JP2019528771A5 - - Google Patents
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- JP2019528771A5 JP2019528771A5 JP2019518229A JP2019518229A JP2019528771A5 JP 2019528771 A5 JP2019528771 A5 JP 2019528771A5 JP 2019518229 A JP2019518229 A JP 2019518229A JP 2019518229 A JP2019518229 A JP 2019518229A JP 2019528771 A5 JP2019528771 A5 JP 2019528771A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- hla
- hpc
- ipsc
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 25
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 238000012258 culturing Methods 0.000 claims 7
- 210000002865 immune cell Anatomy 0.000 claims 7
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 5
- 102100039564 Leukosialin Human genes 0.000 claims 5
- 210000000601 blood cell Anatomy 0.000 claims 5
- 210000000066 myeloid cell Anatomy 0.000 claims 5
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 4
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 4
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 4
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 4
- 230000004069 differentiation Effects 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 210000004698 lymphocyte Anatomy 0.000 claims 4
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 claims 3
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 3
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 102000001267 GSK3 Human genes 0.000 claims 2
- 108060006662 GSK3 Proteins 0.000 claims 2
- 108010002386 Interleukin-3 Proteins 0.000 claims 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 230000024245 cell differentiation Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
- -1 CD31 Proteins 0.000 claims 1
- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical group CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims 1
- 102100029761 Cadherin-5 Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102100033553 Delta-like protein 4 Human genes 0.000 claims 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims 1
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims 1
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims 1
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 1
- 108010075704 HLA-A Antigens Proteins 0.000 claims 1
- 108010058607 HLA-B Antigens Proteins 0.000 claims 1
- 108010052199 HLA-C Antigens Proteins 0.000 claims 1
- 108010010378 HLA-DP Antigens Proteins 0.000 claims 1
- 102000015789 HLA-DP Antigens Human genes 0.000 claims 1
- 108010062347 HLA-DQ Antigens Proteins 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 1
- 101000794587 Homo sapiens Cadherin-5 Proteins 0.000 claims 1
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 1
- 101001078143 Homo sapiens Integrin alpha-IIb Proteins 0.000 claims 1
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims 1
- 102000000646 Interleukin-3 Human genes 0.000 claims 1
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000008672 reprogramming Effects 0.000 claims 1
- 108010056030 retronectin Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022034065A JP7560502B2 (ja) | 2016-10-05 | 2022-03-07 | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662404470P | 2016-10-05 | 2016-10-05 | |
| US62/404,470 | 2016-10-05 | ||
| US201762486895P | 2017-04-18 | 2017-04-18 | |
| US62/486,895 | 2017-04-18 | ||
| PCT/US2017/055369 WO2018067836A1 (en) | 2016-10-05 | 2017-10-05 | Methods for directed differentiation of pluripotent stem cells to hla homozygous immune cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022034065A Division JP7560502B2 (ja) | 2016-10-05 | 2022-03-07 | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528771A JP2019528771A (ja) | 2019-10-17 |
| JP2019528771A5 true JP2019528771A5 (https=) | 2020-11-12 |
| JP7212615B2 JP7212615B2 (ja) | 2023-01-25 |
Family
ID=60302439
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518229A Active JP7212615B2 (ja) | 2016-10-05 | 2017-10-05 | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
