JP2019530649A5 - - Google Patents
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- JP2019530649A5 JP2019530649A5 JP2019510580A JP2019510580A JP2019530649A5 JP 2019530649 A5 JP2019530649 A5 JP 2019530649A5 JP 2019510580 A JP2019510580 A JP 2019510580A JP 2019510580 A JP2019510580 A JP 2019510580A JP 2019530649 A5 JP2019530649 A5 JP 2019530649A5
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| EP3145505A4 (en) | 2014-05-19 | 2018-02-28 | Northeastern University | N-acylethanolamine hydrolyzing acid amidase (naaa) inhibitors and their use thereof |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| WO2018225093A1 (en) * | 2017-06-07 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
| EP3634952A1 (en) * | 2017-06-07 | 2020-04-15 | GlaxoSmithKline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
| CA3068753A1 (en) * | 2017-07-03 | 2019-01-10 | Glaxosmithkline Intellectual Property Development Limited | N-(3-(2-(4-chlorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-2-cyclobutane-1-carboxamide derivatives and related compounds as atf4 inhibitors for treating cancer and other diseases |
| CR20200054A (es) | 2017-08-09 | 2020-03-21 | Denali Therapeutics Inc | Compuestos, composiciones y métodos |
| HUE062446T2 (hu) | 2017-09-01 | 2023-11-28 | Denali Therapeutics Inc | Vegyületek, készítmények és eljárások |
| JP2021501785A (ja) | 2017-11-02 | 2021-01-21 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
| UY37957A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| UY37958A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| UY37956A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| AU2018383675A1 (en) | 2017-12-13 | 2020-07-09 | Altos Labs, Inc. | Inhibitors of integrated stress response pathway |
| KR102526964B1 (ko) | 2018-02-26 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 복제 억제제로서의 치환된 피롤리진 화합물 |
| EP3768660A1 (en) * | 2018-03-23 | 2021-01-27 | Denali Therapeutics Inc. | Modulators of eukaryotic initiation factor 2 |
| WO2019193541A1 (en) * | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors |
| EP3781142A4 (en) * | 2018-04-19 | 2022-03-30 | Merck Sharp & Dohme Corp. | NEW [1.1.1] BICYCLO COMPOUNDS AS INDOLAMINE-2,3-DIOXYGENASE INHIBITORS |
| US10689357B2 (en) | 2018-05-08 | 2020-06-23 | Northeastern University | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof |
| MX2020013269A (es) | 2018-06-05 | 2021-02-18 | Praxis Biotech LLC | Inhibidores de la vía de respuesta al estrés integrada. |
| TWI771621B (zh) * | 2018-10-11 | 2022-07-21 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
| US11248001B2 (en) | 2019-01-18 | 2022-02-15 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
| EA202191890A1 (ru) | 2019-01-18 | 2022-02-03 | Астразенека Аб | Ингибиторы pcsk9 и способы их применения |
| MA54959A (fr) | 2019-02-13 | 2021-12-22 | Denali Therapeutics Inc | Composés, compositions et procédés |
| EP3923935A4 (en) | 2019-02-13 | 2022-10-26 | Denali Therapeutics Inc. | COMPOUNDS, COMPOSITIONS AND METHODS |
| CN113840597A (zh) * | 2019-02-25 | 2021-12-24 | 普拉西斯生物技术有限责任公司 | 整合应激反应通路抑制剂 |
| IL287379B2 (en) | 2019-04-23 | 2025-11-01 | Evotec Int Gmbh | Modulators of the integrated stress response pathway |
| CA3137212A1 (en) * | 2019-04-23 | 2020-10-29 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
| PE20220572A1 (es) * | 2019-04-30 | 2022-04-20 | Calico Life Sciences Llc | Moduladores de la via integrada del estres |
| EP3962899A1 (en) * | 2019-04-30 | 2022-03-09 | Calico Life Sciences LLC | Substituted cyclolakyls as modulators of the integrated stress pathway |
| KR20220024486A (ko) * | 2019-06-12 | 2022-03-03 | 프락시스 바이오테크 엘엘씨 | 통합 스트레스 반응 경로의 억제제 |
| CN114466654A (zh) | 2019-06-12 | 2022-05-10 | 普拉西斯生物技术有限责任公司 | 整合应激反应通路调节剂 |
| CN114929680B (zh) * | 2019-11-19 | 2024-06-14 | 印度鲁宾有限公司 | 制备苯并二氢吡喃化合物的方法 |
| BR112022013865A2 (pt) * | 2020-01-17 | 2022-09-13 | Lupin Ltd | Métodos e composto |
| EP4096665A1 (en) | 2020-01-28 | 2022-12-07 | Evotec International GmbH | Modulators of the integrated stress response pathway |
| CA3165813A1 (en) | 2020-03-11 | 2021-09-16 | Holly Victoria Atton | Modulators of the integrated stress response pathway |
| WO2022013684A1 (en) | 2020-07-11 | 2022-01-20 | Pfizer Inc. | Antiviral heteroaryl ketone derivatives |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| KR20230110509A (ko) | 2020-10-22 | 2023-07-24 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절제 |
| MX2023004626A (es) | 2020-10-22 | 2023-05-23 | Evotec Int Gmbh | Moduladores de la via de respuesta integrada al estres. |
| AU2021363616B2 (en) | 2020-10-22 | 2026-03-26 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
| KR20230116796A (ko) * | 2020-10-30 | 2023-08-04 | 칼리코 라이프 사이언시스 엘엘씨 | 통합된 스트레스 경로의 조절인자 |
| CN117580824A (zh) * | 2020-10-30 | 2024-02-20 | 卡里科生命科学有限责任公司 | 整合应激通路的调节剂 |
| US20250257041A1 (en) * | 2022-05-19 | 2025-08-14 | The Board Of Regents Of The University Of Texas System | Inducers of integrated stress response to treat cancer |
| CN117285524A (zh) | 2022-06-24 | 2023-12-26 | 中国科学院上海药物研究所 | 一类取代的4-氨基异吲哚啉类化合物、其制备方法、药物组合物及应用 |
| CN121263408A (zh) * | 2023-07-14 | 2026-01-02 | 深圳众格生物科技有限公司 | 一种化合物、包含其的药物组合物及其用途 |
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| JO2397B1 (en) * | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
| EP1706384A1 (en) | 2004-01-07 | 2006-10-04 | AstraZeneca AB | Therapeutic agents i |
| KR101302627B1 (ko) | 2005-01-05 | 2013-09-10 | 아비에 인코포레이티드 | 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제 |
| EP1924553A1 (en) | 2005-08-08 | 2008-05-28 | Argenta Discovery Limited | Bicyclo[2.2.]hept-7-ylamine derivatives and their uses |
| WO2011087758A1 (en) | 2009-12-22 | 2011-07-21 | H. Lundbeck A/S | Adamantyl amide derivatives and uses of same |
| AR084457A1 (es) * | 2010-12-22 | 2013-05-15 | Lundbeck & Co As H | Derivados de biciclo[3,2,1]octilamida |
| JP6806562B2 (ja) * | 2013-03-15 | 2021-01-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ｅＩＦ２α経路の調節因子 |
| US20160318856A1 (en) * | 2013-09-11 | 2016-11-03 | The Brigham And Women's Hospital, Inc. | Substituted Urea eIF2alpha Kinase Activators |
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- 2017-05-05 AR ARP170101184A patent/AR108395A1/es unknown
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2020
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2021
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