JP2019525913A5 - - Google Patents
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- Publication number
- JP2019525913A5 JP2019525913A5 JP2019500355A JP2019500355A JP2019525913A5 JP 2019525913 A5 JP2019525913 A5 JP 2019525913A5 JP 2019500355 A JP2019500355 A JP 2019500355A JP 2019500355 A JP2019500355 A JP 2019500355A JP 2019525913 A5 JP2019525913 A5 JP 2019525913A5
- Authority
- JP
- Japan
- Prior art keywords
- amount
- organic solvent
- formula
- temperature
- membered heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C[n](c(*)c1)nc1-c(nc1O)nc(O)c1F Chemical compound *C[n](c(*)c1)nc1-c(nc1O)nc(O)c1F 0.000 description 7
- JYAHXBWSCRHPMZ-UHFFFAOYSA-N Fc1c(C[n](c(-c2n[o]cc2)c2)nc2-c(nc2Cl)nc(Cl)c2F)cccc1 Chemical compound Fc1c(C[n](c(-c2n[o]cc2)c2)nc2-c(nc2Cl)nc(Cl)c2F)cccc1 JYAHXBWSCRHPMZ-UHFFFAOYSA-N 0.000 description 2
- UXYRXGFUANQKTA-UHFFFAOYSA-N OC(c1n[o]cc1)=O Chemical compound OC(c1n[o]cc1)=O UXYRXGFUANQKTA-UHFFFAOYSA-N 0.000 description 1
- BNQFOSYFEVDOMJ-UHFFFAOYSA-N Oc(nc(-c1n[n](Cc(cccc2)c2F)c(-c2n[o]cc2)c1)nc1Cl)c1F Chemical compound Oc(nc(-c1n[n](Cc(cccc2)c2F)c(-c2n[o]cc2)c1)nc1Cl)c1F BNQFOSYFEVDOMJ-UHFFFAOYSA-N 0.000 description 1
- LIVYVCAUBHXIMI-UHFFFAOYSA-N Oc1nc(-c2n[n](Cc(cccc3)c3F)c(-c3n[o]cc3)c2)ncc1F Chemical compound Oc1nc(-c2n[n](Cc(cccc3)c3F)c(-c3n[o]cc3)c2)ncc1F LIVYVCAUBHXIMI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359453P | 2016-07-07 | 2016-07-07 | |
| US62/359,453 | 2016-07-07 | ||
| PCT/US2017/040810 WO2018009597A1 (en) | 2016-07-07 | 2017-07-06 | Novel processes for preparation of soluble guanylate cyclase stimulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525913A JP2019525913A (ja) | 2019-09-12 |
| JP2019525913A5 true JP2019525913A5 (https=) | 2020-08-20 |
| JP7112384B2 JP7112384B2 (ja) | 2022-08-03 |
Family
ID=59416789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500355A Active JP7112384B2 (ja) | 2016-07-07 | 2017-07-06 | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US11319308B2 (https=) |
| EP (2) | EP3481818B1 (https=) |
| JP (1) | JP7112384B2 (https=) |
| KR (1) | KR102487872B1 (https=) |
| CN (2) | CN109563077B (https=) |
| AU (1) | AU2017291827B2 (https=) |
| BR (1) | BR112019000291A2 (https=) |
| CA (1) | CA3029375A1 (https=) |
| CL (2) | CL2019000016A1 (https=) |
| EA (1) | EA201990237A1 (https=) |
| ES (1) | ES2963563T3 (https=) |
| IL (1) | IL263995B (https=) |
| MA (1) | MA45603A (https=) |
| MX (2) | MX389920B (https=) |
| SG (1) | SG11201900096QA (https=) |
| WO (1) | WO2018009597A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109563077B (zh) | 2016-07-07 | 2026-03-10 | 赛克里翁治疗有限公司 | 用于制备可溶性鸟苷酸环化酶刺激剂的新方法 |
| WO2018009602A2 (en) * | 2016-07-07 | 2018-01-11 | Ironwood Pharmaceuticals, Inc. | Novel processes for preparation of soluble guanylate cyclase stimulators |
| MA71753A (fr) | 2018-01-10 | 2025-05-30 | Cyclerion Therapeutics, Inc. | Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de guanylate cyclase soluble |
| WO2019161534A1 (en) * | 2018-02-22 | 2019-08-29 | Ironwood Pharmaceuticals, Inc. | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ603789A (en) * | 2010-05-26 | 2015-03-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| AR088020A1 (es) | 2010-06-30 | 2014-05-07 | Ironwood Pharmaceuticals Inc | Compuestos heterociclicos como estimuladores de sgc |
