JP2019530656A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019530656A5 JP2019530656A5 JP2019511707A JP2019511707A JP2019530656A5 JP 2019530656 A5 JP2019530656 A5 JP 2019530656A5 JP 2019511707 A JP2019511707 A JP 2019511707A JP 2019511707 A JP2019511707 A JP 2019511707A JP 2019530656 A5 JP2019530656 A5 JP 2019530656A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- och
- optionally substituted
- absent
- terminal nucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 55
- 239000002773 nucleotide Substances 0.000 claims 30
- 125000003729 nucleotide group Chemical group 0.000 claims 28
- 239000002777 nucleoside Substances 0.000 claims 21
- -1 nucleoside phosphoramidite Chemical class 0.000 claims 21
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 18
- 229910052717 sulfur Inorganic materials 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 108010024636 Glutathione Proteins 0.000 claims 9
- 229960003180 glutathione Drugs 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 125000006239 protecting group Chemical group 0.000 claims 8
- 108091081021 Sense strand Proteins 0.000 claims 7
- 230000000692 anti-sense effect Effects 0.000 claims 7
- ONIKNECPXCLUHT-UHFFFAOYSA-N 2-chlorobenzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1Cl ONIKNECPXCLUHT-UHFFFAOYSA-N 0.000 claims 6
- 108091030071 RNAI Proteins 0.000 claims 6
- 230000009368 gene silencing by RNA Effects 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 5
- 150000008300 phosphoramidites Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229940124447 delivery agent Drugs 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229910052711 selenium Inorganic materials 0.000 claims 4
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 125000003843 furanosyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- NBSCHQHZLSJFNQ-QTVWNMPRSA-N D-Mannose-6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O NBSCHQHZLSJFNQ-QTVWNMPRSA-N 0.000 claims 1
- SMEROWZSTRWXGI-UHFFFAOYSA-N Lithocholsaeure Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 SMEROWZSTRWXGI-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical group CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- SMEROWZSTRWXGI-HVATVPOCSA-N lithocholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 SMEROWZSTRWXGI-HVATVPOCSA-N 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 235000019155 vitamin A Nutrition 0.000 claims 1
- 239000011719 vitamin A Substances 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- 229940045997 vitamin a Drugs 0.000 claims 1
- 0 BC(C(*)C1O*)OC1OCP(*)(*)=O Chemical compound BC(C(*)C1O*)OC1OCP(*)(*)=O 0.000 description 8
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021180199A JP2022017481A (ja) | 2016-09-02 | 2021-11-04 | ４’－リン酸アナログ及びそれを含むオリゴヌクレオチド |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662383207P | 2016-09-02 | 2016-09-02 | |
| US62/383,207 | 2016-09-02 | ||
| US201662393401P | 2016-09-12 | 2016-09-12 | |
| US62/393,401 | 2016-09-12 | ||
| PCT/US2017/049909 WO2018045317A1 (en) | 2016-09-02 | 2017-09-01 | 4'-phosphate analogs and oligonucleotides comprising the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021180199A Division JP2022017481A (ja) | 2016-09-02 | 2021-11-04 | ４’－リン酸アナログ及びそれを含むオリゴヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019530656A JP2019530656A (ja) | 2019-10-24 |
| JP2019530656A5 true JP2019530656A5 (enExample) | 2020-04-09 |
| JP6978099B2 JP6978099B2 (ja) | 2021-12-08 |
Family
ID=61301649
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511707A Active JP6978099B2 (ja) | 2016-09-02 | 2017-09-01 | ４’−リン酸アナログ及びそれを含むオリゴヌクレオチド |
