JP2019531316A5 - - Google Patents
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- JP2019531316A5 JP2019531316A5 JP2019519648A JP2019519648A JP2019531316A5 JP 2019531316 A5 JP2019531316 A5 JP 2019531316A5 JP 2019519648 A JP2019519648 A JP 2019519648A JP 2019519648 A JP2019519648 A JP 2019519648A JP 2019531316 A5 JP2019531316 A5 JP 2019531316A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 57
- 150000001413 amino acids Chemical class 0.000 claims 30
- 229920001184 polypeptide Polymers 0.000 claims 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims 27
- 239000003795 chemical substances by application Substances 0.000 claims 21
- 210000003527 eukaryotic cell Anatomy 0.000 claims 15
- 102000004169 proteins and genes Human genes 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 15
- 101710163270 Nuclease Proteins 0.000 claims 12
- 239000003550 marker Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 108091033409 CRISPR Proteins 0.000 claims 9
- 230000002209 hydrophobic effect Effects 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 238000010354 CRISPR gene editing Methods 0.000 claims 7
- -1 antibody Proteins 0.000 claims 7
- 210000000172 cytosol Anatomy 0.000 claims 6
- 230000003834 intracellular effect Effects 0.000 claims 6
- 230000026683 transduction Effects 0.000 claims 6
- 238000010361 transduction Methods 0.000 claims 6
- 210000001723 extracellular space Anatomy 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 108010042407 Endonucleases Proteins 0.000 claims 2
- 102000004533 Endonucleases Human genes 0.000 claims 2
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 2
- 108091023040 Transcription factor Proteins 0.000 claims 2
- 102000040945 Transcription factor Human genes 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 102000008682 Argonaute Proteins Human genes 0.000 claims 1
- 108010088141 Argonaute Proteins Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 101100129232 Danio rerio mafaa gene Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 101150099612 Esrrb gene Proteins 0.000 claims 1
- 102100035421 Forkhead box protein O3 Human genes 0.000 claims 1
- 101150032426 HLF gene Proteins 0.000 claims 1
- 102100028404 Homeobox protein Hox-B4 Human genes 0.000 claims 1
- 101000877681 Homo sapiens Forkhead box protein O3 Proteins 0.000 claims 1
- 101000839788 Homo sapiens Homeobox protein Hox-B4 Proteins 0.000 claims 1
- 101001053263 Homo sapiens Insulin gene enhancer protein ISL-1 Proteins 0.000 claims 1
- 101000740178 Homo sapiens Sal-like protein 4 Proteins 0.000 claims 1
- 101000713602 Homo sapiens T-box transcription factor TBX21 Proteins 0.000 claims 1
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 1
- 108050009527 Hypoxia-inducible factor-1 alpha Proteins 0.000 claims 1
- 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims 1
- 101150051019 Klrg1 gene Proteins 0.000 claims 1
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 1
- 102000006830 Luminescent Proteins Human genes 0.000 claims 1
- 108010047357 Luminescent Proteins Proteins 0.000 claims 1
- 101150084866 MAFA gene Proteins 0.000 claims 1
- 101100381525 Mus musculus Bcl6 gene Proteins 0.000 claims 1
- 101100445364 Mus musculus Eomes gene Proteins 0.000 claims 1
- 101000687343 Mus musculus PR domain zinc finger protein 1 Proteins 0.000 claims 1
- 101100189471 Mus musculus Pbx1 gene Proteins 0.000 claims 1