| JP2022034065A Active JP7560502B2 (ja) | 2016-10-05 | 2022-03-07 | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022034065A Active JP7560502B2 (ja) | 2016-10-05 | 2022-03-07 | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20200263139A1 (https=) |
| EP (1) | EP3523423B1 (https=) |
| JP (2) | JP7212615B2 (https=) |
| KR (1) | KR102598351B1 (https=) |
| CN (1) | CN110023491B (https=) |
| AU (1) | AU2017340644B2 (https=) |
| BR (1) | BR112019006910A2 (https=) |
| CA (1) | CA3038701A1 (https=) |
| DK (1) | DK3523423T3 (https=) |
| ES (1) | ES2989469T3 (https=) |
| IL (1) | IL265810B2 (https=) |
| MX (1) | MX2019003689A (https=) |
| WO (1) | WO2018067836A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3177929A1 (en) | 2012-12-21 | 2014-06-26 | Astellas Institute For Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| CN108431211B (zh) | 2015-10-20 | 2026-03-24 | 富士胶片细胞动力公司 | 通过遗传编程的多谱系造血前体细胞产生 |
| JP7212615B2 (ja) * | 2016-10-05 | 2023-01-25 | フジフィルム セルラー ダイナミクス，インコーポレイテッド | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
| WO2018195175A1 (en) | 2017-04-18 | 2018-10-25 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
| WO2019094614A1 (en) * | 2017-11-08 | 2019-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of preparing hematopoietic progenitor cells in vitro |
| CA3130442A1 (en) * | 2019-02-24 | 2020-08-27 | Gamida Cell Ltd. | Method of homing and retention of gammadelta t cells for generating cell compositions for use in therapy |
| CN110106144B (zh) * | 2019-05-17 | 2021-10-08 | 苏州大学 | 一种诱导造血干细胞向前t系细胞分化的方法和试剂盒 |
| CN110564691A (zh) * | 2019-07-19 | 2019-12-13 | 青岛华赛伯曼医学细胞生物有限公司 | Hla纯合子来源的通用型car-t细胞的制备方法 |
| EP4176046A4 (en) * | 2020-07-02 | 2024-07-31 | Accellta Ltd. | PLURIPOTENT STEM CELLS FROM MAMMALIAN CATTLE FROM DELAYED EMBRYOS |
| CN111808812B (zh) * | 2020-08-31 | 2020-12-15 | 首都医科大学附属北京友谊医院 | 一种用于多能干细胞向造血干细胞分化的材料和方法 |
| MX2023011927A (es) | 2021-04-07 | 2023-10-23 | Century Therapeutics Inc | Composiciones y metodos para la generacion de linfocitos t gamma-delta a partir de celulas madre pluripotentes inducidas. |
| US20220333074A1 (en) | 2021-04-07 | 2022-10-20 | Century Therapeutics, Inc. | Compositions and Methods for Generating Alpha-Beta T Cells from Induced Pluripotent Stem Cells |
| CN117957313A (zh) * | 2021-07-19 | 2024-04-30 | 修复免疫股份有限公司 | 从多能干细胞生产免疫细胞群的方法 |
| CN114324126B (zh) * | 2022-01-07 | 2024-03-19 | 南京鼓楼医院 | 一种改变早期b细胞分化的方法 |
| CN115896016B (zh) * | 2022-09-07 | 2023-09-12 | 普华赛尔生物医疗科技有限公司 | 培养组合物及其在培养免疫细胞中的应用 |
| JP2025533907A (ja) * | 2022-10-05 | 2025-10-09 | ガルーダ セラピューティクス， インコーポレイテッド | 多能性細胞に由来する骨髄系統 |
| WO2024077159A1 (en) * | 2022-10-05 | 2024-04-11 | Garuda Therapeutics, Inc. | B cell lineages derived from pluripotent cells |
| WO2024101919A1 (ko) * | 2022-11-10 | 2024-05-16 | 의료법인 성광의료재단 | 전분화능 줄기세포에서 자연살해세포로의 분화 유도용 배지 조성물 및 이를 이용한 분화 방법 |
| CN120283045A (zh) * | 2022-12-02 | 2025-07-08 | 安徽中盛溯源生物科技有限公司 | 用于扩增中脑多巴胺能祖细胞的培养基、包被基质和方法 |
| WO2024220976A2 (en) * | 2023-04-21 | 2024-10-24 | New York Blood Center, Inc. | Patrolling monocyte cellular therapy |
| CN117050941B (zh) * | 2023-10-11 | 2024-01-26 | 苏州艾凯利元生物科技有限公司 | 一种制备自然杀伤细胞的方法 |
| KR102921286B1 (ko) * | 2024-02-23 | 2026-02-04 | ㈜바이오솔빅스 | Op9 세포의 분비단백질을 이용한 cd34 양성 조혈모세포의 제조방법 |
| WO2025237762A1 (en) * | 2024-05-14 | 2025-11-20 | Englmeier Ludwig | Matched t-cells and myeloid cells from cell culture |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| GB2197915B (en) | 1986-11-19 | 1990-11-14 | Rolls Royce Plc | Improvements in or relating to fluid bearings |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
| US5556954A (en) | 1992-02-13 | 1996-09-17 | Beth Israel Hospital Boston Association | Hematopoietic stem cell specific gene expression |
| DE69334225D1 (de) | 1992-07-07 | 2008-07-31 | Japan Tobacco Inc | Verfahren zur transformation einer monokotyledon pflanze |
| US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
| WO1994002620A2 (en) | 1992-07-27 | 1994-02-03 | Pioneer Hi-Bred International, Inc. | An improved method of agrobacterium-mediated transformation of cultured soybean cells |