| JP2021180199A Withdrawn JP2022017481A (ja) | 2016-09-02 | 2021-11-04 | ４’－リン酸アナログ及びそれを含むオリゴヌクレオチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021180199A Withdrawn JP2022017481A (ja) | 2016-09-02 | 2021-11-04 | ４’－リン酸アナログ及びそれを含むオリゴヌクレオチド |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11414659B2 (enExample) |
| EP (2) | EP4101859A1 (enExample) |
| JP (2) | JP6978099B2 (enExample) |
| KR (2) | KR102493872B1 (enExample) |
| CN (1) | CN110072530B (enExample) |
| AU (1) | AU2017321892A1 (enExample) |
| CA (1) | CA3033756A1 (enExample) |
| DK (1) | DK3506909T3 (enExample) |
| ES (1) | ES2924806T3 (enExample) |
| HU (1) | HUE059718T2 (enExample) |
| IL (2) | IL264887B (enExample) |
| MX (1) | MX2019002339A (enExample) |
| PL (1) | PL3506909T3 (enExample) |
| PT (1) | PT3506909T (enExample) |
| WO (1) | WO2018045317A1 (enExample) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2644247C2 (ru) * | 2013-03-15 | 2018-02-08 | Борд оф Риджентс, Дзе Юниверсити оф Тексас Систем | Использование биогенеза микрорнк в экзосомах для диагностики и лечения |
| SG11202003126VA (en) | 2017-10-04 | 2020-05-28 | Avidity Biosciences Inc | Nucleic acid-polypeptide compositions and uses thereof |
| EP3710588A4 (en) | 2018-01-16 | 2021-08-18 | Dicerna Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS TO INHIBIT ALDH2 EXPRESSION |
| CN111971051A (zh) | 2018-04-13 | 2020-11-20 | 迪克纳制药公司 | 用增加tm的核苷酸修饰的双链核酸抑制剂分子 |
| JP7535047B2 (ja) * | 2018-12-12 | 2024-08-15 | ディセルナ ファーマシューティカルズ インコーポレイテッド | トリループを含む二本鎖核酸インヒビター分子 |
| IL284327B2 (en) * | 2018-12-28 | 2024-11-01 | Dicerna Pharmaceuticals Inc | Compositions and methods for inhibiting hmgb1 expression |
| WO2020205473A1 (en) | 2019-03-29 | 2020-10-08 | Decerna Pharmaceuticals, Inc. | Compositions and methods for the treatment of kras associated diseases or disorders |
| AU2020252560A1 (en) | 2019-04-04 | 2021-10-28 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting gene expression in the central nervous system |
| WO2020226960A1 (en) | 2019-05-03 | 2020-11-12 | Dicerna Pharmaceuticals, Inc. | Double-stranded nucleic acid inhibitor molecules with shortened sense strands |
| WO2020236600A1 (en) | 2019-05-17 | 2020-11-26 | Alnylam Pharmaceuticals, Inc. | Oral delivery of oligonucleotides |
| WO2020247782A1 (en) * | 2019-06-06 | 2020-12-10 | Avidity Biosciences, Inc. | Nucleic acid-polypeptide compositions and uses thereof |
| TW202140043A (zh) * | 2020-01-15 | 2021-11-01 | 美商戴瑟納製藥股份有限公司 | 4’-o-亞甲基膦酸酯核酸及其類似物 |
| JP2023515664A (ja) | 2020-03-06 | 2023-04-13 | アリゴス セラピューティクス，インコーポレーテッド | 修飾された短い干渉核酸（ｓｉＮＡ）分子およびそれらの使用 |
| CA3172117A1 (en) | 2020-03-18 | 2021-09-23 | Bob D. Brown | Compositions and methods for inhibiting angptl3 expression |
| TW202204619A (zh) | 2020-04-10 | 2022-02-01 | 美商艾利格斯醫療公司 | 短干擾核酸(siNA)分子及其用於冠狀病毒疾病之用途 |
| MX2023001450A (es) | 2020-08-04 | 2023-04-14 | Dicerna Pharmaceuticals Inc | Composiciones y metodos para la inhibicion de la expresion de plp1. |
| TW202221120A (zh) | 2020-08-04 | 2022-06-01 | 美商黛瑟納製藥公司 | 用於治療代謝症候群之組成物及方法 |
| JP2023537499A (ja) | 2020-08-04 | 2023-09-01 | ディセルナ ファーマシューティカルズ インコーポレイテッド | オリゴヌクレオチドの全身送達 |
| JP2023536999A (ja) | 2020-08-05 | 2023-08-30 | エフ． ホフマン－ラ ロシュ アーゲー | Ｂ型肝炎患者のオリゴヌクレオチド処置 |
| KR20250077604A (ko) | 2020-08-05 | 2025-05-30 | 다이서나 파마수이티컬, 인크. | Lpa 발현을 저해하기 위한 조성물 및 방법 |
| TW202228729A (zh) | 2020-10-08 | 2022-08-01 | 美商戴瑟納製藥股份有限公司 | 選擇性遞送寡核苷酸至膠細胞 |
| IL305634A (en) | 2021-03-05 | 2023-11-01 | Dicerna Pharmaceuticals Inc | Rnai conjugates and uses thereof |
| MX2023012048A (es) | 2021-04-12 | 2023-10-23 | Boehringer Ingelheim Int | Composiciones y metodos para inhibir cetohexoquinasa (khk). |
| KR20230171431A (ko) | 2021-04-14 | 2023-12-20 | 다이서나 파마수이티컬, 인크. | Pnpla3 발현을 조절하기 위한 조성물 및 방법 |
