JP2019528704A5 - - Google Patents

Download PDF

Info

Publication number
JP2019528704A5
JP2019528704A5 JP2019512308A JP2019512308A JP2019528704A5 JP 2019528704 A5 JP2019528704 A5 JP 2019528704A5 JP 2019512308 A JP2019512308 A JP 2019512308A JP 2019512308 A JP2019512308 A JP 2019512308A JP 2019528704 A5 JP2019528704 A5 JP 2019528704A5
Authority
JP
Japan
Prior art keywords
seq
nos
methylation
measuring
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019512308A
Other languages
English (en)
Japanese (ja)
Other versions
JP7293109B2 (ja
JP2019528704A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/049915 external-priority patent/WO2018045322A1/fr
Publication of JP2019528704A publication Critical patent/JP2019528704A/ja
Publication of JP2019528704A5 publication Critical patent/JP2019528704A5/ja
Priority to JP2023019916A priority Critical patent/JP2023058645A/ja
Application granted granted Critical
Publication of JP7293109B2 publication Critical patent/JP7293109B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019512308A 2016-09-02 2017-09-01 肝細胞癌の検出 Active JP7293109B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023019916A JP2023058645A (ja) 2016-09-02 2023-02-13 肝細胞癌の検出

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662383165P 2016-09-02 2016-09-02
US62/383,165 2016-09-02
PCT/US2017/049915 WO2018045322A1 (fr) 2016-09-02 2017-09-01 Détection d'un carcinome hépatocellulaire

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023019916A Division JP2023058645A (ja) 2016-09-02 2023-02-13 肝細胞癌の検出

Publications (3)

Publication Number Publication Date
JP2019528704A JP2019528704A (ja) 2019-10-17
JP2019528704A5 true JP2019528704A5 (fr) 2020-03-05
JP7293109B2 JP7293109B2 (ja) 2023-06-19

Family

ID=61282051

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019512308A Active JP7293109B2 (ja) 2016-09-02 2017-09-01 肝細胞癌の検出
JP2023019916A Pending JP2023058645A (ja) 2016-09-02 2023-02-13 肝細胞癌の検出

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023019916A Pending JP2023058645A (ja) 2016-09-02 2023-02-13 肝細胞癌の検出

Country Status (9)

