JP2019528704A5 - - Google Patents

Download PDF

Info

Publication number
JP2019528704A5
JP2019528704A5 JP2019512308A JP2019512308A JP2019528704A5 JP 2019528704 A5 JP2019528704 A5 JP 2019528704A5 JP 2019512308 A JP2019512308 A JP 2019512308A JP 2019512308 A JP2019512308 A JP 2019512308A JP 2019528704 A5 JP2019528704 A5 JP 2019528704A5
Authority
JP
Japan
Prior art keywords
seq
nos
methylation
measuring
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019512308A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019528704A (ja
JP7293109B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/049915 external-priority patent/WO2018045322A1/fr
Publication of JP2019528704A publication Critical patent/JP2019528704A/ja
Publication of JP2019528704A5 publication Critical patent/JP2019528704A5/ja
Priority to JP2023019916A priority Critical patent/JP2023058645A/ja
Application granted granted Critical
Publication of JP7293109B2 publication Critical patent/JP7293109B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019512308A 2016-09-02 2017-09-01 肝細胞癌の検出 Active JP7293109B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023019916A JP2023058645A (ja) 2016-09-02 2023-02-13 肝細胞癌の検出

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662383165P 2016-09-02 2016-09-02
US62/383,165 2016-09-02
PCT/US2017/049915 WO2018045322A1 (fr) 2016-09-02 2017-09-01 Détection d'un carcinome hépatocellulaire

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023019916A Division JP2023058645A (ja) 2016-09-02 2023-02-13 肝細胞癌の検出

Publications (3)

Publication Number Publication Date
JP2019528704A JP2019528704A (ja) 2019-10-17
JP2019528704A5 true JP2019528704A5 (fr) 2020-03-05
JP7293109B2 JP7293109B2 (ja) 2023-06-19

Family

ID=61282051

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019512308A Active JP7293109B2 (ja) 2016-09-02 2017-09-01 肝細胞癌の検出
JP2023019916A Pending JP2023058645A (ja) 2016-09-02 2023-02-13 肝細胞癌の検出

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023019916A Pending JP2023058645A (ja) 2016-09-02 2023-02-13 肝細胞癌の検出

Country Status (9)

Country Link
US (2) US20180066320A1 (fr)
EP (2) EP4293128A3 (fr)
JP (2) JP7293109B2 (fr)
KR (2) KR102648965B1 (fr)
CN (2) CN109790198B (fr)
AU (2) AU2017318700B2 (fr)
CA (1) CA3034903A1 (fr)
ES (1) ES2956257T3 (fr)
WO (1) WO2018045322A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2816122A1 (fr) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Détection de néoplasme d'un échantillon de selles
CN106460046A (zh) 2014-03-31 2017-02-22 梅奥医学教育和研究基金会 检测结直肠赘生物
EP3574110A4 (fr) 2017-01-27 2021-01-13 Exact Sciences Development Company, LLC Détection de la néoplasie du côlon par analyse d'adn méthylé
CN113811622A (zh) * 2019-04-03 2021-12-17 梅约医学教育与研究基金会 在血浆中检测胰腺导管腺癌
WO2020214798A1 (fr) * 2019-04-17 2020-10-22 The Brigham And Women's Hospital, Inc. Signatures épigénétiques de la maladie d'alzheimer
KR102103885B1 (ko) * 2019-10-08 2020-04-24 주식회사 레피다인 생물학적 시료의 간 조직 유래 여부를 판별하는 방법
KR102155044B1 (ko) * 2019-10-08 2020-09-11 주식회사 레피다인 생물학적 시료의 간암 조직 기원 여부를 판별하는 방법
WO2021075797A2 (fr) * 2019-10-14 2021-04-22 주식회사 젠큐릭스 Composition pour le diagnostic de cancer du foie à l'aide de modifications de la méthylation de cpg dans des gènes spécifiques et son utilisation
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
JP2023510572A (ja) * 2020-01-17 2023-03-14 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 肝細胞がんを診断するための方法
JP2023535004A (ja) * 2020-07-21 2023-08-15 エピゲノミクスアーゲー 肝臓癌を検出する方法
CN112011619A (zh) * 2020-09-17 2020-12-01 山东大学深圳研究院 Sfrp2作为标志物在乙型肝炎病毒相关肝细胞癌早期诊断中的应用及检测试剂盒
CN114634981B (zh) * 2020-12-16 2024-01-26 广州达健生物科技有限公司 肝癌基因甲基化检测引物探针组合及其试剂盒与应用
CN117062915A (zh) * 2021-01-12 2023-11-14 里兰斯坦福初级大学理事会 用于癌症诊断和预后的甲基化生物标志的分层分析
CN117355616A (zh) * 2021-05-21 2024-01-05 奥弗奥密克斯生物技术研究与开发股份公司 用于肝细胞癌的dna甲基化生物标志物
CA3235235A1 (fr) * 2021-10-19 2023-04-27 Inserm (Institut National De La Sante Et De La Recherche Medicale) Signature de methylation de l'adn pour le diagnostic du carcinome hepatocellulaire
CN113897434A (zh) * 2021-11-02 2022-01-07 北京艾克伦医疗科技有限公司 鉴定肝癌状态的方法和试剂盒
CN113862370B (zh) * 2021-12-02 2022-03-22 广州滴纳生物科技有限公司 用于筛查肝癌的引物和探针、试剂盒及其应用
CN116287254B (zh) * 2023-02-22 2024-04-30 中国人民解放军海军军医大学 Scrn1在制备肝细胞癌分型诊断或索拉非尼疗效预测试剂盒中的应用