| IL307154A (en) | 2021-04-19 | 2023-11-01 | Novo Nordisk As | Compositions and methods for inhibiting nuclear receptor subfamily 1 group h member 3 (nr1h3) expression |
| US11655473B2 (en) | 2021-05-28 | 2023-05-23 | Novo Nordisk A/S | Compositions and methods for inhibiting mitochondria amidoxime reducing component 1 (MARC1) expression |
| PE20250353A1 (es) | 2021-06-24 | 2025-02-06 | Lilly Co Eli | Terapeutica con arn novedosos y usos de estos |
| CA3227661A1 (en) | 2021-08-05 | 2023-02-09 | Weimin Wang | 1'-alkyl modified ribose derivatives and methods of use |
| KR20240046843A (ko) | 2021-08-25 | 2024-04-11 | 노보 노르디스크 에이/에스 | 알파-1 항트립신 발현을 억제하기 위한 조성물 및 방법 |
| KR20240099159A (ko) | 2021-09-08 | 2024-06-28 | 알리고스 테라퓨틱스 인코포레이티드 | 변형된 짧은 간섭 핵산(sina) 분자 및 이의 용도 |
| CA3230382A1 (en) | 2021-09-08 | 2023-03-16 | Aligos Therapeutics, Inc. | Modified short interfering nucleic acid (sina) molecules and uses thereof |
| CA3233113A1 (en) | 2021-09-22 | 2023-03-30 | Sanegene Bio Usa Inc. | 2'-alkyl or 3'-alkyl modified ribose derivatives for use in the in-vivo delivery of oligonucleotides |
| US20230227480A1 (en) | 2021-10-05 | 2023-07-20 | Sanegene Bio Usa Inc. | Polyhydroxylated cyclopentane derivatives and methods of use |
| JP7877458B2 (ja) | 2021-12-01 | 2026-06-22 | ディセルナ ファーマシューティカルズ インコーポレイテッド | Ａｐｏｃ３発現を調節するための組成物及び方法 |
| EP4201947A1 (en) | 2021-12-22 | 2023-06-28 | F. Hoffmann-La Roche AG | Process for the backbone deprotection of oligonucleotides containing a terminal alkyl phosphonate group |
| CN119320418A (zh) * | 2022-01-05 | 2025-01-17 | 大睿生物医药科技(上海)有限公司 | 具有核苷酸类似物的双链rna |
| IL314850A (en) | 2022-02-22 | 2024-10-01 | Sanegene Bio Usa Inc | Ribonucleotide derivatives substituted at the 5' position in the carboxyl group and methods of use |
| WO2023177866A1 (en) | 2022-03-18 | 2023-09-21 | Dicerna Pharmaceuticals, Inc. | Decarboxylative acetoxylation using mn(ii) or mn(iii) reagent for synthesis of 4'-acetoxy- nucleoside and use thereof for synthesis of corresponding 4'-(dimethoxyphosphoryl)methoxy- nucleotide |
| JP2025512445A (ja) | 2022-04-15 | 2025-04-17 | ディセルナ ファーマシューティカルズ インコーポレイテッド | Ｓｃａｐ活性を調節するための組成物及び方法 |
| TW202400790A (zh) * | 2022-04-26 | 2024-01-01 | 大陸商上海拓界生物醫藥科技有限公司 | 氘代化學修飾和包含其的寡核苷酸 |
| US20240002857A1 (en) | 2022-05-09 | 2024-01-04 | Sanegene Bio Usa Inc. | Double stranded rna targeting 17-beta hydroxysteroiddehydrogenase 13 (hsd17b13) and methods of use thereof |
| CA3247389A1 (en) | 2022-05-12 | 2023-11-16 | Dicerna Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING THE EXPRESSION OF MAPT |
| JP2025518507A (ja) | 2022-05-13 | 2025-06-17 | ディセルナ ファーマシューティカルズ インコーポレイテッド | Ｓｎｃａの発現を阻害するための組成物及び方法 |
| TWI868755B (zh) | 2022-06-24 | 2025-01-01 | 丹麥商諾佛 儂迪克股份有限公司 | 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法 |
| IL317824A (en) | 2022-07-11 | 2025-02-01 | Sanegene Bio Usa Inc | Ribose derivatives modified at the '2' position and methods of use |
| WO2024031101A1 (en) | 2022-08-05 | 2024-02-08 | Sanegene Bio Usa Inc. | Double stranded rna targeting angiotensinogen (agt) and methods of use thereof |
| US20260049309A1 (en) | 2022-08-15 | 2026-02-19 | Novo Nordisk A/S | Regulation of activity of rnai molecules |
| TW202430191A (zh) | 2022-10-11 | 2024-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於治療伴有晚期纖維化及/或硬化之nash的方法 |
| TW202430192A (zh) | 2022-10-11 | 2024-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於治療nash之劑量方案 |
| WO2024081954A2 (en) | 2022-10-14 | 2024-04-18 | Sanegene Bio Usa Inc. | Small interfering rna targeting c3 and uses thereof |
| TW202430637A (zh) | 2022-11-16 | 2024-08-01 | 美商戴瑟納製藥股份有限公司 | Stat3靶向性寡核苷酸及其用途 |
| JP7812495B2 (ja) * | 2022-11-23 | 2026-02-09 | イーライ リリー アンド カンパニー | ４’－ホスフェート類似体ヌクレオチドホスホラミダイトを合成する方法 |