Country Link
US (2) US20180066320A1 (fr)
EP (2) EP4293128A3 (fr)
JP (2) JP7293109B2 (fr)
KR (2) KR102648965B1 (fr)
CN (2) CN116064795A (fr)
AU (2) AU2017318700B2 (fr)
CA (1) CA3034903A1 (fr)
ES (1) ES2956257T3 (fr)
WO (1) WO2018045322A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2255198A4 (fr) 2008-02-15 2011-05-25 Mayo Foundation Détection de néoplasme
ES2812753T3 (es) 2014-03-31 2021-03-18 Mayo Found Medical Education & Res Detección de neoplasma colorectal
US11118228B2 (en) 2017-01-27 2021-09-14 Exact Sciences Development Company, Llc Detection of colon neoplasia by analysis of methylated DNA
AU2020254760A1 (en) * 2019-04-03 2021-10-28 Exact Sciences Corporation Detecting pancreatic ductal adenocarcinoma in plasma
WO2020214798A1 (fr) * 2019-04-17 2020-10-22 The Brigham And Women's Hospital, Inc. Signatures épigénétiques de la maladie d'alzheimer
KR102155044B1 (ko) * 2019-10-08 2020-09-11 주식회사 레피다인 생물학적 시료의 간암 조직 기원 여부를 판별하는 방법
KR102103885B1 (ko) * 2019-10-08 2020-04-24 주식회사 레피다인 생물학적 시료의 간 조직 유래 여부를 판별하는 방법
JP2022552400A (ja) * 2019-10-14 2022-12-15 ジェンキュリクス インク 特定の遺伝子のcpgメチル化変化を利用した肝癌診断用組成物およびその使用
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
WO2021146570A1 (fr) * 2020-01-17 2021-07-22 The Board Of Trustees Of The Leland Stanford Junior University Méthodes de diagnostic du carcinome hépatocellulaire
US20230287509A1 (en) * 2020-07-21 2023-09-14 Epigenomics Ag Methods for detecting liver cancer
CN112011619A (zh) * 2020-09-17 2020-12-01 山东大学深圳研究院 Sfrp2作为标志物在乙型肝炎病毒相关肝细胞癌早期诊断中的应用及检测试剂盒
CN114634981B (zh) * 2020-12-16 2024-01-26 广州达健生物科技有限公司 肝癌基因甲基化检测引物探针组合及其试剂盒与应用
US20240068040A1 (en) * 2021-01-12 2024-02-29 The Board Of Trustees Of The Leland Stanford Junior University Layered analysis of methylated biomarkers for use in cancer diagnosis and prognosis
EP4341441A1 (fr) * 2021-05-21 2024-03-27 Ophiomics - Investigação e Desenvolvimento em Biotecnologia Biomarqueurs de méthylation de l'adn pour le carcinome hépatocellulaire
EP4419717A1 (fr) * 2021-10-19 2024-08-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Signature de méthylation de l'adn pour le diagnostic du carcinome hépatocellulaire
CN113897434A (zh) * 2021-11-02 2022-01-07 北京艾克伦医疗科技有限公司 鉴定肝癌状态的方法和试剂盒
CN113862370B (zh) * 2021-12-02 2022-03-22 广州滴纳生物科技有限公司 用于筛查肝癌的引物和探针、试剂盒及其应用
CN116287254B (zh) * 2023-02-22 2024-04-30 中国人民解放军海军军医大学 Scrn1在制备肝细胞癌分型诊断或索拉非尼疗效预测试剂盒中的应用
WO2024183797A1 (fr) * 2023-03-09 2024-09-12 上海鹍远健康科技有限公司 Utilisation d'un marqueur de méthylation d'adn acellulaire dans le plasma pour la détection des tumeurs hépatiques
CN116200499B (zh) * 2023-03-23 2024-01-19 北京和瑞精湛医学检验实验室有限公司 一种用于肝癌检测的基因组合与相关试剂和应用

