CN109563077B - 用于制备可溶性鸟苷酸环化酶刺激剂的新方法 - Google Patents

用于制备可溶性鸟苷酸环化酶刺激剂的新方法

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Publication number
CN109563077B
CN109563077B CN201780047020.6A CN201780047020A CN109563077B CN 109563077 B CN109563077 B CN 109563077B CN 201780047020 A CN201780047020 A CN 201780047020A CN 109563077 B CN109563077 B CN 109563077B
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China
Prior art keywords
formula
appropriate amount
amount
equivalents
temperature
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CN201780047020.6A
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English (en)
Chinese (zh)
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CN109563077A (zh
Inventor
薛松
V·V·R·卡纳缇
R·C·利文斯顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cyclone Therapy Co ltd
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Cyclone Therapy Co ltd
Ironwood Pharmaceuticals Inc
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Application filed by Cyclone Therapy Co ltd, Ironwood Pharmaceuticals Inc filed Critical Cyclone Therapy Co ltd
Priority to CN202511803316.9A priority Critical patent/CN121673266A/zh
Publication of CN109563077A publication Critical patent/CN109563077A/zh
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Publication of CN109563077B publication Critical patent/CN109563077B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201780047020.6A 2016-07-07 2017-07-06 用于制备可溶性鸟苷酸环化酶刺激剂的新方法 Active CN109563077B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202511803316.9A CN121673266A (zh) 2016-07-07 2017-07-06 用于制备可溶性鸟苷酸环化酶刺激剂的新方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662359453P 2016-07-07 2016-07-07
US62/359,453 2016-07-07
PCT/US2017/040810 WO2018009597A1 (en) 2016-07-07 2017-07-06 Novel processes for preparation of soluble guanylate cyclase stimulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202511803316.9A Division CN121673266A (zh) 2016-07-07 2017-07-06 用于制备可溶性鸟苷酸环化酶刺激剂的新方法

Publications (2)

Publication Number Publication Date
CN109563077A CN109563077A (zh) 2019-04-02
CN109563077B true CN109563077B (zh) 2026-03-10

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ID=59416789

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CN201780047020.6A Active CN109563077B (zh) 2016-07-07 2017-07-06 用于制备可溶性鸟苷酸环化酶刺激剂的新方法
CN202511803316.9A Pending CN121673266A (zh) 2016-07-07 2017-07-06 用于制备可溶性鸟苷酸环化酶刺激剂的新方法

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Country Status (16)

Country Link
US (4) US11319308B2 (https=)
EP (2) EP3481818B1 (https=)
JP (1) JP7112384B2 (https=)
KR (1) KR102487872B1 (https=)
CN (2) CN109563077B (https=)
AU (1) AU2017291827B2 (https=)
BR (1) BR112019000291A2 (https=)
CA (1) CA3029375A1 (https=)
CL (2) CL2019000016A1 (https=)
EA (1) EA201990237A1 (https=)
ES (1) ES2963563T3 (https=)
IL (1) IL263995B (https=)
MA (1) MA45603A (https=)
MX (2) MX389920B (https=)
SG (1) SG11201900096QA (https=)
WO (1) WO2018009597A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109563077B (zh) 2016-07-07 2026-03-10 赛克里翁治疗有限公司 用于制备可溶性鸟苷酸环化酶刺激剂的新方法
WO2018009602A2 (en) * 2016-07-07 2018-01-11 Ironwood Pharmaceuticals, Inc. Novel processes for preparation of soluble guanylate cyclase stimulators
MA71753A (fr) 2018-01-10 2025-05-30 Cyclerion Therapeutics, Inc. Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de guanylate cyclase soluble
WO2019161534A1 (en) * 2018-02-22 2019-08-29 Ironwood Pharmaceuticals, Inc. Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators

Citations (4)

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CN103038229A (zh) * 2010-05-26 2013-04-10 桑诺维恩药品公司 杂芳基化合物及其使用方法
CN104066731A (zh) * 2011-12-27 2014-09-24 铁木医药有限公司 可用作sgc刺激剂的2-苄基、3-(嘧啶-2-基)取代的吡唑类
CN105408328A (zh) * 2013-03-15 2016-03-16 铁木医药有限公司 sGC刺激剂
WO2016044447A1 (en) * 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. Pyrazole derivatives as sgc stimulators