| EP4635967A1 (en) * | 2022-12-13 | 2025-10-22 | Tuojie Biotech (Shanghai) Co., Ltd. | Oligonucleotide comprising lipophilic monomer and use thereof in non-liver delivery |
| JP2025542234A (ja) | 2022-12-19 | 2025-12-25 | セーンジーン バイオ ユーエスエー インコーポレイティド | 低分子干渉ｒｎａ標的化ｃｆｂ及びその使用 |
| AR131419A1 (es) | 2022-12-21 | 2025-03-19 | Lilly Co Eli | TERAPÉUTICOS NOVEDOSOS DE iARN DE FAS Y USOS DE ESTOS |
| WO2024138111A1 (en) | 2022-12-23 | 2024-06-27 | Eli Lilly And Company | Novel rna therapeutics and uses thereof |
| US20260209772A1 (en) | 2022-12-23 | 2026-07-23 | Eli Lilly And Company | Novel rna therapeutics and uses thereof |
| CN118271378A (zh) * | 2022-12-29 | 2024-07-02 | 中国科学院深圳先进技术研究院 | 一种糖环修饰的核苷亚磷酰胺单体及其制备方法和应用 |
| US20240309383A1 (en) | 2023-02-24 | 2024-09-19 | Suzhou Sanegene Bio Inc. | Small interfering rna targeting hbv and uses thereof |
| WO2024186673A2 (en) | 2023-03-03 | 2024-09-12 | Sanegene Bio Usa Inc. | Small interfering rna targeting apoc3 and uses thereof |
| IL323663A (en) * | 2023-04-06 | 2025-11-01 | Shanghai Argo Biopharmaceutical Co Ltd | Nucleoside analog for 5'-phosphonate modification and oligonucleotide prepared therefrom |
| WO2024227059A2 (en) | 2023-04-27 | 2024-10-31 | Aligos Therapeutics, Inc. | Short interfering nucleic acid (sina) molecules targeting angptl 3 and angptl 8 and methods of using the same |
| TW202539695A (zh) | 2023-05-08 | 2025-10-16 | 美商美國禮來大藥廠 | 使用環磷核苷的寡核苷酸合成法 |
| WO2024233864A2 (en) | 2023-05-10 | 2024-11-14 | Dicerna Pharmaceuticals, Inc. | Galnac-conjugated rnai oligonucleotides |
| JP2026518345A (ja) | 2023-05-26 | 2026-06-05 | イーライ リリー アンド カンパニー | 新規ＳＣＮ１０Ａ ＲＮＡｉ剤及びその使用 |
| KR20260020955A (ko) | 2023-05-31 | 2026-02-12 | 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 | LPA를 표적화하는 dsRNA 및 이의 응용 |
| WO2024259190A2 (en) * | 2023-06-15 | 2024-12-19 | Alnylam Pharmaceuticals, Inc. | 5'-modified monomers, oligonucleotides and double-stranded rnas |
| JP2026522625A (ja) | 2023-06-21 | 2026-07-08 | セーンジーン バイオ ユーエスエー インコーポレイティド | プロタンパク質転換酵素サブチリシン・ケキシン９型（ｐｃｓｋ９）を標的とする二本鎖ｒｎａ、およびその使用方法 |
| AU2024301344A1 (en) | 2023-07-24 | 2026-01-29 | Sanegene Bio Usa Inc. | Lipid-based enhancement agent for rna delivery and therapy |
| TW202511486A (zh) | 2023-07-28 | 2025-03-16 | 美商黛瑟納製藥公司 | 用於程式化死亡配體受體（ｐｄ－ｌ１）表現之組成物和方法 |
| WO2025038971A1 (en) * | 2023-08-17 | 2025-02-20 | Adarx Pharmaceuticals, Inc. | Oligonucleotides containing a ligand at a nucleobase, 2' position, or 3' position |
| WO2025054459A1 (en) | 2023-09-08 | 2025-03-13 | Dicerna Pharmaceuticals, Inc. | Rnai oligonucleotide conjugates |
| WO2025228441A2 (en) | 2024-04-30 | 2025-11-06 | Sanegene Bio Usa Inc. | Small interfering rna targeting inhbe and uses thereof |
| WO2025250605A1 (en) | 2024-05-31 | 2025-12-04 | Eli Lilly And Company | Acvr2a and acvr2b rna interference agents |
| WO2025260011A1 (en) * | 2024-06-14 | 2025-12-18 | Alnylam Pharmaceuticals, Inc. | 5'-modified monomers, oligonucleotides and double-stranded rnas |
| WO2025259992A1 (en) * | 2024-06-14 | 2025-12-18 | Alnylam Pharmaceuticals, Inc. | 5'-modified monomers, oligonucleotides and double-stranded rnas |
| WO2025264948A2 (en) | 2024-06-21 | 2025-12-26 | Eli Lilly And Company | Inhbe rna interference agents |
| WO2025264952A2 (en) | 2024-06-21 | 2025-12-26 | Eli Lilly And Company | Novel rna therapeutics and uses thereof |
| WO2026006109A2 (en) | 2024-06-24 | 2026-01-02 | Eli Lilly And Company | Novel rna therapeutics and uses thereof |
| WO2026017140A2 (en) | 2024-07-18 | 2026-01-22 | Sanegene Bio Usa Inc. | Small interfering rna targeting fxi and uses thereof |
| WO2026030418A2 (en) | 2024-07-31 | 2026-02-05 | Eli Lilly And Company | Oligonucleotide synthesis using cyclic-phosphorous nucleosides |
