603B1 (en) * | 2016-09-01 | 2024-03-06 | Life Technologies Corporation | Compositions and methods for enhanced fluorescence |
| WO2018045275A1 (en) | 2016-09-01 | 2018-03-08 | Nike Innovate C.V. | Vented garment |
-
2017
- 2017-09-01 EP EP17765041.3A patent/EP3507603B1/en active Active
- 2017-09-01 CN CN201780062491.4A patent/CN109844538A/zh active Pending
- 2017-09-01 WO PCT/US2017/049838 patent/WO2018045278A1/en not_active Ceased
- 2017-09-01 US US15/693,772 patent/US20180092993A1/en not_active Abandoned
- 2017-09-01 ES ES17765041T patent/ES2979129T3/es active Active
- 2017-09-01 EP EP24161100.3A patent/EP4425179A3/en not_active Withdrawn
- 2017-09-01 JP JP2019512260A patent/JP7216638B2/ja active Active
-
2020
- 2020-03-11 US US16/816,015 patent/US11857643B2/en active Active
- 2020-05-22 US US16/882,271 patent/US11865191B2/en active Active
-
2022
- 2022-11-09 JP JP2022179386A patent/JP2023025018A/ja active Pending
-
2023
- 2023-10-16 US US18/380,388 patent/US20240042062A1/en active Pending
-
2024
- 2024-11-11 JP JP2024196507A patent/JP2025028883A/ja active Pending
-
2025
- 2025-12-18 JP JP2025264130A patent/JP2026071206A/ja active Pending
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