JP2019524674A5 - - Google Patents
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- JP2019524674A5 JP2019524674A5 JP2018568296A JP2018568296A JP2019524674A5 JP 2019524674 A5 JP2019524674 A5 JP 2019524674A5 JP 2018568296 A JP2018568296 A JP 2018568296A JP 2018568296 A JP2018568296 A JP 2018568296A JP 2019524674 A5 JP2019524674 A5 JP 2019524674A5
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- hydroxyl protecting
- alkyl
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- 0 CC(*)CCCNC Chemical compound CC(*)CCCNC 0.000 description 5
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022073976A JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2024020885A JP2024056892A (ja) | 2016-06-30 | 2024-02-15 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662357031P | 2016-06-30 | 2016-06-30 | |
| US62/357,031 | 2016-06-30 | ||
| PCT/US2017/040401 WO2018006031A1 (en) | 2016-06-30 | 2017-06-30 | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022073976A Division JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524674A JP2019524674A (ja) | 2019-09-05 |
| JP2019524674A5 true JP2019524674A5 (enExample) | 2020-08-06 |
| JP7068204B2 JP7068204B2 (ja) | 2022-05-16 |
Family
ID=60786711
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568296A Active JP7068204B2 (ja) | 2016-06-30 | 2017-06-30 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2022073976A Active JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2024020885A Pending JP2024056892A (ja) | 2016-06-30 | 2024-02-15 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022073976A Active JP7440563B2 (ja) | 2016-06-30 | 2022-04-28 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| JP2024020885A Pending JP2024056892A (ja) | 2016-06-30 | 2024-02-15 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11136335B2 (enExample) |
| EP (1) | EP3478691A4 (enExample) |
| JP (3) | JP7068204B2 (enExample) |
| KR (1) | KR102404629B1 (enExample) |
| CN (2) | CN114805322B (enExample) |
| IL (2) | IL263845B (enExample) |
| MX (1) | MX390072B (enExample) |
| SG (1) | SG11201811671XA (enExample) |
| WO (1) | WO2018006031A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2522663T3 (pl) | 2004-06-03 | 2015-08-31 | Eisai R&D Man Co Ltd | Produkty pośrednie do otrzymywania halichondryny B |
| CN108948039B (zh) | 2007-10-03 | 2021-12-31 | 卫材R&D管理有限公司 | 用于合成软海绵素b类似物的中间体和方法 |
| CN102803254B (zh) | 2010-01-26 | 2016-09-14 | 卫材R&D管理有限公司 | 用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物 |
| CN105683198B (zh) | 2013-11-04 | 2019-03-12 | 卫材R&D管理有限公司 | 软海绵素b的类似物合成中有用的大环化反应和中间体 |
| HUE043088T2 (hu) | 2013-12-06 | 2019-08-28 | Eisai R&D Man Co Ltd | Halikondrin B analógok szintézisében alkalmazható eljárások |
| RU2020141025A (ru) | 2015-05-07 | 2020-12-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Реакции макроциклизации и промежуточные соединения и другие фрагменты, полезные в синтезе макролидов галихондринов |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| KR20250057138A (ko) | 2018-01-03 | 2025-04-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물 |
| US11396515B2 (en) | 2018-03-02 | 2022-07-26 | Beijing Tienyi Lufu Pharmatech Co. Ltd. | Pyran fused ring compound, preparation method therefor and use thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU652180A1 (ru) | 1975-12-16 | 1979-03-15 | Краснодарский политехнический институт | 1(Фурил-2,)-2-(2-,, формилфурил-5,, ) этилен или его метильное производное как промежуточный продукт дл синтеза фуран-2,5-дикарбоновой кислоты и способ его получени |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| TW255880B (enExample) | 1992-09-09 | 1995-09-01 | Hoechst Ag | |
| US6194586B1 (en) | 1996-09-06 | 2001-02-27 | Eli Lilly And Company | Selective sulphonation of the primary alcohol of a diol containing both primary and secondary alcohols |