| WO2026041067A2 (en) | 2024-08-20 | 2026-02-26 | Sanegene Bio Usa Inc. | Small interfering rna targeting myostatin (mstn) and uses thereof |
| WO2026041910A2 (en) | 2024-08-21 | 2026-02-26 | Novo Nordisk A/S | Compositions and methods for inhibiting xdh expression |
| WO2026046411A1 (en) | 2024-09-02 | 2026-03-05 | Sanegene Bio Usa Inc. | Small interfering rna targeting plasminogen (plg) and uses thereof |
| WO2026092658A2 (en) | 2024-10-31 | 2026-05-07 | Sanegene Bio Usa Inc. | Small interfering rna targeting amyloid beta precursor protein (app) and uses thereof |
| WO2026117631A2 (en) | 2024-11-26 | 2026-06-04 | City Therapeutics, Inc. | Factor xi rnai agent compositions and methods of use thereof |
| CN119552122B (zh) | 2025-01-27 | 2025-05-09 | 北京悦康科创医药科技股份有限公司 | 5'-磷酸酯修饰核苷及其制备方法与应用 |
| US20260226475A1 (en) | 2025-01-27 | 2026-08-06 | Sanegene Bio Usa Inc. | Small interfering rna targeting acvr1c and uses thereof |
| WO2026162643A1 (en) | 2025-01-31 | 2026-08-06 | Novo Nordisk A/S | Nucleic acid constructs for inhibiting gys2 expression |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| US4476301A (en) | 1982-04-29 | 1984-10-09 | Centre National De La Recherche Scientifique | Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon |
| US5550111A (en) | 1984-07-11 | 1996-08-27 | Temple University-Of The Commonwealth System Of Higher Education | Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof |
| US5405938A (en) | 1989-12-20 | 1995-04-11 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5264423A (en) | 1987-03-25 | 1993-11-23 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| US5276019A (en) | 1987-03-25 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| US4924624A (en) | 1987-10-22 | 1990-05-15 | Temple University-Of The Commonwealth System Of Higher Education | 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof |
| US5188897A (en) | 1987-10-22 | 1993-02-23 | Temple University Of The Commonwealth System Of Higher Education | Encapsulated 2',5'-phosphorothioate oligoadenylates |
| EP0406309A4 (en) | 1988-03-25 | 1992-08-19 | The University Of Virginia Alumni Patents Foundation | Oligonucleotide n-alkylphosphoramidates |
| US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5194599A (en) | 1988-09-23 | 1993-03-16 | Gilead Sciences, Inc. | Hydrogen phosphonodithioate compositions |
| CA2297294C (en) * | 1989-05-15 | 2005-11-08 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Phosphonomethoxymethylpurine/pyrimidine derivatives |
| US5721218A (en) | 1989-10-23 | 1998-02-24 | Gilead Sciences, Inc. | Oligonucleotides with inverted polarity |
| US5399676A (en) | 1989-10-23 | 1995-03-21 | Gilead Sciences | Oligonucleotides with inverted polarity |
| US5264562A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences, Inc. | Oligonucleotide analogs with novel linkages |
| US5264564A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| US5177198A (en) | 1989-11-30 | 1993-01-05 | University Of N.C. At Chapel Hill | Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates |
| US5587361A (en) | 1991-10-15 | 1996-12-24 | Isis Pharmaceuticals, Inc. | Oligonucleotides having phosphorothioate linkages of high chiral purity |
| US6001840A (en) | 1990-03-06 | 1999-12-14 | Southern Research Institute | Methods of treatment of viral infections using carbocyclic deoxyguanosine analogs |
| US5321131A (en) | 1990-03-08 | 1994-06-14 | Hybridon, Inc. | Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling |
| US5470967A (en) | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
| US5618704A (en) | 1990-07-27 | 1997-04-08 | Isis Pharmacueticals, Inc. | Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling |
