JP2019526606A5 - - Google Patents
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- JP2019526606A5 JP2019526606A5 JP2019513756A JP2019513756A JP2019526606A5 JP 2019526606 A5 JP2019526606 A5 JP 2019526606A5 JP 2019513756 A JP2019513756 A JP 2019513756A JP 2019513756 A JP2019513756 A JP 2019513756A JP 2019526606 A5 JP2019526606 A5 JP 2019526606A5
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- hydrogen
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662393209P | 2016-09-12 | 2016-09-12 | |
| US62/393,209 | 2016-09-12 | ||
| PCT/US2017/050886 WO2018049296A1 (en) | 2016-09-12 | 2017-09-11 | Heteroaryl inhibitors of pad4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526606A JP2019526606A (ja) | 2019-09-19 |
| JP2019526606A5 true JP2019526606A5 (enExample) | 2020-10-22 |
| JP7118951B2 JP7118951B2 (ja) | 2022-08-16 |
Family
ID=59955657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019513756A Active JP7118951B2 (ja) | 2016-09-12 | 2017-09-11 | Ｐａｄ４のヘテロアリール阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11026937B2 (enExample) |
| EP (1) | EP3510025B1 (enExample) |
| JP (1) | JP7118951B2 (enExample) |
| KR (1) | KR102502992B1 (enExample) |
| CN (1) | CN110248934B (enExample) |
| ES (1) | ES2924522T3 (enExample) |
| MA (1) | MA46193A (enExample) |
| WO (1) | WO2018049296A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3419969B1 (en) | 2016-02-23 | 2019-12-18 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of pad4 |
| WO2018022897A1 (en) | 2016-07-27 | 2018-02-01 | Padlock Therapeutics, Inc. | Covalent inhibitors of pad4 |
| BR112020023107A2 (pt) * | 2018-05-14 | 2021-02-02 | Ariad Pharmaceuticals, Inc. | sais farmacêuticos de derivados de pirimidina e método de tratamento de distúrbios |
| KR102089476B1 (ko) * | 2018-07-11 | 2020-03-16 | 이화여자대학교 산학협력단 | 피부 염증 질환 예방 또는 치료용 조성물 |
| EP3833440A1 (en) | 2018-08-08 | 2021-06-16 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of pad enzymes |
| CN112566916B (zh) | 2018-08-08 | 2023-10-20 | 百时美施贵宝公司 | 作为pad4抑制剂的经取代的噻吩并吡咯 |
| CN109467549B (zh) * | 2018-12-07 | 2021-02-09 | 中国药科大学 | 喹啉取代查尔酮类化合物、其制备方法及用途 |
| KR102173983B1 (ko) | 2019-04-18 | 2020-11-04 | 현대모비스 주식회사 | 전자식 유압 브레이크 장치 |
| WO2021158840A1 (en) | 2020-02-06 | 2021-08-12 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| PE20230488A1 (es) | 2020-04-30 | 2023-03-21 | Gilead Sciences Inc | Inhibidores macrociclicos de las peptidilarginina deiminasas |
| EP4267562A1 (en) | 2020-12-22 | 2023-11-01 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| US12240862B2 (en) | 2020-12-22 | 2025-03-04 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| WO2024112749A1 (en) * | 2022-11-23 | 2024-05-30 | The Children's Medical Center Corporation | Methods of treating heart failure |
| CN115778930B (zh) * | 2022-12-08 | 2024-02-27 | 陕西中医药大学 | 一种具有血管舒张活性的二硫缩醛类化合物在制备具有血管舒张活性药物方面的应用 |
| US11731942B1 (en) | 2023-01-12 | 2023-08-22 | King Faisal University | 3-substituted quinolin-2-one compounds as antibacterial agents |