- 101100078259 Mus musculus Runx1t1 gene Proteins 0.000 claims 1
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 1
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 1
- 241000204974 Natronobacterium Species 0.000 claims 1
- 101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 claims 1
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 1
- 101150086694 SLC22A3 gene Proteins 0.000 claims 1
- 101150106167 SOX9 gene Proteins 0.000 claims 1
- 102100037192 Sal-like protein 4 Human genes 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 102100036840 T-box transcription factor TBX21 Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 101001023030 Toxoplasma gondii Myosin-D Proteins 0.000 claims 1
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 1
- 101100445365 Xenopus laevis eomes gene Proteins 0.000 claims 1
- 101001062349 Xenopus tropicalis Forkhead box protein A1 Proteins 0.000 claims 1
- 101150053182 Zfp37 gene Proteins 0.000 claims 1
- 102100023552 Zinc finger protein 37 homolog Human genes 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 230000000875 corresponding effect Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 102000034287 fluorescent proteins Human genes 0.000 claims 1
- 108091006047 fluorescent proteins Proteins 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 101150111214 lin-28 gene Proteins 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002438 mitochondrial effect Effects 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 claims 1
- 210000002824 peroxisome Anatomy 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022180534A JP2023010788A (ja) | 2016-10-12 | 2022-11-10 | ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット |
| JP2024231097A JP2025062600A (ja) | 2016-10-12 | 2024-12-26 | ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662407232P | 2016-10-12 | 2016-10-12 | |
| US62/407,232 | 2016-10-12 | ||
| US201762535015P | 2017-07-20 | 2017-07-20 | |
| US62/535,015 | 2017-07-20 | ||
| US15/666,139 | 2017-08-01 | ||
| US15/666,139 US9982267B2 (en) | 2016-10-12 | 2017-08-01 | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
| PCT/CA2017/051205 WO2018068135A1 (en) | 2016-10-12 | 2017-10-11 | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022180534A Division JP2023010788A (ja) | 2016-10-12 | 2022-11-10 | ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531316A JP2019531316A (ja) | 2019-10-31 |
| JP2019531316A5 true JP2019531316A5 (https=) | 2020-11-26 |
| JP7177047B2 JP7177047B2 (ja) | 2022-11-22 |
Family
ID=61905066
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019519648A Active JP7177047B2 (ja) | 2016-10-12 | 2017-10-11 | ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット |
| JP2022180534A Pending JP2023010788A (ja) | 2016-10-12 | 2022-11-10 | ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット |
| JP2024231097A Pending JP2025062600A (ja) | 2016-10-12 | 2024-12-26 | ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022180534A Pending JP2023010788A (ja) | 2016-10-12 | 2022-11-10 | ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット |
| JP2024231097A Pending JP2025062600A (ja) | 2016-10-12 | 2024-12-26 | ポリペプチドカーゴを標的真核細胞の細胞外間隙からサイトゾルおよび／または核に送達するための合理的に設計された合成ペプチドシャトル剤、その使用、それに関連する方法およびキット |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12286632B2 (https=) |
| EP (2) | EP4556567A3 (https=) |
