JP2019530699A5 - - Google Patents
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- Publication number
- JP2019530699A5 JP2019530699A5 JP2019518406A JP2019518406A JP2019530699A5 JP 2019530699 A5 JP2019530699 A5 JP 2019530699A5 JP 2019518406 A JP2019518406 A JP 2019518406A JP 2019518406 A JP2019518406 A JP 2019518406A JP 2019530699 A5 JP2019530699 A5 JP 2019530699A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- alkoxy
- substituted
- bicyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 80
- 229910052799 carbon Inorganic materials 0.000 claims 65
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 63
- 125000003545 alkoxy group Chemical group 0.000 claims 63
- 125000002950 monocyclic group Chemical group 0.000 claims 60
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 48
- 125000000623 heterocyclic group Chemical group 0.000 claims 45
- 125000001072 heteroaryl group Chemical group 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000005842 heteroatom Chemical group 0.000 claims 16
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 15
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 15
- 125000005843 halogen group Chemical group 0.000 claims 15
- 229910052757 nitrogen Inorganic materials 0.000 claims 15
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 15
- 229910052760 oxygen Inorganic materials 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 15
- 229910052717 sulfur Inorganic materials 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662405309P | 2016-10-07 | 2016-10-07 | |
| US62/405,309 | 2016-10-07 | ||
| PCT/US2017/054710 WO2018067432A1 (en) | 2016-10-07 | 2017-10-02 | Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019530699A JP2019530699A (ja) | 2019-10-24 |
| JP2019530699A5 true JP2019530699A5 (enExample) | 2020-11-12 |
| JP7097875B2 JP7097875B2 (ja) | 2022-07-08 |
Family
ID=60117794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518406A Active JP7097875B2 (ja) | 2016-10-07 | 2017-10-02 | Ｉｌ－１２、ｉｌ－２３および／またはｉｆｎアルファ応答の調節剤として有用なイミダゾピリダジン化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10836770B2 (enExample) |
| EP (1) | EP3523305B1 (enExample) |
| JP (1) | JP7097875B2 (enExample) |
| KR (1) | KR102531036B1 (enExample) |
| CN (1) | CN110036015B (enExample) |
| ES (1) | ES2902995T3 (enExample) |
| MA (1) | MA46453A (enExample) |
| WO (1) | WO2018067432A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201940483A (zh) | 2018-03-12 | 2019-10-16 | 美商艾伯維有限公司 | 酪胺酸激酶２介導的傳訊之抑制劑 |
| EP3849981B1 (en) | 2018-09-10 | 2023-02-01 | Eli Lilly and Company | Pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives useful in the treatment of psoriasis and systemic lupus erythematosus |
| US12084426B2 (en) * | 2018-09-13 | 2024-09-10 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
| CA3117200A1 (en) | 2018-10-22 | 2020-04-30 | Esker Therapeutics, Inc. | Tyk2 inhibitors and uses thereof |
| BR112021008675A2 (pt) | 2018-11-05 | 2021-08-10 | Syngenta Participations Ag | compostos de azole-amida pesticidamente ativos |
| TWI800696B (zh) | 2018-12-10 | 2023-05-01 | 美商美國禮來大藥廠 | 7-(甲基胺基)吡唑并[1,5-a]嘧啶-3-甲醯胺衍生物 |
| CN113348021B (zh) * | 2019-01-23 | 2025-07-11 | 武田药品工业株式会社 | Tyk2抑制剂和其用途 |
| WO2020182649A1 (en) | 2019-03-08 | 2020-09-17 | Syngenta Crop Protection Ag | Pesticidally active azole-amide compounds |
| JP7549601B2 (ja) | 2019-03-20 | 2024-09-11 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物活性アゾールアミド化合物 |
| WO2020193341A1 (en) | 2019-03-22 | 2020-10-01 | Syngenta Crop Protection Ag | N-[1-(5-bromo-2-pyrimidin-2-yl-1,2,4-triazol-3-yl)ethyl]-2-cyclopropyl-6-(trifluoromethyl)pyridine-4-carboxamide derivatives and related compounds as insecticides |
| CA3138473A1 (en) | 2019-04-30 | 2020-11-05 | Celgene Corporation | Combination therapies comprising apremilast and tyk2 inhibitors |
| JP7375214B2 (ja) | 2020-02-12 | 2023-11-07 | イーライ リリー アンド カンパニー | 置換７－（メチルアミノ）ピラゾロ［１，５－ａ］ピリミジン－３－カルボキサミド誘導体 |
| TWI810520B (zh) | 2020-02-12 | 2023-08-01 | 美商美國禮來大藥廠 | 7-(甲基胺基)吡唑并[1,5-a]嘧啶-3-甲醯胺化合物 |
| EP3944859A1 (en) | 2020-07-30 | 2022-02-02 | Assistance Publique Hôpitaux de Paris | Method for treating immune toxicities induced by immune checkpoint inhibitors |
| WO2022037694A1 (zh) * | 2020-08-20 | 2022-02-24 | 轶诺(浙江)药业有限公司 | 一类五元并六元杂环化合物及其作为蛋白受体激酶抑制剂的用途 |
| IL301385A (en) * | 2020-09-16 | 2023-05-01 | Alumis Inc | TYK2 inhibitors and their use |
| WO2022193499A1 (en) | 2021-03-16 | 2022-09-22 | Anrui Biomedical Technology (Guangzhou) Co., Ltd. | Amino heteroaryl compounds and compositions |
| MX2024004993A (es) | 2021-10-25 | 2024-05-07 | Kymera Therapeutics Inc | Agentes degradantes de la proteina tirosina cinasa 2 (tyk2) y usos de los mismos. |
| CN116655636A (zh) * | 2022-02-17 | 2023-08-29 | 上海轶诺药业有限公司 | 一类五元并六元杂环化合物及其作为蛋白激酶抑制剂的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7176214B2 (en) | 2003-05-21 | 2007-02-13 | Bristol-Myers Squibb Company | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same |
| US8389527B2 (en) | 2008-02-06 | 2013-03-05 | Bristol-Myers Squibb Company | Substituted imidazopyridazines useful as kinase inhibitors |
| JP6073343B2 (ja) * | 2011-10-20 | 2017-02-01 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ |
| EP3080131B1 (en) * | 2013-12-10 | 2018-10-10 | Bristol-Myers Squibb Company | Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses |
| KR102782807B1 (ko) * | 2015-11-18 | 2025-03-14 | 브리스톨-마이어스 스큅 컴퍼니 | Il-12, il-23 및/또는 ifn 알파 반응의 조정제로서 유용한 이미다조피리다진 화합물 |
-
2017
- 2017-10-02 CN CN201780075174.6A patent/CN110036015B/zh active Active
- 2017-10-02 EP EP17784774.6A patent/EP3523305B1/en active Active
- 2017-10-02 MA MA046453A patent/MA46453A/fr unknown
- 2017-10-02 US US16/339,744 patent/US10836770B2/en active Active
- 2017-10-02 WO PCT/US2017/054710 patent/WO2018067432A1/en not_active Ceased
- 2017-10-02 JP JP2019518406A patent/JP7097875B2/ja active Active
- 2017-10-02 ES ES17784774T patent/ES2902995T3/es active Active
- 2017-10-02 KR KR1020197012692A patent/KR102531036B1/ko active Active