| US5608046A (en) | 1990-07-27 | 1997-03-04 | Isis Pharmaceuticals, Inc. | Conjugated 4'-desmethyl nucleoside analog compounds |
| US5489677A (en) | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
| US5677437A (en) | 1990-07-27 | 1997-10-14 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5998603A (en) | 1994-09-29 | 1999-12-07 | Isis Pharmaceuticals, Inc. | 4'-desmethyl nucleoside analogs, and oligomers thereof |
| US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
| US5541307A (en) | 1990-07-27 | 1996-07-30 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs and solid phase synthesis thereof |
| US5623070A (en) | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| JPH06502300A (ja) | 1990-08-03 | 1994-03-17 | サノフィ | 遺伝子発現の抑制のための化合物及び方法 |
| US5177196A (en) | 1990-08-16 | 1993-01-05 | Microprobe Corporation | Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof |
| US5214134A (en) | 1990-09-12 | 1993-05-25 | Sterling Winthrop Inc. | Process of linking nucleosides with a siloxane bridge |
| US5561225A (en) | 1990-09-19 | 1996-10-01 | Southern Research Institute | Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages |
| WO1992005186A1 (en) | 1990-09-20 | 1992-04-02 | Gilead Sciences | Modified internucleoside linkages |
| US5672697A (en) | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
| US5571799A (en) | 1991-08-12 | 1996-11-05 | Basco, Ltd. | (2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response |
| US5792608A (en) | 1991-12-12 | 1998-08-11 | Gilead Sciences, Inc. | Nuclease stable and binding competent oligomers and methods for their use |
| US5633360A (en) | 1992-04-14 | 1997-05-27 | Gilead Sciences, Inc. | Oligonucleotide analogs capable of passive cell membrane permeation |
| US5434257A (en) | 1992-06-01 | 1995-07-18 | Gilead Sciences, Inc. | Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages |
| US5476925A (en) | 1993-02-01 | 1995-12-19 | Northwestern University | Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups |
| GB9304618D0 (en) | 1993-03-06 | 1993-04-21 | Ciba Geigy Ag | Chemical compounds |
| HU9501974D0 (en) | 1993-03-31 | 1995-09-28 | Sterling Winthrop Inc | Oligonucleotides with amide linkages replacing phosphodiester linkages |
| US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| US5625050A (en) | 1994-03-31 | 1997-04-29 | Amgen Inc. | Modified oligonucleotides and intermediates useful in nucleic acid therapeutics |
| US5646269A (en) | 1994-04-28 | 1997-07-08 | Gilead Sciences, Inc. | Method for oligonucleotide analog synthesis |
| US5977061A (en) | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
| US5981501A (en) | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| US7422902B1 (en) | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| CA2289702C (en) | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| EP1015469B2 (en) | 1997-09-12 | 2015-11-18 | Exiqon A/S | Bi- and tri-cyclic nucleoside, nucleotide and oligonucleoide analogues |
| ES2356342T3 (es) | 1998-01-05 | 2011-04-07 | The University Of Washington | Mejora de transporte utilizando agentes de alteración de membrana. |
| AU2764801A (en) | 2000-01-07 | 2001-07-24 | University Of Washington | Enhanced transport of agents using membrane disruptive agents |
| EP1299085B1 (en) | 2000-06-30 | 2005-11-16 | Inex Pharmaceuticals Corp. | Improved liposomal camptothecins and uses thereof |
| CN100523215C (zh) | 2000-12-01 | 2009-08-05 | 马普科技促进协会 | 介导rna干涉的小rna分子 |
| WO2003040395A2 (en) | 2001-11-07 | 2003-05-15 | Applera Corporation | Universal nucleotides for nucleic acid analysis |
| US20030190626A1 (en) * | 2002-04-09 | 2003-10-09 | Vasulinga Ravikumar | Phosphorothioate monoester modified oligomers |