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
CA1340807C (fr) 1988-02-24 1999-11-02 Lawrence T. Malek Procede d'amplification d'une sequence d'acide nucleique
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
CA2036946C (fr) 1990-04-06 2001-10-16 Kenneth V. Deugau Molecules de liaison pour indexation
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US6872816B1 (en) 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5338671A (en) 1992-10-07 1994-08-16 Eastman Kodak Company DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
AU8102694A (en) 1993-11-17 1995-06-06 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
ATE178939T1 (de) 1993-11-30 1999-04-15 Univ Mcgill Dna methyltransferase inhibierung
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
ATE248224T1 (de) 1994-04-25 2003-09-15 Avitech Diagnostics Inc Die bestimmung von mutationen durch spaltung mit resolvase
ES2185719T3 (es) 1994-12-23 2003-05-01 Dade Behring Inc Deteccion de acidos nucleicos por formacion de un producto catalizada por diana.
US5882867A (en) 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
CA2239683A1 (fr) 1995-12-22 1997-07-03 Dade Behring Marburg Gmbh Amplification et detection homogenes des acides nucleiques
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
EP0892808B1 (fr) 1996-04-12 2008-05-14 PHRI Properties, Inc. Sondes, trousses et dosages de detection
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
WO1998056952A1 (fr) 1997-06-09 1998-12-17 University Of Southern California Methode de diagnostic du cancer basee sur des differences de methylation d'adn
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
AU753273B2 (en) 1998-02-04 2002-10-10 Variagenics, Inc. Mismatch detection techniques
US6235502B1 (en) 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
AU2001289617A1 (en) * 2000-06-30 2002-01-08 Epigenomics Ag Diagnosis of diseases associated with signal transduction
US7662594B2 (en) 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
EP2354253A3 (fr) 2003-09-05 2011-11-16 Trustees of Boston University Procede de diagnostic prenatal non effractif
US20080039413A1 (en) * 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
SI3002338T1 (sl) 2006-02-02 2019-11-29 Univ Leland Stanford Junior Neinvaziven genetski pregled zarodka z digitalno analizo
JP2009095262A (ja) * 2007-10-15 2009-05-07 Japan Found Cancer Res Znフィンガータンパク質
WO2009117327A2 (fr) 2008-03-15 2009-09-24 Hologic, Inc. Compositions et procédés pour analyse de molécules d’acide nucléique pendant des réactions d’amplification
EP2233590A1 (fr) * 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Analyse de méthylation
US20110256538A1 (en) 2010-04-15 2011-10-20 Philadelphia Health & Education Corporation D/B/A Drexel University College Of Medicine Epigenomic dna modifications for tissue typing, early cancer detection, and disease management
WO2012037128A2 (fr) * 2010-09-14 2012-03-22 The University Of North Carolina At Chapel Hill Procédés et kits pour la détection du mélanome
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
US20130129668A1 (en) * 2011-09-01 2013-05-23 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
MX2014014356A (es) * 2012-05-24 2015-07-06 Fundació Inst D Investigació Biomédica De Bellvitge Idibell Metodo para la identificacion del origen de un cancer de origen primario desconocido.
WO2014046198A1 (fr) * 2012-09-19 2014-03-27 シスメックス株式会社 Méthode permettant d'obtenir des informations sur le carcinome hépatocellulaire, marqueur et kit associés
CA2922005A1 (fr) * 2012-09-27 2014-04-03 Population Diagnostics, Inc. Procedes et compositions de depistage et de traitement de troubles du developpement
US9506116B2 (en) * 2013-03-14 2016-11-29 Mayo Foundation For Medical Education And Research Detecting neoplasm
JP6369857B2 (ja) * 2013-05-29 2018-08-08 シスメックス株式会社 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット
WO2015116837A1 (fr) * 2014-01-30 2015-08-06 The Regents Of The University Of California Haplotypage de méthylation pour le diagnostic non invasif (monod)
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
EP3034624A1 (fr) * 2014-12-18 2016-06-22 Hospital Clínic de Barcelona Procédé pour le pronostic d'un carcinome hépatocellulaire
CN107532124B (zh) * 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
CN104762301B (zh) * 2015-04-24 2017-12-26 武汉大学 一种检测肝癌风险基因tspyl5甲基化水平的试剂盒及方法
US11078543B2 (en) * 2016-04-14 2021-08-03 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia