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
CA1340807C (fr) 1988-02-24 1999-11-02 Lawrence T. Malek Procede d'amplification d'une sequence d'acide nucleique
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
CA2036946C (fr) 1990-04-06 2001-10-16 Kenneth V. Deugau Molecules de liaison pour indexation
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US6872816B1 (en) 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5338671A (en) 1992-10-07 1994-08-16 Eastman Kodak Company DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
WO1995014106A2 (fr) 1993-11-17 1995-05-26 Id Biomedical Corporation Detection cyclique par scission de sondes de sequences d'acides nucleiques
JPH09506253A (ja) 1993-11-30 1997-06-24 マクギル・ユニヴァーシティ Dnaメチルトランスフェラーゼの阻害
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
CA2188660C (fr) 1994-04-25 2005-01-18 Richard G. H. Cotton Detection de mutations par clivage par resolvase
EP1260593A3 (fr) 1994-12-23 2003-12-03 Dade Behring Inc. Détection d'acides nucléiques par formation d'un produit catalysé par une nucléase
US5882867A (en) 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US5914230A (en) 1995-12-22 1999-06-22 Dade Behring Inc. Homogeneous amplification and detection of nucleic acids
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
AU713667B2 (en) 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US6251594B1 (en) 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
CA2319712A1 (fr) 1998-02-04 1999-08-12 Variagenics, Inc. Procedes de detection d'un mauvais appariement
US6235502B1 (en) 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
EP1294947A2 (fr) * 2000-06-30 2003-03-26 Epigenomics AG Procede et acides nucleiques pour analyse de methylation pharmacogenomique
US7662594B2 (en) 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
WO2005023091A2 (fr) 2003-09-05 2005-03-17 The Trustees Of Boston University Procede de diagnostic prenatal non effractif
US20080039413A1 (en) * 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
PL3002338T3 (pl) 2006-02-02 2019-12-31 The Board Of Trustees Of The Leland Stanford Junior University Nieinwazyjne badania przesiewowe płodu poprzez analizę cyfrową
JP2009095262A (ja) * 2007-10-15 2009-05-07 Japan Found Cancer Res Znフィンガータンパク質
BRPI0908748A2 (pt) 2008-03-15 2015-07-28 Hologic Inc Composições e métodos para análise de moléculas de ácido nucleico durante reações de amplificação
EP2233590A1 (fr) * 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Analyse de méthylation
US20110256538A1 (en) * 2010-04-15 2011-10-20 Philadelphia Health & Education Corporation D/B/A Drexel University College Of Medicine Epigenomic dna modifications for tissue typing, early cancer detection, and disease management
US20130237445A1 (en) * 2010-09-14 2013-09-12 The University Of North Carolina At Chapel Hill Methods and kits for detecting melanoma
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US20130129668A1 (en) * 2011-09-01 2013-05-23 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
CA2874407A1 (fr) 2012-05-24 2013-11-28 Fundacio Institut D'investigacio Biomedica De Bellvitge (Idibell) Procede pour l'identification de l'origine d'un cancer d'origine primaire inconnue par analyse de methylation
EP2899274A4 (fr) * 2012-09-19 2016-06-01 Sysmex Corp Méthode permettant d'obtenir des informations sur le carcinome hépatocellulaire, marqueur et kit associés
EP2900835A4 (fr) * 2012-09-27 2016-05-11 Population Diagnotics Inc Procédés et compositions de dépistage et de traitement de troubles du développement
US9994911B2 (en) * 2013-03-14 2018-06-12 Mayo Foundation For Medical Education And Research Detecting neoplasm
JP6369857B2 (ja) * 2013-05-29 2018-08-08 シスメックス株式会社 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット
CA2938451C (fr) * 2014-01-30 2023-10-17 The Regents Of The University Of California Haplotypage de methylation pour le diagnostic non invasif (monod)
US10184154B2 (en) * 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
EP3034624A1 (fr) * 2014-12-18 2016-06-22 Hospital Clínic de Barcelona Procédé pour le pronostic d'un carcinome hépatocellulaire
US10435755B2 (en) * 2015-03-27 2019-10-08 Exact Sciences Development Company, Llc Detecting esophageal disorders
CN104762301B (zh) * 2015-04-24 2017-12-26 武汉大学 一种检测肝癌风险基因tspyl5甲基化水平的试剂盒及方法
KR102380690B1 (ko) * 2016-04-14 2022-03-29 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 췌장 고도 이형성증의 검출방법

Similar Documents

Publication Publication Date Title
JP2019528704A5 (fr)
JP2018526029A5 (fr)
JP2019520037A5 (fr)
Garrett-Bakelman et al. Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution
Mitchell et al. A panel of genes methylated with high frequency in colorectal cancer
Estécio et al. Dissecting DNA hypermethylation in cancer
CN107847515B (zh) 实体瘤甲基化标志物及其用途
HRP20210953T1 (hr) Postupci i pripravci za određivanje dnk profila
JP2020506680A5 (fr)
JP2016195614A5 (fr)
JP2014519310A5 (fr)
JP2013055956A5 (fr)
EA202192446A1 (ru) Диагностика фетальной хромосомной анэуплоидии с использованием геномного секвенирования
Bethge et al. Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma
RU2019109011A (ru) Композиции и способы с использованием фармакогеномного маркера
JPWO2019108626A5 (fr)
DK3105324T3 (en) NGS SYSTEM CONTROL AND PROCEDURES COMPREHENSIVE THESE
JP2016512437A5 (fr)
US20220177973A1 (en) Methylation modification-based tumor marker stamp-ep6
EP3428291A3 (fr) Séquençage génomique ion torrent
Sant et al. Methods for analysis of DNA methylation
RU2471872C1 (ru) Способ дифференциации штаммов yersinia pestis различных подвидов и биоваров методами полимеразной цепной реакции и мультилокусного сиквенс-типирования
Liyanapathirana et al. Application of a target enrichment-based next-generation sequencing protocol for identification and sequence-based prediction of pneumococcal serotypes
Yigit et al. A Microbiome DNA Enrichment Method for Next‐Generation Sequencing Sample Preparation
JP2011520456A5 (fr)