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR088020A1 (es) 2010-06-30 2014-05-07 Ironwood Pharmaceuticals Inc Compuestos heterociclicos como estimuladores de sgc
US9487508B2 (en) * 2012-09-19 2016-11-08 Ironwood Pharmaceuticals, Inc. SGC stimulators
JP2016540017A (ja) * 2013-12-11 2016-12-22 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激物質
EP3194386A2 (en) * 2014-09-17 2017-07-26 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US20170298055A1 (en) * 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
KR20170055531A (ko) * 2014-09-17 2017-05-19 아이언우드 파마슈티컬스, 인코포레이티드 에스지씨 자극제
CA3006746C (en) * 2015-11-30 2024-01-30 Ironwood Pharmaceuticals, Inc. Solid dispersions comprising a sgc stimulator
WO2018009602A2 (en) 2016-07-07 2018-01-11 Ironwood Pharmaceuticals, Inc. Novel processes for preparation of soluble guanylate cyclase stimulators
MX389964B (es) * 2016-07-07 2025-03-19 Cyclerion Therapeutics Inc Formas sólidas de un estimulador de guanilato ciclasa soluble (sgc).
CN109563077B (zh) 2016-07-07 2026-03-10 赛克里翁治疗有限公司 用于制备可溶性鸟苷酸环化酶刺激剂的新方法
CA3086207A1 (en) * 2017-12-19 2019-06-27 Cyclerion Therapeutics, Inc. Sgc stimulators
MA71753A (fr) * 2018-01-10 2025-05-30 Cyclerion Therapeutics, Inc. Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de guanylate cyclase soluble

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103038229A (zh) * 2010-05-26 2013-04-10 桑诺维恩药品公司 杂芳基化合物及其使用方法
CN104066731A (zh) * 2011-12-27 2014-09-24 铁木医药有限公司 可用作sgc刺激剂的2-苄基、3-(嘧啶-2-基)取代的吡唑类
CN105408328A (zh) * 2013-03-15 2016-03-16 铁木医药有限公司 sGC刺激剂
WO2016044447A1 (en) * 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. Pyrazole derivatives as sgc stimulators

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A new route to the synthesis of 5-fluorouracil;B.Baasner等;《Journal of Fluorine Chemistry》;19891231;第45卷(第3期);第418页及第419-420页第2节 *
Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans;Takashi Nakai等;《ACS Medicinal Chemistry Letters》;20160224;第7卷(第5期);supporting information第10页Scheme S7 *
Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II;Ali Raoof等;《Journal of Medicinal Chemistry》;20130716;第56卷(第16期);第6356页Scheme 12 *

Also Published As

Publication number Publication date
BR112019000291A2 (pt) 2019-04-16
KR102487872B1 (ko) 2023-01-12
EP4249488A2 (en) 2023-09-27
EP3481818A1 (en) 2019-05-15
IL263995A (en) 2019-02-28
MX2019000105A (es) 2019-04-22
US20260103457A1 (en) 2026-04-16
NZ750123A (en) 2025-02-28
CL2023000228A1 (es) 2023-09-29
EP3481818C0 (en) 2023-09-06
EP4249488A3 (en) 2023-12-20
MA45603A (fr) 2019-05-15
AU2017291827A1 (en) 2019-02-07
US20240059684A1 (en) 2024-02-22
EA201990237A1 (ru) 2019-08-30
CL2019000016A1 (es) 2019-05-03
AU2017291827B2 (en) 2021-10-21
US20210323951A1 (en) 2021-10-21
SG11201900096QA (en) 2019-02-27
MX389920B (es) 2025-03-20
WO2018009597A1 (en) 2018-01-11
CN109563077A (zh) 2019-04-02
KR20190025986A (ko) 2019-03-12
CN121673266A (zh) 2026-03-17
JP2019525913A (ja) 2019-09-12
MX2022001495A (es) 2022-03-11
ES2963563T3 (es) 2024-03-27
US11319308B2 (en) 2022-05-03
JP7112384B2 (ja) 2022-08-03
CA3029375A1 (en) 2018-01-11
IL263995B (en) 2021-02-28
US20220227748A1 (en) 2022-07-21
EP3481818B1 (en) 2023-09-06
US11773089B2 (en) 2023-10-03

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Effective date of registration: 20190925

Address after: Massachusetts, USA

Applicant after: Cyclone Therapy Co.,Ltd.

Address before: Massachusetts, USA

Applicant before: IRONWOOD PHARMACEUTICALS, Inc.

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