| US6870058B2 (en) | 1996-12-03 | 2005-03-22 | The Trustees Of The University Of Pennsylvania | Compounds which mimic the chemical and biological properties of discodermolide |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| HU227912B1 (en) | 1998-06-17 | 2012-05-29 | Eisai R & D Man Co | Halichondrin analogs and methods of their use and preparation |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| DE10106647A1 (de) | 2001-02-12 | 2002-08-22 | Univ Hannover | Ratjadon-Derivate zum Hemmen des Zellwachstums |
| PL2522663T3 (pl) | 2004-06-03 | 2015-08-31 | Eisai R&D Man Co Ltd | Produkty pośrednie do otrzymywania halichondryny B |
| US20060045846A1 (en) | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
| EP1831697A4 (en) | 2004-12-09 | 2011-01-26 | Eisai R&D Man Co Ltd | SEARCH FOR TUBULINISOTYPES IN CANCER THERAPY USING HALICHONDRIN B ANALOG |
| JP2009510005A (ja) | 2005-09-26 | 2009-03-12 | シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト | 分子内プリンス反応および該反応に適する触媒 |
| WO2008010776A1 (en) | 2006-07-21 | 2008-01-24 | Agency For Science, Technology And Research | Aigialomycin d and derivatives thereof and their use in treating cancer or malaria or a microbial infection |
| US8119839B2 (en) | 2007-07-20 | 2012-02-21 | Yamada Apiculture Center, Inc. | Carboxylic acid and antidepressant composition containing the same as active ingredient |
| CN108948039B (zh) | 2007-10-03 | 2021-12-31 | 卫材R&D管理有限公司 | 用于合成软海绵素b类似物的中间体和方法 |
| US20090203771A1 (en) | 2007-11-16 | 2009-08-13 | Eisai R&D Management Co., Ltd. | Novel intermediate for halichondrin b analog synthesis and novel desulfonylation reaction used for the intermediate |
| CN105801599A (zh) | 2008-04-04 | 2016-07-27 | 卫材R&D管理有限公司 | 软海绵素b类似物 |
| JP5371091B2 (ja) | 2009-01-23 | 2013-12-18 | 三菱レイヨン株式会社 | モノスルホン酸エステルの製造方法 |
| CN102803254B (zh) | 2010-01-26 | 2016-09-14 | 卫材R&D管理有限公司 | 用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物 |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| CA2857385A1 (en) | 2011-11-30 | 2013-06-06 | Alphora Research Inc. | Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene |
| US9278979B2 (en) | 2012-03-30 | 2016-03-08 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein |
| US9850254B2 (en) | 2013-07-03 | 2017-12-26 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO2-(p-tolyl) groups |
| CN105683198B (zh) * | 2013-11-04 | 2019-03-12 | 卫材R&D管理有限公司 | 软海绵素b的类似物合成中有用的大环化反应和中间体 |
| HUE043088T2 (hu) | 2013-12-06 | 2019-08-28 | Eisai R&D Man Co Ltd | Halikondrin B analógok szintézisében alkalmazható eljárások |
| EP3191479B1 (en) | 2014-09-09 | 2020-04-08 | Cipla Limited | "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof" |
| RU2020141025A (ru) | 2015-05-07 | 2020-12-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Реакции макроциклизации и промежуточные соединения и другие фрагменты, полезные в синтезе макролидов галихондринов |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| WO2018217894A1 (en) | 2017-05-24 | 2018-11-29 | Eisai R&D Management Co., Ltd. | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
| KR20250057138A (ko) | 2018-01-03 | 2025-04-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물 |
-
2017
- 2017-06-30 SG SG11201811671XA patent/SG11201811671XA/en unknown
- 2017-06-30 KR KR1020197002930A patent/KR102404629B1/ko active Active
- 2017-06-30 US US16/313,196 patent/US11136335B2/en active Active
- 2017-06-30 CN CN202210653392.6A patent/CN114805322B/zh active Active
- 2017-06-30 MX MX2018016329A patent/MX390072B/es unknown
- 2017-06-30 EP EP17821400.3A patent/EP3478691A4/en not_active Withdrawn
- 2017-06-30 WO PCT/US2017/040401 patent/WO2018006031A1/en not_active Ceased
- 2017-06-30 JP JP2018568296A patent/JP7068204B2/ja active Active
- 2017-06-30 CN CN201780052964.2A patent/CN109641917B/zh active Active
-
2018
- 2018-12-19 IL IL263845A patent/IL263845B/en unknown
-
2021
- 2021-11-28 IL IL288460A patent/IL288460B2/en unknown
-
2022
- 2022-04-28 JP JP2022073976A patent/JP7440563B2/ja active Active
-
2024
- 2024-02-15 JP JP2024020885A patent/JP2024056892A/ja active Pending
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