CN109641854B - 整合应激通路的调节剂 - Google Patents
整合应激通路的调节剂 Download PDFInfo
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- CN109641854B CN109641854B CN201780039590.0A CN201780039590A CN109641854B CN 109641854 B CN109641854 B CN 109641854B CN 201780039590 A CN201780039590 A CN 201780039590A CN 109641854 B CN109641854 B CN 109641854B
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/38—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing five carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/40—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing six carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms
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| US62/332,272 | 2016-05-05 | ||
| PCT/US2017/031393 WO2017193063A1 (en) | 2016-05-05 | 2017-05-05 | Modulators of the integrated stress pathway |
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| CN109641854A CN109641854A (zh) | 2019-04-16 |
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Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3145505A4 (en) | 2014-05-19 | 2018-02-28 | Northeastern University | N-acylethanolamine hydrolyzing acid amidase (naaa) inhibitors and their use thereof |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CA3066328A1 (en) * | 2017-06-07 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
| WO2018225093A1 (en) * | 2017-06-07 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
| JP2020525513A (ja) * | 2017-07-03 | 2020-08-27 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 癌および他の疾患を治療するためのatf4阻害剤としてのn−(3−(2−(4−クロロフェノキシ)アセトアミドビシクロ[1.1.1]ペンタン−1−イル)−2−シクロブタン−1−カルボキサミド誘導体および関連化合物 |
| MA49858A (fr) | 2017-08-09 | 2021-04-28 | Denali Therapeutics Inc | Composés, compositions et procédés |
| JP7382308B2 (ja) | 2017-09-01 | 2023-11-16 | デナリ セラピューティクス インコーポレイテッド | 化合物、組成物、及び、方法 |
| UY37956A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| UY37957A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| WO2019090088A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| UY37958A (es) * | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| EP3723762A4 (en) | 2017-12-13 | 2021-12-08 | Praxis Biotech LLC | STRESS INTEGRATED RESPONSE PATH INHIBITORS |
| KR102526964B1 (ko) | 2018-02-26 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 복제 억제제로서의 치환된 피롤리진 화합물 |
| WO2019183589A1 (en) * | 2018-03-23 | 2019-09-26 | Denali Therapeutics Inc. | Modulators of eukaryotic initiation factor 2 |
| WO2019193541A1 (en) * | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors |
| EP3781142A4 (en) * | 2018-04-19 | 2022-03-30 | Merck Sharp & Dohme Corp. | NEW [1.1.1] BICYCLO COMPOUNDS AS INDOLAMINE-2,3-DIOXYGENASE INHIBITORS |
| US10689357B2 (en) * | 2018-05-08 | 2020-06-23 | Northeastern University | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof |
| WO2019236710A1 (en) | 2018-06-05 | 2019-12-12 | Praxis Biotech LLC | Inhibitors of integrated stress response pathway |
| TWI771621B (zh) * | 2018-10-11 | 2022-07-21 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
| MX2021008661A (es) | 2019-01-18 | 2021-08-19 | Astrazeneca Ab | Inhibidores de la pcsk9 y metodos de uso de los mismos. |
| CA3129609A1 (en) | 2019-02-13 | 2020-08-20 | Denali Therapeutics Inc. | Eukaryotic initiation factor 2b modulators |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CN113840597A (zh) * | 2019-02-25 | 2021-12-24 | 普拉西斯生物技术有限责任公司 | 整合应激反应通路抑制剂 |
| EA202192900A1 (ru) * | 2019-04-23 | 2022-03-18 | Эвотек Интернешнл Гмбх | Модуляторы пути интегрированной реакции на стресс |
| KR20220004105A (ko) | 2019-04-23 | 2022-01-11 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절제 |
| AU2020264485A1 (en) * | 2019-04-30 | 2021-12-02 | Abbvie Inc. | Substituted cycloalkyls as modulators of the integrated stress pathway |
| SG11202111970WA (en) * | 2019-04-30 | 2021-11-29 | Calico Life Sciences Llc | Substituted cyclolakyls as modulators of the integrated stress pathway |
| CN114466654A (zh) | 2019-06-12 | 2022-05-10 | 普拉西斯生物技术有限责任公司 | 整合应激反应通路调节剂 |
