CA3038701A1 - Methods for directed differentiation of pluripotent stem cells to hla homozygous immune cells - Google Patents

Methods for directed differentiation of pluripotent stem cells to hla homozygous immune cells Download PDF

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Publication number
CA3038701A1
CA3038701A1 CA3038701A CA3038701A CA3038701A1 CA 3038701 A1 CA3038701 A1 CA 3038701A1 CA 3038701 A CA3038701 A CA 3038701A CA 3038701 A CA3038701 A CA 3038701A CA 3038701 A1 CA3038701 A1 CA 3038701A1
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Prior art keywords
cells
hla
cell
homozygous
differentiation
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CA3038701A
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English (en)
French (fr)
Inventor
Maksym A. Vodyanyk
Xin Zhang
Andrew J. Brandl
Deepika Rajesh
Bradley Swanson
Christie MUNN
Sarah BURTON
Wen Bo Wang
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Fujifilm Cellular Dynamics Inc
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Fujifilm Cellular Dynamics Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0636—T lymphocytes
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • C12N5/0602—Vertebrate cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • A61K2121/00—Preparations for use in therapy
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2307—Interleukin-7 (IL-7)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3038701A 2016-10-05 2017-10-05 Methods for directed differentiation of pluripotent stem cells to hla homozygous immune cells Pending CA3038701A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662404470P 2016-10-05 2016-10-05
US62/404,470 2016-10-05
US201762486895P 2017-04-18 2017-04-18
US62/486,895 2017-04-18
PCT/US2017/055369 WO2018067836A1 (en) 2016-10-05 2017-10-05 Methods for directed differentiation of pluripotent stem cells to hla homozygous immune cells

Publications (1)

Publication Number Publication Date
CA3038701A1 true CA3038701A1 (en) 2018-04-12

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CA3038701A Pending CA3038701A1 (en) 2016-10-05 2017-10-05 Methods for directed differentiation of pluripotent stem cells to hla homozygous immune cells

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US (1) US20200263139A1 (https=)
EP (1) EP3523423B1 (https=)
JP (2) JP7212615B2 (https=)
KR (1) KR102598351B1 (https=)
CN (1) CN110023491B (https=)
AU (1) AU2017340644B2 (https=)
BR (1) BR112019006910A2 (https=)
CA (1) CA3038701A1 (https=)
DK (1) DK3523423T3 (https=)
ES (1) ES2989469T3 (https=)
IL (1) IL265810B2 (https=)
MX (1) MX2019003689A (https=)
WO (1) WO2018067836A1 (https=)

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IL265810B1 (en) 2024-04-01
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JP7212615B2 (ja) 2023-01-25
KR102598351B1 (ko) 2023-11-08
JP7560502B2 (ja) 2024-10-02
MX2019003689A (es) 2019-08-22
CN110023491A (zh) 2019-07-16
AU2017340644B2 (en) 2024-05-09
CN110023491B (zh) 2024-03-08
ES2989469T3 (es) 2024-11-26
IL265810B2 (en) 2024-08-01
DK3523423T3 (da) 2024-09-02
EP3523423A1 (en) 2019-08-14
KR20190057387A (ko) 2019-05-28
US20200263139A1 (en) 2020-08-20
AU2017340644A1 (en) 2019-04-18
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