| CN106117194A (zh) | 2011-12-27 | 2016-11-16 | 铁木医药有限公司 | 可用作sgc刺激剂的2‑苄基、3‑(嘧啶‑2‑基)取代的吡唑类 |
| US9487508B2 (en) * | 2012-09-19 | 2016-11-08 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
| SI2970243T1 (sl) * | 2013-03-15 | 2020-04-30 | Cyclerion Therapeutics, Inc. | SGC stimulatorji |
| JP2016540017A (ja) * | 2013-12-11 | 2016-12-22 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | ｓＧＣ刺激物質 |
| US20170291889A1 (en) * | 2014-09-17 | 2017-10-12 | Ironwood Pharmaceuticals, Inc. | Pyrazole derivatives as sgc stimulators |
| EP3194386A2 (en) * | 2014-09-17 | 2017-07-26 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| US20170298055A1 (en) * | 2014-09-17 | 2017-10-19 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| KR20170055531A (ko) * | 2014-09-17 | 2017-05-19 | 아이언우드 파마슈티컬스, 인코포레이티드 | 에스지씨 자극제 |
| CA3006746C (en) * | 2015-11-30 | 2024-01-30 | Ironwood Pharmaceuticals, Inc. | Solid dispersions comprising a sgc stimulator |
| WO2018009602A2 (en) | 2016-07-07 | 2018-01-11 | Ironwood Pharmaceuticals, Inc. | Novel processes for preparation of soluble guanylate cyclase stimulators |
| MX389964B (es) * | 2016-07-07 | 2025-03-19 | Cyclerion Therapeutics Inc | Formas sólidas de un estimulador de guanilato ciclasa soluble (sgc). |
| CN109563077B (zh) | 2016-07-07 | 2026-03-10 | 赛克里翁治疗有限公司 | 用于制备可溶性鸟苷酸环化酶刺激剂的新方法 |
| CA3086207A1 (en) * | 2017-12-19 | 2019-06-27 | Cyclerion Therapeutics, Inc. | Sgc stimulators |
| MA71753A (fr) * | 2018-01-10 | 2025-05-30 | Cyclerion Therapeutics, Inc. | Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de guanylate cyclase soluble |
-
2017
- 2017-07-06 CN CN201780047020.6A patent/CN109563077B/zh active Active
- 2017-07-06 MX MX2019000105A patent/MX389920B/es unknown
- 2017-07-06 CN CN202511803316.9A patent/CN121673266A/zh active Pending
- 2017-07-06 EA EA201990237A patent/EA201990237A1/ru unknown
- 2017-07-06 MA MA045603A patent/MA45603A/fr unknown
- 2017-07-06 CA CA3029375A patent/CA3029375A1/en active Pending
- 2017-07-06 KR KR1020197003459A patent/KR102487872B1/ko active Active
- 2017-07-06 ES ES17745553T patent/ES2963563T3/es active Active
- 2017-07-06 EP EP17745553.2A patent/EP3481818B1/en active Active
- 2017-07-06 US US16/315,218 patent/US11319308B2/en active Active
- 2017-07-06 EP EP23185002.5A patent/EP4249488A3/en active Pending
- 2017-07-06 SG SG11201900096QA patent/SG11201900096QA/en unknown
- 2017-07-06 WO PCT/US2017/040810 patent/WO2018009597A1/en not_active Ceased
- 2017-07-06 AU AU2017291827A patent/AU2017291827B2/en active Active
- 2017-07-06 JP JP2019500355A patent/JP7112384B2/ja active Active
- 2017-07-06 BR BR112019000291A patent/BR112019000291A2/pt not_active Application Discontinuation
-
2018
- 2018-12-27 IL IL263995A patent/IL263995B/en active IP Right Grant
-
2019
- 2019-01-04 CL CL2019000016A patent/CL2019000016A1/es unknown
- 2019-01-07 MX MX2022001495A patent/MX2022001495A/es unknown
-
2022
- 2022-03-30 US US17/708,296 patent/US11773089B2/en active Active
-
2023
- 2023-01-24 CL CL2023000228A patent/CL2023000228A1/es unknown
- 2023-08-24 US US18/237,435 patent/US20240059684A1/en not_active Abandoned
-
2025
- 2025-04-23 US US19/187,279 patent/US20260103457A1/en active Pending
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