| US20210317102A1 (en) * | 2019-06-12 | 2021-10-14 | Praxis Biotech LLC | Inhibitors of integrated stress response pathway |
| AU2020386871A1 (en) * | 2019-11-19 | 2022-06-30 | Lupin Limited | Process for preparing chroman compounds |
| AU2021207775B2 (en) * | 2020-01-17 | 2025-12-11 | Lupin Limited | Methods, processes and intermediates for preparing chroman compounds |
| KR20220133252A (ko) | 2020-01-28 | 2022-10-04 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절자 |
| US12441720B2 (en) | 2020-03-11 | 2025-10-14 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| MX2023004677A (es) | 2020-10-22 | 2023-05-24 | Evotec Int Gmbh | Moduladores de la via de respuesta integrada al estres. |
| LT4232154T (lt) | 2020-10-22 | 2025-02-10 | Evotec International Gmbh | Integruoto streso atsako kelio moduliatoriai |
| KR20230110511A (ko) | 2020-10-22 | 2023-07-24 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절제 |
| IL302440A (en) * | 2020-10-30 | 2023-06-01 | Calico Life Sciences Llc | Combined pressure pathway modulators |
| EP4526291A1 (en) * | 2022-05-19 | 2025-03-26 | The Board of Regents of the University of Texas System | Inducers of integrated stress response to treat cancer |
| US20250270202A1 (en) | 2022-06-24 | 2025-08-28 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Substituted 4-aminoisoindoline compound, preparation method therefor, pharmaceutical composition thereof, and use thereof |
| AU2024291624A1 (en) * | 2023-07-14 | 2025-11-20 | Shenzhen Zhongge Biological Technology Co., Ltd. | Compound, pharmaceutical composition comprising same, and use thereof |
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| EP1924553A1 (en) | 2005-08-08 | 2008-05-28 | Argenta Discovery Limited | Bicyclo[2.2.]hept-7-ylamine derivatives and their uses |
-
2017
- 2017-05-04 TW TW106114861A patent/TW201808888A/zh unknown
- 2017-05-05 CA CA3023261A patent/CA3023261A1/en not_active Abandoned
- 2017-05-05 AR ARP170101184A patent/AR108395A1/es unknown
- 2017-05-05 UY UY0001037230A patent/UY37230A/es not_active Application Discontinuation
- 2017-05-05 MA MA044863A patent/MA44863A/fr unknown
- 2017-05-05 AU AU2017261336A patent/AU2017261336B2/en active Active
- 2017-05-05 CN CN201780039590.0A patent/CN109641854B/zh active Active
- 2017-05-05 US US16/098,679 patent/US10913727B2/en active Active
- 2017-05-05 WO PCT/US2017/031393 patent/WO2017193063A1/en not_active Ceased
- 2017-05-05 JP JP2019510580A patent/JP6899063B2/ja active Active
- 2017-05-05 EP EP17723904.3A patent/EP3452456B1/en active Active
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2020
- 2020-12-01 US US17/108,416 patent/US20220106281A1/en not_active Abandoned
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2021
- 2021-05-18 JP JP2021083653A patent/JP2021138718A/ja active Pending
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| CN103369961A (zh) * | 2010-12-22 | 2013-10-23 | H.隆德贝克有限公司 | 双环[3.2.1]辛基酰胺衍生物及其用途 |
| WO2014144952A2 (en) * | 2013-03-15 | 2014-09-18 | Peter Walter | Modulators of the eif2alpha pathway |
| WO2015038778A1 (en) * | 2013-09-11 | 2015-03-19 | The Brigham And Women's Hospital, Inc. | SUBSTITUTED UREA EIF2α KINASE ACTIVATORS |
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Also Published As
| Publication number | Publication date |
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| JP2019530649A (ja) | 2019-10-24 |
| UY37230A (es) | 2017-11-30 |
| US20190135772A1 (en) | 2019-05-09 |
| CN109641854A (zh) | 2019-04-16 |
| JP2021138718A (ja) | 2021-09-16 |
| JP6899063B2 (ja) | 2021-07-07 |
| US10913727B2 (en) | 2021-02-09 |
| AU2017261336A1 (en) | 2018-11-22 |
| MA44863A (fr) | 2021-03-31 |
| AU2017261336B2 (en) | 2021-11-04 |
| CA3023261A1 (en) | 2017-11-09 |
| WO2017193063A1 (en) | 2017-11-09 |
| TW201808888A (zh) | 2018-03-16 |
| AR108395A1 (es) | 2018-08-15 |
| EP3452456B1 (en) | 2023-07-05 |
| EP3452456A1 (en) | 2019-03-13 |
| US20220106281A1 (en) | 2022-04-07 |
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