KR102487872B1 - 가용성 구아닐레이트 시클라제 자극제의 신규 제조 방법 - Google Patents
가용성 구아닐레이트 시클라제 자극제의 신규 제조 방법 Download PDFInfo
- Publication number
- KR102487872B1 KR102487872B1 KR1020197003459A KR20197003459A KR102487872B1 KR 102487872 B1 KR102487872 B1 KR 102487872B1 KR 1020197003459 A KR1020197003459 A KR 1020197003459A KR 20197003459 A KR20197003459 A KR 20197003459A KR 102487872 B1 KR102487872 B1 KR 102487872B1
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- base
- organic solvent
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359453P | 2016-07-07 | 2016-07-07 | |
| US62/359,453 | 2016-07-07 | ||
| PCT/US2017/040810 WO2018009597A1 (en) | 2016-07-07 | 2017-07-06 | Novel processes for preparation of soluble guanylate cyclase stimulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190025986A KR20190025986A (ko) | 2019-03-12 |
| KR102487872B1 true KR102487872B1 (ko) | 2023-01-12 |
Family
ID=59416789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197003459A Active KR102487872B1 (ko) | 2016-07-07 | 2017-07-06 | 가용성 구아닐레이트 시클라제 자극제의 신규 제조 방법 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US11319308B2 (https=) |
| EP (2) | EP3481818B1 (https=) |
| JP (1) | JP7112384B2 (https=) |
| KR (1) | KR102487872B1 (https=) |
| CN (2) | CN109563077B (https=) |
| AU (1) | AU2017291827B2 (https=) |
| BR (1) | BR112019000291A2 (https=) |
| CA (1) | CA3029375A1 (https=) |
| CL (2) | CL2019000016A1 (https=) |
| EA (1) | EA201990237A1 (https=) |
| ES (1) | ES2963563T3 (https=) |
| IL (1) | IL263995B (https=) |
| MA (1) | MA45603A (https=) |
| MX (2) | MX389920B (https=) |
| SG (1) | SG11201900096QA (https=) |
| WO (1) | WO2018009597A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109563077B (zh) | 2016-07-07 | 2026-03-10 | 赛克里翁治疗有限公司 | 用于制备可溶性鸟苷酸环化酶刺激剂的新方法 |
| WO2018009602A2 (en) * | 2016-07-07 | 2018-01-11 | Ironwood Pharmaceuticals, Inc. | Novel processes for preparation of soluble guanylate cyclase stimulators |
| MA71753A (fr) | 2018-01-10 | 2025-05-30 | Cyclerion Therapeutics, Inc. | Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de guanylate cyclase soluble |
| WO2019161534A1 (en) * | 2018-02-22 | 2019-08-29 | Ironwood Pharmaceuticals, Inc. | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013101830A1 (en) | 2011-12-27 | 2013-07-04 | Ironwood Pharmaceuticals, Inc. | 2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators |
| WO2014144100A2 (en) | 2013-03-15 | 2014-09-18 | Takashi Nakai | Sgc stimulators |
| WO2015089182A1 (en) | 2013-12-11 | 2015-06-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| WO2016044447A1 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | Pyrazole derivatives as sgc stimulators |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ603789A (en) * | 2010-05-26 | 2015-03-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| AR088020A1 (es) | 2010-06-30 | 2014-05-07 | Ironwood Pharmaceuticals Inc | Compuestos heterociclicos como estimuladores de sgc |
| US9487508B2 (en) * | 2012-09-19 | 2016-11-08 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
| EP3194386A2 (en) * | 2014-09-17 | 2017-07-26 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| US20170298055A1 (en) * | 2014-09-17 | 2017-10-19 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| KR20170055531A (ko) * | 2014-09-17 | 2017-05-19 | 아이언우드 파마슈티컬스, 인코포레이티드 | 에스지씨 자극제 |
| CA3006746C (en) * | 2015-11-30 | 2024-01-30 | Ironwood Pharmaceuticals, Inc. | Solid dispersions comprising a sgc stimulator |
| WO2018009602A2 (en) | 2016-07-07 | 2018-01-11 | Ironwood Pharmaceuticals, Inc. | Novel processes for preparation of soluble guanylate cyclase stimulators |
