CN110036015B - 可用作IL-12、IL-23和/或IFNα应答的调节剂的咪唑并哒嗪化合物 - Google Patents

可用作IL-12、IL-23和/或IFNα应答的调节剂的咪唑并哒嗪化合物 Download PDF

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Publication number
CN110036015B
CN110036015B CN201780075174.6A CN201780075174A CN110036015B CN 110036015 B CN110036015 B CN 110036015B CN 201780075174 A CN201780075174 A CN 201780075174A CN 110036015 B CN110036015 B CN 110036015B
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alkyl
cycloalkyl
compound
pharmaceutically acceptable
methyl
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CN110036015A (zh
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S·H·什派尔盖
M·E·默茨曼
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201780075174.6A 2016-10-07 2017-10-02 可用作IL-12、IL-23和/或IFNα应答的调节剂的咪唑并哒嗪化合物 Active CN110036015B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662405309P 2016-10-07 2016-10-07
US62/405,309 2016-10-07
PCT/US2017/054710 WO2018067432A1 (en) 2016-10-07 2017-10-02 Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses

Publications (2)

Publication Number Publication Date
CN110036015A CN110036015A (zh) 2019-07-19
CN110036015B true CN110036015B (zh) 2022-07-19

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CN201780075174.6A Active CN110036015B (zh) 2016-10-07 2017-10-02 可用作IL-12、IL-23和/或IFNα应答的调节剂的咪唑并哒嗪化合物

Country Status (8)

Country Link
US (1) US10836770B2 (enExample)
EP (1) EP3523305B1 (enExample)
JP (1) JP7097875B2 (enExample)
KR (1) KR102531036B1 (enExample)
CN (1) CN110036015B (enExample)
ES (1) ES2902995T3 (enExample)
MA (1) MA46453A (enExample)
WO (1) WO2018067432A1 (enExample)

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AR117398A1 (es) 2018-03-12 2021-08-04 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa 2
US11891400B2 (en) 2018-09-10 2024-02-06 Eli Lilly And Company Pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives useful in the treatment of psoriasis and systemic lupus erythematosus
CN112673001B (zh) * 2018-09-13 2024-06-25 百时美施贵宝公司 作为激酶抑制剂的吲唑甲酰胺
KR102850357B1 (ko) 2018-10-22 2025-08-27 알루미스 인크. Tyk2 억제제 및 이의 용도
CN120699009A (zh) 2018-11-05 2025-09-26 先正达农作物保护股份公司 杀有害生物活性的唑-酰胺化合物
TWI800696B (zh) 2018-12-10 2023-05-01 美商美國禮來大藥廠 7-(甲基胺基)吡唑并[1,5-a]嘧啶-3-甲醯胺衍生物
CA3126034A1 (en) * 2019-01-23 2020-07-30 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
BR112021017646A2 (pt) 2019-03-08 2021-11-16 Syngenta Crop Protection Ag Compostos de azol-amida ativos em termos pesticidas
WO2020188014A1 (en) 2019-03-20 2020-09-24 Syngenta Crop Protection Ag Pesticidally active azole amide compounds
CN113597426A (zh) 2019-03-22 2021-11-02 先正达农作物保护股份公司 N-[1-(5-溴-2-嘧啶-2-基-1,2,4-三唑-3-基)乙基]-2-环丙基-6-(三氟甲基)吡啶-4-甲酰胺衍生物及相关的化合物作为杀昆虫剂
KR20220002488A (ko) 2019-04-30 2022-01-06 셀진 코포레이션 아프레밀라스트 및 tyk2 억제제를 포함하는 조합 요법
AR121251A1 (es) 2020-02-12 2022-05-04 Lilly Co Eli Compuestos de 7-(metilamino)pirazolo[1,5-a]pirimidina-3-carboxamida
EP3944859A1 (en) 2020-07-30 2022-02-02 Assistance Publique Hôpitaux de Paris Method for treating immune toxicities induced by immune checkpoint inhibitors
WO2022037694A1 (zh) * 2020-08-20 2022-02-24 轶诺(浙江)药业有限公司 一类五元并六元杂环化合物及其作为蛋白受体激酶抑制剂的用途
AU2021345181A1 (en) * 2020-09-16 2023-05-04 Alumis Inc Tyk2 inhibitors and uses thereof
US20240246944A1 (en) 2021-03-16 2024-07-25 Anrui Biomedical Technology (Guangzhou) Co., Ltd. Amino heteroaryl compounds and compositions
US20250051338A1 (en) 2021-10-25 2025-02-13 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
CN116655636A (zh) * 2022-02-17 2023-08-29 上海轶诺药业有限公司 一类五元并六元杂环化合物及其作为蛋白激酶抑制剂的用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101981033A (zh) * 2008-02-06 2011-02-23 百时美施贵宝公司 用作激酶抑制剂的取代的咪唑并哒嗪化合物
CN105992768A (zh) * 2013-12-10 2016-10-05 百时美施贵宝公司 用作IL-12、IL-23和/或IFNα响应的调节剂的咪唑并哒嗪化合物
CN108473500A (zh) * 2015-11-18 2018-08-31 百时美施贵宝公司 用作IL-12、IL-23和/或IFNα响应的调节剂的咪唑并哒嗪化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176214B2 (en) 2003-05-21 2007-02-13 Bristol-Myers Squibb Company Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
CN104394869A (zh) 2011-10-20 2015-03-04 葛兰素史密斯克莱有限责任公司 用作沉默调节蛋白调节剂的取代的双环氮杂杂环化合物和类似物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101981033A (zh) * 2008-02-06 2011-02-23 百时美施贵宝公司 用作激酶抑制剂的取代的咪唑并哒嗪化合物
CN105992768A (zh) * 2013-12-10 2016-10-05 百时美施贵宝公司 用作IL-12、IL-23和/或IFNα响应的调节剂的咪唑并哒嗪化合物
CN108473500A (zh) * 2015-11-18 2018-08-31 百时美施贵宝公司 用作IL-12、IL-23和/或IFNα响应的调节剂的咪唑并哒嗪化合物

Also Published As

Publication number Publication date
CN110036015A (zh) 2019-07-19
JP2019530699A (ja) 2019-10-24
EP3523305B1 (en) 2021-12-08
US20190225620A1 (en) 2019-07-25
JP7097875B2 (ja) 2022-07-08
ES2902995T3 (es) 2022-03-30
WO2018067432A1 (en) 2018-04-12
KR102531036B1 (ko) 2023-05-09
MA46453A (fr) 2019-08-14
KR20190057132A (ko) 2019-05-27
EP3523305A1 (en) 2019-08-14
US10836770B2 (en) 2020-11-17

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