| JP (3) | JP7177047B2 (https=) |
| KR (1) | KR102626671B1 (https=) |
| CN (2) | CN110291100B (https=) |
| AU (2) | AU2017341736B2 (https=) |
| CA (1) | CA3038839A1 (https=) |
| IL (1) | IL265920B2 (https=) |
| WO (1) | WO2018068135A1 (https=) |
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| CA2981716C (en) | 2015-04-10 | 2022-04-12 | Feldan Bio Inc. | Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same |
| US11629170B2 (en) | 2016-10-12 | 2023-04-18 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
| CN110291100B (zh) | 2016-10-12 | 2024-06-11 | 费尔丹生物公司 | 用于将多肽负荷从细胞外空间递送至靶真核细胞的胞质溶胶和/或细胞核的合理设计的合成肽穿梭剂，其用途、与其相关的方法和试剂盒 |
| WO2018232356A1 (en) | 2017-06-15 | 2018-12-20 | The Regents Of The University Of California | Targeted non-viral dna insertions |
| JP7101419B2 (ja) | 2017-10-27 | 2022-07-15 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 内因性ｔ細胞受容体の標的置換 |
| US11732009B2 (en) * | 2018-06-08 | 2023-08-22 | Glympse Bio, Inc. | Activity sensor with tunable analyte |
| US11028425B2 (en) | 2018-06-08 | 2021-06-08 | Glympse Bio, Inc. | Diagnosis and monitoring of liver disease |
| CN109232717B (zh) * | 2018-08-31 | 2021-08-20 | 东北农业大学 | 一种针对革兰氏阴性菌靶向抗菌肽及制作方法与应用 |
| CN109232719B (zh) * | 2018-09-21 | 2021-06-29 | 中国科学院理化技术研究所 | 一种pH响应的抗菌肽及其制备方法和应用 |
| CN113166209B (zh) * | 2018-10-08 | 2025-01-07 | 弗里堡大学阿道夫梅克尔研究所 | 成孔肽的基于寡核苷酸的调节以增加孔尺寸、膜亲和性、稳定性和抗菌活性 |
| MX2021006208A (es) | 2018-11-28 | 2021-10-01 | Univ Texas | Edición por multiplexación del genoma de células inmunitarias para mejorar la funcionalidad y resistencia al entorno supresor. |
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| US12338483B2 (en) | 2019-02-28 | 2025-06-24 | Georgia Tech Research Corporation | Compositions and methods for logic-gated profiling of biologic activity |
| WO2020198151A1 (en) * | 2019-03-22 | 2020-10-01 | Spotlight Therapeutics | Targeted active gene editing agent and methods of use |
| CA3040645A1 (en) * | 2019-04-18 | 2020-10-18 | Feldan Bio Inc. | Peptide-based non-proteinaceous cargo delivery |
| WO2021050601A1 (en) * | 2019-09-09 | 2021-03-18 | Scribe Therapeutics Inc. | Compositions and methods for use in immunotherapy |
| WO2021152402A1 (en) * | 2020-01-29 | 2021-08-05 | Jenthera Therapeutics Inc. | Nuclease-scaffold composition delivery platform |
| CN111518168B (zh) * | 2020-03-30 | 2022-02-08 | 东北农业大学 | 一种衍生自肉食杆菌素的抗菌肽及其制备方法和应用 |
| CN115397843A (zh) * | 2020-04-15 | 2022-11-25 | 杭州卫本医药科技有限公司 | 用于筛选药物的靶标多肽和筛选方法 |
| CN115698036B (zh) * | 2020-05-28 | 2026-04-21 | 米托奎斯特有限公司 | 新型抗炎肽及其用途 |
| JP2023542867A (ja) | 2020-09-11 | 2023-10-12 | グリンプス バイオ， インコーポレイテッド | 疾患の検出／診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出 |
| JP2023545546A (ja) * | 2020-10-18 | 2023-10-30 | フェルダン・バイオ・インコーポレーテッド | 遺伝子発現調節のための非アニオン性ポリヌクレオチド類似体のペプチドに基づく導入 |
| AU2021366976A1 (en) * | 2020-10-22 | 2023-06-08 | Feldan Bio Inc. | Shuttle agent peptides of minimal length and variants thereof adapted for transduction of cas9-rnp and other nucleoprotein cargos |
| WO2022120423A1 (en) * | 2020-12-08 | 2022-06-16 | James Cook University | Peptides and uses thereof |
| MX2023009816A (es) * | 2021-02-24 | 2024-03-25 | Univ Jagiellonski | Una jaula de proteínas artificial que comprende una carga de huésped encapsulada en la misma. |
| JP2024511537A (ja) * | 2021-03-29 | 2024-03-13 | フェルダン・バイオ・インコーポレーテッド | 細胞内カーゴ送達のための合成ペプチドシャトル媒介物バイオコンジュゲート |
