ES2924522T3 - Inhibidores heteroarilo de PAD4 - Google Patents

Inhibidores heteroarilo de PAD4 Download PDF

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Publication number
ES2924522T3
ES2924522T3 ES17772181T ES17772181T ES2924522T3 ES 2924522 T3 ES2924522 T3 ES 2924522T3 ES 17772181 T ES17772181 T ES 17772181T ES 17772181 T ES17772181 T ES 17772181T ES 2924522 T3 ES2924522 T3 ES 2924522T3
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Prior art keywords
disease
mmol
phenyl
dihydroquinolin
prop
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ES17772181T
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Spanish (es)
Inventor
Rajesh Devraj
Gnanasambandam Kumaravel
Cristina Lecci
Pui Loke
Mirco Meniconi
Nat Monck
Carl North
Mark Ridgill
Heather Tye
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Padlock Therapeutics Inc
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Padlock Therapeutics Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
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