| US7247621B2 (en) | 2002-04-30 | 2007-07-24 | Valeant Research & Development | Antiviral phosphonate compounds and methods therefor |
| SG182849A1 (en) | 2003-04-25 | 2012-08-30 | Gilead Sciences Inc | Antiviral phosphonate analogs |
| DK1661905T3 (da) | 2003-08-28 | 2012-07-23 | Takeshi Imanishi | Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| AU2005251691A1 (en) | 2004-05-17 | 2005-12-22 | Tekmira Pharmaceuticals Corporation | Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof |
| US7718193B2 (en) | 2006-03-16 | 2010-05-18 | University Of Washington | Temperature- and pH-responsive polymer compositions |
| CN101500548A (zh) | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
| WO2008100447A2 (en) | 2007-02-09 | 2008-08-21 | Gilead Sciences, Inc. | Nucleoside analogs for antiviral treatment |
| US20110250138A1 (en) | 2007-08-01 | 2011-10-13 | Alnylam Pharmaceuticals, Inc. | Single-stranded and double-stranded oligonucleotides comprising a metal-chelating ligand |
| WO2009140421A2 (en) | 2008-05-13 | 2009-11-19 | University Of Washington | Polymeric carrier |
| WO2009140423A2 (en) | 2008-05-13 | 2009-11-19 | University Of Washington | Targeted polymer bioconjugates |
| MX2010012238A (es) | 2008-05-13 | 2011-04-11 | Univ Washington | Copolimeros dibloque y sus complejos con polinucleotidos destinados a introducirlos en celulas. |
| CA2724014C (en) | 2008-05-13 | 2016-09-13 | University Of Washington | Micellic assemblies |
| MX2010012237A (es) | 2008-05-13 | 2011-04-28 | Univ Washington | Micelas para el suministro intracelular de agentes terapeuticos. |
| CA2734917A1 (en) | 2008-08-22 | 2010-02-25 | University Of Washington | Heterogeneous polymeric micelles for intracellular delivery |
| WO2010033225A2 (en) | 2008-09-22 | 2010-03-25 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for the specific inhibition of gene expression by dsrna possessing modifications |
| EP2447274B1 (en) | 2008-10-24 | 2017-10-04 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds and methods |
| EP2364330B1 (en) | 2008-11-06 | 2015-03-25 | University Of Washington | Multiblock copolymers |
| US20110281934A1 (en) | 2008-11-06 | 2011-11-17 | Phaserx, Inc. | Micelles of hydrophilically shielded membrane-destabilizing copolymers |
| KR20110110776A (ko) | 2008-12-18 | 2011-10-07 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| WO2010093788A2 (en) | 2009-02-11 | 2010-08-19 | Dicerna Pharmaceuticals, Inc. | Multiplex dicer substrate rna interference molecules having joining sequences |
| KR20220038506A (ko) | 2009-06-10 | 2022-03-28 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| US8927513B2 (en) | 2009-07-07 | 2015-01-06 | Alnylam Pharmaceuticals, Inc. | 5′ phosphate mimics |
| AU2010292172A1 (en) * | 2009-09-09 | 2012-05-03 | Centrose, Llc | Extracellular targeted drug conjugates |
| WO2011123621A2 (en) * | 2010-04-01 | 2011-10-06 | Alnylam Pharmaceuticals Inc. | 2' and 5' modified monomers and oligonucleotides |
| US9725479B2 (en) * | 2010-04-22 | 2017-08-08 | Ionis Pharmaceuticals, Inc. | 5′-end derivatives |
| WO2011139702A2 (en) * | 2010-04-28 | 2011-11-10 | Isis Pharmaceuticals, Inc. | Modified nucleosides and oligomeric compounds prepared therefrom |
| RU2582235C2 (ru) | 2010-12-29 | 2016-04-20 | Ф.Хоффманн-Ля Рош Аг | Низкомолекулярные конъюгаты для внутриклеточной доставки нуклеиновых кислот |
| JP2015529467A (ja) | 2012-09-14 | 2015-10-08 | ダイセルナ ファーマシューティカルズ， インコーポレイテッドＤｉｃｅｒｎａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 二本鎖ｒｎａによるｍｙｃの特異的阻害に関する方法および組成物 |
| EP2928877B1 (en) | 2012-12-06 | 2020-01-22 | Merck Sharp & Dohme Corp. | Disulfide masked prodrug compositions and methods |
