JP2019530648A5 - - Google Patents

Info

Publication number

JP2019530648A5

JP2019530648A5 JP2019508893A JP2019508893A JP2019530648A5 JP 2019530648 A5 JP2019530648 A5 JP 2019530648A5 JP 2019508893 A JP2019508893 A JP 2019508893A JP 2019508893 A JP2019508893 A JP 2019508893A JP 2019530648 A5 JP2019530648 A5 JP 2019530648A5

Authority

JP

Japan

Prior art keywords

depot

lesions

patient

regimen

rrms

Prior art date

2017-08-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108010072051 Glatiramer Acetate Proteins 0.000 claims 26
• FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 claims 22
• 229960003776 glatiramer acetate Drugs 0.000 claims 22
• 230000003902 lesion Effects 0.000 claims 13
• 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 claims 11
• 238000009472 formulation Methods 0.000 claims 11
• 239000000203 mixture Substances 0.000 claims 11
• 239000003405 delayed action preparation Substances 0.000 claims 9
• 208000024891 symptom Diseases 0.000 claims 6
• 238000010255 intramuscular injection Methods 0.000 claims 5
• 239000007927 intramuscular injection Substances 0.000 claims 5
• VKZRWSNIWNFCIQ-WDSKDSINSA-N (2s)-2-[2-[[(1s)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-WDSKDSINSA-N 0.000 claims 4
• YLOCGHYTXIINAI-XKUOMLDTSA-N (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 YLOCGHYTXIINAI-XKUOMLDTSA-N 0.000 claims 4
• 229940042385 glatiramer Drugs 0.000 claims 4
• 238000010254 subcutaneous injection Methods 0.000 claims 4
• 239000007929 subcutaneous injection Substances 0.000 claims 4
• 230000003190 augmentative effect Effects 0.000 claims 3
• 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
• 229920000954 Polyglycolide Polymers 0.000 claims 2
• 210000004556 brain Anatomy 0.000 claims 2
• 238000002347 injection Methods 0.000 claims 2
• 239000007924 injection Substances 0.000 claims 2
• 201000006417 multiple sclerosis Diseases 0.000 claims 2
• 229920000747 poly(lactic acid) Polymers 0.000 claims 2
• 230000002035 prolonged effect Effects 0.000 claims 2
• 238000003756 stirring Methods 0.000 claims 2
• 239000008215 water for injection Substances 0.000 claims 2
• 206010008096 Cerebral atrophy Diseases 0.000 claims 1
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 230000009266 disease activity Effects 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 238000004945 emulsification Methods 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 239000012729 immediate-release (IR) formulation Substances 0.000 claims 1
• 230000000977 initiatory effect Effects 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1