| CN113214355B (zh) * | 2021-04-09 | 2022-02-25 | 东北农业大学 | 一种专杀真菌的抗菌肽gl4w及其制备方法和应用 |
| CN114177306B (zh) * | 2021-07-16 | 2024-01-30 | 吉林医药学院 | 一种iNGR/R9双重修饰的阿霉素靶向脂质体及抗肿瘤活性评价 |
| JP2024537991A (ja) | 2021-10-14 | 2024-10-18 | アーセナル バイオサイエンシズ インコーポレイテッド | 共発現されるｓｈＲＮＡと論理ゲートシステムとを有する免疫細胞 |
| US20230158136A1 (en) * | 2021-11-24 | 2023-05-25 | Versitech Limited | Viral nucleic acid molecules, and compositions and methods of use thereof |
| CN114716569B (zh) * | 2022-04-13 | 2023-11-10 | 浙江大学 | 一种携带目标蛋白自主进入真核细胞的重组蛋白、重组表达载体和重组菌及应用 |
| CN116178519B (zh) * | 2022-08-09 | 2025-04-22 | 成都医学院 | 一种蜂毒肽糖肽及其制备方法和用途 |
| EP4651880A1 (en) * | 2023-01-17 | 2025-11-26 | Research Institute at Nationwide Children's Hospital | Methods of targeting glycogen synthase kinase 3 beta in nk cells |
| KR20250137596A (ko) | 2023-01-27 | 2025-09-18 | 도레이 카부시키가이샤 | 폴리아미드 복합 단면 섬유, 폴리아미드 멀티 필라멘트 및 폴리아미드 복합 단면 헛꼬임 가공사 |
| CN115974972B (zh) * | 2023-02-07 | 2023-08-29 | 安徽农业大学 | 一种防治猕猴桃溃疡病菌的抗菌肽、制备方法及其应用 |
| CN116375805B (zh) * | 2023-03-27 | 2023-09-08 | 中山大学附属口腔医院 | 一种兼具抗菌和成骨活性的多肽、其制剂及应用 |
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| WO2025106604A1 (en) * | 2023-11-14 | 2025-05-22 | The University Of North Carolina At Chapel Hill | Compositions and methods relating to antiviral therapeutics |
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| CN110291100B (zh) | 2016-10-12 | 2024-06-11 | 费尔丹生物公司 | 用于将多肽负荷从细胞外空间递送至靶真核细胞的胞质溶胶和/或细胞核的合理设计的合成肽穿梭剂，其用途、与其相关的方法和试剂盒 |
| US11629170B2 (en) | 2016-10-12 | 2023-04-18 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
| EP3597223A1 (en) | 2018-07-17 | 2020-01-22 | Centre National De La Recherche Scientifique | Peptides for use as cell-penetrating peptides |
| CA3040645A1 (en) | 2019-04-18 | 2020-10-18 | Feldan Bio Inc. | Peptide-based non-proteinaceous cargo delivery |
| JP2023545546A (ja) | 2020-10-18 | 2023-10-30 | フェルダン・バイオ・インコーポレーテッド | 遺伝子発現調節のための非アニオン性ポリヌクレオチド類似体のペプチドに基づく導入 |
| AU2021366976A1 (en) | 2020-10-22 | 2023-06-08 | Feldan Bio Inc. | Shuttle agent peptides of minimal length and variants thereof adapted for transduction of cas9-rnp and other nucleoprotein cargos |
| JP2024511537A (ja) | 2021-03-29 | 2024-03-13 | フェルダン・バイオ・インコーポレーテッド | 細胞内カーゴ送達のための合成ペプチドシャトル媒介物バイオコンジュゲート |
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2017
- 2017-10-11 CN CN201780076076.4A patent/CN110291100B/zh active Active
- 2017-10-11 EP EP25155395.4A patent/EP4556567A3/en active Pending
- 2017-10-11 EP EP17860971.5A patent/EP3526235A4/en not_active Withdrawn
- 2017-10-11 IL IL265920A patent/IL265920B2/en unknown
- 2017-10-11 CN CN202410666609.6A patent/CN118909050A/zh active Pending
- 2017-10-11 KR KR1020197013023A patent/KR102626671B1/ko active Active
- 2017-10-11 WO PCT/CA2017/051205 patent/WO2018068135A1/en not_active Ceased
- 2017-10-11 AU AU2017341736A patent/AU2017341736B2/en active Active
- 2017-10-11 CA CA3038839A patent/CA3038839A1/en active Pending
- 2017-10-11 JP JP2019519648A patent/JP7177047B2/ja active Active
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2022
- 2022-11-10 JP JP2022180534A patent/JP2023010788A/ja active Pending
- 2022-12-06 US US18/062,234 patent/US12286632B2/en active Active
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2024
- 2024-12-26 JP JP2024231097A patent/JP2025062600A/ja active Pending
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