| CA3120574A1 (en) | 2013-03-14 | 2014-09-25 | Dicerna Pharmaceuticals, Inc. | Process for formulating an anionic agent |
| WO2015106128A2 (en) | 2014-01-09 | 2015-07-16 | Alnylam Pharmaceuticals, Inc. | MODIFIED RNAi AGENTS |
| EP3865576A1 (en) | 2014-12-15 | 2021-08-18 | Dicerna Pharmaceuticals, Inc. | Ligand-modified double-stranded nucleic acids |
| WO2016099982A2 (en) | 2014-12-15 | 2016-06-23 | Emory University | Phosphoramidates for the treatment of hepatitis b virus |
| WO2016106050A1 (en) | 2014-12-26 | 2016-06-30 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| EP3067369A1 (en) | 2015-03-11 | 2016-09-14 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Methods and compositions for the treatment of anti-angiogenic resistant cancer |
| US10087209B2 (en) | 2015-04-28 | 2018-10-02 | Ku Leuven Research & Development | Antiviral compounds, a process for their preparation, and their use for treating viral infections |
| MX2019002075A (es) | 2016-08-23 | 2019-07-01 | Dicerna Pharmaceuticals Inc | Composiciones que comprenden oligonucleotidos modificados reversiblemente, y sus usos. |
-
2017
- 2017-09-01 WO PCT/US2017/049909 patent/WO2018045317A1/en not_active Ceased
- 2017-09-01 CA CA3033756A patent/CA3033756A1/en active Pending
- 2017-09-01 EP EP22175611.7A patent/EP4101859A1/en active Pending
- 2017-09-01 PL PL17847638.8T patent/PL3506909T3/pl unknown
- 2017-09-01 DK DK17847638.8T patent/DK3506909T3/da active
- 2017-09-01 EP EP17847638.8A patent/EP3506909B1/en active Active
- 2017-09-01 HU HUE17847638A patent/HUE059718T2/hu unknown
- 2017-09-01 CN CN201780068124.5A patent/CN110072530B/zh active Active
- 2017-09-01 AU AU2017321892A patent/AU2017321892A1/en not_active Abandoned
- 2017-09-01 ES ES17847638T patent/ES2924806T3/es active Active
- 2017-09-01 MX MX2019002339A patent/MX2019002339A/es unknown
- 2017-09-01 KR KR1020227000736A patent/KR102493872B1/ko active Active
- 2017-09-01 KR KR1020197008956A patent/KR102350647B1/ko active Active
- 2017-09-01 JP JP2019511707A patent/JP6978099B2/ja active Active
- 2017-09-01 PT PT178476388T patent/PT3506909T/pt unknown
- 2017-09-01 US US16/328,546 patent/US11414659B2/en active Active
-
2019
- 2019-02-18 IL IL264887A patent/IL264887B/en unknown
-
2021
- 2021-11-04 JP JP2021180199A patent/JP2022017481A/ja not_active Withdrawn
- 2021-11-25 IL IL288418A patent/IL288418A/en unknown
-
2022
- 2022-07-07 US US17/859,781 patent/US12037586B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022106928A (ja) | 可逆的に修飾されたオリゴヌクレオチドを含む組成物及びその使用 | |
| ES2924806T3 (es) | Análogos de 4'-fosfato y oligonucleótidos que comprenden el mismo | |
| JP2019526555A5 (enExample) | ||
| US20170362270A1 (en) | Modified oligonucleotides and methods for their synthesis | |
| JP6542662B2 (ja) | オリゴヌクレオチドアナログのボロン酸結合体 | |
| CN103052711A (zh) | 具有含氮脂环式骨架的单链核酸分子 | |
| JP2022513111A5 (enExample) | ||
| WO2025072881A2 (en) | Oligonucleotide compositions and methods thereof | |
| AU2024348542A1 (en) | Oligonucleotide compositions and methods thereof | |
| EP3366774A1 (en) | Nucleic acid complex having at least one bulge structure | |
| WO2025072879A1 (en) | Oligonucleotide compositions and methods thereof | |
| JP6634095B2 (ja) | プロレニン遺伝子またはプロレニン受容体遺伝子の発現を抑制する一本鎖核酸分子およびその用途 | |
| CN118475355A (zh) | 肾毒性减轻剂 | |
| WO2023282344A1 (ja) | 腎毒性軽減剤 | |
| US10337009B2 (en) | Single-stranded nucleic acid molecule for inhibiting TGF-β1 expression | |
| HK40084990A (en) | 4'-oxymethylphosphonate nucleotide analogs and oligonucleotides comprising the same | |
| NZ750307B2 (en) | Compositions comprising reversibly modified oligonucleotides and uses thereof | |
| HK40005478A (en) | Compositions comprising reversibly modified oligonucleotides and uses thereof |