JP2023547405A5 - - Google Patents

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Publication number
JP2023547405A5
JP2023547405A5 JP2023524767A JP2023524767A JP2023547405A5 JP 2023547405 A5 JP2023547405 A5 JP 2023547405A5 JP 2023524767 A JP2023524767 A JP 2023524767A JP 2023524767 A JP2023524767 A JP 2023524767A JP 2023547405 A5 JP2023547405 A5 JP 2023547405A5
Authority
JP
Japan
Prior art keywords
synthetic peptide
peptide shuttle
residues
hydrophobic
gnsn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023524767A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023547405A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CA2021/051490 external-priority patent/WO2022082315A1/en
Publication of JP2023547405A publication Critical patent/JP2023547405A/ja
Publication of JP2023547405A5 publication Critical patent/JP2023547405A5/ja
Pending legal-status Critical Current

Links

JP2023524767A 2020-10-22 2021-10-22 Cas9-RNP及び他の核タンパク質カーゴの形質導入のために適合された最小長のシャトル剤ペプチド及びそのバリアント Pending JP2023547405A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063104340P 2020-10-22 2020-10-22
US63/104,340 2020-10-22
PCT/CA2021/051490 WO2022082315A1 (en) 2020-10-22 2021-10-22 Shuttle agent peptides of minimal lengh and variants thereof adapted for transduction of cas9-rnp and other nucleoprotein cargos

Publications (2)

Publication Number Publication Date
JP2023547405A JP2023547405A (ja) 2023-11-10
JP2023547405A5 true JP2023547405A5 (https=) 2024-10-31

Family

ID=81291096

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023524767A Pending JP2023547405A (ja) 2020-10-22 2021-10-22 Cas9-RNP及び他の核タンパク質カーゴの形質導入のために適合された最小長のシャトル剤ペプチド及びそのバリアント

Country Status (9)

Country Link
US (1) US20230399661A1 (https=)
EP (1) EP4232590A4 (https=)
JP (1) JP2023547405A (https=)
KR (1) KR20230088828A (https=)
CN (1) CN116615227A (https=)
AU (1) AU2021366976A1 (https=)
CA (1) CA3196066A1 (https=)
IL (1) IL302227A (https=)
WO (1) WO2022082315A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110291100B (zh) 2016-10-12 2024-06-11 费尔丹生物公司 用于将多肽负荷从细胞外空间递送至靶真核细胞的胞质溶胶和/或细胞核的合理设计的合成肽穿梭剂,其用途、与其相关的方法和试剂盒
CA3040645A1 (en) 2019-04-18 2020-10-18 Feldan Bio Inc. Peptide-based non-proteinaceous cargo delivery
WO2024206311A1 (en) * 2023-03-31 2024-10-03 The Trustees Of The University Of Pennsylvania Hybrid antimicrobial peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2981716C (en) * 2015-04-10 2022-04-12 Feldan Bio Inc. Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same
CN110291100B (zh) * 2016-10-12 2024-06-11 费尔丹生物公司 用于将多肽负荷从细胞外空间递送至靶真核细胞的胞质溶胶和/或细胞核的合理设计的合成肽穿梭剂,其用途、与其相关的方法和试剂盒
CA3040645A1 (en) * 2019-04-18 2020-10-18 Feldan Bio Inc. Peptide-based non-proteinaceous cargo delivery

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