| MX389964B (es) * | 2016-07-07 | 2025-03-19 | Cyclerion Therapeutics Inc | Formas sólidas de un estimulador de guanilato ciclasa soluble (sgc). |
| CN109563077B (zh) | 2016-07-07 | 2026-03-10 | 赛克里翁治疗有限公司 | 用于制备可溶性鸟苷酸环化酶刺激剂的新方法 |
| CA3086207A1 (en) * | 2017-12-19 | 2019-06-27 | Cyclerion Therapeutics, Inc. | Sgc stimulators |
| MA71753A (fr) * | 2018-01-10 | 2025-05-30 | Cyclerion Therapeutics, Inc. | Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de guanylate cyclase soluble |
-
2017
- 2017-07-06 CN CN201780047020.6A patent/CN109563077B/zh active Active
- 2017-07-06 MX MX2019000105A patent/MX389920B/es unknown
- 2017-07-06 CN CN202511803316.9A patent/CN121673266A/zh active Pending
- 2017-07-06 EA EA201990237A patent/EA201990237A1/ru unknown
- 2017-07-06 MA MA045603A patent/MA45603A/fr unknown
- 2017-07-06 CA CA3029375A patent/CA3029375A1/en active Pending
- 2017-07-06 KR KR1020197003459A patent/KR102487872B1/ko active Active
- 2017-07-06 ES ES17745553T patent/ES2963563T3/es active Active
- 2017-07-06 EP EP17745553.2A patent/EP3481818B1/en active Active
- 2017-07-06 US US16/315,218 patent/US11319308B2/en active Active
- 2017-07-06 EP EP23185002.5A patent/EP4249488A3/en active Pending
- 2017-07-06 SG SG11201900096QA patent/SG11201900096QA/en unknown
- 2017-07-06 WO PCT/US2017/040810 patent/WO2018009597A1/en not_active Ceased
- 2017-07-06 AU AU2017291827A patent/AU2017291827B2/en active Active
- 2017-07-06 JP JP2019500355A patent/JP7112384B2/ja active Active
- 2017-07-06 BR BR112019000291A patent/BR112019000291A2/pt not_active Application Discontinuation
-
2018
- 2018-12-27 IL IL263995A patent/IL263995B/en active IP Right Grant
-
2019
- 2019-01-04 CL CL2019000016A patent/CL2019000016A1/es unknown
- 2019-01-07 MX MX2022001495A patent/MX2022001495A/es unknown
-
2022
- 2022-03-30 US US17/708,296 patent/US11773089B2/en active Active
-
2023
- 2023-01-24 CL CL2023000228A patent/CL2023000228A1/es unknown
- 2023-08-24 US US18/237,435 patent/US20240059684A1/en not_active Abandoned
-
2025
- 2025-04-23 US US19/187,279 patent/US20260103457A1/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013101830A1 (en) | 2011-12-27 | 2013-07-04 | Ironwood Pharmaceuticals, Inc. | 2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators |
| WO2014144100A2 (en) | 2013-03-15 | 2014-09-18 | Takashi Nakai | Sgc stimulators |
| WO2015089182A1 (en) | 2013-12-11 | 2015-06-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| WO2016044447A1 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | Pyrazole derivatives as sgc stimulators |
Also Published As
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| US11773089B2 (en) | Process for preparation of soluble guanylate cyclase stimulators | |
| US12247025B2 (en) | Processes for preparation of soluble guanylate cyclase stimulators | |
| US20220024909A1 (en) | Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators | |
| HK40103206A (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
| HK40007031A (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
| HK40007031B (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
| EA047613B1 (ru) | Новые способы получения стимуляторов растворимой гуанилатциклазы | |
| EA041479B1 (ru) | Новые способы получения промежуточных соединений для синтеза стимуляторов растворимой гуанилатциклазы | |
| OA19467A (en) | Novel processes for preparation of soluble Guanylate Cyclase stimulators. | |
| EA040047B1 (ru) | Новые способы получения стимуляторов растворимой гуанилатциклазы | |
| OA19466A (en) | Novel processes for preparation of soluble Guanylate Cyclase stimulators. | |
| HK40007032A (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
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