| AR131956A1 (es) * | 2023-02-28 | 2025-05-21 | Chugai Pharmaceutical Co Ltd | Compuesto heterocíclico que contiene nitrógeno con actividad inhibidora de myt1 |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2876000A (en) * | 1999-02-10 | 2000-08-29 | Trustees Of The University Of Pennsylvania, The | Tyrosine kinase inhibitors and methods of using the same |
| WO2002098425A1 (en) * | 2001-06-04 | 2002-12-12 | Cytovia, Inc. | Substituted 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1h)-quinolinones and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| JP2002371078A (ja) * | 2001-06-12 | 2002-12-26 | Sankyo Co Ltd | キノリン誘導体及びキノロン誘導体 |
| JP4815773B2 (ja) * | 2003-09-17 | 2011-11-16 | 住友化学株式会社 | シンナモイル化合物及びその用途 |
| AU2004274328B2 (en) * | 2003-09-17 | 2011-11-10 | Sumitomo Chemical Company, Limited | Cinnamoyl compound and use of the same |
| JP2008501804A (ja) * | 2004-06-08 | 2008-01-24 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | ヘテロアリール、スルホン及びスルホンアミド並びにそれらの治療用途 |
| JP2006273848A (ja) * | 2005-03-02 | 2006-10-12 | Sumitomo Chemical Co Ltd | シンナモイル化合物の用途 |
| AU2006219222A1 (en) * | 2005-03-02 | 2006-09-08 | Sumitomo Chemical Company, Limited | Use of cinnamoyl compound |
| CA2611608A1 (en) * | 2005-06-08 | 2006-12-14 | Temple University - Of The Commonwealth System Of Higher Education | 3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof |
| JP5642963B2 (ja) * | 2006-06-30 | 2014-12-17 | スネシス ファーマシューティカルズ，インコーポレイティド | ピリジノニルｐｄｋ１阻害剤 |
| EP1987717A1 (de) * | 2007-04-30 | 2008-11-05 | Bayer CropScience AG | Pyridoncarboxamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
| US20120190707A1 (en) * | 2008-04-25 | 2012-07-26 | Ronai Ze Ev | Selective inhibitors of akt and methods of using same |
| WO2014015905A1 (en) * | 2012-07-26 | 2014-01-30 | Glaxo Group Limited | 2 - (azaindol- 2 -yl) benz imidazoles as pad4 inhibitors |
| CN105315333A (zh) * | 2014-06-10 | 2016-02-10 | 首都医科大学 | 异喹啉-3-甲酰-RV-OBzl,其制备,纳米结构,活性和应用 |
| US10577349B2 (en) * | 2015-03-02 | 2020-03-03 | Sanford Burnham Prebys Medical Discovery Institute | Quinolinones as inhibitors of translation initiation complex |
| CA3199601A1 (en) | 2015-05-21 | 2016-11-24 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as pad4 inhibitors |
| AR107030A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| EP3419969B1 (en) | 2016-02-23 | 2019-12-18 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of pad4 |
| CN105820058A (zh) * | 2016-03-01 | 2016-08-03 | 南开大学 | 精氨酸脱亚氨酶4的新型抑制剂 |
| WO2018022897A1 (en) | 2016-07-27 | 2018-02-01 | Padlock Therapeutics, Inc. | Covalent inhibitors of pad4 |
-
2017
- 2017-09-11 CN CN201780070039.2A patent/CN110248934B/zh active Active
- 2017-09-11 WO PCT/US2017/050886 patent/WO2018049296A1/en not_active Ceased
- 2017-09-11 JP JP2019513756A patent/JP7118951B2/ja active Active
- 2017-09-11 ES ES17772181T patent/ES2924522T3/es active Active
- 2017-09-11 EP EP17772181.8A patent/EP3510025B1/en active Active
- 2017-09-11 MA MA046193A patent/MA46193A/fr unknown
- 2017-09-11 US US16/331,622 patent/US11026937B2/en active Active
- 2017-09-11 KR KR1020197010110A patent/KR102502992B1/ko active Active
-
2021
- 2021-05-12 US US17/318,078 patent/US20210299115A1/en not_active Abandoned
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