MA46453A - Composés imidazopyridazine utiles en tant que modulateurs de réponses il-12, il-23 et/ou ifn alpha - Google Patents
Composés imidazopyridazine utiles en tant que modulateurs de réponses il-12, il-23 et/ou ifn alphaInfo
- Publication number
- MA46453A MA46453A MA046453A MA46453A MA46453A MA 46453 A MA46453 A MA 46453A MA 046453 A MA046453 A MA 046453A MA 46453 A MA46453 A MA 46453A MA 46453 A MA46453 A MA 46453A
- Authority
- MA
- Morocco
- Prior art keywords
- compounds useful
- ifn alpha
- response modulators
- alpha response
- imidazopyridazine compounds
- Prior art date
Links
- 150000005233 imidazopyridazines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662405309P | 2016-10-07 | 2016-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA46453A true MA46453A (fr) | 2019-08-14 |
Family
ID=60117794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA046453A MA46453A (fr) | 2016-10-07 | 2017-10-02 | Composés imidazopyridazine utiles en tant que modulateurs de réponses il-12, il-23 et/ou ifn alpha |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10836770B2 (enExample) |
| EP (1) | EP3523305B1 (enExample) |
| JP (1) | JP7097875B2 (enExample) |
| KR (1) | KR102531036B1 (enExample) |
| CN (1) | CN110036015B (enExample) |
| ES (1) | ES2902995T3 (enExample) |
| MA (1) | MA46453A (enExample) |
| WO (1) | WO2018067432A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6557436B1 (ja) | 2018-03-12 | 2019-08-07 | アッヴィ・インコーポレイテッド | チロシンキナーゼ２媒介性シグナル伝達の阻害剤 |
| US11891400B2 (en) | 2018-09-10 | 2024-02-06 | Eli Lilly And Company | Pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives useful in the treatment of psoriasis and systemic lupus erythematosus |
| ES2945220T3 (es) * | 2018-09-13 | 2023-06-29 | Bristol Myers Squibb Co | Indazol carboxamidas como inhibidores de cinasas |
| BR112021007679A2 (pt) | 2018-10-22 | 2021-07-27 | Esker Therapeutics, Inc | inibidores de tyk2 e seus usos |
| JP2022509019A (ja) | 2018-11-05 | 2022-01-20 | シンジェンタ パーティシペーションズ アーゲー | 殺有害生物的に活性なアゾール－アミド化合物 |
| TWI800696B (zh) | 2018-12-10 | 2023-05-01 | 美商美國禮來大藥廠 | 7-(甲基胺基)吡唑并[1,5-a]嘧啶-3-甲醯胺衍生物 |
| WO2020154474A1 (en) | 2019-01-23 | 2020-07-30 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| ES2953140T3 (es) | 2019-03-08 | 2023-11-08 | Syngenta Crop Protection Ag | Compuestos de azol-amida activos de manera plaguicida |
| WO2020188014A1 (en) | 2019-03-20 | 2020-09-24 | Syngenta Crop Protection Ag | Pesticidally active azole amide compounds |
| CN113597426A (zh) | 2019-03-22 | 2021-11-02 | 先正达农作物保护股份公司 | N-[1-(5-溴-2-嘧啶-2-基-1,2,4-三唑-3-基)乙基]-2-环丙基-6-(三氟甲基)吡啶-4-甲酰胺衍生物及相关的化合物作为杀昆虫剂 |
| AU2019443366A1 (en) | 2019-04-30 | 2021-12-02 | Celgene Corporation | Combination therapies comprising apremilast and Tyk2 inhibitors |
| AR121251A1 (es) | 2020-02-12 | 2022-05-04 | Lilly Co Eli | Compuestos de 7-(metilamino)pirazolo[1,5-a]pirimidina-3-carboxamida |
| EP3944859A1 (en) | 2020-07-30 | 2022-02-02 | Assistance Publique Hôpitaux de Paris | Method for treating immune toxicities induced by immune checkpoint inhibitors |
| WO2022037694A1 (zh) * | 2020-08-20 | 2022-02-24 | 轶诺(浙江)药业有限公司 | 一类五元并六元杂环化合物及其作为蛋白受体激酶抑制剂的用途 |
| JP2023541203A (ja) * | 2020-09-16 | 2023-09-28 | アルミス インコーポレイテッド | Ｔｙｋ２阻害剤およびその使用 |
| CN117083268B (zh) | 2021-03-16 | 2024-07-30 | 安锐生物医药科技(广州)有限公司 | 氨基杂芳基化合物和组合物 |
| WO2023076161A1 (en) | 2021-10-25 | 2023-05-04 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
| CN116655636A (zh) * | 2022-02-17 | 2023-08-29 | 上海轶诺药业有限公司 | 一类五元并六元杂环化合物及其作为蛋白激酶抑制剂的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7176214B2 (en) | 2003-05-21 | 2007-02-13 | Bristol-Myers Squibb Company | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same |
| JP5394404B2 (ja) * | 2008-02-06 | 2014-01-22 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用な置換イミダゾピリダジン類 |
| CN104394869A (zh) * | 2011-10-20 | 2015-03-04 | 葛兰素史密斯克莱有限责任公司 | 用作沉默调节蛋白调节剂的取代的双环氮杂杂环化合物和类似物 |
| ES2702126T3 (es) * | 2013-12-10 | 2019-02-27 | Bristol Myers Squibb Co | Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa |
| KR102782807B1 (ko) * | 2015-11-18 | 2025-03-14 | 브리스톨-마이어스 스큅 컴퍼니 | Il-12, il-23 및/또는 ifn 알파 반응의 조정제로서 유용한 이미다조피리다진 화합물 |
-
2017
- 2017-10-02 MA MA046453A patent/MA46453A/fr unknown
- 2017-10-02 ES ES17784774T patent/ES2902995T3/es active Active
- 2017-10-02 KR KR1020197012692A patent/KR102531036B1/ko active Active
- 2017-10-02 US US16/339,744 patent/US10836770B2/en active Active
- 2017-10-02 EP EP17784774.6A patent/EP3523305B1/en active Active
- 2017-10-02 CN CN201780075174.6A patent/CN110036015B/zh active Active
- 2017-10-02 WO PCT/US2017/054710 patent/WO2018067432A1/en not_active Ceased
- 2017-10-02 JP JP2019518406A patent/JP7097875B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3523305B1 (en) | 2021-12-08 |
| US20190225620A1 (en) | 2019-07-25 |
| JP2019530699A (ja) | 2019-10-24 |
| JP7097875B2 (ja) | 2022-07-08 |
| CN110036015A (zh) | 2019-07-19 |
| EP3523305A1 (en) | 2019-08-14 |
| CN110036015B (zh) | 2022-07-19 |
| KR20190057132A (ko) | 2019-05-27 |
| WO2018067432A1 (en) | 2018-04-12 |
| ES2902995T3 (es) | 2022-03-30 |
| US10836770B2 (en) | 2020-11-17 |
| KR102531036B1 (ko) | 2023-05-09 |
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