Similar Documents

Publication Publication Date Title
JP2019528704A5 (fr)
JP2019520037A5 (fr)
JP2018526029A5 (fr)
Garrett-Bakelman et al. Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution
Mitchell et al. A panel of genes methylated with high frequency in colorectal cancer
Estécio et al. Dissecting DNA hypermethylation in cancer
JP2020506680A5 (fr)
CN107847515B (zh) 实体瘤甲基化标志物及其用途
JP2016195614A5 (fr)
JP2014519310A5 (fr)
JP2013055956A5 (fr)
EA202192446A1 (ru) Диагностика фетальной хромосомной анэуплоидии с использованием геномного секвенирования
JP2008506407A5 (fr)
Bethge et al. Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma
RU2019109011A (ru) Композиции и способы с использованием фармакогеномного маркера
DK3105324T3 (en) NGS SYSTEM CONTROL AND PROCEDURES COMPREHENSIVE THESE
JPWO2019108626A5 (fr)
JP2016512437A5 (fr)
US20220177973A1 (en) Methylation modification-based tumor marker stamp-ep6
Sant et al. Methods for analysis of DNA methylation
RU2471872C1 (ru) Способ дифференциации штаммов yersinia pestis различных подвидов и биоваров методами полимеразной цепной реакции и мультилокусного сиквенс-типирования
Liyanapathirana et al. Application of a target enrichment-based next-generation sequencing protocol for identification and sequence-based prediction of pneumococcal serotypes
Yigit et al. A Microbiome DNA Enrichment Method for Next‐Generation Sequencing Sample Preparation
JP2011520456A5 (fr)
Krasnov et al. MethyMer: Design of combinations of specific primers for bisulfite sequencing of complete CpG islands