| DE4228457A1 (de) | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
| GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
| US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
| FR2722208B1 (fr) | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| AU5389096A (en) | 1996-04-11 | 1997-10-29 | Human Genome Sciences, Inc. | Human hematopoietic-specific protein |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
| US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| DE10224242A1 (de) | 2002-05-29 | 2003-12-11 | Max Delbrueck Centrum | Frog Prince, ein Transposonvektor für den Gentransfer bei Wirbeltieren |
| CA2504451A1 (en) * | 2004-08-10 | 2006-02-10 | Geron Corporation | Dendritic cell vaccines for treating cancer made from embryonic stem cells |
| US7606580B2 (en) | 2005-05-11 | 2009-10-20 | Aol Llc | Personalized location information for mobile devices |
| JPWO2007049749A1 (ja) | 2005-10-28 | 2009-04-30 | ディナベック株式会社 | 血液凝固異常の治療方法 |
| EP2712921B1 (en) * | 2008-05-06 | 2018-07-11 | Astellas Institute for Regenerative Medicine | Hemangio colony forming cells and non-engrafting hemangio cells |
| KR101720961B1 (ko) * | 2009-02-27 | 2017-03-29 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 다능성 세포의 분화 |
| AU2015200413B2 (en) * | 2009-06-05 | 2017-08-24 | FUJIFILM Cellular Dynamics, Inc. | Reprogramming t cells and hematopoietic cells |
| DK2438160T3 (en) | 2009-06-05 | 2016-01-11 | Cellular Dynamics Int Inc | Reprogramming of T cells and hematopoietic cells |
| KR101774206B1 (ko) | 2009-08-07 | 2017-09-04 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 유도된 다능성 줄기 세포의 효율적인 확립 방법 |
| US8464599B2 (en) | 2011-01-10 | 2013-06-18 | GM Global Technology Operations LLC | Eight speed dual clutch transmission |
| JP6677631B2 (ja) * | 2013-03-13 | 2020-04-08 | ウイスコンシン アラムナイ リサーチ ファウンデーシヨンＷｉｓｃｏｎｓｉｎ Ａｌｕｍｎｉ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 定義された条件下におけるヒト多能性幹細胞の造血内皮分化のための方法及び材料 |
| AU2014248119B2 (en) * | 2013-04-03 | 2019-06-20 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted T-cells derived from pluripotent stem cells |
| WO2015057261A1 (en) * | 2013-10-16 | 2015-04-23 | The Brigham And Women's Hospital, Inc. | Methods of generating intermediate mesoderm cells from human pluripotent stem cells |
| CN105722975A (zh) | 2013-11-13 | 2016-06-29 | 康奈尔大学 | 出生后造血内皮细胞及其分离和应用 |
| EP3134515B1 (en) * | 2014-04-24 | 2019-03-27 | Board of Regents, The University of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
| BR112016028537A2 (pt) * | 2014-06-04 | 2017-08-22 | Hutchinson Fred Cancer Res | expansão e enxerto de células-tronco utilizando agonistas de notch 1 e/ou de notch 2 |
| JP7212615B2 (ja) | 2016-10-05 | 2023-01-25 | フジフィルム セルラー ダイナミクス，インコーポレイテッド | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
| WO2018195175A1 (en) * | 2017-04-18 | 2018-10-25 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
-
2017
- 2017-10-05 JP JP2019518229A patent/JP7212615B2/ja active Active
- 2017-10-05 AU AU2017340644A patent/AU2017340644B2/en active Active
- 2017-10-05 CA CA3038701A patent/CA3038701A1/en active Pending
- 2017-10-05 CN CN201780071847.0A patent/CN110023491B/zh active Active
- 2017-10-05 ES ES17797460T patent/ES2989469T3/es active Active
- 2017-10-05 MX MX2019003689A patent/MX2019003689A/es unknown
- 2017-10-05 IL IL265810A patent/IL265810B2/en unknown
- 2017-10-05 EP EP17797460.7A patent/EP3523423B1/en active Active
- 2017-10-05 DK DK17797460.7T patent/DK3523423T3/da active
- 2017-10-05 BR BR112019006910-0A patent/BR112019006910A2/pt active Search and Examination
- 2017-10-05 US US16/339,676 patent/US20200263139A1/en active Pending
- 2017-10-05 WO PCT/US2017/055369 patent/WO2018067836A1/en not_active Ceased
- 2017-10-05 KR KR1020197013026A patent/KR102598351B1/ko active Active
-
2022
- 2022-03-07 JP JP2022034065A patent/JP7560502B2/ja active Active
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